Mankhwala "Avastin" mtima pamene umboni uperekedwa, malangizo ntchito, mavuto

Mankhwala "Avastin" amati ndi wothandizila antitumor, kutanthauza chitetezo monoclonal. Pa ntchito mankhwala ndi kuchepa Kukula kwa matendawa metastatic ndi microvascular permeability mu zotupa zilonda amitundumitundu, makamaka zokhudza chifuwa wamkazi, m'matumbo, ndi kapamba ndi prostate.

mankhwala

Mukhozanso mankhwala "Avastin" mu mawonekedwe a maganizo amene anafuna kuti akonze njira yothetsera kulowetsedwa mwina colorless kapena pang'ono brownish amaonekera.

Mankhwala mankhwala lakuti bevacizumab. chida lilipo phukusi la 100 mg, ndi 4 ml ya mankhwala yogwira ndi 400 mg / 16 ml.

zotsatira pharmacological

"Avastin" - ndi chotupa mankhwala kumabwezera mmbuyo mapangidwe ziwiya latsopano magazi kuti kupereka mpweya ndi zakudya zimakhala neoplasms ndipo potero zimathandiza kulanda khansa ndi mwamakani pa siteji aakulu. "Avastin" (mayankho a odwala ndi madokotala - umboni) amachita nthumanzi mu metastasis a zotupa zosiyanasiyana zilonda.

Pakuti chida ichi amakhala ndi kuchuluka kochepa wa kufalikira mu thupi, kuwonjezera, ndi utali wokwanira m'thupi, zomwe zimathandiza kusunga chofunika kuchuluka kwa chigawo chachikulu cha mankhwala ndi jekeseni izo mosamalitsa monga malangizo - kamodzi mu masiku 14-20. Linachokera mankhwala mankhwala si mu chiwindi ndi impso, ndi maselo onse a m'thupi kwa masiku 18 kwa amuna ndi akazi - 20.

Koma ndi bwino "Avastin"? Umboni kuti uyu ndi mankhwala othandiza kwambiri, ngati inu kuphatikiza ndi mankhwala amphamvu mu mitundu yosiyanasiyana ya kansa. Izi zikutanthauza kwambiri kumawonjezera nthawi kupulumuka odwala mu magulu onse, ndi kupitirira kwa matenda amapezeka.

"Avastin": zikuonetsa ntchito

Izi mankhwala chimagwiritsidwa ntchito mankhwala khansa. Madokotala mankhwala kuti:

1. Mu metastatic khansa colorectal. mankhwala akulimbikitsidwa kugwiritsa ntchito molumikizana ndi mankhwala amphamvu zochokera 'fluoropyrimidine.
2. Mu khansa ya m'mawere metastatic. Izo ntchito monga mzere woyamba wa mankhwala molumikizana ndi "paclitaxel".
3. Pamene inoperable, limodzi ndi ambiri metastases kapena neplosko-, si yaing'ono khansa selo m'mapapo - monga woyamba mzere mankhwala osakaniza ndi mankhwala amphamvu pulatinamu zochokera kukonzekera mankhwala.
4. Khansa zapamwamba kapena metastatic, zokhudza maselo a impso - ngati wothandizira kwa mankhwala chachikulu molumikizana ndi "Interferon Alpha-2a".
5. Pamene glioblastoma molumikizana ndi mankhwala cheza ndi 'temozolomide' odwala amene angoyamba kumene matenda, mu monotherapy kapena molumikizana ndi "irinotecan" odwala ndi glioblastoma kobwereza kapena kupitirira khansa.
6. Odwala amene anapezeka ndi "zilonda chotupa a aziwadula maliseche", ndi khansa chachikulu peritoneal. Pankhaniyi tikulimbikitsidwa kuti perekani mankhwala "Avastin" monga mankhwala oyamba zachipatala molumikizana ndi "carboplatin" ndi "paclitaxel".

Komanso, mankhwala kutumikiridwa ndi "carboplatin" ndi "Gemcitabine" linaperekedwa matenda zapamwamba kapena tcheru wothandizila pulatinamu ofotokoza odwala khansa ya ziwalo wamkazi maliseche kapena peritoneum, zimene ankachita ndi chida, kapena mtundu wina woletsa wa VEGF.

Kodi kulowa "Avastin"?

"Avastin" (mayankho a odwala ndi madokotala titsimikizire kuti) - mankhwala abwino, koma ziyenera bwino kutumikiridwa, ndi kokha kuyang'aniridwa ndi madokotala. Izo kutiletsa kulowa ndege - m'nsinga yekha, ndipo kenako pang'onopang'ono zotheka. The mawerengedwe ndi 5 mg pa makilogalamu 1 thupi 1 nthawi mu masabata awiri.

