"Farmadipin" (madontho) ku chiyani?

Panopa, pali zambiri mankhwala osiyana oopsa ndi stenokardicheskie kuukira. Mmodzi wa iwo ndi monga "Farmadipin" (madontho) mankhwala. Kodi mankhwala, zambiri zokhudza nkhani mwatsatanetsatane.

kapangidwe

The yogwira pophika mu nkhani iyi ndi nifedipine (nifedipine). 1 ml ya njira, ndi mu muyezo winawake. Ndiko kuti, 100%, zochokera youma-mtundu mankhwala - 20 mg. Likukhalira madontho atatu.

"Farmadipin" (m'malovu), malangizo amene ntchito akambirana pansipa, mu dongosolo ndi kukhalapo kwa zinthu wothandiza monga polyethylene glycol 400 ndi 96% Mowa.

katundu pharmacological

Izi mankhwala ali pharmacodynamics achilendo. Monga tanenera kale pamwambapa, "Farmadipin" (madontho) lili mankhwala nifedipine amene amapereka antihypertensive ndi odana anginal kanthu. Imalimbikitsa kutsekereza kulowa ayoni kashiamu mu cardiomyocytes ndi maselo yosalala minofu ina mitsempha zotumphukira ndi inatsekeratu kupyolera voteji-mtundu njira pang'onopang'ono ziwalo za nembanemba selo. Mundawu zofunika. Nifedipine amatipatsanso zosangalatsa za mtima yosalala minofu, kuchuluka zotumphukira ndi inatsekeratu mitsempha, kuwonongedwa kwa spasms. Izi amachepetsa magazi, zokhudza zonse mtima kukana, afterload mtima ndi kufunika m'mnyewa wamtima oxygen. Komanso, pamene mukumwa mankhwala akupitiriza kusonyeza zizindikiro zina. Ndicho, pali kuchepa pang'ono contractility m'mnyewa wamtima nchito mtima, komanso penapake yafupika kupatsidwa zinthu za m'mwazi loitanirana.

Pharmacokinetics

Pa nkhani imeneyi, "Farmadipin" (madontho), malangizo ntchito zomwe imatengedwa mu lipoti lino, ali ndi makhalidwe yake. Pamene phwando mkati anali thirakiti m'mimba bwino odzipereka. bioavailability ake ndi za 40-60 peresenti. A chitukuko zotsatira makamaka mofulumira (pambuyo mphindi 5-10) anamuona pa kukhazikitsa utsogoleli sublingual. Nkofunika kudziwa. Childs, zotsatira kwambiri zimaoneka mu mphindi 30-40. Kukhazikitsa ingestion si makamaka bwanji mlingo wa mayamwidwe wothandizila lapansi. Chiwonetsero cha mmene hemodynamic adzakhala angakhale kwa maola 4-6. Choncho 90 peresenti ya nifedipine womangidwa kwa mapulotini madzi a m'magazi. Iwo zimapukusidwa kukonzekera monga "Farmadipin" (dontho) mu chiwindi. Kupezeka kwa okwana chilolezo cha nifedipine ndi kuchokera 0.4 kuti 0,6 L / kg / hr. Iwo chimaonekera thupi makamaka ngati metabolites anafooka mtundu. Nthawi ya theka moyo zingasiyane maola 2 kapena 4. Okalamba ndi odwala matenda a chiwindi, nifedipine kagayidwe kubweza pansi kwambiri. Chifukwa, iwo ndi theka moyo wa chizindikiro njira akhoza zochuluka pafupifupi 2 khola. Pankhaniyi m'pofunika kuchepetsa mlingo ndi kuonjezera imeneyi pakati pa madyerero a chiphunzitso anati. Nifedipinv thupi osati cumulated. Komanso mu pang'ono amatha kulowa magazi ndi ubongo ndi chotchinga placental. Pankhaniyi, izo excreted mu mkaka wa m'mawere.

zikuonetsa

Yoikika "Farmadipin" (dontho) milandu zotsatirazi:

• Mu chochitika cha matenda oopsa zofunikira ndipo symptomatic.
• Mankhwala ndi kapewedwe stenokardicheskie kuukira.
• Pamene hypertrophic cardiomyopathy.
• Pamene matenda Raynaud a.

