Monocytes magazi kuchuluka: zikuonekera mwa Kupenda

Tonsefe nthawi kukumana ndi mawu samveka zachipatala. Popeza Ndondomekoyi kukwaniritsa chirichonse, pali funso n'lakuti, kodi monocytes, ndi angati a iwo ayenera kukhala magazi, ndipo umboni ndi phindu analandira pamene monocytes magazi kuchuluka?

Monocytes - lalikulu kukula kwa maselo ofiira a magazi, a kalasi ya maselo oyera. Malinga ndi dongosolo la - chowulungika maselo ndi phata lalikulu ndi kusowa kwa tirigu cytoplasm (agranulocytes) amatsatira njira yotupa mu kuwonjezeka thupi m'magazi mwawo. A chikhalidwe kumene monocytes magazi okwera, wotchedwa monocytosis.

Maselo amenewa anapanga mu fupa mafuta a monoblastov, pamene iwo zidzasankhidwa ndi meiosis, ndipo masiku angapo kenako amasamukira magazi mu zimakhala, ndipo pa mlingo ma nawo phagocytosis. Nthawi zambiri, mnjira zimawonedwa poyankha malowedwe a matenda pamene monocytes kukhala macrophages kale ogwirizana kuchirikiza chitetezo chokwanira ndi kutsekereza mapuloteni achilendo kupanga Antigen-oteteza kuphatikiza. Mu ndondomeko ya phagocytosis wa monocytes sizidzawonongedwa, monga zambiri zimachitika ndi eosinophils ndi neutrophils, koma kupanga kutsinde liwulo malo a kutupa. Mbali khalidwe ndi ofanana khalidwe la maselo amenewa mapangidwe acidic.

Monocyte lili ambiri lysosomes, amene kudya selo fagotsitiruemye zinthu kuchipala chotupa malo ndi kukonza kuti asinthidwe. Makamaka monocytes m'magazi, ndi zochuluka pano mu ndulu ya, lymph mfundo ndi mafupa, kotero zoipa mmodzi wa iwo adzakhala ndichepe monocytes. Monocytosis kutchulidwa zotupa zilonda, matenda opatsirana (chindoko, TB), matenda zokhudza zonse (lupus erythematosus, matenda a m'magazi), collagenosis, granulomatosis.

Nkhani za leukocytes izi mononuclear mu yachibadwa magazi zotumphukira - osapitirira 0,03 - 1,00 × 109 / L ndi kuchuluka awo okwana sayenera upambana 8-10% ya leukocytes okwana. Ngati monocytes pamwamba mwakale, ndi nthawi yoti mayeso zina kuzindikira gwero la matenda ndi koyenera kumwa mankhwala. Monocytes kukhudza cytotoxic (ingafooketse maselo chotupa komanso matenda monga malungo), kutulutsa mankhwala yogwira (IFN), ali nawo kuzindikira wothandizila yachilendo.

Ngakhale monocytes magazi kuchuluka, sikutheka molondola pofotokoza chithunzi predictive za ndondomeko yotupa, zochokera yekha zizindikiro zawo kachulukidwe. Chifukwa chaichi ife amati okwana leukocyte chilinganizo cha mwazi: ngati zambiri monocytes, ndi kuchuluka kwa lymphocytes ndi, ndipo chiwerengero chomwecho cha eosinophils, koma chepetse chiwerengero cha zili T-lymphocytes, zikhoza kuonedwa monga chifukwa ndi zotsatira zabwino za chikhalidwe pathological. Mosiyana ndi boma kumene monocytes magazi chinawonjezeka chiwerengero cha neutrophil leukocyte kosangalatsa lamanzere, ndi imodzi kuchepa kwa chiwerengero cha eosinophils ndi T-lymphocytes.

Ngati sakuyendetsa lakuthwa chiwerengero cha monocytes zimawonedwa mu magazi, ndiye izo zifika ku boma monga monocytopenia (monotsitopeniya). cithunzithunzi ici anati mu magazi a zotupa m'mafupa, pamene ndondomeko gemapoeza linaphwanya mu purulent matenda zowombetsa mkota, matenda magazi, mankhwala m'thupi, zinthu nkhawa ndi mantha, pobereka ndi popanga munthu opaleshoni, komanso kuvulala matupi kumene monocytes zochokera. Kukachitika chiwerengero cha monocytes mu magazi zotumphukira m'pofunika kuchita yachiwiri magazi mayeso. Pa mfundo imeneyi, izo ndi nkhani chogwirizana zovuta mankhwala a matenda chachikulu. Popeza monocytes kuyankha pamaso pa matenda mu thupi, zikhoza motsimikiza kuti chamene adzakhala mankhwala mankhwala kuphatikiza mankhwala symptomatic.