Chofunika kuchuluka kwa maganizo ndiye kuti sitimadzipereka mu sodium kolorayidi 100 ml 0,9%. Mlingo woyamba tikulimbikitsidwa kulowa ola limodzi ndi theka pambuyo mankhwala amphamvu, jekeseni zina za "Avastin" ndi isanayambe kapena itatha ndondomeko. Ngati utsogoleli loyamba la mankhwala wodwala analibe mavuto, m'pamenenso angathe kuperekedwa mu ola ndi jakisoni onse wotsatira - kwa theka la ola, koma pokhapokha ngati wachiwiri wakhala anasamutsa pokha odwala.

Ngakhale mlingo ali osavomerezeka kuchepetsa pamaso pa zotsatira osafunika, ngati n'koyenera, suspend kapena isiye chithandizo.

Ngati wodwala wakhala wapezeka metastatic colorectal khansara, tikulimbikitsidwa koyamba mlingo wa 5 mg pa thupi makilogalamu kamodzi pa masiku 14 kapena 7.5 mg / kg pa, koma pambuyo pa masiku 21. Ngati yachiwiri mzere mankhwala mlingo kwambiri chifukwa ndi nthawi 2.

Ngati mkazi anapezeka ndi khansa ya m'mawere, mu nkhani iyi, jekeseni woyamba tikulimbikitsidwa kuti chiphunzitso cha 10 mg / kg ndi kuchita jakisoni iwiri iliyonse. Kapena atatu, koma mu nkhani iyi amatengedwa kuti 15 mg pa kulemera makilogalamu thupi.

Ngati pali zizindikiro za Kukula kwa matendawa, chithandizo ayenera kusiyidwa.

Ndi ambiri inoperable, kobwereza, kapena metastatic neplosko- ina yaing'ono khansa selo m'mapapo mu mankhwala ikuchitika molumikizana ndi mankhwala amphamvu mankhwala pt (zosaposa 6 m'zinthu), ndi pambuyo mankhwala ntchito monga monotherapy.

mufunika kuleka kulowa "Avastin" Pamene inu muwona zizindikiro za kupitilira khansa. Malangizo ntchito limati ngati palibe kupitilira, mawerengedwe ndi 7.5 mg / kg pa masiku 14 kapena mlingo ndi chinawonjezeka ndi theka ndipo kutumikiridwa kamodzi pa masabata atatu kuwonjezera pa "cisplatin" ndi "carboplatin".

Kansa aimpso selo kumwa mankhwala sayenera upambana 10 mg / kg pa masiku 15 kamodzi. Ngati pali zizindikiro za Kukula kwa matenda, mankhwala ayenera kusiyidwa.

Anthu achikulire safuna kusintha mlingo.

"Avastin" ambiri osokoneza

mankhwala ambiri osokoneza bongo limapezeka kaŵirikaŵiri kukachitika kuti odwala anatchulidwa mkulu mlingo - 20 mg wa pa makilogalamu mtima thupi iliyonse masiku 14.

Pankhaniyi, angagwe kuukira migraine mu mawonekedwe mwachilungamo zovuta, kuwonjezera pamenepo, pakhala kuwonjezeka mavuto pansipa. adakalibe Special kulibe, kokha symptomatic mankhwala ntchito.

"Avastin": mavuto

"Avastin" - mankhwala abwino kwambiri, nthawi zambiri kumathandiza amachepetsa mphamvu ya matenda aakulu, koma nthawi zambiri odwala anati zotsatira osafunika. Nthawi zina, iwo akhoza kukhala zoopsa ndithu:

1. Perforation ya m'mimba ndipo matumbo.
2. Internal magazi.
3. Wolumikizira thromboembolism.
4. Kuthamanga magazi ndi proteinuria akufotokozera. Ambiri mwina, ichi ndi chifukwa mmene mtima mlingo.

Komanso, odwala amene anasankhidwa mankhwala "Avastin" mavuto ndi zizindikiro zina amaoneka:

• kwambiri mtsempha thrombosis, kuipidwa mawonekedwe a matenda a mtima, supraventricular tachycardia, magazi;
• leukopenia, neutropenia, otsika hemoglobin thrombocytopenia;
• kusapeza mu peritoneum ndi matenda m'mimba, magazi m'manyi, opatsirana zidzolo pa kamwa, magazi m'kamwa, matumbo kutsekeka;
• magazi kuchokera mphuno, kusowa kwa mpweya, thromboembolism m'mapapo mwanga;
• khungu youma, dermatitis, khungu kamvekedwe;
• imfa ya kulawa, imfa mofulumira kulemera, syncope, migraine, sitiroko, kusinza;
• amaona masomphenya;
• kupweteka kumene medicament chikuyendetsedwera;
• magazi kwa chiberekero, matenda thirakiti mkodzo, lingaliro la kutopa, kuchepa madzi m'thupi.

contraindications

Kaya onse yoyenera "Avastin"? Umboni kuti uyu ndi mankhwala kwambiri, komabe alinso contraindications ntchito, ndipo musanayambe chithandizo, dokotala ayenera kukuuzani iwo. mankhwala sayenera mankhwala milandu zotsatirazi:

• ngati pali tsankho wapadera yaikulu yogwira pophika;
• Pali matenda a maso ndi malo periocular;
• zimachitika Intraocular kutupa;
• zaka 18;
• Mimba ndi mkaka wa m'mawere.

