Chotupa Necrosis Factor: Kukonzekera

Chotupa necrosis Chinthu (TNF) - gulu la cytokines yeniyeni mapuloteni - timadzi ngati zinthu opangidwa ndi chitetezo cha m'thupi. Izo zimayambitsa chidwi kwambiri ndi mankhwala chifukwa katundu - luso kupangira selo imfa (necrosis) intratumoral minofu. Izi yojambula weniweni mankhwala, kulola kugwiritsa ntchito mankhwala ndi TNF zochizira khansa.

History of anapeza

Ndi chiyambi cha XX atumwi zochiritsira wakhala wapezeka chitsanzo: odwala ena panali kuchepa ndi / kapena mofulumira mapangidwe chotupa pambuyo kulanda matenda aliwonse. Ndiye American katswiri William Coley anayamba mwadala kutumikiridwa ndi mankhwala khansa munali opatsirana kunyumba (mabakiteriya ndi poizoni awo). njira sanapezedwa kukhala othandiza kwambiri ngati mmene ali ndi amphamvu poizoni zotsatira pa mtima. Koma chinali chiyambi cha angapo kafukufuku wopita ku Kupezeka kwa mapuloteni, wotchedwa chotupa necrosis china. Anapeza chinthu kuchititsa imfa mofulumira maselo a khansa anapatsa pansi pa khungu la mbewa experimental. Patapita kanthawi, izo anali yekhayekha TNF woyera, amene amaloledwa ntchito zolinga kafukufuku.

kupezeka chinathandiza yojambula mu mankhwala khansa. Poyamba, ntchito mapuloteni cytokines akhoza bwinobwino kuchitira khansa ndi zochepa chabe mwa Education - khansa khansa ya pakhungu, khansa impso. Komabe, patsogolo kwambiri munda walola kuphunzira katundu wogwidwa ndi chotupa necrosis china. Kukonzekera ofotokoza aphatikizidwa ndondomeko mankhwala amphamvu.

limagwirira kanthu

chotupa necrosis chinthu amachita pa foni yeniyeni - chandamale. Pali njira zingapo kanthu:

• Kudzera zolandilira wapadera TNF imalankhula ndi Mipikisano gawo limagwirira - ma selo imfa (aputosisi). Zimenezi amatchedwa cytotoxic. Pa nthawi yomweyo kusunga mofulumira wathunthu wa zotupa, kapena kuchepetsa kukula kwake.
• Kudzera kuyenda kapena kuchotsa kwa mkombero selo. Cancer selo sadzatha kugawanitsa ndi kukula chotupa ndi ndinayima. Zimenezi amatchedwa cytostatic. Childs kutupa mmene kapena zimaleka kuwonjezeka, kapena mwayamba kufooka kukula.
• Ndi kutsekereza mapangidwe ndondomeko ya neovascularization chotupa minofu ndi kuwonongeka capillaries analipo. Chotupa akapanda chakudya, necrotic, amachepetsa ndi kusiyiratu.

Pali zinthu komwe maselo a khansa ndi chisoni kwa jekeseni mankhwala chifukwa masinthidwe. Pamenepo asilikali pamwambapa osadzuka.

The ntchito mankhwala

Chotupa necrosis Chinthu ntchito otchedwa Cytokine mankhwala - mankhwala mapulotini enieni amene amayambira ndi maselo magazi udindo chitetezo chokwanira. Kayendesedwe n'zotheka pa siteji iliyonse ya ndondomeko chotupa osati contraindicated anthu ndi comorbidities - mtima, aimpso, kwa chiwindi. Kuchepetsa kawopsedwe ntchito akhudzidwa recombination chotupa necrosis china.