ntchito

Tengani "Farmadipin" (madontho) sublingually. Pakumuka kwa lakuthwa magazi (mwachitsanzo, 180 / 100-190 / 110 mamilimita Hg. V.), A osakwatira koyamba mlingo wa mankhwala wamkulu zambiri pafupifupi 3-5 madontho (2-3,35 mg). Odwala ndi ukalamba waperekedwanso mlingo yeniyeni. Ndicho - zosaposa 3 madontho (2 mg). Komanso, nambala mwachindunji akhoza adzagwa pa chidutswa ka mkate wouma kapena shuga. wodwalayo ayenera kugwira ngati n'zotheka pakamwa. Ndi osakwanira chifukwa mlingo wa mankhwala ndi chinawonjezeka pang'onopang'ono mpaka efficacy matenda. Pankhaniyi, izo zidalira pa munthuyo. Pa mawonetseredwe wotsatira cha kuchuluka kwa magazi ayenera kutsatira enieni kuika mlingo. Komanso, pali muyezo wina yeniyeni. Yankholo mu chakuti ngati magazi anakonzeka 190 / 100-220 / 110 mamilimita Hg. v., ndiye kutenga madontho mankhwala akhoza pang'onopang'ono kuchuluka kwa 10-15 (6,7-10 mg). Iwo ayenera kuganizira kusintha kuthamanga wodwalayo anapatsidwa. Nkofunika kudziwa.

Muyeneranso kuganizira pamaso pa kuchuluka tilinazo odwala ena kuti mankhwala monga "Farmadipin" (madontho), zomwe ndemanga abwino. Zikatero, mlingo amusankha payekha. Yambani ndi madontho 3, ndiyeno pang'onopang'ono anamuukitsa kwa 2-3 (1,34-2 mg) mpaka nthawi imene kufunika kwenikweni matenda zimatheka.

Tiyenera kukumbukira kuti owonjezera mlingo woyambilira wa mankhwala zingachititse kuchepa lakuthwa magazi!

mbali zotsatira

Mu ntchito yokonza zimenezi monga "Farmadipin" (dontho la kuthamanga), pangakhale zizindikiro za nseru, tachycardia, hypotension, "mafunde" magazi kwa nkhope. Nthawi zina, angayambitse thupi lawo siligwirizana mu mawonekedwe a mwendo edema, zotupa pa khungu. Iwonso kuonetsa zizindikiro za kufooka, chizungulire, mutu.

contraindications

Phwando chotero mankhwala, monga "Farmadipin" (dontho) zoletsedwa kunyamula pamaso pa kuchuluka kudziwa zigawo zake, cardiogenic mantha, kung'ambika kwambiri ndi mitral stenosis, hypotension, tachycardia, komanso pa mimba ndi mkaka wa m'mawere.

ambiri osokoneza

Pankhaniyi, zizindikiro zina ndi zoipa kumachitika. Ndicho ambiri osokoneza mankhwala monga "Farmadipin" (madontho), akhoza limodzi ndi pakutchulidwa kulephera mtima, mantha, kagayidwe kachakudya acidosis ndi khunyu, dontho lakuthwa magazi. Pamene mawonetseredwe a zizindikiro zimenezi n'kofunika amachita zinthu mopanda ena mwamsanga thandizo. Iwo MUKACHULUKIDWE lavage chapamimba, adamulowetsa mpweya, calcium mankhwala enaake ndi sympathomimetics oyamba mankhwala symptomatic.

ntchito Features

"Farmadipin" (dontho la kuthamanga) kapena m'malo izo kuchitidwa yekha ndi kusamala matenda kuwunika odwala okalamba ndi odwala amene ali ndi:

- wosakhazikika angina.

- woopsa mtima kulephera.

- hypertrophic cardiomyopathy.

- pachimake kung'ambika stenosis.

- aakulu m'mapapo mwanga oopsa.

- pachimake sitiroko.

- shuga.

- aimpso ntchito ndi chiwindi.

Mlingo wa mankhwala ena ntchito nifedipine ayenera kukhazikitsidwa payekha. glycosides mtima komanso angagwiritsidwe ntchito pa phwando la mankhwala monga "Farmadipin" (madontho), analogs amene pansipa mu nkhani iyi.

