Treponema pallidum (Treponema pallidum) - nthumwi causative a chindoko

Treponema pallidum - ndi bakiteriya choopsa kwambiri, nthumwi causative a chindoko. Izo mofulumira likulowerera mu thupi la munthu ndipo pa mlingo yomweyo propagates, motero kwambiri okhudza ziwalo.

Kufotokozera mabakiteriya

Treponema pallidum - mabakiteriya kukhala khungu nembanemba. Ndi moyo nthawi zina chilengedwe. bakiteriya ili spirochaetes lapansi. Ikukhala ngati mapini yaing'ono mwauzimu, zimenezi kwa zidutswa eyiti kwa khumi ndi ziwiri. Monga mwa kuchuluka zawo ndi maonekedwe a bakiteriya ndi wapezeka pamene kuipitsa mbiri wamamamayikirosikopu zichitike.

bakiteriya Izi sizingagwirizane akuda utoto, amene ntchito ku tizilombo tosaoneka ndi maso. Pofuna kuona bakiteriya ntchito mosiyana wamamamayikirosikopu. Ichi ndi chifukwa chakuti chipolopolo kwambiri woonda yaying'ono-chamoyo atamwa mowa mwamsanga zowonongeka (ndi chabe ntchito pa mtundu fixation). Pamene siliva-yokutidwa mabakiteriya amakhala bulauni-wakuda mtundu.

nthawi yaitali bwanji moyo mabakiteriya

Treponema pallidum anakumana ndi zinthu (makamaka zofunda ndi matawulo) anakhalabe mpaka gawo lapansi youma, chimene chinali. Nthawi zambiri malovu anamasulidwa madzimadzi zilonda ndi erosions, umuna, ndi zina zotero. D. Pa kutentha makumi asanu madigiri bakiteriya akhoza kukhala pafupifupi maminiti khumi ndi asanu. Pa kufa apamwamba mwamsanga. Pa otentha mabakiteriya kufa mu nkhani masekondi, ndiye nthawi yomweyo.

Amene chimawononga mabakiteriya

Pakuti Treponema pallidum ena chilengedwe zoipa ndi zinthu:

• bismuth ndi Arsenic;
• Mercury;
• penicillin;
• soda ndi asidi;
• antiseptics ndi disinfectants;
• viniga ndi mowa;
• UFO ndi kuwala.

Malinga ndi maphunziro ndi zatsopano wochitidwa ndi asayansi, chinapezeka kuti bakiteriya izi nthawi zina amapitirizabe kwa nthawi yaitali ndipo zinthu chokhwima kwa izo. Mwachitsanzo, mu malo oipa, pansi kuunika, boma zouma kapena pamaso pa oxygen. Ngati inu inadza mpukutu wa bakiteriya, iwo akhoza kukhalamo sizili kuti iye zaka zitatu.

Treponema kukula ndi antigens yaikulu

Treponema pallidum bwino nakulitsa chifukwa cha capriciousness ake. Maselo a mazira mwana wankhuku ndi anthu sali oyenera kulima chamoyo ichi. Pali njira ziwiri, momwe chikhalidwe kuzindikiridwa. The choyamba - bakiteriya kupatsira zasayansi akalulu, ndipo dikirani kuti chitukuko cha nyama zimenezi orchitis. Chachiwiri - treponemu akhoza kukhala wamkulu pa wapadera atolankhani pansi mchere mafuta. Kupezeka kwa zinthu izi ndi zofunika kutenga antigens amene chindoko anatsimikiza.

Pathogenicity Treponema pallidum

Tizilombo mabakiteriya treponema pallidum ali makhalidwe ake kuti:

• chifukwa cha adhesin mapuloteni kuti interacts ndi fibronectin mucosal anapereka "kum'mamatira" mwamantha maselo;
• pamaso pa myofibrils ndi mwauzimu mawonekedwe Treponema pallidum kulimbikitsa chozama malowedwe ndi chifukwa Kusamuka kwa thupi;
• ntchito antifagotsitarnaya ndi chifukwa cha luso mabakiteriya wakumanga fibronectin;
• amakhala ndi kuvutika chifukwa kukhalapo kwa nembanemba lipoprotein;
• treponema pallidum kugonjetsedwa ndi wothandizila antibacterial chifukwa masiyanidwe a katundu antigenic ndi luso la mapangidwe-mitundu L, zomwe zimachititsa kuti sizingatheke kuti kulenga katemera;
• mabakiteriya Awa ndi wokhoza kukhala interstices, komanso kuchulukitsa kumeneko.

