Mankhwala "Maxipime": malangizo ntchito, analogs ndi ndemanga

Kupezeka kwa woyamba maantibayotiki (Penicillin onse odziŵika lerolino) pakati pa zaka mazana makumi awiri anali yojambula mankhwala. Pa nkhondo yachiwiri ya padziko lonse, mankhwalawa anapulumutsa miyoyo ya zikwi zokometsera wa Mama.

Kuyambira pamenepo, sayansi ndi malonda mankhwala mofulumira osauka ndipo amapereka makasitomala zambiri mankhwala. Mmodzi wa zapamwamba kwambiri ndipo ankagwiritsa ntchito zosiyanasiyana za mankhwala ndi "Maxipime" zomwe amakambirana zonse chida ichi monga kwambiri, othandiza kwambiri zosiyanasiyana matenda bakiteriya.

Kapangidwe ndi Kaonekedwe

Waukulu yogwira pophika mankhwala ndi tsefepimadigidrohlorida monohydrate. Thomas Yopanga - chikasu ufa yochitidwa hue njira yothetsera kwa wotsatira mu mnofu kapena mtsempha utsogoleli. Mu Mlingo angapo wopanga amapereka makasitomala awo mankhwala "Maxipime." mankhwala akhoza kugulidwa ku mabotolo mlingo wa 500 mg ndi 1 g

The zikuchokera okonzekera makonzedwe akhoza kusungidwa firiji kwa tsiku limodzi. Mu zikhalidwe za firiji alumali moyo wa njira okonzeka kuchuluka kwa sabata 1. Mu mawonekedwe ufa ndi mu stoppered kukonzekera vial akhoza kusungidwa kwa zaka 3. Prerequisites - kutentha kwa + 30 ° C ndi kutetezedwa ku kuwala. Kusintha mtundu wa njira sikumangotikhudza ntchito mankhwala.

chikoka pharmacological

"Malangizo Maxipime 'ntchito ali pabwino ngati wothandizira antibacterial kuti wa 4 m'badwo cephalosporins gulu. zotsatira mfundo ndi kuwononga maselo makoma tizilombo ta bakiteriya. Mankhwala ali sipekitiramu yotakata chikoka poyerekezera osiyanasiyana tizilombo galamu HIV ndi galamu alibe, yodziwika ndi kukana kwawo kwa aminoglycosides ndi antibaktrialnym zikutanthauza lachitatu m'badwo cephalosporin gulu.

Pakuti "Maksipima" khalidwe la kukana kuti beta-lactamases ndi yogwira motsutsana ambiri galamu HIV ndi galamu alibe thupi (zofunikila mndandanda - malangizo ntchito). Koma mankhwala si yogwira ndi metitsillinoustoychivym staphylococci, pneumococci penitsillinoustoychivye.

Pambuyo oyamba a maantibayotiki "Maxipime" (malangizo Buku zikuphatikizapo mfundo zimenezi) ndi atamezedwa kotheratu. Therapeutically woipa zogwirizana wa chachikulu chigawo yogwira ali wapezeka mu mkodzo, ya ndulu, secretions bronchial, ku prostate ndi madzimadzi peritoneal.

Hafu ya moyo pafupifupi maola awiri. Yerekezerani, tikhoza kunena kuti, mwachitsanzo, wamkulu odwala amene masiku 9 ndi mtsempha analandira 2 ga mankhwala ndi imeneyi nthawi pakati mankhwala kwa maola osachepera 8 cefepime kudzikundikira mu thupi sanapezeke. Kuchuluka kwambiri excreted mu mkodzo (anaona kuti 85% ya poyamba analandira Mlingo mtima ngati zikutsatiridwa cefepime).

zikuonetsa

Antibacterial "Maxipime" malangizo ntchito akulimbikitsidwa kuti asankhe pa mitundu yosiyanasiyana kudwala zachilengedwe opatsirana ndi yotupa. zotsatira zabwino zopezera chithandizo cha matenda m'munsi kupuma thirakiti (chibayo ndi chifuwa kuphatikizapo) ndi ducts mkodzo (onse si zovuta ndi mavuto kuphatikizapo pyelonephritis). mphamvu zabwino zimawonedwa mankhwalawa matenda kwapakati pa-m'mimba zotupa zosiyanasiyana (osati osaphatikiza biliary thirakiti matenda ndi peritonitis).

Komanso, "Maxipime" chimagwiritsidwa ntchito ndi ogwira ntchito pa matenda a matenda matenda, matenda a khungu ndi zotupa minofu zofewa, septicemia (sepsis). Mankhwalawa odwala neutropenia febrile, "Maxipime" Buku analimbikitsa monga mankhwala wazotsatira.

