"Dopamine": malangizo Buku, ndemanga, mafotokozedwe, analogs

Pharmacological zotsatira "Dopamine" mankhwala chifukwa chake yoperekedwa kwa mankhwala adrenergic ndi kuchepetsedwa ndi kuwonjezeka chonse kamvekedwe, yotithandiza mtima minofu ndi mitsempha, kutsegula njira zinkachitika mu chapakati mantha dongosolo. Mofananamo, thupi amachitira zinthu masoka timadzi dopamine, amene apanga m'mikhalidwe yachibadwa ya maselo a mu ubongo. Kugwiritsa ntchito chida ichi mankhwala malinga ndi kufunika kuthana ndi zotsatira za limati mantha, matenda a mtima (arrhythmia kuphatikizapo), poizoni chakudya ndi maganizo.

Kagayidwe ndi kinetics

Malinga ndi malangizo a ntchito, "Dopamine", malingana ndi mlingo, akhoza kukhala wothandizira causative wa beta adrenergic ndi mtundu Alpha, ndi ubwino zokhudza zonse hemodynamics ndi qualitatively bwino ntchito musculature a mitsempha ya magazi ndi impso. Thunthu yogwira ndi anagawira uniformly thupi lonse, mmene gawo la reactants ndi chililaka magazi ndi ubongo chotchinga.

Zotsatira achire amapezeka mkati mphindi zisanu makonzedwe mankhwala ndi kupitiriza kwa okwana pafupifupi maminiti khumi. Zotsatirazi kagayidwe, lomwe limapezeka mu chiwindi, impso mwina mu plasma anapanga mankhwala kulalikira. Pafupifupi 80% mlingo excreted mu mkodzo monga metabolites pa tsiku loyamba.

Pamene izo tikulimbikitsidwa kugwiritsa ntchito mankhwala "Dopamine"?

Malangizo ntchito n'chakuti mndandanda wa milandu:

• mantha ya chiyambi zosiyanasiyana (.. mwa T H boma chifukwa cha opaleshoni anasamutsa kapena matenda akupha, ndi matenda mtima);
• magazi insufficiency (pachimake mawonekedwe);
• Integrated kapena ochiritsira chakudya poizoni (mankhwala timapitiriza diuresis, amene akutsutsana amakhudza mlingo linanena bungwe la poizoni);
• hypotension.

The ntchito ndi mlingo wa "dopamine"

mankhwala ananena kuti gulu limene lalandira kukonzekera mtsempha kukapanda kuleka. mlingo mawerengedwe wapangidwa kutenga nkhani mantha weniweni wa nkhaniyi ndipo ndi kusintha kuvomerezedwa kwa magazi. Komanso, kupita naye nkhani zimene wodwalayo kwa kulowetsedwa wonse.

Nkofunika kudziwa kuti mlingo (mg) - osati muyezo okha zolosera za. Zotsatira komaliza zimadalira liwiro limene mankhwala adzakhala anayambitsa "Dopamine". Malangizo ntchito chimasiyanitsa zitsanzo izi:

• mkodzo phindu - kuchokera 100 mpaka 250 g / Mph;
• mankhwala ndi opaleshoni conjugate - kuchokera 300 mpaka 700 g / Mph;
• mtima mavuto kapena zazikulu mantha septic khalidwe - kuchokera 750 mpaka 1500 mcg / min.

Ngati oyamba a mwana kuchuluka kwa arrhythmia mtima wakhala kuzindikiridwa njira mlingo osati pokuza. Odwala ana mankhwala inagwetsa ndi mphamvu ya 4 mpaka 6 mg / kg pa / min. Liwiro kusintha payekha, potengera mmene akadakwanitsira zotani.

Mlingo pazipita dopamine kwa wodwala yemweyo angakhale osiyana - kalozera akutumikira cholinga (malemeredwe impso minofu, mitsempha ya magazi, mtima, etc ...). Koma kuonjezera mphamvu ya kubala mankhwala kwa mlingo wa 30 mcg / kg / mphindi kapena zambiri ali osavomerezeka, monga izi zingathe kusokoneza alili.

