Mankhwala "Ursodez" - malangizo ntchito. Miyala "Ursodez": analogs ndi ndemanga

Mankhwala "Ursodez" - hepatoprotective mankhwala. Iwo ali choleretic medicament, hypolipidemic, holeliticheskoe kanthu, ali hypocholesterolemic ndi immunomodulating zotsatira negligible. Yogwira mankhwala - asidi ursodeoxycholic. Mankhwala alibe maonekedwe mlingo "mankhwala". "Ursodez" amapangidwa mu mawonekedwe a makapisozi.

limagwirira ntchito

The yogwira mankhwala mankhwala amatha kukhala mbali nembanemba wa hepatocytes, wosasunthika matabwa ake. Chifukwa, maselo ndiotetezedwa ku zinthu ovutitsa, ntchito ya mchere ya ndulu acid. Zotsatira achire mankhwala owonetseredwa Choncho kutsitsa cytotoxic kwenikweni. Against maziko a cholestasis imayendetsa Ca2 + yozungulira protease alpha-inalimbikitsa exocytosis. Amatanthauza "Ursodez" (wogwiritsa ntchito limasonyeza kuti) ndithu amachepetsa poizoni zidulo ya ndulu (deoxycholic, lithocholic, chenodeoxycholic ndi ena) pa woipa okwera odwala ndi pathologies kwa chiwindi m'njira aakulu.

Pamene kulandira mankhwala amalembedwa kuchepa mafuta kaphatikizidwe ndi katulutsidwe, chopinga wa mayamwidwe ake mu intestine lapansi. Chifukwa ichi, amachepetsa machulukitsidwe wa ya ndulu ndi pawiri izi. lokonzekera amatha competitively ndichepe absorbability zidulo lipophilic mu intestine ndi wowonjezera awo fractional zolowa nthaka enterohepatic kufalitsidwa. Mankhwala kumapangitsa munthu excretion zidulo poizoni, kuchuluka ndimeyi.

Limagwirira cha zochita za mankhwala amadziwikanso zochokera pa kuphimba nonpolar ya ndulu zidulo. Chifukwa cha ichi poizoni micelles losanganikirana. Zikutanthauza Poipa mu dongosolo biliary, ndi solubility wa mafuta m'thupi, ziziyenda kupanga ndi katulutsidwe wa ya ndulu. The mankhwala kumachepetsa lithogenicity ake, kumaonjezera ndende ya zidulo, motero n'zothandiza kuwonjezeka mu ntchito ya katulutsidwe pancreatic ndi muzituluka.

Pamene kulandira makapisozi anali kuvunda wathunthu kapena tsankho miyala. Ndi kuchepetsa ya ndulu mafuta machulukitsidwe kumatheka yolimbikitsa miyala. ntchito Immunomodulatory ali anasonyeza chifukwa chikoka pa zimene analemba ndi chiwindi. Mankhwala amachepetsa mawu angapo a antigens histocompatibility. The medicament ali zimakhudzanso mlingo wa T-lymphocytes, chepetse chiwerengero cha eosinophils.

Pharmacokinetics njira

Mayamwidwe mankhwala "Ursodez" (malangizo Buku limauza) mu intestine yaing'ono kuchitidwa ndi ndondomeko ya mayamwidwe chabe. Zotsatira ndi 90% wa chigawo yogwira. Mu ileum thunthu ndi chosakanikirana ndi zoyendera yogwira. The zili chapamwamba chigawo yogwira ukufika pafupifupi ola limodzi. Pawiri ali amaposa mapuloteni kumanga - 99%. asidi Ursodeoxycholic amatha umalowa mu nsengwa.

The achire efficacy wa mankhwala zimadalira ambiri yogwira pophika mu ya ndulu ya. Pa kulandira zonse mwadongosolo izi asidi ya ndulu wobwezera seramu chachikulu. ursodeoxycholic asidi ndende ndi za 48%.

Pawiri ndi zimapukusidwa, umadutsa maselo chiwindi. Chifukwa cha zimenezi, anapanga glycine ndi taurine conjugates. The mankhwala kuwola ndi tochoka mu ya ndulu. About 50-70% analandira mankhwala ndi excreted mu chimbudzi. A pang'ono mankhwala chimadzera mu m'matumbo. Pamenepo inang'ambika chifukwa zochita za tizilombo (7-dehydroxylation).

asidi Lithocholic, amene aumbike mwa ndondomeko imeneyi, a pansi ndi mayamwidwe tsankho za m'mimba, koma akudutsa sulfation mu chiwindi ndi excreted monga sulfolitoholiltaurinovogo kapena sulfolitoholilglitsinovogo conjugate.

umboni

Medicine "Ursodez" analimbikitsa monga mankhwala symptomatic kwa biliary matenda enaake yaikulu popanda zizindikiro decompensation. Kusonyeza njira kupasuka sing'anga ndi miyala mafuta yaing'ono, ndi ndulu yogwira. Prescribers ndi biliary Reflux gastritis.

