Mafotokozedwe "Levodopa": malangizo ntchito, maonekedwe, zikuchokera, analogs ndi ndemanga

ndi mankhwala "Levodopa" n'chiyani? Malangizo ntchito, mtengo, ndemanga za mankhwala ayankhidwa patsogolo pang'ono. Inunso kuphunzira zimene Kwalamulidwa mankhwala, ngati iye anali zochita chilichonse chowawa ndi contraindications, mu zomwe ndi lilipo zogulitsa, zomwe zili m'gulu kapangidwe kake, ndi zina zotero.

The zikuchokera, mawonekedwe, malongosoledwe

Amene zigawo lili mankhwala "Levodopa"? Malangizo ntchito limasonyeza kuti yogwira pophika mankhwala ndi levodopa. Mu kugulitsa ndi mu maonekedwe a mapiritsi zozungulira spigot mtundu woyera, mmatumba mu mizere selo ndi makatoni mabokosi, motero.

Mfundo ntchito medicament ndi

mankhwala "Levodopa" Kodi ntchito? Malangizo ntchito, ndemanga mwasonyeza kuti kuphatikiza antiparkinsonian wothandizira. Ndi cholinga kuthetsa chinthu chimodzimodzi, hypokinesia, kugwedeza, drooling ndi dysphagia.

Mu thupi, akuchita mankhwala chigawo ndi kutembenukira ku dopamine (CNS), potero kupanga kuchepa kwa mchitidwe wa.

Dopamine kuti amapezeka zimakhala zotumphukira, sakusonyeza zotsatira odana Parkinson a levodopa. Ichi ndi chifukwa chakuti zilibe kudutsa chapakati mantha dongosolo ndi chifukwa chachikulu cha zochita chowawa mankhwala.

Kuchepetsa mlingo wa mankhwala yogwira m'thupi la munthu akapatsidwa medicament osakaniza ndi zoletsa zotumphukira dopa-decarboxylase. Njira imeneyi kumathandiza kuchepetsa mavuto kuchokera kutenga mankhwala.

Pharmacokinetics

Zingati mankhwala odzipereka "Levodopa"? Malangizo pa limati ntchito kuti pambuyo mankhwala mu thupi ilo ndithu mofulumira odzipereka kwa intestine lapansi.

Mayamwidwe wa chinthu yogwira ndi za 20-30%. Kwenikweni izi achire unkachitika pambuyo pa 3 h.

Chakudya wambiri (kuphatikizapo zakudya zina) likukhudza mayamwidwe mankhwala.

mankhwala ndi zimapukusidwa, potero kupanga metabolites angapo. Excretion wa chinthu yogwira kumachitika kudzera impso, ndipo kudzera intestine lapansi.

zikuonetsa

Kodi zinthu odwala chinafotokoza mankhwala "Levodopa"? Malangizo ntchito mogwirizana ndi zizindikiro zotsatirazi:

• postencephalitic syndrome kuti amapezeka matenda cerebrovascular kapena kuledzera poizoni;
• Parkinson matenda Komanso, zimene chifukwa cha ntchito mankhwala antipsychotic;
• Parkinson matenda.

contraindications

Ngati pali contraindications mu "L-dopa" mankhwala? Malangizo ntchito inanena kuti mankhwala ndi amaletsedwa kujambula milandu zotsatirazi:

• hypersensitivity kwa zigawo zikuluzikulu;
• pamodzi Mao zoletsa;
• pa mimba ndi pa kuyamwitsa mwana;
• odwala pansi zaka 18.

