"Quinidine": malangizo ntchito, zikuchokera, kufotokoza ndi ndemanga

N'chifukwa chiyani tiyenera chida monga "quinidine"? Malangizo ntchito, mtengo, ndi ndemanga poika mankhwala omwe anapereka m'munsimu. Mudzaphunziranso zimene zimatha pharmacological khalidwe la mankhwala, kaya ndi mbali zochita za khalidwe ndi kaya iye ali ndi malamulo alionse ntchito.

The zikuchokera, mawonekedwe, malongosoledwe

Kodi maonekedwe makampani mankhwala kupanga mankhwala "quinidine"? Malangizo Ntchito, zaikidwa zimenezi, ndiye kuti zikhoza kugulidwa mu mawonekedwe a mapiritsi mosabisa ndi lozungulira. Iwo amakhala othandiza kwa nthawi yaitali ndiponso filimu-lokutidwa.

Chofunika waukulu wa mankhwala awa ndi quinidine sulphate. Malangizo, mankhwala kufotokoza sapereka mfundo iliyonse pa zinthu zina.

Asatayike mankhwala Zamgululi

Kodi mankhwala "quinidine"? Malangizo ntchito, maonekedwe, ndemanga onena kuti ndi yothetsera Maphunziro IA arrhythmia. Iwo amatha msanga mayendedwe a ayoni kudzera Na njira maselo makoma kusala kudya kwa cardiomyocytes ndi kuchepetsa liwiro depolarization nadzawonjezapo pa nthawi ya angathe kuchitapo kanthu ndi refractory (zothandiza) kutalika kwa nthawi.

Phwando medicament ndi attenuates m'mnyewa wamtima excitability, kubweza automaticity ndi AV-conduction mu mfundo ndi, mtolo chipika nthambi, matenda ndi nyumba zina. Komanso ankaona njira lili ndi zotsatira vagolytic kuwawonetsera mamita-anticholinergic tingati amachepetsa ntchito (contractility) a minofu mtima ndipo amachititsa kuchepetsa magazi.

katundu wa mankhwala

Kodi chidwi ndi mankhwala monga "quinidine"? Malangizo ntchito limati akhoza kukhala oipa inotropic kwenikweni. Izi zimachitika chifukwa cha deceleration wa mkati mphamvu ndondomeko kutembenuka mu mitochondria. Ndi nkhani ya katundu antiarrhythmic mankhwala, iwo ali oyanjana ndi pamaso pa magulu amide mu dongosolo molekyulu wa chinthu yogwira.

Malinga ndi akatswiri, zakudya za medicament izi kwambiri yafupika malemeredwe ndi kafalitsidwe mathamangidwe, amene amagwirizana ndi padzuwa la mbali yogwira mankhwala kuti ndondomeko depolarization.

Poletsa mamita-cholinergic zolandilira, ankaona mankhwala kumapangitsa AV-conduction. Pa mlingo achire izo akusonyeza katundu hypotensive kugwirizana ndi kucheperachepera kamvekedwe mitsempha zotumphukira ndi mitsempha, komanso oipa inotropic kwenikweni.

Sitingathe kunena kuti mankhwala akhoza kusonyeza m'dera zotsatira akutivutitsa. Lilinso analgesic ndi antipyretic katundu amene anagwirizana ndi kumafooketsa pa ubongo.

Makhalidwe pharmacokinetic wa

Odzipereka ngati amenewa pophika yogwira mankhwala monga quinidine sulphate? Malangizo ntchito imatiuza kuti phwando la wothandizila m'kamwa amalimbikitsa ndende lake lalikulu magazi pambuyo Mphindi 95.

Zimene ndi mapuloteni medicament ndi za 77-80%. biotransformation ake amapezeka m'chiwindi. Komabe, ena ofanana nawo amakuonani kanthu cardiotonic.

Hafu ya moyo chida pafupifupi 7 maola. Iwo anali anasamutsidwa mu impso. Ndi acidification ya mkodzo excretion medicament ukuwonjezeka ndi pamene alkalization ake - imathetsa.

Ndi zimene zinafotokozedwa?

ndi zizindikiro ntchito mankhwala ali "quinidine" n'chiyani? Malangizo Ntchito limanena kuti cholinga cha mankhwala yilungamitsidwa pokha pokha zotsatirazi:

• pa matenda tachycardia, AV-tachycardias, extrasystoles yamitsempha yamagazi ndi supraventricular, matenda fibrillation matenda ndi flutter;
• kuteteza matenda tachycardia (supraventricular ndi yamitsempha yamagazi), ndipo yamitsempha yamagazi fibrillation;
• pambuyo cardioversion kukhalabe nkusani mungoli.