Wina kudera la mphamvu ya mankhwala - bakiteriya meninjaitisi ana. Apa, mankhwala ndi bwino kutsimikiziridwa.

Ngati muyeso njira mankhwala ntchito kupewa matenda mu njira ya opaleshoni m'mimba.

Ambiri tinganene kuti "Maxipime" ntchito chovomerezeka pansi matenda onse opatsirana, chitukuko chimene chikwiyire atenge tizilombo ta. Pofuna kudziwa causative chamoyo ndi kudziwa kwake (kapena awo) kudziwa mankhwala akuyenera kuchita mayesero. Komabe, "Maxipime" amakhudza osiyanasiyana waukulu tizilombo ta bakiteriya ndiponso kuti monga monotherapy angathe kumwedwa ngakhale pamaso kudziwa tizilomboto. Ngati pali chiopsezo losakanizika matenda (aerobic-anaerobic), ndiye mayesero pa kuzindikira tizilombo toyambitsa matenda akhoza kuyamba chithandizo "Maksipimom" mu tandem ndi mankhwala okhudza anaerobes.

N'zimene ndi dosing regimens

Mlingo ndi yoyendetsa mawonekedwe (w / yakumadzulo kapena yakumadzulo / o) anatsimikiza malingana tilinazo mabakiteriya, kuopsa kwa boma matenda a mtima ndi impso. Ndipo ine / O njira monyengerera pa nthawi imene matenda ndi zovuta ndi likuoneka moyo wodwalayo.

Anthu ndi impsozo wathanzi ndi masekeli oposa 40 makilogalamu jakisoni pa intervals wa maola 12 mu mlingo zotchulidwa dokotala. Matenda wa kapepalako mkodzo wofatsa zikuwonjezera zolimbitsa, matenda ena zikuchitika pa mphamvu omwewo kutichitira Mlingo wa 0.5-1 ga, kutumikiridwa m'nsinga kapena intramuscularly (monga dokotala afuna). Pofuna kuthetsa matenda aakulu ankachita m'nsinga kutumikiridwa pa 2 ga mankhwala (periodicity ali yemweyo - maola 12). Pakuti lolemera kwambiri ndi kumapitiriza kuukira moyo matenda wodwalayo ndi mlingo chofunikila ndi 2 ga, koma periodicity - mawola 8.

Mankhwala "Maxipime" ntchito fuluwenza pokha pokha kumene komanso bakiteriya olumikizidwa ku otaya matenda enaake.

M'kupita kwa ntchito opaleshoni (1 ora pamaso) prophylactically m'nsinga pa ora 2 kutsogolera ga 'Maksipima "ndiye anatsanulira zina 500 mg wa metronidazole. Imodzi kutumikiridwa zinthu ziwiri sayenera.

Kuchuluka avareji mankhwala kwa odwala ndi kulemera thupi sizinawakhudze makilogalamu 40, mu mankhwala a matenda a njira ya mkodzo thirakiti (zovuta ndi wopepuka), minofu zofewa ndi khungu (osati obstructed), kutupa m'mapapo mwanga ndi mankhwala wazotsatira malungo neutropenic ndi 50 mg pa kulemera kilogalamu thupi. Majekeseni pa intervals wa maola 12. Mu meninjaitisi bakiteriya ndi malungo neutropenic chomwecho 50 mg / kg kutumikiridwa amalangiza intervals pakati mankhwala ofanana maola 8.

Kwa odwala matenda kuvutika mu uziyenda impso, chofunika kusintha yokonza mlingo. Mankhwala "Maxipime" ponena za mankhwala (mlingo malingana ndi mtundu wa tizilomboto ndi kuopsa kwa nthenda adzakhala anatola ndi dokotala nawo) akuonetsa kuti buku koyamba mankhwala kutenga ndi chimodzimodzi kwa anthu impso wathanzi, uku akugwira ntchito mlingo kusintha malinga ndi mfundo za creatine chilolezo.

Anthu odwala amene 'Maxipime "ndi likufa hemodialysis, tikulimbikitsidwa kumapeto kwa ndondomeko kachiwiri lowetsani mlingo watsopano wa mankhwala ofanana ku chiyambi. Izi ndi zofunika, mwachitsanzo. K. ora 3 dialysis adzachotsedwa thupi mpaka 68% kuchuluka okwana mankhwala "Maxipime" (wosuta muli mfundo izi).

