Hypothalamic kumasuka mahomoni

Kutulutsa mahomoni ndi neurohormone anthu amene apanga hypothalamic phata. Iwo ziletsa (statins) kapena yotithandiza (liberiny) kupanga lotentha pituitary mahomoni. Iwo imayendetsa zopangitsa za endocrine, ndipo pali lamulo za kumasulidwa kwa mahomoni. Mbali apamwamba a dongosolo chapakati mantha ndi dongosolo endocrine zikugwirizana kwambiri chifukwa cha timadzi kumasuka.

ntchito hypothalamic

Chimodzi zofunika a dongosolo endocrine udindo ulimi wa mahomoni - ndi ubongo imene imalamulira kutentha. Yopangidwa ndi ubongo imene imalamulira kutentha zinthu ndi mahomoni nawo njira kagayidwe kachakudya za thupi.

Mu ubongo imene imalamulira kutentha pali maselo mitsempha kuti kuonetsetsa yopanga zinthu zofunikira m'thupi ayenera kuti uziyenda yachibadwa. Maselo amenewa amatchedwa neurosecretory. ntchito yawo - kulandira nyemba kuti zimafalitsa m'madera osiyanasiyana ya ubongo. zinthu kudzipatula kumachitika mwa synapses aksovazalnye.

Yopangidwa ndi hypothalamic kumasuka mahomoni, kapena ngati iwo amatchedwa mosiyana statins ndi liberiny, zofunika kugwira ntchito wabwinobwino wa pituitary England. Ndi chikhalidwe chawo mankhwala, ali mapeputisayidi. Chifukwa mankhwala ndi mitsempha zikhumbo ndi kaphatikizidwe awo, iwo amadutsa mu magazi ndi pituitary hypothalamic-pituitary dongosolo.

Gawo mahomoni

Taganizirani odziwika bwino kwambiri kumasuka mahomoni:

• Inhibiting ndi katulutsidwe wa pituitary ntchito - ndi somatostatin melanostatin, prolaktostatine.
• Stimulant - tikulankhula melanoliberine, prolaktoliberine, folliberine, lyuliberine, somatoliberin, thyrotropin-kumasuka timadzi, gonadotropin-kumasuka timadzi ndi corticotropin.

zinthu izi, kapena m'malo ena a iwo, akhoza ziri opangidwa ndi matupi zina, osati ubongo imene imalamulira kutentha (mwachitsanzo, kapamba).

Statins ndi liberiny

Kugwira ntchito kwa pituitary England mwachindunji amadalira iwo. iwonso zimakhudza kugwira ntchito kwa zopangitsa endocrine zotumphukira:

• chithokomiro;
• mazira atsikana;
• testes amuna.

Statins ndi liberiny omwe odziwika ndi:

• dopamine;
• GnRH (lyuliberin, folliberin);
• melonostatin;
• somatostatin;
• tireoliberin.

The katulutsidwe wa luteinizing timadzi timadzi follicle-zolimbikitsa za pituitary GnRH kupereka.

Pa ntchito ya androgen anthu kusokoneza GnRH, zimathandiza kuti ponso ntchito umuna ndi mlingo wa libido.

Ndipo akazi neurohormone udindo kuzungulira kusamba, kuchuluka kwa timadzi zimasiyanasiyana ndi gawo la mkombero izo.

Osakwanira yopanga kumasuka mahomoni zimayambitsa osabereka ndi kusabala.

Makhalidwe mahomoni

timadzi Corticotropin udindo nkhawa, opangidwa ndi ubongo imene imalamulira kutentha kwa. Izi ina yofunika kumasuka chinthu, zinthu molumikizana ndi mahomoni ndi pituitary ndi zotsatira zawo pa zopangitsa kwa adrenal. Anthu ndi kusowa kwa timadzi kawirikawiri amadwala matenda oopsa, ndi adrenal insufficiency.

GnRH - ndi timadzi kuti timapitiriza yopanga gonadotropins - komanso mankhwala a ubongo imene imalamulira kutentha kwa. Limatchedwanso gonadotropin-kumasuka timadzi.

Uziyenda yachibadwa ziwalo zoberekera simungakhoze kuchita popanda GnRH. Ndi timadzi izi ndi udindo njira yachibadwa ya msambo mu akazi. Ndi sachita amatenga ikani ndondomeko ya kusasitsa ndi kutulutsidwa kwa dzira. timadzi Ichi ndi udindo libido (kugonana galimoto). Pamene pali osakwanira kupanga timadzi mwa ubongo imene imalamulira kutentha mu nthawi zambiri akazi kukhala osabereka. Kodi aliyense ali kumasuka mahomoni?

somatoliberin

Kwambiri mofulumira anamasulidwa ku ubwana ndi unyamata. Mbali yake yaikulu ili m'kati normalization wa a thupi kukula limba ndi. Kuyambira kupanga umadalira pa chitukuko zonse ndi mapangidwe mwanayo. Osakwanira kutulutsidwa kwa timadzi ku ubongo imene imalamulira kutentha kwa kungachititse kuti dwarfism (dwarfism).

Prolaktoliberin

kukula kwambiri yogwira zidzachitika gestation ndipo mu nthawi kudyetsa mayi a mwanayo. Izi chinthu kumasuka normalizes yopanga prolactin, kupanga ducts wa zopangitsa za mammary.