Mosamala mankhwala akhoza kuikidwa pa:

• ndiko kumayambitsa;
• pamaso pa matenda a m'mapapo, matenda a mtima, chiwindi ndi endocrine dongosolo ndi nsupa;
• bronchial mphumu;
• maonekedwe a psychosis;
• khansa (kuphatikizapo mbiri);
• njingayo-kutsekedwa khungu;
• khunyu mobwerezabwereza (khunyu);
• otsegula ngodya khungu, lomwe limapezeka mu mawonekedwe aakulu;
• impso ndi chiwindi kulephera;
• m'mnyewa wamtima infarction (mbiri), komanso mitundu ya mitundu yosiyanasiyana ya arrhythmias;
• mmatumbo chilonda ndi m'mimba;
• CNS maonekedwe a chinyengo;
• mtima mungoli chisokonezo.

The mankhwala ndi "L-dopa": malangizo ntchito

Kufotokozera za mankhwala waperekedwa pamwamba. Monga chiyenera kukhalira?

Malinga ndi malangizo, mankhwala akutengedwa pakamwa. Mlingo pang'ono ndi pang'ono kuchuluka kwa osachepera kuti pazipita ndi (malingana ndi mtima munthu).

Anayamba mankhwala ndi mlingo wa 0.25-1 ga kuchuluka Izi lagawidwa mbali zitatu. Mlingo pang'ono ndi pang'ono kuchuluka kwa 0,125-0,75 ga Kodi pa nthawi wofanana nthawi (mwachitsanzo, masiku atatu), kuganizira za mmene wodwala munthu, mpaka nthawi imene zotsatira akadakwanitsira udzachitika ku chithandizocho.

Mlingo pazipita patsiku sayenera upambana magalamu eyiti.

Mankhwala Mulimonsemo, Musasinthe zikuchepa. Lekani kutenga pang'onopang'ono.

zosiyanasiyana chokhwima

Kodi mavuto a mankhwala "Levodopa"? Malangizo Ntchito limanena kuti nkhani ya phwando ake pa munthu kupeza zochita chowawa zokhudza ntchito machitidwe onse a thupi:

• dongosolo mtima: palpitations mtima, arrhythmia, chosokoneza cha kuthamanga, zochita orthostatic, syncope, ndi zina zotero.
• M'mimba thirakiti: m'mimba, kusanza, dyspepsia, anorexia, kudzimbidwa, kusintha kukoma, pakamwa wouma magazi kuchokera thirakiti m'mimba.

Iwo ayenera kukumbukira kuti si lilibe zochita mbali okhudza ntchito hematopoiesis, mkodzo, kupuma, ndi kachitidwe mantha. Nthawi zambiri odwala kulandira mankhwala, thupi lawo siligwirizana zidzachitika, kusintha mu magawo zasayansi ndi zotsatira osafunika pa khungu.

Nthawi cha mankhwala osokoneza bongo (zizindikiro mankhwala)

Pogwiritsa ntchito mlingo waukulu anasonyeza kuwongola kwambiri mavuto. zinthu zimenezi zimafuna chithandizo mu mawonekedwe a lavage, wodwala matenda polojekiti ambiri ndi ntchito za mtima. Ngati ndi kotheka, achite mankhwala antiarrhythmic.

Mwanjira mankhwala

Munthawi yomweyo phwando ndi kuganizira lokonzekera "ditilina" beta-agonists ndi wothandizira amene anafuna inhalation mankhwala, kumachititsa wa arrhythmias za mtima.

Bioavailability "Levodopa" kungachepetse antidepressants tricyclic.

Kuphatikiza mankhwala ndi "thioxanthenes," "ntchito diazepam" antipsychotic "Phenytoin" mamita-holinoblokatorami "clonidine", "Difenilbutilpiperidinom" "Papaverine", "Clozapine", "phenothiazine" "pyridoxine" ndi "reserpine" nthawi zambiri amachepetsa zotsatira zake antiparkinsonian.

Lifiyamu formulations kuonjezera Mwina zosayembekezereka wa dyskinesias ndi kuyerekezera zinthu m'maganizo, ndipo "methyldopa" medicament kumawonjezera zochita mbali.