contraindications

Kumatanthauza "Ursodez" malangizo ntchito salola kuti kopita ngati rentgenpolozhitelnyh mtima (wa mkulu wa ndende Ca2 +) gallstones tsankho medicament zigawo zikuluzikulu. Contraindications monga matenda enaake mogwirizana decompensation anasonyeza matenda a kapamba, impso. Analimbikitsa mankhwala kwa anthu amene sanali lizigwira ndulu, pachimake yotupa pathologies zachilengedwe ake, komanso matenda matumbo ndi ya ndulu ritsa. Musati mankhwala kuti apakati ndi unamwino. Kumatanthauza contraindicated akuluakulu ndi ana yolemera makilogalamu zosakwana 34.

zotsatira zoyipazi

Nthawi zina, kukhala zotsatira osafunika tikadwala mankhwala, "Ursodez". Malangizo ntchito kuchenjeza za kuthekera kwa nseru, m'mimba, kusanza. Mankhwala nthaka akhoza kupanga gallstones calcified. Amveke chiwindi transaminase ntchito, kupweteka m'mimba, thupi lawo siligwirizana (kuphatikizapo urticaria) nayonso osafunika zotsatira ingestion "Ursodez".

Umboni kusonyeza tolerability wabwino. Mutu kuti zotsatira dokotala mankhwala mbali zimavuta. Nthawi zina, pa mankhwala a matenda enaake biliary anati chosakhalitsa decompensation. Monga ulamuliro, zodabwitsazi yekha amalimbikira pambuyo discontinuation mankhwala.

Mankhwala "Ursodez". Price. malangizo

Kumatanthauza madzulo. Mlingo tsiku kwa Kutha miyala - avareji 10 mg / kg. Kwa anthu masekeli mpaka makilogalamu 60 izo limafanana makapisozi 2 pa tsiku 81 kg- 3-m, 100 makilogalamu - 4 zambiri 100 - 5. Nthawi - kuchokera miyezi isanu ndi umodzi kwa miyezi 12. Pambuyo Kutha miyala kuteteza mapangidwe wambiri latsopano analimbikitsa miyezi ingapo.

Chithandizo biliary matenda enaake ikuchitika pa mlingo wa 250 mg / tsiku. Nthawi Maphunzirowa - masiku 10-14. mpaka miyezi isanu ndi umodzi. Nthawi zina, nthawi ya mankhwala ndi kuchuluka kwa zaka ziwiri. Monga mankhwala symptomatic medicament kutumikiridwa 10-15 mg / tsiku. Pamene misa ndi makilogalamu 34 Analimbikitsa njira inaimitsidwa mawonekedwe. Mtengo wa mankhwala mawonekedwe kapisozi - kuchokera rubles zana.

Iwo umachita izo zikutanthauza "Ursodez" Anzawo?

Mankhwala ali yemweyo yogwira mankhwala, opangidwa ndithu kwambiri. Mwa iwo ndi ofunika ponena njira monga "Ursodoksa", "Ursol". Mmodzi wa anthu otchuka ndi mankhwala "Ursosan". Zikuonetsa ntchito mankhwala penapake zambiri. Makamaka, ndi kutumikiridwa mu enaake fibrosis chiwindi skleroziluyuschem cholangitis mtundu aakulu.

odwala ambiri amachita chidwi ndi kukonzekera zimene bwino "Ursodez" kapena "Ursosan". Izo ziyenera kuti dokotala amasankha munthu kapena njira zina malinga ndi chikhalidwe, njira ya kudwala ndi mtima analekerera mankhwala. Mu matenda a chiwindi, ndi ndulu si kwambiri analimbikitsa kudzikonda. Tisanayambe aliyense mankhwala muyenera kuona ndi kufunsa katswiri.

Kuunikira mphamvu ya mankhwala ayenera kuchitidwa aliyense miyezi 6. Pa nkhani imeneyi kuti akapatsidwa ultrasound zonse ndi X-ray tione chaka choyamba cha mankhwala. Ngati mu miyezi sikisi ya kuvunda kwa miyala sizinachitike, zikuoneka kupitiriza kumene ndi kosathandiza chifukwa inefficiency.

zina zambiri

Kuti kuvunda bwino miyala m'pofunika kuti miyalayo inali kokha mafuta m'thupi, koma kukula si upambana 15 kapena 20 millimeters. Pa nthawi yomweyo wodzazidwa ndi chikhodzodzo ndulu sayenera oposa theka, ndi kapepala biliary ayenera kusunga ntchito yake kwathunthu.

Pankhani ya kopita yaitali chithandizo, kuposa mwezi umodzi, m'pofunika kuti achite zofufuza amuzolengedwa kwa potaya ntchito transaminases mu chiwindi. Komanso, ayenera kulamulira ndende ya bilirubin ndi mankhwala ena. siyani kumwa "Ursodez" njira pokhalabe ntchito yapamwamba. Reviews a akatswiri ambiri Komabe, zabwino za mphamvu ya mankhwala.

Pomaliza

Ngati palibe chifukwa awerenge medicament wina kapena njira mankhwala kwathunthu amasintha. Musanagwiritse ntchito mankhwala ayenera kukhala bwino ndi Zamkati lapansi.