"Klarotadin": malangizo ntchito. Kumene kugula "Klarotadin"? Kuchokera pa zimene mankhwala "Klarotadin"? Analogs "Klarotadina"

thupi lawo siligwirizana - mutu ndi zogwirizana kwambiri, makamaka kwa makolo. Ndipotu angapo otchedwa "ziwengo" zikuchulukirachulukira chaka chilichonse. Choncho, tikambirana mwatsatanetsatane kukonzekera "Klarotadin". Malangizo ntchito adzayamba taphunzira za mankhwala. Worth kuwona izo pamaso ntchito. Gulani "Klarotadin" pa mankhwala aliwonse mu mzinda wanu ndi wopanda dotolo.

pamene ntchito

medicament mwina ntchito matupi awo sagwirizana conjunctivitis, angioedema, ndi urticaria (pachimake aakulu idiopathic). Mankhwala "Klarotadin" ndi wogwira chaka chonse kapena rhinitis nyengo; pseudoallergic pamene zochita chifukwa cha histamine adzamasulidwa; amadana ndi tizilombo uyo osiyana; komanso dermatoses kuyabwa. Mndandanda akhoza wodzilemekeza.

Amapangidwa

Taonani kaye mankhwala "Klarotadin" -sirop. pa ntchito malangizo ake adzapatsidwa pansipa. Mlingo - 5 mg / 5 ml. Loratodina (yogwira pophika) milligram imodzi milliliter wa madzi. Excipients: propylene glycol, shuga, asidi benzoic asidi, ethyl mowa, citric acid, tropeolin, madzi oyera, flavorings chakudya.

Amagulitsidwa botolo la galasi mdima, mphamvu zomwe zana Botolo. kuwira Izi mukatoni. The zida mulinso wapadera chingwe supuni.

Tsopano tiyeni tione mapiritsi "Klarotadin". Aliyense piritsi ali mamiligalamu khumi loratodina. Kuyambira auxiliaries - MCC, lactose, calcium stearate, glycolate, wowuma ndi sodium. Anaikidwa matuza, aliyense ndi zidutswa zisanu kapena khumi. Nthochizo mwina ili ndi atatu mapaketi mbale.

pharmacodynamics

mankhwala wa H1-mankhwala, amene alibe anticholinergic ndi kanthu chapakati. Kumayamba pa theka la ola pambuyo kumwa ndi zochita tsiku lonse. Nkofunika kuti utsogoleli wa mankhwala aakulu woterewu kukana izo. Tikumbukenso kuti thunthu loratodin ndi metabolites ake sangathe umalowa mu BBB.

Pharmacokinetics

Koma wambiri pa nthawi ya madyedwe mu Mlingo wa analimbikitsa ndi Mlengi, mbali yaikulu loratodin mofulumira ndi kwathunthu odzipereka mu m'magazi kudzera thirakiti m'mimba. Anthu ambiri amene angathe kale kudziwa, kuwonekera zikuchokera ndi madzi a m'magazi maminiti khumi ndi asanu mutadya. Koma nthawi kukwaniritsa Cmax mu plasma loratodina, izo zimasiyanasiyana mphindi ola limodzi makumi anayi maola awiri ndi mphindi makumi atatu.

Koma nthawi kukwaniritsa Cmax metabolite ake yogwira ndi maola atatu. Monga kukumbukira kuti ntchito munthawi yomweyo chakudya pamodzi ndi mankhwala amatha m'mbuyo kupambana Cmax loratodina ndi metabolite ake mwakhama plasma kwa ola limodzi. Pa nthawi yomweyo Cmax zinthu zimenezi zidzakhala zikutsatiridwa, ndi chakudya sangathe mwa njira iliyonse zimakhudza zotsatira.

Tsopano okalamba. "Klarotadin" (malangizo zolemba ntchito), iwo akhoza kumwedwa popanda zosungitsa zapadera za m'badwo. Monga kukumbukira kuti nthawi kukwaniritsa Cmax ndi chinawonjezeka ndi ola limodzi ndi theka, mosiyana ndi achinyamata. Mokhudzana ndi kuwonongeka mowa chiwindi, malingana ndi kuopsa kwa matenda komanso kukwaniritsa chodziwa Cmax.

Mu madzi a m'magazi zili loratodina metabolite ake yogwira umalandira ambiri odwala mlingo n'kupuma pa tsiku lachisanu pambuyo ingestion. A kwambiri ndi mapulotini plasma - 97%.

kagayidwe

Chiwindi loratodin mankhwala yogwira ndi zimapukusidwa kupanga yogwira metabolite dezkarboetoksiloratadina. Izi zimachitika chifukwa chikoka cha cytochrome P450 isoenzyme CYP3A4. Impact cytochrome P450 isoenzyme CYP2D6 nawonso amakhudza, ngakhale Pamlingo wamng'ono. Kektonazol pano, ndi woletsa wa CYP3A4 timatha loratodinu n'kukhala dezkarboetoksiloratadin. Ichi ndi chifukwa zotsatira za CYP2D6.

kuswana

Achire wa mankhwala "Klarotadin" (malangizo ntchito ndi akutchula) kudzera impso, komanso pamodzi ndi ya ndulu. Wapakati T1 / 2 loratadine mankhwala ndi maola asanu ndi atatu ndi mphindi makumi awiri (osiyanasiyana mwina maola atatu ndi ziwiri). Pankhani ya metabolite yogwira, pafupifupi ake ndi maora makumi awiri ndi asanu ndi atatu (osiyanasiyana kungakhale kwa maola asanu maminiti makumi anai ndi maola makumi asanu ndi awiri).

