"Esomeprazole": malangizo ntchito kwenikweni Anzawo

"Esomeprazole" - mankhwala wa Organotropona mankhwala m'mimba. Mankhwala ali kanthu antiulcer ndipo ndi pulotoni mpope woletsa.

The zikuchokera, amasulidwe mawonekedwe "esomeprazole" mankhwala

Mankhwala akupezeka mu mawonekedwe a miyala ndi mlingo wa 20 ndi 40 mg wa yogwira pophika esomeprazole, komanso mu mawonekedwe a ufa anafuna njira jekeseni (40 mg wa mbale). TACHIMATA mapiritsi, yanyumba zomwe zimachitika intestine lapansi.

Pharmacological kanthu "esomeprazole" mankhwala

ndi mankhwala "esomeprazole" n'chiyani? Malangizo ntchito imasonyeza kuti wothandizila antiulcer, lomwe, pokhala chofooka m'munsi, amalandira thupi lithe pambuyo ingestion. "Esomeprazole" kumabwezera mmbuyo enzyme H ⁺ -K ⁺ -ATPase ntchito, ndipo katulutsidwe wa acid amathiridwa (inalimbikitsa, woyambira). kanthu kofunika chimachitika mu ola pambuyo ingestion mankhwala. Pamene kulandira "esomeprazole" anapanga tsiku kwa masiku asanu, kololeka tsiku mlingo - 20 mg wa pambuyo kukondoweza mwa pentagastrin mlingo pazipita acid amathiridwa yafupika zayamba (90%).

Pharmacokinetics

"Esomeprazole" malangizo ntchito monga mankhwala amene, ozama mkati thupi, mofulumira komanso odzipereka, chimamanga zonsezo pafupifupi 100% (97%). The bioavailability chinawonjezeka ndi ntchito mobwerezabwereza mankhwala kwa 64 kuti 89%. The medicament zimatengera mtundu wa metabolites ndi excreted makamaka mu mkodzo, gawo laling'ono zace pano mu chimbudzi.

Zikuonetsa "esomeprazole" kukonzekera

"Esomeprazole" analogues ntchito odwala ndi gastroesophageal matenda Reflux mankhwala ndi muyambirenso kupewa. Chida ntchito pa matenda a zilonda za m'mimba kapena duodenum, pofuna kupewa matenda akuwuka chifukwa NSAIDs.

Mankhwala ntchito chironda chachikulu pamene anakhudzidwa duodenum kapena m'mimba. Thiabendazole angagwiritsidwe ntchito kwa odwala amene wochiritsidwa esophagitis, nthawi yaitali kupewa kumwa. Chovomerezeka ntchito limodzi ndi njira "esomeprazole" mankhwala antibacterial. Mapiritsi ndi jekeseni mu mankhwala zovuta Pankhaniyi amalola kuononga Helicobacter pylori.

Contraindications kulandira "esomeprazole" mankhwala

Contraindications monga zaka zosakwana zaka khumi ndi ziwiri, hypersensitivity kuti esomeprazole, nthawi yoyamwitsa. Zotsatira za mankhwala sanali kukhazikika pa mimba.

Kagwiritsidwe mankhwala

mankhwala ntchito mlingo tsiku la 20-40 mg. Kutalika kwa mankhwala anatsimikiza zikuonetsa kamwedwe ndi phwando Mwachangu medicament "esomeprazole". Mapiritsi ndi zovuta madzi yankho pa insufficiency aimpso ntchito mlingo pazipita 20 mg.

Erosive Reflux esophagitis chithandizo cha masabata anayi ndi mlingo tsiku la 40 mg. Pa kupewa yaitali zisadzachitikenso zochokera phwando zikutanthauza wodwala amene esophagitis wochiritsidwa uja, tsiku mlingo amayikidwa mu osiyanasiyana 20 mg.

Mu mankhwala a Reflux oesophagitis, kuthetsa zakuya zizindikiro matenda, kutenga 20 mg wa mankhwala "esomeprazole". Kukonzekera mu mawonekedwe a miyala ndi fumbi ntchito kupha H. Pylori, pamene pali kulankhulana ndi mmatumbo chilonda, osakaniza mankhwala ndi - "esomeprazole" (20 mg), "Clarithromycin (500 mg)," amoxicillin "(1 g). mankhwala onse atengedwa kawiri pa tsiku.

zilonda zam'mimba chifukwa cha NSAIDs, Ndi bwino kuchitira 20 mg wa "esomeprazole" patsiku. Mlingo anakhumba nthawi zonse anatumizidwa dokotala amaganizira thanzi la wodwala matendawa, choopsa kumene ake, ndi zinthu zina zofunika.

