4 (mfulu): ponseponse. Timadzi T4 (mfulu): kuyesa kwa magazi kwa mahomoni chithokomiro

Chofunika kwambiri kugwira ntchito yachibadwa ya chithokomiro England ndi hypothalamic-pituitary chithokomiro dongosolo. Imakhala kulamulira kaphatikizidwe kupanga ndi ntchito mahomoni chithokomiro.

mwachidule

The ubongo imene imalamulira kutentha amatulutsa mafuta (tireotro-pini-kumasuka chinthu). Izo, nawonso, kumapangitsa munthu kumasuka ndi kaphatikizidwe chithokomiro zolimbikitsa timadzi (TSH - TTG). TSH kumatanthauza njira kugwirizana ndi mankhwala ena. Kwenikweni, kumapangitsa katulutsidwe, kudzikundikira, kagayidwe ndi kaphatikizidwe triiodothyronine (T3) ndi thyroxine (T4). Pa 99% ya mankhwala awa awiri m'magazi kufalitsidwa kugwirizana mapuloteni zoyendera mawonekedwe. peresenti pasanathe wina ali ndi ufulu mawonekedwe. Unbound milingo steroid anthu ambiri chiri cholukanalukana ndi boma zinchito za chithokomiro England.

katundu thyroxine

Timadzi T4 (mfulu) facilitates lamulo kukula zachilendo ndipo chitukuko, kuonetsetsa yokonza thupi kutentha ndipo potero kukhalabe kutentha buildup. Pawiri ali zimakhudzanso magawo onse a zimam'patsa kagayidwe, mu gawo - pa vitamini ndi zamadzimadzi kagayidwe. Timadzi T4 (mfulu) ndi yofunika zikuluzikulu za chitukuko utero ndi nthawi neonatal. ndende limasonyeza chikhalidwe matenda a udindo chithokomiro, monga kusintha mlingo ambiri thyroxine amayamba ndi chisokonezo ntchito ya chithokomiro England kapena kusintha kuchuluka kwa mapulotini zoyendera. Masana, nkhani pazipita steroid anatsimikiza kwa maola 8 mpaka 12, ndi osachepera - ndi 23 3. pa chaka, mlingo wokweretsa 4 (mfulu) umalandira kuchokera September mpaka February, otsika - chilimwe. Mu nthawi akalandire chithandizo (pa gestation) thyroxine ndende kuchuluka, kufika mlingo pazipita kwa pang'onopang'ono lachitatu trimester. Mu moyo wa thyroxin okhutitsidwa anthu mosaganizira jenda amakhalabe ndi zonse. Yafupika timadzi ta m'thupi anati patapita zaka makumi anai.

Kodi ndikuuzeni mlingo wa thyroxine?

Ngati T4 (mfulu) chinawonjezeka bwino, ndiye amaona chitsimikiziro cha hyperthyroidism. Yafupika ndende limasonyeza hypothyroidism. Ufulu wa okhutira steroid wa thyroxine globulin kumanga limachititsa ntchito monga odalirika mayeso matenda. Zimenezi n'zofunika kwambiri zinthu zimene limodzi ndi kusintha kuchuluka kwa zimene thyroxine-amamanga globulin. Zikuphatikizapo kulera m'kamwa (m'kamwa), mimba, kutenga androgen kapena esitirojeni. Kusintha khalidwe ndi anthu ndi kutengera za kumtundu kuwonjezera kapena kuchepa ndende ya globulin. Ndalama magazi kwaulere T4 akulimbikitsidwa mtundu matenda a hypothyroidism sekondale chifukwa pathologies mu mlingo hypothalamo-pituitary. Pankhaniyi TTG zili sasintha kapena ukuwonjezeka. Childs, amaudindo apamwamba thyroxine zikhoza kukhala chifukwa mpweya wambiri wa seramu bilirubin, kunenepa kwambiri, komanso tourniquet, pamene adzatuluka magazi. 4 (mfulu) sasintha pansi matenda aakulu ntchito sanali chithokomiro. Mlingo wa okwana thyroxine mwina ndichepe.

