Alt kuchuluka. Kodi kuchita?

alanine aminotransferase (alt) enzyme ali chiwindi ntchito ngati chizindikiro kudziwa matenda ntchito zake. Kodi mfundo yakuti, ngati milingo alt kuchuluka?

Pakati pa michere ambiri amene zizindikiro za matenda hepatocellular, kwambiri zothandiza ndi zofunikira ndi alanine aminotransferase (alt) ndi aspartate aminotransferase (Ast). Kudzera mwa iwo inapita patsogolo kutengerapo anachita mu Popanga madzi a gamma-Popanga madzi a gamma gulu ketoglutarate alanine ndi magulu aspartate. Chifukwa cha ndondomeko iyi inatulutsa pyruvic acid oxaloacetic.

Ndipo alt ndi Ast - ma michere impso, chiwindi, mtima. Komabe, alanine aminotransferase, makamaka ili mu chiwindi ndi zofunika kwambiri chizindikiro chake, ndipo aspartate aminotransferase -. Monga mbali ya ambiri (kupatulapo amene tatchula) ziwalo ndipo zimakhala, kuphatikizapo minofu chigoba, ubongo, etc. Ichi ndi chifukwa chake chinsinsi enzyme Ast ndi wofala monga chizindikiro cha ntchito chiwindi, ndipo amatenga gawo mu kagayidwe kwa amino acid.

Ngati pali kuwonongedwa kwa maselo chiwindi, mtima, impso, alanine aminotransferase (alt) atagwa magazi. Kuwonjezeka kwa enzyme ma mu zikuchokera magazi limasonyeza matenda zobisika. Pamene kafukufuku akusonyeza kuti kofunikira kwambiri alt, angathe matenda aakulu kwambiri magazi, monga:

- matenda enaake,

- tizilombo matenda a chiwindi,

- myocarditis,

- khansa chiwindi,

- mtima kulephera,

- vuto la mtima.

Ndipo kuwonjezeka aspartate aminotransferase magazi kungayambitse

- mtima,

- khansa chiwindi,

- akulu dystrophy ,

- kapamba,

- paroxysmal myoglobinuria,

- chiwindi,

- dermatomyositis,

- mtima kulephera.

Koma ngati mlingo wonse wa Ast ndi alt kuchuluka, pangakhale:

- yaikulu kwa chiwindi necrosis,

- choipa toksinogennye chiwindi,

- woopsa tizilombo matenda a chiwindi,

- kuleza mtima kugwa.

Pafupifupi matenda onse a maphunziro magazi a anthu amasonyeza kuti mlingo ndi Ast, ndi alt kuchuluka, yemwe ndi mlingo wa michere onse mu milandu ndi pafupi zofanana ndipo ikusonyeza pamaso pa kudwala. Koma pali kusiyana wina. Ngati milingo alt kuchuluka Pamlingo kuposa aminotransferase aspartate, zimene zikusonyeza makulitsidwe nthawi ya matenda a chiwindi B. Ngati magazi ACAT kwambiri, kawirikawiri kwambiri ndi matenda a mtima.

Munthu akakhala wathanzi nkhani za michere awa ma ayenera kukhala pa mlingo:

- amuna kuti mayunitsi 41 pa lita (U / L);

- akazi mpaka mayunitsi 31 pa lita (U / L).

Kudziwa mlingo wa michere imeneyi, mapuloteni kagayidwe, kutenga umagwirira magazi. Ponseponse kuti alt m'menemo Zidzakhala 28-190 nmol / (c l) kapena 0,1, 68 mmol / (mL hr) ndi ACAT - 28-25 nmol / (c l) kapena 0,1-, 45 pmol / (mL hr). ulamuliro Izi milandu onse kwapatsidwa kwa njira Reitman-Frankel (colorimetric njira ya kafukufuku).

Kawirikawiri, MAGAZI alanine aminotransferase imachitika kuphunzira za mmene chiwindi, ndi aspartate aminotransferase - kuona chikhalidwe cha myocardium (mtima minofu). Ngati kusanthula limasonyeza magazi awo okwezeka, zikutanthauza kuti ndondomeko ya kuwonongedwa ndi selo imfa zimachitika ziwalo zimenezi. Choncho, ngati Ast kuposa mlingo wake mu magazi mu nthawi 2-20, ndiye n'zotheka chitukuko cha infarction m'mnyewa wamtima. Ngati milingo alt kuchuluka, pali ndondomeko pathological mu chiwindi.

Pansi yafupika chizindikiro cha magazi alanine aminotransferase ndi aspartate akatswiri aminotransferase mukudziwa kuti kusowa thupi pyridoxine (vitamini B6). Kawirikawiri izi zimachitika pa mimba, ndi hemodialysis pafupipafupi ndi kulephera aimpso.

Mwatsoka, kuchokera ku seramu magazi a munthu wathanzi ndi michere imeneyi silikudziwika, kotero unintelligible ndi njira zawo za chilolezo (mlingo wa liwiro la mankhwala plasma, bioliquid ena ndipo zimakhala zinthu chifukwa cha kusokonekera awo, biotransformation, kuwonongedwa kwa thupi).