Atalandira ntchito munthawi yomweyo nifedipine ndi mtsempha mankhwala enaake a sulphate amayi oyembekezera ayenera kusonyeza polojekiti mosamala magazi. Izi zichitike chifukwa pali kuthekera kwa kutsitsa magazi zimene zingasokoneze mayi ndi mwana wosabadwayo.

Odwala ndi mkhutu kwa chiwindi magwiridwe, amafuna polojekiti mosamala. Zikavuta, mlingo ayenera kuchepetsedwa.

Nifedipine tsitohromichnuyu zimapukusidwa kudzera dongosolo P450 3A4. Chifukwa, mankhwala ziletsa kapena kupangira mwachindunji m'dera enzyme akhoza kusintha zotsatira za "HIV koyamba" kapena chilolezo cha thunthu. Ngati concomitant ntchito nifedipine ndi mankhwala a mtundu zimenezi ziyenera kulamulidwa magazi. Ngati ndi kotheka, ayenera amachita kuchepetsa mlingo wa mankhwala, monga "Farmadipin" (madontho).

Akafuna kutulukira zinthu zosiyana mu m'galasi ndakufotokozerani ubale pakati pa ntchito muzikangana kashiamu mu izi nifedipine mlandu ndi amuzolengedwa kusintha osiyanitsidwa spermatozoa zokhudza kuwonongeka kwa luso yotsirizira kugwiritsa umuna.

Kutenga "Farmadipin" (madontho), tiyenera kupewa zinthu zingakhale woopsawo mtundu, zofuna kusintha. Ndicho, pamene si koyenera kuyendetsa galimoto ndi ntchito ndi njira zina, ndi zina zotero.

mogwirizana

"Farmadipin" (droplet) ali ndi kanthu hypotensive. Mbali imeneyi timapitiriza mankhwala kuchokera gulu blockers. Kuti, "Farmadipin" (dontho) kumawonjezera β-adrenergic zotsatira, okodzetsa, ku feteleza, ndi zina antihypertensive wothandizira, kukonzekera ndi zakumwa zokhala ndi mowa, tricyclic antidepressants. Nthawi zina, nifedipine amachepetsa quinidine ndende mu madzi a m'magazi. Koma kulipira wake zambiri zolemera. Choncho, ntchito osakaniza mankhwala tikulimbikitsidwa kuti aziona pa kaperekedwe ka quinidine ndende mu madzi a m'magazi.

"Diltiazem" amachepetsa chilolezo cha mankhwala monga "Farmadipin" (m'malovu). "Fentanyl" kwambiri timapitiriza chiwonetsero cha zotsatira hypotensive. Chifukwa, isanafike utsogoleli wa mankhwala (mu maola 36.) Kodi kusiya phwando "Farmadipina". Olowa ntchito β-blockers ndi nifedipine kungayambitse hypotension. "Farmadipin" (akutsikira) bwino ndende ya theophylline, carbamazepine ndi digoxin m'magazi. "Rifampicin" kumayambitsa chifooke zotsatira akangofika nifedipine, motero kufulumiza khalidwe la kagayidwe ake. "Cimetidine" timapitiriza ndende "Farmadipina" mu madzi a m'magazi.

Terms ndi zinthu yosungirako

Pankhaniyi, pali muyezo ena. Store "Farmadipin" (dontho) ayenera kukhala firiji mu malo ouma. mankhwala ayenera kutetezedwa kuwala ndi ana sangawapeze. Kusungiramo mankhwala lakonzedwa kuti 1 chaka ndi miyezi 6. Kamodzi anatsegula nsupa - masiku 28.

holide

"Farmadipin" (akutsikira) akhoza anazindikira yekha ndi mankhwala.

wazolongedza

Mu mbale 25 ml ya kapena 5 ml. Iwo padera mu paketi.

"Farmadipin" (madontho) analogues ku Russia

Pali mmalo ambiri mankhwala. The akuluakulu ndi:

- "cordipin".

- "Nifedipine".

- "Adalat".

- "Kordafleks".

- "Corinfar Uno".

- "Kordafleks Rd".

- "fenigidin".

- "Osmo-Adalat".

- "cordipin achigonjetse."

- "cordipin XL".

Pomaliza

Tsopano inu mukudziwa chomwe monga "Farmadipin" (dontho) mankhwala, amene zimathandiza ndi zomwe katundu. Mulimonsemo, asanadye mankhwala ayenera kuonana ndi dokotala oyenerera.