Zamchere phosphatase - ndi chikhomo enzyme

Zochita clinicians nthawi zambiri anakumana ndi kuwonjezeka mwadzidzidzi ntchito zamchere phosphatase. Pogwiritsa ntchito zida Mipikisano chiyeso maphunziro amuzolengedwa kuti ali ndi mwayi kulamulira ntchito enzyme ndi. Malinga ndi mlingo wa ntchito ya anati enzyme angazindikire matenda a dongosolo hepatobiliary ndi minofu fupa.

Zamchere phosphatase - puloteni kuti wa gulu la hydrolases, anadziphatika gulu mankwala ku biopolymers osiyana (mapuloteni, zidulo mkati alkaloids). Mwapamwamba ntchito enzyme unkachitika m'malo zamchere. The puloteni lili maselo kugwirizana ndi plasma nembanemba a boma, chotero akunena za michere Kakhungu-womangidwa. Zamchere phosphatase (ALP) wapangidwa ndi isozymes osiyanasiyana amene anayikidwa mu epithelium zhelchnovyvodnyh ducts nembanemba plasmatic wa hepatocytes ndi manyuroni, fupa, intestine, nsengwa, impso.

Kudziwa Ntchito ya isoenzymes pogwiritsa ntchito electrophoresis. Komabe, ALP isozymes mulibe bwino limba kulunjika, ndi njira electrophoretic zovuta. Choncho, wosalira kafukufuku pogwiritsa ntchito njira zomwe zachokera isoenzymes osiyana kudziwa kutentha. Matumbo zamchere phosphatase chikukhudza kachigawo thermostable ndi isozymes a chiwindi ndi fupa - ndi thermolabile. tcheru kwambiri kutentha ndi fupa phosphatase.

Seramu zamchere phosphatase ndi osakaniza a mafupa ndi chiwindi isoenzymes. Amasulidwe enzyme ku magazi zimakhala zosiyana zimadalira boma thupi ndi m'badwo wa chamoyo (mimba, parturition, mkaka wa m'mawere mwamphamvu). Ntchito mkulu wa phosphatase zamchere mu mwazi wa achinyamata chifukwa ntchito lochita osteoblasts mu minofu fupa, amene amayamba ndi njira kukula yogwira lake. Nthawi imeneyi, ntchito enzyme mu ukuwonjezeka magazi chifukwa isoenzyme fupa. Mu theka lachiwiri la mimba, pobereka mwachangu Kuonjezera ndi chiwonongeko cha nsengwa ndi kuchititsa kuwonjezeka mu ndende ya isoenzyme placental.

Kuwonjezera ndende ya phosphatase zamchere m'magazi zambiri m'kaundula mu kudwala a chiwindi ndi fupa. kuwonongeka Parenchymal chiwindi amachititsa kuwonjezeka pang'ono ntchito enzyme mu seramu magazi, monga phosphatase zamchere kugwirizana ndi nembanemba selo. Mu matenda isoenzyme hepatology chiwindi ndi zimasonyeza kuti matenda a cholestasis. Ichi ndi chifukwa kuchuluka kaphatikizidwe ya ndulu ritsa maselo AP kulakwila enzyme kudzipatula mu ya ndulu. Hyperenzymemia makamaka mkulu pa chitukuko cha ndondomeko pathologic ndi ya ndulu stasis mu chiwindi ya ndulu ducts. Ndiye ntchito enzymatic wa phosphatase zamchere mu seramu magazi kuchuluka tenfold. Ngati kuwonongeka intrahepatic biliary enzyme ntchito ukuwonjezeka magazi kokha 2-3. zamchere phosphatase ponseponse akuluakulu zaka 31 amapanga 39,0-92,0 IU / L patapita zaka 31 - 39,0-117,0 IU / L. Zamchere mlingo phosphatase ana osaposera zaka 10 - 106,0-213,0 IU / L kwa zaka 3 - 71,0-213,0 IU / l, ndi kwa ana - 35,0-106,0 IU / L.

Mu kudwala fupa, pamene pali chinawonjezeka ntchito osteoclasts, pa chitukuko cha rickets, osteodistorofii, hyperparathyroidism m'magazi kumawonjezera ntchito phosphatase fupa zamchere. Pankhaniyi, chiwerengero zamchere phosphatase ntchito magazi chinawonjezeka ndi nthawi 3-10. Pakuti matenda oyambirira rickets ndi osteodystrophy ndi kuwonjezeka yeniyeni ntchito phosphatase mu madzimadzi synovial. Kuwonjezeka ntchito zamchere phosphatase mu madzimadzi cerebrospinal ndi chizindikiro cha kugonjetsedwa kwa nembanemba okhudza mitsempha, kumene isanafalikire.