Ziletso ntchito

Kodi mmene wodwalayo kuletsa kugwiritsa ntchito mankhwala "quinidine"? Malangizo ntchito (mtengo wa mankhwala amene ali m'munsi) malipoti contraindications mankhwala, monga:

• cardiogenic mantha;
• AV-chipika (wachiwiri kapena wachitatu digiri);
• thrombocytopenic purpura, kumene pambuyo kutenga mankhwala;
• matenda (aakulu) intraventricular conduction;
• mtolo chipika nthambi
• digitalis kuledzera, amene anatsagana ndi kuvutika conduction;
• ndi matupi awo sagwirizana anachita mankhwala;
• myasthenia gravis.

Medicament "quinidine": malangizo ntchito

Landirani chida ayenera kukhala mkati mphindi 60 musanamwe kapena pambuyo Mphindi 125 pambuyo chakudya ndi galasi ndi madzi. Ngati mukufuna kuchepetsa zotsatira irritant mankhwala pa Kakhungu mucous pa mundawo m'mimba, m'pofunika m'malo madzi ndi mkaka.

Yaitali mankhwala ali osavomerezeka kutafuna kapena kugona tulo.

Mlingo muyezo imatengedwa 200-300 mg kanayi pa tsiku. Ngati supraventricular tachycardia (ndi paroxysms) kuchuluka izi kuchuluka kwa 400-600 mg ndi mawola 3 pamaso mavuto onse a paroxysm. Mu fibrillation matenda, medicament kulandira 200 mg lililonse 2 chasa (5-8 nthawi tsiku lililonse). M'menemo yokonza mlingo ndi 200-300 mg ndi kanayi pa tsiku.

Njira regimens: 400 mg (ngati kuukira sanali atazikocheza, 200 mg) aliyense mphindi 60 mpaka kuchotsa wathunthu kuukira, kapena kukwaniritsa mlingo okwana 1 g

Popeza mavuto pambuyo mlingo woyamba ku phwando wotsatira kuchuluka kwa medicament zochuluka 600 mg. Kutenga mankhwala owonjezera magalamu 4 pa tsiku ndikoletsedwa.

N'zimene ana

Mu mlingo wa mankhwala Kwalamulidwa kwa ana "quinidine Dyuruls"? Malangizo ntchito, madokotala mavoti amanena kuti muyezo mlingo wa wothandizila ili kwa ana 6 mg wa / kg nthawi 5 pa tsiku. Prescribers akhale yekha dokotala wodziwa, mosamalitsa pa umboni.

Zochita ndi-khalidwe

zotsatira zoipa angagwe pambuyo ntchito mankhwala "quinidine Durules"? Malangizo ntchito, ikulongosola za mankhwala zikusonyeza zotsatirazi zochita chowawa:

• asthenia, yowonjezera QRS imeneyi, myasthenia gravis;
• ectopic yamitsempha yamagazi kumenyedwa, kumva imfa;
• kusafuna kudya, yamitsempha yamagazi fibrillation, thrombosis wolumikizira m'munsi magazi;
• msokonezo zithunzi, yamitsempha yamagazi tachycardia, paroxysmal, tinnitus,
• asystole;
• nseru, nkusani bradycardia, matenda a chiwindi, kupweteka m'mimba, chisokonezo;
• gastralgia, mutu, kusanza, thrombocytopenia, kutsegula m'mimba, chizungulire, hemolytic magazi m'thupi;
• malungo, lupus-monga matenda, zotupa pa khungu.

Nthawi cha mankhwala osokoneza bongo

ndi zizindikiro cha mankhwala osokoneza bongo zingachititse mankhwala "quinidine Dyuruls" n'chiyani? Malangizo, ndemanga akatswiri kulankhula za mawonetseredwe monga tinnitus, maganizo a ntchito mtima, akuponya magazi, chizungulire, matenda flutter, diplopia, quinidine mantha, kumva imfa.

Kuthetsa limati ngati anakhudzidwa Kwalamulidwa chapamimba lavage, kotunga mpweya, hypertensive wothandizira, AKUYENDA, hemodialysis ndi othandizira.

Mwanjira mankhwala

Kodi kuchitira mankhwala interacts ndi zinthu monga kwinini? Malangizo ntchito (ndemanga mtengo wa medicament Adzaperekedwa ku mapeto a nkhani) inanena kuti kuphatikiza kumawonjezera kawopsedwe wa onse.