Kukonzekera kukayezetsa zasayansi

Patatsala mwezi umodzi kupereka magazi silikuphatikiza wa utsogoleli wa mahomoni (pokhapokha pali malangizo m'thupi yemwenso). Kwa masiku awiri kapena atatu kuletsa ntchito ya kusanthula mankhwala ayodini munali. Magazi ndidzadutsa asanayambe maphunziro radiological ntchito mosiyana wothandizira. Madzulo kupereka magazi sayenera zolimbitsa thupi, kuthetsa mavuto. Isanafike phunziro, theka la ola, muyenera kukhadzikika, chifukwa kupuma mwakale. kuwunika amachitidwa pa chopanda kanthu m'mimba. Ndi chakudya otsiriza ayenera kukhala osachepera asanu ndi atatu maola (makamaka 12 hours). Iwo saloledwa kumwa khofi, tiyi kapena madzi. Kodi madzi okha.

Yafupika kaperekedwe ka thyroxine

4 (mfulu) (yachibadwa akazi ndi amuna - 9-19 pmol / l) zikhoza kuchepetsedwa mu nthawi postoperative, pamene hypothyroidism sekondale (kutupa kwa pituitary, tireotropinome, matenda, Sheehan). Kuchepetsa ndende ndi ananenanso pamaziko a anabolics phwando, thyreostatics, mankhwala anticonvulsant, kukonzekera lifiyamu. Thyroxine mlingo amachepetsa pamene ka kulera m'kamwa, octreotide, methadone, clofibrate. zingayambitse mulinso zakudya ndi zochepa zomanga thupi, akusowa ayodini, ntchito heroin, kukhudzana ndi kutsogolera. 4 (mfulu) mwina kuchepetsedwa ndi ukachenjede (mitsempha ubongo imene imalamulira kutentha TBI), anapeza, kobadwa nako hypothyroidism (pakati resection kwambiri chotupa ndi chithokomiro, autoimmune thyroiditis, kuderako khosi lotupa).

kuwonjezeka magawanidwe

Mlingo wa timadzi monga T4 (mfulu) (akazi ndi amuna tanena yachibadwa) akhoza chinawonjezeka pamene poizoni Chotupa chija, TSH-palokha hyperthyroidism, kunenepa. Kuwonjezeka ndende anaona pa maziko a syndrome nephrotic, heparin mankhwala. Zifukwa mulinso choriocarcinoma, phwando la thyroxine pamaziko a hypothyroidism, positi-Natal kusintha mu ntchito ya chithokomiro England, aakulu chiwindi matenda. 4 (mfulu) akhoza kukwezeka mu chithokomiro kukana syndrome steroids majini dizalbunemicheskoy hyperthyroxinemia, anati, n'zothandiza kuchepa tiroksinsyazyvayuschego globulin ndende.

Thyroxine ndi mimba

mahomoni chithokomiro zimakhudzidwa pafupifupi ndondomeko mu thupi. Monga tanena mankhwala zonse kagayidwe, bwanji ntchito mankhwala ena. Chithokomiro kudwala akhoza limodzi ndi onse ponso ndi kuchepa mu ntchito zake. Wa zinthu zofunika kwambiri kuphwanya ntchito limba ndi pa kubala ana a. The kusintha kwa boma zinchito za chithokomiro England amakhudza Inde mimba, khalidwe lake, ndipo zotsatira za udindo wa ana akhanda. Kawirikawiri vynashivanie akudutsa pamene anafotokoza endocrine pathologies. Matenda a mtundu uwu, monga ulamuliro, kuyambitsa kukanika ubereki, osabereka. Nthawi zambiri anapezeka pa mimba Chotupa chija (kuwonjezeka mu chithokomiro akakufunsani authunthu) ndi euthyrosis kuteteza komanso autoimmune thyroiditis, n'zothandiza kusintha mu maziko m'thupi. Pakuti nthawi akalandire chithandizo amakhala ndi kusintha kwa boma zinchito za England lapansi.

ayamikira

Kuti molondola kutanthauzira zotsatira za mayesero zasayansi pa mimba ayenera kuganizira mfundo zina. Khama la okwana T3 ndi T4 si nkhani. Ichi ndi chifukwa chakuti woyembekezera, maganizo awo ndi chinawonjezeka ndi theka. Pamene kafukufuku unbound thyroxine mlingo ndende ake ayenera kukhala wotsimikiza molumikizana ndi nkhani TTG. Thyroxine penapake adakulabe mu 2% ya amayi apakati. Mu zoyambirira za munthu wabwinobwino akalandire chithandizo nthawi amalembedwa ndichepe TTG (pafupifupi 20-30% odwala ndi singletons ndi milandu yonse ya mimba angapo). Mankhwalawa hyperthyroidism T4 ankafufuza okha (mfulu). Unbound thyroxine mlingo mu magawo ina akhoza marginally yafupika. Choncho TSH ndende adzakhala anakhalabe mu osiyanasiyana yachibadwa.