Hyperandrogenism mu akazi: amachititsa, zizindikiro, chithandizo. The hyperandrogenism zowopsa akazi

Mu mankhwala, vuto kudziwika monga hyperandrogenism mu akazi. Zoyambitsa, zizindikiro, mankhwala ndi matenda amenewa amafuna kuwunika ndi nawo madokotala oyenerera. Ngakhale matenda ndi zovuta kuthetsa kwathunthu, kutembenukira kwa madokotala bwino mosataya nthawi.

Akamanena za matenda

Pankhani matenda monga hyperandrogenism mu akazi, amachititsa zizindikiro, mankhwala ndi njira zodzitetezera nthawi kugwirizana ndi vuto, monga momwe polojekitiyi pa adrogenov thupi. Zimenezi zimabweretsa kuoneka maonekedwe wamkazi wa makhalidwe chachimuna ndi ena kusintha si choncho zosangalatsa. Mwatsatanetsatane, tikulankhula za mawonetseredwe monga maonekedwe a ndevu ndi tsitsi thupi, chakuya mawu, ndipo amasintha ena zinthu chithunzi.

Dziwani mfundo yakuti akazi endocrine dongosolo kudwala Sizachilendo, ndipo sangathe amadzachita kusintha zosasangalatsa zakunja komanso chifukwa osabereka. Choncho, pamene zizindikiro loyamba hyperandrogenism, ayenera yomweyo amakonza ulendo kwa dokotala.

N'chifukwa chiyani kukhala ndi kudwala

Mutu wa "hyperandrogenism mu akazi: amachititsa zizindikiro mankhwala» Nkofunika kuti kugonana fairer, chifukwa vutoli zikusonyezedwa pafupifupi 20% odwala. Choncho n'zomveka kulabadira zinthu ndi zomwe zingachititse kuti chitukuko cha matenda.

chifukwa chachikulu zingadziŵike AGS - syndrome adrenogenital. Mfundo yofunika ndi kuti zopangitsa adrenal angathe kubala mahomoni zina zambiri, kuwonjezera adrogenov, monga glucocorticoids. Yotsirizira kuoneka mchikakamizo cha enzyme ena. Maziko asayembekezere ali anasonkhanitsa androgens. Nthawizina akazi ali kale pa kubadwa chilema cha enzyme, chifukwa mu mahomoni mwamuna si atatembenuzidwa, ndipo anasonkhana nthawi zonse, akhale chifukwa cha kusintha zosasangalatsa mu thupi wamkazi.

Pali ndondomeko ina imene akufotokozera chifukwa hyperandrogenism chiyambi adrenal. Tikuyankhula zokhudza zotupa za zopangitsa kwa adrenal. Iwo anapanga pa maziko a kuwonjezeka magawanidwe a androgens.

Ngozi ya matenda pamwambawa amapezeka mu choncho pamene pali ulimi wa mahomoni wamwamuna ambiri m'mimba mkazi. Komanso, maselo yotulutsa Adrogué zingachititse chotupa mapangidwe ambiri m'mimba lapansi.

hyperandrogenism syndrome ndi zina chifukwa cha kukhudzana kwa endocrine pathologies ziwalo zina, monga pituitary England.

Zizindikiro za owonjezera androgen

Ngati ife kulankhula za zizindikiro matenda a woipa okwera wa timadzi wamwamuna, iwo tinganene motere:

• ziphuphu zakumaso;
• mu imfa mphumi tsitsi ndi mawanga dazi (alopecia adrogennaya);

• zopangitsa sebaceous anayamba kubala yambiri katulutsidwe, chifukwa wochuluka ukuwonjezeka khungu;
• barifoniya kuti kumatanthauza kukulitsa mawu;
• pa mimba yake ndi chifuwa tsitsi kuonekera.

Dziwani chakuti hirsutism - kukula kwambiri tsitsi osachiritsika pa thupi wamkazi, amawapeza 80% odwala ndi vuto limeneli syndrome hyperandrogenism.

Ndi matenda ngati ena a fairer kugonana zotheka kusokonezeka kwa msambo, ndi anasiya kusamba, komanso m'mnyewa wamtima hypertrophy, kunenepa, osabereka, ndi matenda oopsa.

Anthu ambiri mahomoni wamwamuna zingachititse amveke wa mkazi thupi chiwopsezo matenda a mitundu yosiyanasiyana. N'zothekanso kutopa ndi chizolowezi nkhawa.

Ziphuphu zakumaso ndi sebaceous zopangitsa

Kuti timvetse bwino zoyenera kuchita ndi vuto monga hyperandrogenism azimayi osiyanasiyana, zizindikiro, chithandizo, ndi matenda muyenera kuganizira bwinobwino. Monga zinthu kuchititsa chitukuko cha matenda, takambiranazi pamwamba, n'zomveka kuphunzira makhalidwe zizindikiro.