The dezkaboetoksiloratadina apakatikati ndi maola khumi ndi mphindi makumi atatu (osiyanasiyana, khumi ndi makumi asanu ndi atatu maola). Ngati ndi chiwindi chotupa mowa, ndi T1 / 2 zingawonjezere ndi kuwonjezeka zovuta matenda. Koma odwala amene ali ndi kulephera impso ndi likufa hemodialysis, pharmacokinetics alibe anasintha.

pregnancy

Iwo akhoza kumwedwa ndi amayi apakati mankhwala, chifukwa "Klarotadin" ana amene ali m'mimba, akhoza zoipa. Ngati m'pofunika kugwiritsa ntchito mayi mankhwala unamwino, ndiye m'pofunika kusiya kuyamwitsa mwana mkaka bola ngati mankhwala udzatha.

contraindications

Mofanana ndi mankhwala ena ali contraindications ndi "Klarotadin". Malangizo pa ntchito limanena kuti mankhwala sayenera kugwiritsidwa ntchito ngati wodwalayo hypersensitivity kwa chigawo chilichonse kukonzekera izi. Mimba ndi mkaka wa m'mawere komanso zinthu zina zimene chida si anatumizidwa kapena analandira. Odwala amene ali kulephera chiwindi, kutenga mankhwala "Klarotadin" mosamala.

zotsatira zoyipazi

Tsopano m'pofunika kuti ndikuuzeni za momwe izi zingathe kusokoneza mankhwala pa thupi la munthu. Zizindikiro zotheka matenda mantha dongosolo, ndicho nkhawa, asthenia, hyperkinesia, mukubwadamuka wa mwana, somnolence, kugwedeza, paresthesias, maganizo ndi amnesia. Subcutaneous mafuta ndi khungu angalankhule mankhwala zigawo zikuluzikulu dermatitis.

Ngati ife kulankhula za dongosolo genitourinary, ndiye gawo chake kusintha mu mtundu wa mkodzo, wodwalayo angaganize kuti chilakolako kukodza, amene adzakhale limodzi ndi ululu. Lusoli kukhala vaginitis, dysmenorrhea ndi menorrhagia.

Pa mbali ya dongosolo endocrine ndi kuyan'anila zotheka. Kulemera akhoza zochuluka, wodwalayo adzamva ludzu, ndipo achuluke thukuta. dongosolo minofu ndi mafupa amathanso kukumana ena monyanyira mu ntchito yawo. Izi omangana mwendo ndipo myalgia, ndi arthralgia.

Dongosolo m'mimba akhoza kuvutika. Kupotozedwa kulawa, kudzimbidwa kapena m'mimba, anorexia, gastritis, kudzimbidwa, kuchuluka njala, stomatitis ndi flatulence - zonsezi ndi Mwina ena kumachitika pamene ntchito "Klarotadina".

Sachedwa kulephera ndi dongosolo kupuma. Kuphwanya adzaonetsera monga bronchoconstriction, chifuwa, sinusitis, ndi dryness nembanemba mucous mu mphuno. Ungayambenso conjunctivitis, masomphenya maganizo, ululu makutu ndi maso. Dongosolo mtima ndi phunziro kwa mankhwalawo kuti akhoza kusonyeza kuti palpitations, kuthamanga magazi, ndi kuchepetsa izo.

Milandu thupi lawo siligwirizana, anawonetseredwa mu mawonekedwe angioedema, pruritus, urticaria ndi photosensitivity. Mukhozanso kulandira kupweteka m'thupi kutentha thupi, hoarseness, kupweteka m'chifuwa, kuzizira, blepharospasm, ndi ululu chifuwa kumbuyo.

Monga mukuonera, zotsatira zikhoza kukhala zoopsa kwambiri, kotero musaiwale za izo. Kufunsa chofunika onse pamaso pa makonzedwe loyamba la mankhwala ndi zinachitikira kudziwika pa mavuto pamwamba.