Chitetezo kwa Treponema pallidum

Treponema pallidum makamaka pamodzi zimagwira ntchito zosiyanasiyana pa mucous. Choncho mosavuta opatsirana osati kupyolera mu kugonana, komanso moyo wa tsiku ndi tsiku. Nthawi zambiri mwa matawulo, ziwiya kapena kupsompsona. Mwatsoka, thupi la munthu sangathe kukhala asanazolowere mabakiteriya izi. Choncho, ngakhale pambuyo wathunthu mankhwala a matenda chindoko akhoza kubwerera.

Kudziwa matenda magazi amatengedwa kuti chindoko. Ambiri mwa matenda ndi chitetezo kwa Treponema pallidum. Mu pulayimale ndi kobwereza matenda - mu 88 78%, motero. Ena mwina si zimadziŵika kapena osakhala sakupezeka. Koma pakalibe chitetezo sizikutsimikizira kuti mankhwala ndi bwino. Mu siteji zobisika za oteteza matenda ambiri imapezeka mu 20 peresenti ya odwala.

Patapita masabata 1-2 kuyambira chiyambi cha matenda ndi kusanthula seramu. IgM ndi IgA chitetezo kwa treponema pallidum ku seramu kuoneka nthawi imeneyi. Nthawi kuchokera miyezi isanu ndi miyezi isanu ndi inayi titers wa immunoglobulin likutuluka, ndiye umayamba kuchepa kwa chiwerengero chawo. Mu nthawi imagwera pansi pa mtengo anatsimikiza ndi mlingo wa chitetezo. Ena sangathe kuchoka mayi kupita kwa mwana.

IgG chitetezo Kupezeka 3-4 masabata pambuyo matenda ndi chindoko. A sabata 6-9 kufika pachimake. A ndende yaikulu ya oteteza ndi anakhalabe kwa nthawi yaitali, ndipo amachepetsa pang'onopang'ono ndipo pambuyo mankhwala. A yotsalira titers kungapitirire mu thupi kwa moyo.

chitetezo Treponemal akhoza kupangidwa kokha ndi Treponema pallidum. Choncho, pamene kukhalapo kwawo molondola amanena kuti chindoko ilipo panthawi kapena lizikhala kale.

Zizindikiro za matenda a Treponema pallidum

Pali zizindikiro zikusonyeza kukhalapo mu thupi Treponema pallidum. Pamene iwo amaoneka zofunika kuti apereke magazi chindoko. Zizindikiro zingasiyane malingana siteji ya matenda.

Choyamba:

• chowawa zilonda kuoneka ndi chancre, ili m'kamwa, rectum kapena maliseche;
• kutupa lymph mfundo;
• paokha zilonda ali omangika masabata osachepera atatu, ndondomeko ukhoza mpaka miyezi isanu ndi umodzi.

Pa tsiku lachiwiri:

• symmetrical wotumbululuka chinzonono totupa limapezeka pa thupi;
• mutu, malaise, malungo;
• kutupa lymph mfundo;
• Nthawi zina kutaya tsitsi lake, ndi njerewere maliseche kuoneka onse.

Wachitatu pali kugonjetsedwa:

• mantha dongosolo;
• ubongo ndi msana;
• ziwalo;
• mafupa.

Mu masiteji yoyamba ndi yachiwiri chithandizo bwino mabuku monga mankhwala physiotherapy, bracing ndi immunostimulants kukonzekera. Koma ngati nthawi safuna dokotala, zaka ndiye ochepa kenako anayamba Mbali yachitatu ya matenda, kuchiza kuti kuli kovuta.

Monga tawerenga wotumbululuka treponema?

Kuti adziwe ngati pali mu thupi la mabakiteriya amene amayambitsa chindoko, ndi Khadili yoyenera. khama Treponema pallidum wa mankhwala amakono angathe kuonedwa mu njira zingapo:

• Mu gawo loyamba la chindoko wodwala kwambiri opatsirana ndipo likusonyeza mu dziko kwambiri mabakiteriya. Pankhaniyi chopaka wamamamayikirosikopu. Kuti zotsatira zolondola, zilonda mankhwala washout saline kwa n'kusokoneza zomera. Kenako anapanga kuchipala, ndipo anapanga kuipitsa mbiri.
• Non-treponemal mayesero. Pali ntchito njira mosamala. Iwo ali wabwino kwa matenda poyamba yotsatira pa mankhwala ndi kuona matenda. Koma mayeso amenewa kupereka zotsatira zabwino onyenga. Treponema pallidum mu mulandu sangakhale pano mu thupi. Ndi chifukwa oopsa (akupha antigens) ali Sadadzipangire tizilomboto.
• mayesero Treponemal zimagwiritsidwa ntchito kuti azindikire Treponema pallidum. Njirazi ntchito pofuna kutsimikizira matenda chowasiyanitsa a chindoko pa cholakwika mosamala mayeso.