Pamene inu musakhudze vuto limeneli ziphuphu zakumaso, ndi Dziwani kuti ndizo zotsatira za keratinization a linga follicle ndi kuchuluka kupanga sebum, amene kumapangitsa woipa androgen, kuphatikizapo plasma. Zizindikiro amenewa amakhala akuchipatala COCs kapena antiandrogens, amene amalola kwambiri kusintha mmene alili.

Komanso mchikakamizo mahomoni mwamuna mabacteria androgenozavisimyh kuoneka inki, wandiweyani, coarse tsitsi m'malo vellus. Nthawi zambiri amapezeka mu msinkhu. Pankhaniyi, mmene androgen pa nsidze, ndi nsidze, kanthawi ndi occipital mbali ndi kochepa.

adrenal hyperandrogenism

M'pofunikanso kukumbukira kuti England adrenal - ndi zopangitsa awiri endocrine kuti zili chabe pamwamba impso okha.

Iwo ali gwero la 95% umatulutsa androgen (DHEA-sulfate). Kuvuta kwa hyperandrogenism kugwirizana ndi zopangitsa awa, inali yakuti kudwala ndi kobadwa nako mu chirengedwe, ndi kuvumbitsira lokha anamva pa maziko androgenitalnogo syndrome. Zimadzetsa kuonongeka kwa kuchepa msinkhu zovuta thupi michere wamkazi zofunika kutulutsa mahomoni monga glucocorticoids.

Hyperandrogenism cha adrenal chiyambi oubslovlena ndi vuto limeneli, imbaenda ndi kuwonjezeka mu woipa mahomoni ena -. pregnenolone, progesterone, etc. kusintha oterewa anamaliza chodziwa yopanga androgen mu thupi wamkazi.

Nthawi zina matenda kudwala, omwe chifukwa cha zotupa za zopangitsa adrenal amene mudameretsa timadzi wamwamuna. Malinga ndi kafukufuku, mawonekedwe a matenda monga hyperandrogenism adrenal chili mu 30-50% ya akazi ndi vuto androgen.

Impact pa thumba losunga mazira ndi

The mkulu wa ndende mahomoni wamwamuna zingakhudze ntchito kwa thumba losunga mazira ndi. Nthawi zambiri, vuto izi zimawapangitsa yokha imaonekera mu njira ziwiri: gipertekoz ndi polycystic. Nkofunika kulabadira chakuti kudwala matenda izi akazi kumawonjezera ndi zonse amasonyeza mphamvu masewera.

Yamchiberekero hyperandrogenism ndi zotsatira za liwiro kukula follicles mchikakamizo cha androgens. Chifukwa cha izi ndi zigwirizana mazira, chifukwa cha njira zoterozo amakhala imperforate zapitazi. Dzina chamankhwala vutoli - follicular atresia.

Koma si mavuto onse kuti ayende yamchiberekero hyperandrogenism chiyambi. Mfundo yofunika ndi kuti timadzi mwamuna amachita ngati chinthu chimodzi umene akufotokozera nthenda mapangidwe fibrous connective minofu, imbaenda polycystic. Imeneyi, uthenga wabwino ndi chakuti nayenso anakumana% 5 okha pa akazi.

Komanso Dziwani kuti mawonekedwe hyperandrogenism, kugonana fairer ndi chifukwa cha kulephera kwa lamulo chapakati milingo androgen. ndondomeko izi zikuchitika pa mlingo wa ubongo imene imalamulira kutentha ndi pituitary. Chifukwa cha kusintha m'thupi kwambiri.

Zizindikiro kuti muyenera kulabadira

Pali zizindikiro zikusonyeza pakutchulidwa vuto tafotokozazi. Mfundo yakuti ife kukhala monga kudwala chiyambi hyperandrogenism yamchiberekero, mungazipeze pa mawonetseredwe zotsatirazi:

• kufooka kwa mafupa;
• seborrhea;
• pa nkhope, kuwonjezera ziphuphu zakumaso, pali ukuchoka ndi kutupa, amene ali ovuta n'chongoletsa njira kabwerebwere wa cosmetology;
• minofu ya manja;
• kunenepa;
• kusintha anapangira thupi wamkazi - masculinization;
• kuzama kwa mawu (barifoniya);
• kukula kwa tsitsi lonse thupi, ngakhale mu nkhope;
• mapangidwe yamawangamawanga dazi pamutu.