Contraindications "Meksipima"

Ngakhale osiyanasiyana kwambiri ndi zotsatira antibacterial za mankhwala, alibe mndandanda wa contraindications. "Maxipime" malangizo Buku salola ndi hypersensitivity munthuyo cefepime ndi L-arginine. Komanso, ndi zosavomerezeka anapatsidwa odwala ndi zochita za hypersensitivity nthawi yomweyo penicillin, zina wothandizila beta-lactam, mankhwala monga cephalosporin.

Mwatcheru boma wake wa thanzi pamene mankhwala "Maksipimom" ayenera kuchitira akazi apakati ndi mayi woyamwitsa, anthu akuvutika ndi matenda a thirakiti m'mimba, makamaka matenda monga anam'peza kapena mankhwala-kugwirizana matenda a m'matumbo, dera enteritis.

Nkhani yaikulu ntchito ubereki, ziyenera kuti m'mayesero matenda nyama palibe mavuto pa mayi ndi mwana wosabadwa akhala sakudziwika. Komabe, maphunziro komanso womwe mmene thupi la mkazi zinachitikadi. Choncho, akazi apakati zovomerezeka "Maxipime" kokha moyang'aniridwa ndi achipatala. Mu chifuwa anthu mankhwala mkaka adzamasulidwa zedi ochepa, koma si ofunika chiopsezo. M'nthawi ya mkaka wa m'mawere ayenera kutenga mankhwala mosamala.

Komanso, mankhwala "Maxipime" Buku amalimbikitsa ntchito ndi chisamaliro kwa anthu amene akudwala aakulu aakulu kulephera aimpso. Kafukufuku wasonyeza kuti odwala ndi kulephera aakulu aimpso kuchuluka theka moyo wa thunthu kwa thupi. Pa nthawi yomweyo, anthu ndi chiwindi matenda, kapena enaake fibrosis si maganizo kusintha kulikonse pharmacokinetic chifukwa mayamwidwe ndi excretion wa cefepime.

Zotsatira zoyipa za mankhwalawa, ndi owonjezera mlingo chovomerezeka

Ambiri tinganene kuti "Maxipime" bwino analekerera, ndi zochitika za zochitika chowawa si mkulu. Milandu polisi makamaka zinali za ntchito kwa matenda m'mimba thirakiti (dyspepsia, kutsekula m'mimba, kudzimbidwa, nseru, kusanza), ndi zochita hypersensitivity (totupa, kuyabwa, malungo).

Komanso, zimene zilipo pa mankhwala monga mankhwala "Maxipime" - ikulongosola lokonzekera, malangizo ntchito yake, - umboni wa kuthekera anachita pa mbali ya dongosolo mtima mu mawonekedwe a tachycardia (mtima palpitations) ndi ululu pachifuwa. dongosolo kupuma akhoza kunena yokha zilonda zapakhosi, kufupika kwa mpweya ndi chifuwa. Kuyankha zambiri kuchokera CNS adzakhala kusowa tulo, mutu zotheka, chizungulire, nkhawa, chisokonezo, paresthesia. Pakati pa zinthu zina tikhoza kulankhula za kutopa, vaginitis, thukuta, ululu, kupweteka kwa nsana, edema zotumphukira. Komanso, monga mavuto madokotala kulankhula za kusintha zotheka mu magawo zasayansi.

Koma impermissibly kulandira Mlingo wa mankhwala Buku "Maxipime" malangizo imatiuza za mphamvu ya hemodialysis mu Zikatero.

Kodi muyenera kulabadira?

Kulemera kwa zinthu zosiyanasiyana zapadera angathe pa nthawi imene Kwalamulidwa mankhwala "Maxipime." Kodi ntchito kuti nkhani iyi? Ngati maziko a "Maksipima" anayamba pseudomembranous matenda a m'matumbo ndi kutsekula m'mimba kwa nthawi yaitali, siyani kumwa mankhwalawa konse ndi kutumikiridwa vancomycin kapena metronidazole.

Ngati wodwala akudwala aakulu ophatikizana chiwindi ndi impso kulephera, ogwira ntchito kuchipatala ayenera kukhala polojekiti kopitirira ndende mankhwala madzi a m'magazi ndipo, malingana ndi magawo, kusintha mlingo.

Ngati mankhwala chakhala chilipo kwa nthawi yaitali, n'kofunika nthawi zonse kuwunika zikuchokera magazi zotumphukira ndi zizindikiro zinchito a impso ndi chiwindi.