Mankhwalawa cytokines - latsopano ndi pang'onopang'ono osauka munda wa Oncology. Ntchito TNF imatengedwa bwino kwambiri. Popeza mankhwala kwambiri poizoni, amagwiritsidwanso ntchito ndi otchedwa perfusion dera. njira tichipeza mu chakuti matendawa chotupa chiwalo kapena thupi gawo mothandizidwa ndi zipangizo zina zapadera kupulumutsidwa ku kufalitsa ambiri. Ndiye chongopeka zimachititsa kuti magazi aziyenda ndi jekeseni TNF.

zotsatira zowawa

Zochita matenda, chotupa necrosis chinthu kugwiritsidwa ntchito mosamala. chiwerengero cha maphunziro anasonyeza kuti TNF - chigawo chimodzi chofunika kwambiri pa chitukuko cha sepsis, mantha poizoni. Kupezeka kwa mapuloteni izi adakula pathogenicity matenda bakiteriya ndi tizilombo, omwe ndi owopsa pamaso pa HIV wodwalayo. Inatsimikizira kuti TNF kumafuna pochititsa matenda autoimmune (mwachitsanzo, nyamakazi) imene chitetezo cha m'thupi molakwika amalandira zimakhala ndi maselo a chamoyo cha matupi yachilendo amawonongeka iwo.

Kuchepetsa mkulu poizoni zotsatira kusunga miyezo zotsatirazi:

• ntchito kwanuko yekha pa malo mapangidwe chotupa;
• zimagwirizizirana ndi mankhwala ena;
• Iwo ntchito ndi zochepa poizoni ZOOPSA mapuloteni TNF;
• kutumikiridwa neutralizing chitetezo.

zinthu izi kukakamiza tingagwire chotupa necrosis china. Chithandizo iwo ayenera mwadongosolo.

matenda chizindikiro

A magazi alibe kudziwa TNF mu thupi lathanzi. Koma mlingo wake kumawonjezera kwambiri matenda opatsirana kumene magazi amachokera tizilomboto poizoni. Ndiye izo zikhoza kupezeka mu mkodzo. Chotupa necrosis imayambitsa madzimadzi synovial a nyamakazi limanena.

Kuwonjezera pa chizindikiro ikunena za thupi lawo siligwirizana, matenda a khansa ndipo ndi chizindikiro cha kukana ziwalo mwiniwake kuziika. Pali umboni kuwonjezeka mu chizindikiro ichi zingasonyeze kuti matenda si opatsirana monga matenda a mtima, bronchial mphumu.

Mu immunodeficiency zosiyanasiyana (kuphatikizapo AIDS) ndi matenda aakulu tizilombo zikuchitika komanso kuvulala ndi amayaka, zinthu analengedwa amene kuchepetsa chotupa necrosis china. A mankhwala amene ali ndi zotsatira immunosuppressive, kupereka kuchita chimodzimodzi.

kukonzekera

zochokera mankhwala TNF otchedwa akulimbana - kuthekera kuchita aiming pa mamolekyulu yeniyeni ya maselo a khansa, kuchititsa imfa ya masika. Zotsatira ziwalo zina ndi kochepa, zimene zimachititsa kawopsedwe, amene ali ndi chotupa necrosis china. mankhwala pogwiritsa ntchito monga TNF yekha (monotherapy) ndi kaphatikizidwe ndi atumiki.

Masiku ano, pali mankhwala angapo pamaziko a TNF, akuti:

• NGR-TNF - mankhwala achilendo, zosakaniza yogwira ndilochokera wa TNF. Iwo akhoza kuwononga mitsempha a chotupa cha azilephera izo a mphamvu yake.
• "Alnorin" - chitukuko Russian. Ndi kwambiri zothandiza osakaniza interferon.

"Refnot" - Russia latsopano mankhwala okhala ndi chotupa necrosis Chinthu ndi thymosin Alpha 1. kawopsedwe zake otsika kwambiri, koma dzuwa ndi wofanana ndi TNF zachilengedwe, ndipo ngakhale kuposa izo ndi kanthu immunostimulatory. mankhwala analengedwa mu 1990. Iwo bwinobwino zapita zofunika mayesero onse ovutika ndi yekhayo mu 2009 chinalembedwa, amene anapereka chilolezo boma pofuna kuchiza khansa awo.

Self-ka mankhwala pamaziko a chotupa necrosis chinthu mwamtheradi zoletsedwa. Cancer mankhwala - mwadongosolo ndondomeko chimene chimachitika yekha kuyang'aniridwa ndi katswiri.