Komanso, ngati wodwalayo ali ndi mwayi sitiroko, ndiye pokha "Avastin" kuika pokhapokha wodwala bwinobwino ndipo mwazindikira kuti athandize mankhwala.

Kusamala

Azichitira mankhwala ayenera dokotala amene amadziwa kuchita jakisoni intraocular.

Pambuyo chida polima, pamene osavomerezeka apite kumbuyo gudumu la galimoto ndi kuchita ntchito kugwirizana ndi zimagwirira ndi onse chifukwa cha zimene angathe chosakhalitsa chisokonezo zithunzi.

"Avastin" (Mlengi imaonekera mu malangizo) ayenera yekha kusungidwa mu firiji, pamene Mulimonsemo siiyenela kukhala zii. Idatha kusintha ndi mankhwala okha.

Mmene angalankhulire "Avastin" ndi mankhwala ena?

Mankhwala "Avastin" ndi yosemphana ndi njira dextrose. Komanso, mankhwala akhoza azitaya zosiyanasiyana chokhwima pamene anatengedwa molumikizana ndi njira imeneyi:

• "Sunitinib malate" - kumachitika kukhala microangiopathic hemolytic magazi m'thupi;
• pulatinamu ndi taxanes - zotheka mavuto a pathologies opatsirana, neutropenia kwambiri, kuchuluka chiopsezo imfa;
• "Panitumumab" ndi "Cetuximab" - kumawonjezera zotsatira poizoni mankhwala ndi limadzetsa imfa.

"Avastin" mu pochiza matenda a maso

Posachedwapa, zimene anaonekera atolankhani kuti mankhwala "Avastin" ntchito ndi ophthalmologists kuchiza matenda diso amapereka zotsatira zabwino kwambiri. Koma kodi? Kodi likunena za Mlengi? Chida amalola kuti musiye osati kukula kwa zotupa, komanso kuchiza matenda a masomphenya?

Inde, Ndipotu pali zambiri odwala ena tamva za phindu la mankhwala kwa diso, ndi angayerekeze kuti kuwombera "Avastin" mu vitreous, koma zotsatira zake zinali zoopsa. Mankhwala iwo sanali kubweretsa machiritso aliwonse M'malo mwake, zinachititsa kuti anthu ali akhungu basi. "Roche" kampani mobwerezabwereza anatsindika kuti "Avastin" sangathe ntchito mu pochiza matenda a maso cholinga chake ndi chosiyana.

mankhwala cholinga kuchepetsa mphamvu ya kukula kwa mitsempha kuti chakudya khansa, motero kuchepetsa mwamphamvu chotupa chitukuko. N'chifukwa chake musanayambe mankhwala ndipo mverani malangizo unsubstantiated bwino kukaonana ndi dokotala.

"Avastin": Anzawo

Koma ngati pali wogwirizira, womwe ndi mu kapangidwe kake ndi zofanana mankhwala, izo sizimapanga iwo "Avastin". Analogs wa limagwirira kanthu ndi komanso zotsatira zabwino mu liwiro kukula kwa mitsempha ndi chitukuko cha zotupa khansa. Njirazi ndi monga:

• "Arzerru".
• "Campath".
• "Rituximab".
• "MabThera" neri Al.

Koma tiyenera kukumbukira kuti dotolo ali kusankha analogue.

"Avastin": mayankho a odwala ndi madokotala

"Avastin" (malangizo Buku zikutsimikiziridwa) ndi mankhwala okhawo amene muli mu zikuchokera bevacizumab ake, zimathandiza kuti m'mbuyo kukula kwa mitsempha kudyetsa chotupa, potero liwiro matenda kupitirira. Ambiri mwa asing'anga amene anaona mphamvu ya matenda wodwalayo makamaka, iwo amati angapo jakisoni chimaonekadi liwiro kukula chotupa, chinthu chachikulu - ufulu kutenga mankhwala ndipo musati kuphatikiza ndi mankhwala osakaniza akhoza amavutitsa kwambiri wodwalayo.

Kufotokoza, tikhoza kunena motsimikiza kuti "Avastin" (sewerolo - F. HOFFMANN-La Roche) - wokongola, amene amathandiza kutalikitsa moyo wa odwala ndi zotupa khansa. Koma kuti ndizofunikira yekha ntchito kuti kuyang'aniridwa okhwima dokotala, mwinamwake zotsatira zake zingakhale sizingasinthe ndi kutha mwachisoni.