Ntchito ndi mlingo

Syrup ndi miyala "Klarotadin 'limene - kumvetsa. Tsopano tiyeni tikambirane za mmene ayenera kumwedwa. Mankhwalawa ukunenedwa ntchito mkati. Ana amene ali zaka zoposa khumi, komanso wamkulu wa akulimbikitsidwa kudya tsiku ndi mamiligalamu khumi. Izi scoops awiri madzi madzi kapena piritsi limodzi. Koma ana kwa zaka ziwiri kwa khumi ndi ziwiri zakubadwa, thupi osachepera makilogalamu makumi atatu, tikulimbikitsidwa kuti atenge mamiligalamu asanu. Izi ngwanjula imodzi kapena theka la piritsi. Mlingo tsiku sayenera upambana chithunzi ichi. Ngati kulemera kwa makilogalamu oposa makumi atatu, mlingo adzakhala yemweyo monga akuluakulu.

ambiri osokoneza

Ngati mulibe mverani malangizo ndi kutenga mankhwala lalikulu zedi, angachititse zizindikiro akuluakulu, omwe tsopano kutchulidwa. tachycardia ichi, mutu ndi tulo. Ndipo ana amene kulemera ndi makilogalamu zosakwana makumi atatu, ambiri osokoneza zikhoza palpitations, ndi zizindikiro extrapyramidal.

Ngati wodwala anavomereza ambiri osokoneza, muyenera yomweyo funsani dokotala. M'pofunikanso kukhwimitsa kuonetsetsa kuti mankhwala inachotsedwa thirakiti m'mimba ndi mayamwidwe anali yafupika. Izi zachitika kulimbikitsa emesis, chapamimba lavage, ndi kugwiritsa ntchito adamulowetsa mpweya. Pankhani ya mankhwala symptomatic angathe kuchitidwa akufunika kutero. Tiyenera kukumbukira kuti mankhwala yogwira ndi loratadine sangathe anaganiza m'thupi mwa hemodialysis. Komanso, palibe deta pa excretion wa chinthu ichi pa dialysis peritoneal.

Mogwirizana ndi mankhwala ena

Ngati ife kutsatira "Klarotadin" mu mlingo achire, potentiating zotsatira za mowa anapezeka. Komanso kugwiritsa ntchito mankhwala opha tizilombo monga "cimetidine", "mankhwalawa" ndi "ketoconazole" kumaonjezera ndende mu madzi a m'magazi loratodina. zodabwitsazi sasonyeza kukomoka, ndipo alibe mphamvu pa electrocardiogram lapansi.

Pali umboni kuti inductors wa microsomal makutidwe ndi okosijeni, monga Mowa, phenytoin, barbiturates, rifampicin, ziksorin, antidepressants tricyclic, phenylbutazone, angathe kuchepetsa mphamvu ya mankhwala.

Kusamala

Odwala amene amadwala ntchito mkhutu kwa chiwindi, ndi amene walephera impso (glomerular kusefera ali mathamangidwe ndi zosakwana makumi atatu ml ya / mphindi), analimbikitsa koyamba mlingo "Klarotadin" sayenera upambana mamiligalamu khumi (ichi ndi limodzi, kapena awiri kuyeza supuni ya madzi) awiri tsiku. Ndipo sitingathe kupereka mankhwala kwa ana, amene zaka zosakwana zaka ziwiri.

Onse amene anayamba kumwa mankhwala ayenera anasiya kwa nthaŵi ya magawo chithandizo kwa mtundu uliwonse wa zinthu zingakhale woopsawo amene amafuna ndende mkulu ndi zochita psychomotor liwiro.

analogs

M'pomveka kunena kuti si zosowa ndi mankhwala "Klarotadin". Analogues nazo zonse mwa mankhwala zoweta ndi kunja. Zofala yachilendo "anzake" ndi mankhwala "Claritin". katundu wake ali pafupi mofanana pamwambapa ankaona mankhwala "Klarotadin". Price - ndiko kusiyana chachikulu. kukonzekera kunja kwambiri zodula. Mtengo zoweta ali yemweyo, malingana kasinthidwe lapansi. Choncho, kumunyamula 7 ma PC. Ndalama pafupifupi 100 rubles ma CD metering mizere 10 × 3 -. Pafupifupi 270 rubles, ndi 100 ml ya madzi -. Pafupifupi 135 rubles.

Sitidzakhala apa kuti alankhulepo za zomwe kugwiritsa ntchito bwino - "Klarotadin" kapena "Claritin". Izi payekha, ndipo muyenera kusankha nokha, kugula wotchipa mankhwala zoweta, kapena kupereka mmalo akunja odula kwambiri. Koma Dziwani kuti pa zaka kwambiri bwino kutsimikiziridwa mankhwala "Klarotadin". Analogs motero amaoneka tsiku lililonse.

Mulimonsemo, musanayambe kumwa mankhwala awa ndi zambiri kotero kuti anaika ana awo, onetsetsani kukaonana ndi dokotala. Izi adzakutetezani ku zotsatirapo zotheka zoipa zimene zingachitike chifukwa cha tsankho mankhwala, zosayenera ntchito cha mankhwala osokoneza bongo wake kapena. Nthawi zonse anakumbukira kuti mavuto amenewa akhoza kusokoneza kwambiri thanzi lanu, thanzi la ana anu, ndi moyo wanu.