Zotsatira zoyipa "esomeprazole" mankhwala

Odwala amene akutenga mankhwala kwa nthawi yaitali, ndi zambiri sachedwa mapangidwe cysts glandular m'mimba kuposa ena odwala. Nthawi zambiri chowawa maonekedwe a thupi pa chithandizo amatanthauza "esomeprazole" malangizo ntchito allocates mutu ndi zina kukwiya kwa mundawo m'mimba, monga: kudzimbidwa, flatulence, kutsekula m'mimba, nseru, kusanza, pamaso pa ululu pamimba. Ndi zotsatira n'kukhala mbali monga kuyanika wa mucosa mkamwa, chizungulire, urticaria, kuyabwa, dermatitis. Machitidwe ena nzotheka, kotero mankhwala ziyenera kuperekedwa mosamalitsa kuyang'aniridwa ndi katswiri.

Ambiri osokoneza limodzi ndi kufooka ambiri, kuchuluka zochitika mavuto, kuphatikizapo ya thirakiti m'mimba. Zikatero, chithandizo imagwiridwa ndi kuchotsa zizindikiro cha mankhwala osokoneza bongo ndi kukonza mankhwala. Dialysis ali pafupifupi ziribe mphamvu ankafunila, palibe yothetsera.

Kusamala

Amayi oyembekezera "esomeprazole" analogs kutumikiridwa ndi kusamala kwambiri. Chithandizo pa mimba ayenera kuyang'anira ndi dokotala. mankhwala Kwalamulidwa kwa amayi oyembekezera okha milandu kumene Impact zabwino matupi awo kwambiri kuposa mavuto lingathe mwana osabadwa. deta zodalirika zotsatira za mankhwala pa Ndisanaumbidwe sichinafike, kutali zedi ayenera kupewa chithandizo ndi mankhwala. Ntchito mankhwala "esomeprazole" pamene kuyamwitsa ndikoletsedwa.

Pamene kuyan'anila za chiwindi choposa kuika mlingo n'koopsa thanzi (ngati kuyan'anila izi zimakhala zoopsa).

Zizindikiro wodwalayo amalembedwa mbendera, monga hematemesis, dysphagia, nseru, kwambiri kuchepetsa thupi pa chithandizo nthawi "esomeprazole" pofuna kuthetsa kapena chilonda chifukwa kutenga mankhwala pamaso pa matenda anaganiza, chotupa chija ayenera zichotsedwa. Kudziwa chikhalidwe zilonda za zotupa m'pofunika kuti aziphunzira naye.

Odwala amene alibe sucrase-isomaltase, kumtundu fructose tsankho khalidwe Sudzaloledwa "esomeprazole" ofanana.

Mogwirizana "esomeprazole" ndi mankhwala ena

Ndi ntchito munthawi yomweyo mankhwala ndi "citalopram", "clomipramine", "imipramine" zotheka potentiation wa wothandizila awa, kusintha kwa mankhwala yogwira m'magazi. Pamene ntchito molumikizana ndi "esomeprazole" yafupika Mwachangu "ketoconazole" "Itraconazole" worsens mayamwidwe awo.

Pamene kaphatikizidwe ndi "esomeprazole" ndi "ATV" wakhala kuchepa kwambiri padzuwa la mankhwala. "Esomeprazole" malangizo opaleshoni ali osavomerezeka ntchito imodzi ndi "phenytoin", "clomipramine", "imipramine" ndi mankhwala monga "citalopram", "ntchito diazepam", "Nelfinavir" ndi "Atazanavir". Mlingo wa mankhwala akhoza kukwera magazi, kotero izo zikhoza kukhala zofunika kuti ndichepe Mlingo wawo. Concomitant ntchito «esomeprazole" ndipo limatanthauza "clarithromycin" kumabweretsa kusintha yokulirapo mu kukhudzana "esomeprazole" zimachitika kuwonjezeka ake kugwirizana ndi chopinga wa kagayidwe mankhwala. Amene ayenera mosamala instrukiyu kuti mankhwala ndi kukaonana ndi katswiri.