Komanso, pali zizindikiro zambiri sekondale, monga kuchepetsa magazi shuga, wolumikizira oopsa, chitetezo chokwanira yafupika, ndi ena.

kulemera owonjezera

Kunenepa mu akazi zingachititse yamchiberekero hyperandrogenism tafotokozazi. Mu mawonekedwe a matenda kawirikawiri atathana kulera estradiol.

phunziro Medical kunachitidwa, chimene kutsimikizira mfundo izi: mmene mkulu Kuchuluka kwa timadzi wamwamuna, ndipo imawalamulira wa estrogens ndi zimakhudza mwachindunji pa chitukuko cha kunenepa, ofanana wamwamuna mtundu.

Zimene zimachitika chifukwa cha insulin amadalira amveke ndi ndende wotsatira kukula timadzi mu thupi la akazi wamwamuna akudwala matenda tafotokozazi. Nthawi zina, androgens bwanji akazi ayi sikelo kudzera chapakati mantha dongosolo.

mawonekedwe wosanganiza

Madokotala fupipafupi kuthana ndi njira zosiyanasiyana za chiwonetsero cha hyperandrogenism. Zimenezi anafotokoza chifukwa chakuti nthawi yomweyo pali siudzalandilidwa ngathi lamulo la ntchito adrenal ndi yamchiberekero.

Kutheka mavuto ngati n'kofunika kuganizira mu kuphunzira zimene n'koopsa hyperandrogenism mu akazi. Ndipotu, izi zikuchitika: androgens adrenal, akupanga mu zopangitsa kwa adrenal, motero patsogolo mlingo wa mahomoni wamwamuna ambiri m'mimba lapansi. ndondomeko izi zimachitika mu magazi, imbaenda kuchuluka kupanga luteinizing timadzi. Otsiriza, nayenso, amakwiya maonekedwe a syndrome hyperandrogenism.

Zadzidzidzi wosanganiza mitundu ya kudwala akhoza zimachitika zoopsa kwambiri, kuledzera ubongo kapena pituitary chotupa.

diagnostics

Poyamba, dokotala ayenera anapambulwa pa matenda ena hyperandrogenic umene akufotokozera (acromegaly, syndrome Cushing ndi, matenda a chiwindi ndi ena.). Chotsatira ndi kudziwa timadzi ta m'thupi. Ndondomeko ziyenera kuchitidwa pa chopanda kanthu m'mimba m'mawa. Kupenda zinthu ayenera kuchita katatu mahomoni ndi mkulu androgen ndende zonse kusintha.

Akunena kwa mlingo wa dehydroepiandrosterone, nkhani mkulu amene adzakhala umboni wa hyperandrogenism adrenal. M'pofunikanso ndi mlingo wa ketosteroids mu mkodzo. Ngati zili kunja mwakale, n'zomveka kuganiza chitukuko cha kudwala.

zochiritsira

Hyperandrogenism - ichi kwambiri moti nkhani kunyalanyaza kuti madokotala oyenerera. Ndipo ngati ife tisanthule njira yonse ya mankhwala, Ndizachidziwikire kuti umalimbana kukwaniritsa zolinga zinayi izi:

• mawonetseredwe removals khungu;
• normalization wa kuzungulira kusamba;
• chithandizo kukhala osabereka, amene chifukwa cha anovulation;
• Kupha ndi kuteteza matenda kagayidwe kachakudya zokhudzana ndi matenda chachikulu.

Kudya hyperandrogenism mu akazi Amasankhidwa zinachitikira Kuwonjezeka kulemera. Pankhaniyi, ndikofunika ndendende kutsatira malangizo onse a dokotala, koma pansi chikhalidwe ichi, ndipo mukhoza kupeza zotsatira zolondola.

Anthu odwala omwe ali mwana, nthawi zambiri, mankhwala timadzi mankhwala amene angathe kupereka ovulation zonse.

Akazi amene sali akukonzekera kukhala ndi pakati, kukumana mankhwala, kuphatikizapo kulera m'kamwa, ndi zina, yamchiberekero mphero resection.

Kukonzekera chithandizo cha hyperandrogenism mu abambo komanso mwakhama ntchito ngati thupi sangathe n'chongoletsa kofunikira kwambiri pa androgen yekha. Tikuyankhula zokhudza zipangizo monga "metipred" "Dexamethasone" ndi ena. Opaleshoni akhoza ziletso kukachitika kuti zinayambitsa chotupa kudwala.

zotsatira

The mkulu wa ndende mahomoni wamwamuna mu thupi wamkazi - zoposa vuto lalikulu limene zambiri akufotokozera pa maziko a matenda chimodzimodzi oopsa. Choncho, pamene woyamba zizindikiro za matenda ndi mankhwala ayenera kuchitidwa ndithu.