Kuphatikiza Mao zoletsa ndi "Levodopa" kumayambitsa mkhutu kufalitsidwa. Mu nkhani imeneyi, imeneyi pakati Mlingo wa mankhwala amenewa ayenera kukhala masiku osachepera 14.

Amowabu kuchepetsa kuthamanga anaona ndi osakaniza mankhwala ndi kuti "tubocurarine".

Mankhwala mankhwala "metoclopramide" kumawonjezera kupezeka zamoyo "Levodopa", mofulumira chapamimba Ndikudzikhuthula. Izi zingathe kusokoneza zochita za matenda.

ayamikira enieni kugwiritsa ntchito mankhwala

Kodi mukufuna kudziwa asanadye miyala "Levodopa"? Malangizo ntchito (mtengo pansipa) akuchenjeza za kuopa thanzi ndi Kulipira mwadzidzidzi wa medicament a.

Pa nthawi imene n'zosatheka kupewa kuchepetsa mlingo kapena achire mankhwala amafunika kuti wodwalayo zonse alili.

Pamaso mankhwala ali osavomerezeka kudya zakudya zokhala ndi zomanga thupi, chifukwa kumachepetsa absorbability wa chinthu yogwira.

mankhwala amafuna polojekiti mosalekeza kachitidwe, ziwalo, ndi magawo osiyanasiyana magazi.

Price ndi analogues

Wapafupi analogues "L-dopa" kukonzekera zikutanthauza ndi monga "levodopa benserazide" ndi "Levodopa Carbidopa". Malangizo ntchito inanena kuti mankhwala ali ndi zizindikiro zomwezo, mavuto, njira ya kanthu ndi contraindications. Kusiyana komwe kulipo pakati pa ndalama izi ndi zikuchokera awo.

Zinthu zimenezi yogwira monga carbidopa ndi benserazide kuchepetsa kupanga dopamine mu minofu zotumphukira, potero kukula kuchuluka kwa levodopa kulowa CNS.

Choncho, mukhoza bwinobwino kudziŵika kuti mankhwala "Levodopa Carbidopa" ndi "levodopa benserazide" (malangizo ntchito njira izi Komanso anapatsa ma CD) kumatha zina zoletsa phwando zotumphukira dopa-decarboxylase.

Koma anzawo ena, ndiye dama mankhwala monga "Isik Meath", "Tremonorm", "Dopar 275", "Tidomet", "Duellin ',' Sinemet ',' Zimoks", "Sindopa", "Isik" "Lac". Iwo kukhala akapitawo dokotala yekha.

Mtengo wa "Levodopa" mankhwala si mkulu. Mu pharmacies, mukhoza kugula mankhwala mkati 1500-1850 rubles.

mankhwala Reviews

Chithandizo cha matenda aliyense ayenera kuchitidwa kokha kwa cholinga cha dokotala wa maso. Ndipo Parkinson yotero.

Odwala amene anatenga mankhwala "Levodopa" nzeru zake yekha, ndipo alibe HIV achire zotsatira. Nthawi zambiri izi ndemanga medicament zoipa. Adadandaula kuti kuti ngakhale ntchito yaitali mankhwala patsogolo lodziwika bwino anaona.

Ngati mankhwala watengedwera pansi kulingalira ndi chiwembu, yemwe anayamba ndi akatswiri odziwa akutsatira njira ya matenda, ndondomeko mankhwala ndi pafupifupi zonse bwino. Ichi ndi chifukwa chakuti mankhwala yogwira ziyenera kutengedwa mlingo okhwima, potsata wodwala, makhalidwe a matenda ndi zifukwa zina.

Odwala mosamalitsa zosagwirizana ndi mankhwala chakudya, onena kuti mankhwala "Levodopa" othandiza kwambiri kuthetsa matenda.

Ndipotu, ambiri akudandaula za kukwera mtengo kwa mankhwala. Komabe, akatswiri amanena kuti mtengo wa mankhwala n'chofunikira kwathunthu.