Contraindications kuti "dopamine"

Panthawi imene ntchito mankhwala ali contraindicated, imatiuza malangizo onse yomweyo ntchito. "Dopamine", makamaka alibe mankhwala odwala matenda ndi kudwala zovuta za chithokomiro England kapena ali ndi matenda osachiritsika zokhudza zopangitsa adrenal. Inde, chiletso ayenera kukhala ndi mbali yapadera ya zigawo mankhwala.

Mtima mungoli chisokonezo wodwala kapena mwapang'onopang'ono atherosclerosis - wina awiri aakulu kwambiri chimene akhoza kupanga maziko a udindo anawauza za sanali kugwiritsa ntchito mankhwala njira kulowetsedwa. Komanso, ndi osafunika amachita atakhala drippers "dopamine", ngati onse a diagnoses zotsatirazi:

• hyperthyroidism;
• shuga;
• pheochromocytoma.

Musalole utsogoleli munthawi yomweyo mankhwala ndi njira mankhwala, anapanga pamaziko a halogen (kapena ofanana nawo). Pa poika mankhwala amayi oyembekezera anaganiza ndi dokotala nawo.

Zotsatira zoyipa za mankhwalawa: Zizindikiro ndi khalidwe la

Mankhwala "Dopamine" (malangizo ntchito mwachindunji monga mmene) ndi chida multifunctional kwa kukhudzana anthu. Komanso, makonzedwe mzere pakati chopindulitsa zotsatira sewero, pamene kulowetsedwa amakwiya chitukuko mavuto, kotero woonda kuti, kugwiritsa ntchito ndalama akhoza anasankha monga wapadera wa akatswiri odziwa ndipo kwambiri oyenerera.

Mwachitsanzo, anayesa zinalephereka kungothandiza mtima dongosolo kutembenuka masoka mfundo kapena zovuta (anaona kudumpha lakuthwa magazi, ululu waukulu mwamphamvu osiyana m'chigawo cha chifuwa, ndi zina zotero. P.). Mwa zochita zina matupi awo sagwirizana - bronchial spasms, nseru, mutu kwambiri, boma okondwa, alternating causeless nkhawa, kupuma movutikira.

Nthawi zina pali ang'ono khungu necrosis, m'mphuno ndi magazi muzituluka. Ndi amphamvu ambiri osokoneza chizindikiritso cha mavuto sikovuta. Komabe, muyeso yodalira mulingo woyenera mlingo (mg) zochepa amatha kumasulira mu njira zobisika ndi ovuta oterewa, zikhale zovuta n'chongoletsa ndi zotheka mavuto obwera chifukwa cha mtsempha athandizira "dopamine."

Kusamala

The yeniyeni anachita limagwirira amasankha zinthu zina ntchito "Dopamine" mankhwala. Malangizo Ntchito limati:

• njira isanafike makonzedwe ngati wodwala amene akukhala mu mkhalidwe mantha, m'pofunika kuti kusintha kwa hypovolemia chifukwa zakumwa magazi jakisoni;
• odwala mu masabata posachedwapa ankachenjeza monoamine oxidase zoletsa, kutumikiridwa osapitirira 10% ya mlingo wabwinobwino;
• kulowetsedwa ayenera limodzi ndi ulamuliro kuvomerezedwa mlingo wa mlingo pokodza ndi periodicals mtima; Tiyeneranso kuchita kuwunika magazi (kuthamanga khola pa zotengera mwazi, ndi kuchepa zikusintha linanena bungwe mkodzo - mbendera kuti mlingo "dopamine" ayenera kuchepetsedwa);
• odwala pansi zaka 18 amadziwitsidwa anaika pangozi, chifukwa ichi msinkhu sipanatenge zikuluzikulu maphunziro pa zimene ziwalo ndi kachitidwe mu zigawo zikuluzikulu za mankhwala;
• kuyambitsa njira mu thupi monga kusowa zotheka kuchita kudzera lalikulu mzere magazi (kuchepetsa chiopsezo extravasation); Ngati magazi kuchokera Mitsempha mu minofu komabe panali kufunika kukhwimitsa nthawi yomweyo kusalola;
• pa kukayikirana loyamba la chitukuko cha ischemia zotumphukira, kugwiritsa ntchito mankhwala ndi ndinayima.