Pa nthawi imene wodwala ku zofunika kutali opatsirana anati kufalitsa meningeal (kufala kwa tizilombo toyambitsa matenda, onse mwa moto, ndipo thupi lonse), pali kukayikitsa oumitsa khosi kapena matenda kale anaika, m'pofunika kukana chithandizocho "Maksipimom" ndipo perekani kakoe- kapena zina antibacterial wothandizila ndi efficacy zatsimikiziridwa kwa matenda.

Pali kuthekera kudziwa anachita zabwino mayeso Coombs, onyenga HIV - pamaso pa shuga mu mkodzo.

"Maxipime" wa chimfine ndi chimfine (i.e. ku matenda tizilombo) sadzagwira ntchito.

Mogwirizana ndi zinthu zina

Ngati wodwala ulipo kulandira "Maxipime" kufanana ntchito mankhwala ena akhale moyang'aniridwa ndi achipatala. mankhwala si pharmaceutically yogwirizana ndi mankhwala ena antimicrobial ndi heparin.

Tubular katulutsidwe cefepime bude zayamba yafupika pamene pamodzi okodzetsa, aminoglycosides ndi polymyxin B. The chomwecho kuwonjezeka tandem PM ndende "Maksiprima" mu seramu magazi kukula mpaka kukula kwa nephrotoxicity nefronekroza. Komanso, kuwonjezera theka moyo.

Yonseyi "Maksiprima" ndi NSAIDs (sanali steroidal mankhwala odana ndi yotupa) kusokoneza excretion wa cephalosporins thupi ndi zingachititse magazi.

The ntchito limodzi ndi ena mankhwala bactericidal (aminoglycosides) chingandithandize chiwonetsero cha synergy, ndi bacteriostatic - chidani.

mankhwala analogues

Medicaments analogs amasankhidwa zochokera mayiko dzina nonproprietary (alendo), apa ndi yaikulu yogwira pophika (kuti "Maksipima" amenewa ndi cefepime). The Anzawo wotchuka antibacterial wothandizila "Maxipime" ndemanga akatswiri amatchedwa mankhwala monga "Cefepime-Alpes", "Cefepime", "Movizar", "maxicef" "Cefepime wosabala."

Izi si mndandanda ndipo ngati dzina "Cefepime", apa, kuwonjezera pa pamwamba, pali "Cefepime-nsupa", "Cefepime-Agio" "Cefepime-Dzhodas" "Cefepime-Alkema," "Cefepime Hydrochloride ".

Komanso mitundu yosiyanasiyana ya matenda bakiteriya wosamalira mankhwala mankhwala kulandira "Ladef", "Efipim", "Kefsepim", "Tsefomaks", "chainsWe".

Pankhani mankhwala anzawo, sangakhale nthawi opindula monga mankhwala chiphatso.

Opinion odwala ndi ogwira ntchito zaumoyo

Popeza mankhwala ali osiyanasiyana ntchito zosiyanasiyana matenda ndi tizilombo tating'onoting'ono, ndiye maganizo a "Maksipime" pali malangizo abwino ndi oipa. anthu ambiri mankhwala, nakhuta ndi zotsatira zake. Abwinopo, ngakhale m'njira choopsa cha matenda bakiteriya zinachitika masiku 2-3 kuyambira chiyambi cha mankhwala. Malinga ndi ogwira ntchito zachipatala, mankhwala komanso watsimikizira yekha zosiyanasiyana matenda. Ndi mtengo wa mankhwala si choncho kwambiri (pali mankhwala otsika mtengo koma pa nthawi yomweyo, pali kwambiri mtengo kuposa "Maxipime").

Komabe, pali wachidaliro maganizo mankhwala. Makamaka ndemanga sizabwino odwala amene Ndaliwonetsera okha njira ya zotsatira chithandizo mbali. Komanso, amadana unakhalapo ndi gulu osiyana anthu amene maantibayotiki "Maxipime" kwa chimfine. Ngakhale kuti zotsatira, monga anali kuyembekezera. Aliyense ozizira chilengedwe tizilombo ndi "Maxipime" - ndi germicide, mfundo zomwe zachokera zotsatira za kuwonongedwa kwa khungu nembanemba mabakiteriya.

Kugula mankhwala akhoza kukhala mankhwala a dokotala. Ndipo pachifukwa: a dokotala ndi chidziwitso apadera ndi zinachitikira, kotero kusankha antimicrobial ndi kuwerengera osachepera ogwira mlingo, kuti mavuto onse mavuto amachepa zabwino pa thupi adzakhala maximized.