Mtengo wa mankhwala, ndemanga za mankhwala "esomeprazole"

mankhwala makamaka anagula mu mawonekedwe piritsi. Pharmacies "esomeprazole" mungazipeze pa maina malonda "Nexium" ndi "Emanera". Pamene inu kugula mankhwala "esomeprazole" mtengo zimadalira mlingo wa mankhwala yogwira mu kapangidwe kake. Mtengo wa mankhwala pa mlingo wa 20 mg ( "Emanera") ndi pafupifupi 500 rubles. chifukwa mapiritsi 28 ndipo watsimikiza ndi Mlengi. Mankhwala ndi mlingo wa mg wa 40 wa yogwira pophika ( "Nexium" mapiritsi 28) zikhoza kugulidwa kwa rubles 3000.

"Esomeprazole" ali ndemanga makamaka positive. Iwo anati mankhwala katundu ziletsa asidi katulutsidwe, onse woyambira ndi chidwi. Mankhwala wasonyeza mkulu efficacy mankhwalawa zinthu zimene zikugwirizana ndi zizindikiro zafotokozeredwa malangizo. Pa mankhwala, izi zikutanthauza kuti pali Mwina pang'ono mavuto. Osati aliyense mosavuta kupeza mankhwala mu pharmacies, odwala ena amene adalandira "esomeprazole", mtengo zikuwoneka mkulu.

Amene anatenga mankhwala zotchulidwa dokotala pambuyo tanthauzo lenileni la matenda ndi mlingo, yang'anirani kuwongolera kwambiri thanzi. Monga mauniko, "Nexium" chotchuka kwambiri pakati pa odwala kuposa "Emanera". Pamene "Nexium" chapamimba amapereka kuoneka mukufuna pambuyo mwezi ukatha mwambo wa mankhwala. Kuwonjezera chikhalidwe angayambe pambuyo masabata 1.5 chithandizo. Zotsatira zake zoyipa n'zochepa kwambiri. Mankhwala "Nexium" chothandiza, amawathandiza kuwonongedwa kwa zinthu anatchula malangizo. Kuti Zotsatira zake zinali zabwino, m'pofunika kumaliza njira yonse ndi mtima wonse kutsatira malangizo dokotala.

Analogs "esomeprazole"

Mungachite zotsatirazi zikhoza siyanitsa ndi analogues wa mankhwala:

• "Omeprazole" - amatchedwanso "Losek", "Omez", "Ultop";
• "Rabeprazole" - yokonzekera amadziwika pansi maina "Ontaym", "Zulbeks", "Noflyuks" "Pariet", "Hayrabezol";
• "Pantoprazole" ( "Sanpraz", "Kontrolok", "Nolpaza");
• "Lansoprazole" ( "lanza", "Lanzoptol").

mankhwala onsewa ndi mavuto ofanana, koma amasiyana ndi mnzake mu phindu.

Zikufanana "esomeprazole" ndi "Omeprazole". Kusiyana mankhwala awa ndi zoonekeratu. "Esomeprazole" ndi isomer "omeprazole". kukonzekera ili, kuyambira deta zachipatala mabuku, ali ndi mwayi ndithu, koma chinthu chimodzimodzi medicaments. "Omeprazole" ndi mankhwala ziriri phindu kwa kuchuluka kwa mavuto. Ngati tikulingalira zimatha "esomeprazole", mankhwala zikufotokozedwa monga bwino Baibulo la "omeprazole", mtengo umene kwachititsa odwala ambiri. Komabe, "esomeprazole" zokayikitsa chifukwa zochita zapathengo, kotero kugula ake imatengedwa yopindulitsa kwambiri pogula "Omeprazole".

"Rabeprazole" ndi "esomeprazole" ndi ofanana mipweya, amachitira matenda omwewo. Koma akatswiri amakhulupirira kuti matenda ena, monga matenda gastroesophageal Reflux, "Rabeprazole" kumatha bwino, izo amachotsa zizindikiro bwino, izo kumathandiza kuti ayambe mofulumira ntchito kum'mero. Chosowa ndi ubwino mankhwalawa "esomeprazole" akhoza kugwirizana ndi makhalidwe munthu wa chamoyo.

Ngati ndi kotheka, kusankha analogue ayenera kukaonana ndi dokotala. Kuchitira kwambiri tcheru thanzi lawo, ndi mayesowo nthawi, ndiye ayambe adzakhala mofulumira ndipo tidzapewa mavuto ambiri.