Mogwirizana ndi mankhwala ena

Potengera makhalidwe a dongosolo mankhwala mankhwala "Dopamine" (ponena za kukonzekera anapatsidwa pamwamba), n'zotheka kunena kuti ngakhale mankhwala. Makamaka, njira Kodi samva kuti madzi a mchere (deactivating zigawo zikuluzikulu), komanso ayironi ndi mchere, thiamine (vitamini molekyulu cleaves otsiriza B1). Zotsatira hypotensive wa kulowetsedwa damped ngati yomweyi kuti "dopamine" m'kupita akangofika sewero mecamylamine (kapena ofanana nawo Hud).

Maloboti ndi ntchito levodopa mankhwala pafupifupi amatitsimikizira pakutchulidwa wa kupata fibrillation. Nayenso zinthu zimenezi yogwira monga ergometrine ndi ergotamine kungachititse kuti chilonda, ndipo "dopamine" ambiri osokoneza yovuta - ngakhale intracranial kukha magazi.

Akuti ngakhale wabwino ndi glycosides, ntchito cardiology, ndi okodzetsa.

Popular analogues "dopamine"

maina malonda mankhwala, chilinganizo yogwira Chofanana kapangidwe ka "Dopamine" mankhwala (analogs amene timapemphera kuti kosonyeza mlingo wa kupezeka pa msika zoweta):

• "Dopamine," kubala dziko - Russia.
• "Dopamine-Admeda", Germany.
• "Dopamine-Solvay 200», Germany.
• "Dopamine 50 Solvay", Germany.
• "Dopamine hydrochloride", Poland.
• "Dopmin", Finland.

"Dopamine" malingaliro ndi ndemanga

Chifukwa chikhalidwe cha mankhwala kuti ndizolowere maganizo a odwala za nchito zake kuli kovuta (odwala kukumana ndondomeko kulowetsedwa, kukhala mu mkhalidwe mantha, ali odwala mwakayakaya kapena mwachindunji pa tebulo ya opareshoni). Professional chomwecho kutsutsana zinachitika pa masamba a maonekedwe imachitika makamaka Anesthesiologists ndi utumiki ndodo "Emergency Medical Thandizo".

"Dopamine", ndemanga imene ambiri a iwo adzakhala zovuta kumvetsa munthu wopanda maphunziro oyenera - malo kuchipatala limagwirira sanali ndiwofatsa kanthu: zimene ukulamulidwa ndi oyamba a mlingo chachikulu kukwaniritsa chimene mukufuna, ndiye utali wonse wa imeneyi nthawi. Komanso sing'anga ndi kusintha voliyumu ndi otaya mlingo wa njira kudzera otaya vekitala angasinthe katundu achire.

Natural timadzi dopamine ndi muzikangana

dzina Mwamwayi zikumveka ngati dopamine ndege timadzi. Ndi zovuta mankhwala pawiri ndi apanga ndi maselo ubongo ndi imapereka yachibadwa (mwachizolowezi kumvetsa anthu) ntchito magulu onse minofu osati. Mtendere, mosatekeseka, kukonzekera mayeso aliyense - ndi mmene psychophysical munthu chithunzi, Mudali kumasulidwa kwa thupi la timadzi lapansi. Pa akusowa zinthu zifika "zosangalatsa mavuto": khalidwe anawona detachment kusafuna kuvomereza zimene zikuchitika, womangidwa kayendedwe, njira maganizo zinthu mochedwa.

Nthawi zina pali kufunika kutsekereza zolandilira yokumba amene amathandiza ndege timadzi. Ntchito akuluakulu chotchinga ntchito dopamine muzikangana. Mankhwala a gulu ili silikuphatikiza Mwina kupezako "kukhutitsidwa chachibadwidwe 'Ndipotu, kuzimitsidwa ntchito psycho m'thupi la wodwalayo. Chiphunzitso ntchito muzikangana wa timadzi izi wolungama akuchita misala, mankhwala, aakulu migraine, matenda a m'mimba.