Komanso, "quinidine" mankhwala kucheza ndi mankhwala zotsatirazi:

• mankhwala Antiarrhythmic patsogolo kanthu cardiodepressive.
• Anticholinesterase mankhwala ndi mankhwala patsogolo zotsatira kalisodergaszczye "Quinidine".
• mankhwala Anticonvulsant kuchepetsa milingo magazi a "Quinidine" ndi kuchepetsa nchito zake chifukwa kukondoweza kwa kagayidwe ake.
• Mankhwalawa kuchepetsa mphamvu ndi ndende ya mankhwala mu magazi pansi obwereza.
• Mankhwala alkalising ya mkodzo, kumaonjezera ngozi ya zochita poizoni.
• Mankhwala "amiloride" ndi "Amiodarone" kuchepetsa mphamvu ya "Quinidine" ndi kutalika imeneyi ake QT, motero.
• asidi Acetylsalicylic chimafikira magazi, petechiae ndi kulimbikitsa magazi kuchokera ku ziwalo m'mimba.
• Medicaments "Warfarin" ndi "Verapamil" - kumatheka anticoagulant zotsatira za yoyamba ndi yachiwiri yafupika mlingo wa excretion.
• Mankhwala "Haloperidol" - kumawonjezera wokhutira mwa magazi ndi kumaonjezera ngozi ya zochita chowawa.
• Mankhwala "Hydroxyzine" ndi "dextromethorphan" - kumachititsa wa arrhythmia kwambiri ndi phwando woyamba ndi wachiwiri magazi.

tsatanetsatane

Mosamala wapadera anatchulidwa mankhwala osavomerezeka chifukwa aakulu mtima kulephera siteji 2-3, tachyarrhythmia (yamitsempha yamagazi) ndi elongation imeneyi QT, nkusani mfundo, AV-anatseka misewu 1 digiri, mphumu, hyperthyroidism, hypotension, matenda opatsirana pachimake, ndiko kumayambitsa , njingayo-kutsekedwa khungu, hypokalemia, chiwindi kulephera, thrombocytopenia, Prostate hyperplasia, aakulu aimpso kulephera, mkaka wa m'mawere, mimba ndi psoriasis.

Anthu ndi myocarditis ndi matenda ena m'mnyewa wamtima pamene kulandira "Quinidine" zonse ulamuliro mankhwala chofunika. Pamaso chithandizo, wodwala ayenera kupanga kuwukonza zizindikiro za hypokalemia ndi kulephera kwa mtima.

chithandizocho chofunika zonse kuwunika deta ECG wa magazi zotumphukira ndi hemodynamics.

Similar njira, mtengo

analogues mankhwala takambiranazi kwambiri. Akatswiri amanena kuti iwo njira zotsatirazi: "Kinidin Durules", "Bretilat", "procainamide", "Etatsizin" "lidocaine wa", "Amiokordin", "Propanorm", "Amiodarone" "Verapamil", "Propranolol", "Ritmonorm ".

Koma mitengo ya mankhwala monga "quinidine" ndi "quinidine Durules" nzika za dziko lathu, iwo sakudziwika chifukwa chakuti mankhwala awa salinso anagulitsa ku Russia. Komabe, iwo zikhoza kugulidwa ku Ukraine. Mtengo wa mankhwala dziko ndi za 540 ndi 670-679 hryvnia, motero, umene uli wofanana 1380 ndipo 1760-1780 rubles.

Reviews

Kodi anthu amanena zokhudza ankaona madokotala medicament ndi akatswiri ena? Malinga ndi iwo, chida ichi zikutsimikizira kuti kwambiri antiarrhythmic mankhwala, zimene zili zabwino ndi kudya zokwanira kuchiza matenda monga yamitsempha yamagazi ndi supraventricular tachycardia. Komabe, tisaiwale kuti apeze "quinidine" mapiritsi mu pharmacies Russian sizingatheke. Ichi ndi chifukwa chakuti mankhwala anali amachotsedwa ufulu aziyenda ndi salinso ntchito mu zipatala. Madokotala kufotokoza imeneyi chakuti pali abwino ndi othandiza kwambiri komanso mofanana angakwanitse mu msika mankhwala, amene mwachangu ntchito zizindikiro zomwezo. Pankhaniyi, akatswiri amanena kuti quinidine sulphate akupitiriza ntchito monga constituent zinthu multicomponent mu mankhwala ambiri odana arrhythmic.