Prolaktostatin

Prolaktostatin amatanthauza subclass wa statins opangidwa ndi ubongo imene imalamulira kutentha, ndiye amachititsa chopinga wa prolactin.

Ndi prolaktostatinam monga:

· Dopamine;

· Somatostatin;

· Melanostatin.

kanthu yaikulu umalimbana kupondereza mahomoni nkhalango ya pituitary ndi ubongo imene imalamulira kutentha.

Melanotropin-kumasuka timadzi

Mu ndondomeko ya melanin pigment ndi kulekana kwa maselo amakhudza melanoliberin. Iye amachita pa nyengo ya DWP pituitary.

Zikoka neurophysiological khalidwe. Izo ntchito kuchotsa mankhwala a limati mukakhala ndi parkinsonism.

Thyrotropin-kumasuka timadzi (TRH)

Ndi mahomoni thyrotropin-kumasuka ya ubongo imene imalamulira kutentha kwa imagwiranso thyroliberine. Imalimbikitsa kupanga timadzi wa zapambuyo pituitary thyritropic.

Pamlingo yaing'ono anakopa ndondomeko ya prolactin. Thyroliberine timapitiriza ndende ya thyroxine m'magazi.

CNS ali ndi chikoka chachikulu pa njira ya ulimi wa mahomoni. Kwa kupanga neurohormones ndi udindo neurosecretory selo zolimbana dongosolo.

ntchito Basic liberinov

hypothalamic Izi kumasuka mahomoni. Ntchito zolimbana. GnRH matenda kugwira ntchito ziwalo zoberekera za amayi ndi abambo.

Ali ndi udindo kwa kubalana wa follicle-zolimbikitsa timadzi kusintha kugwira ntchito kwa testes ndi thumba losunga mazira.

Chotero chigawo monga lyuliberin, asabwezere cholekanitsa zimakhudzanso ovulation, kupanga kuthekera yoopsa pathupi.

Akazi amene safuna kumva moyo wapamtima, ndipo lyuliberin folliberin opangidwa zedi osakwanira.

Pali zifukwa kumasuka zokhudza gawo avareji ubongo imene imalamulira kutentha, koma chaubale kwa pituitary zapambuyo maselo pituitary ndipo osati afufuza.

Agonists kumasuka timadzi: mankhwala

Monga tanenera kale, mahomoni amenewa ndi ubongo imene imalamulira kutentha kwa. Pamene adafuna Zimachititsa mazira, mwachitsanzo pamaso ndondomeko lidzawagwiritsenso, ntchito agonists kapena corticotropin kumasuka timadzi analogs. Ndiko kuti, pa thupi zotsatira mofanana timadzi yake.

Koma mwayi wa zosiyanasiyana chokhwima pa mbali ya thupi wamkazi. Izi zimachitika chifukwa milingo m'munsi esitirojeni. Zotsatira ambiri monga:

• mutu;
• kwambiri thukuta;
• otentha cheza;
• ukazi dryness;
• mmene alili;
• maganizo.

Mankhwala amagwiritsidwa ntchito motere:

• "Diferelin" ndi yokumba decapeptide analogue wa timadzi zachilengedwe kumasuka.
• "Dekapeptil" monga triptorelin a, an analogue yokumba wa GnRH. Hafu ya moyo wautali. Nthawi zambiri ntchito ubwamuna m'thupi mwake.
• "Lyukrin zofikira" - leuprorelin. Iwo ali wotsutsa-esitirojeni, odana ndi androgenic tingati akuchiritsa endometriosis, timadzi amadalira zotupa - kansa ya prostate, fibroids uterine. "Lyukrin zofikira" amachepetsa ndende ya testosterone anthu, estradiol mu akazi, kuwonjezera, kumabwezera mmbuyo pituitary incretia FSH, LH.
• Mmene mankhwala pang'onopang'ono imatsitsimula katulutsidwe thupi mahomoni.
• 'Zoladex' - kupanga analogue mwachibadwa timadzi-kumasuka timadzi (LH). Amagwilitsidwa ntchito lidzawagwiritsenso. Amachepetsa ndende ya estradiol m'magazi, izi zimachitika chifukwa cha yimitsira wa LH katulutsidwe wa zapambuyo pituitary.
  

Tinakambirana kukonzekera agonists kumasuka timadzi.

muzikangana

Popeza pamene kulandira kumasuka timadzi agonists ukuwonjezeka kwambiri estradiol angagwe mwadzidzidzi amasulidwe luteinizing timadzi. Zimenezi zimabweretsa ovulation msanga ndi chiwonongeko cha mazira. Popewa izi, ndi muzikangana kumasuka ntchito timadzi. Chifukwa cha zochita zawo zikhoza Zimachititsa pituitary England kachiwiri. Yamchiberekero hyperstimulation syndrome alibe kuonekera, koma nthawi zambiri chifukwa cha ntchito yaitali GnRH agonists. Kodi kutumikiridwa patapita masiku asanu kuchokera pa chiyambi cha ntchito follicle popatsana timadzi.

Mankhwala ndi bwino zonse cholinga kukonzekera ayenera kukhala katswiri.