PTH kuchuluka - umboni ndi kuwunika?

Parathyroid timadzi (mwinamwake otchedwa parathyroid timadzi, parathyrin) - ndi timadzi opangidwa ndi parathyroid zopangitsa minofu (parathyroid), zomwe zili mbali anterolateral wa khosi. Iwo amachititsa chithokomiro England, amene ali kwambiri pafupi ndi pamwamba kumbuyo kwake ndi mmunsi mwa onse cholowa. Parathyroid timadzi mu chikhalidwe chawo mankhwala ndi zovuta mapuloteni mankhwala - polypeptide kwa amino opangidwa kuchokera acid.

Ntchito yake yaikulu ili nawo ndi lamulo kashiamu ndi phosphorous kagayidwe mu thupi. The zili kashiamu mu magazi ndi katulutsidwe wa timadzi parathyroid ndi mwachindunji yozungulira Chrixitu. The timadzi angadwale kashiamu ndende mumatsatira fupa minofu, impso ndi kapepala m'mimba. Fupa parathyrin kumawonjezera logoff Kutha mbali mchere ndi zolimbikitsa kaphatikizidwe michere zopatsa udindo kuwonongedwa kwa zinthu fupa. Bone minofu ndi pansi pa chikoka cha PTH resorption ndi calcium ayoni zili magazi. Pamodzi ndi kashiamu kuwombola paratgormot umathandiza kuti nthaŵi zonse mlingo wa mankwala mu thupi. Kuchepetsa mphamvu ya ndondomeko loyamba zamoyo izo amakulitsa otaya chachiwiri. Komanso, timadzi wa kumatanthauza utithandize kaphatikizidwe calcitriol mu intestine, kuwathandiza kashiamu reabsorption. Parathyroid timadzi amatenga gawo mozungulira mu lamulo la zochitika za onse michere kashiamu amadalira katalirizuemye angachitire. Muulamuliro wake afika dongosolo magazi coagulation.

Ngati PTH ndi kukwezeka, ndiye anapanga matenda aakulu endocrine kugwirizana ndi fupa kukhulupirika kuphwanya - hyperparathyroidism, ndi kufooka kwa mafupa. The Chifukwa chilema thupi zikuchepa amachepetsa madzi a kashiamu magazi, imbaenda chinawonjezeka neuromuscular excitability. Comorbidities Pankhaniyi angathe kutumikira mkulu soda zili mu thupi ndi chitukuko cha kulephera aimpso. Ndi kuchepetsa zili kashiamu mu mandala maso mathithi amapezeka.

Kuchuluka kwa timadzi wa zopangitsa parathyroid mu magazi umamumvera kayimbidwe kotani circadian. Mlingo woyambira amamasulidwa pa za 8 am, pamene mu maola 14-16 la tsiku, pamene munthu ali pa nsonga ya ntchito, parathyroid timadzi kuchuluka. atayezetsa ikuchitika ndi nambala ya parathyrin immunohemilyuminestsentsii. Izo ziyenera kukhala chopanda kanthu m'mimba, ndi tsiku kapena awiri pamaso magazi zitsanzo zosankhidwazi kuthetsa mowa wambiri, masewera olimbitsa thupi wolemera kwa maola angapo pa ndondomeko, musasute.

Pa kusanthula timadzi parathyroid Kwalamulidwa kokha pamene wodwala amaganiziridwa kuli matenda monga hyper- ndi gipokaltsimiya, urolithiasis ndi neurofibromatosis. Komanso zikuonetsa kuti cholinga kusanthula ingakhale monga iyi: kufooka kwa mafupa psevdoperelomy mafupa yaitali, thupi aliyense amasintha fupa osteosclerosis kapena matupi vertebral ndi amaganiziridwa angapo endocrine neoplasia mtundu 1 ndi mtundu 2 (ANTHU 1.2). Pa mlingo parathormone munthu wamkulu amaona 9,5-75 PG / ml. Izi ntchito kwa amuna ndi akazi a zaka ubereki. Ngati wapezeka kuti PTH ndi kukwezeka, pali zifukwa kuganiza kuti wodwalayo pulayimale, sekondale, ukachenjede hyperparathyroidism, pseudohypoparathyreosis kapena matenda Zollinger-Ellison.

Pansi ophatikizana chachikulu hyperparathyroidism hyperplasia ya England parathyroid, khansa ya prostate minofu ndi endocrine neoplasia mitundu iwiri. Co. sekondale hyperparathyroidism monga aakulu aimpso insufficiency, hypervitaminosis D, anam'peza matenda a m'matumbo, rickets, matenda amene amatupitsa. Ngati PTH ndi kukwezeka, ndiye kuwunika kawiri kawiri zimachitika molumikizana ndi tanthauzo la mlingo wa kashiamu mu magazi komanso m'tsogolo kufanizitsa zizindikiro awiri ndi kuzindikira dependencies.