Benzathine benzylpenicillin: kufotokoza, katundu ndi ntchito, analogs

Benzathine Benzylpenicillin ndi maantibayotiki ndi wa gulu Penicillin. Amagwiritsidwa ntchito pofuna kuchiza mitundu yonse ya matenda oyamba ndi bakiteriya atengeke kanthu ake. M'nkhaniyi tiona mulamulo malangizo ntchito, zizindikiro ndi contraindications kuti mankhwala, komanso mndandanda anzake angapo.

Benzathine benzylpenicillin: ikulongosola za mankhwala

Izi mankhwala ndi amodzi mwa gulu loyamba la mankhwala a penicillin. Ngakhale ntchito yayitali akuti, izo sanataye kufunika kwake chifukwa zosiyanasiyana za lonse zochita ndi luso kupha zosiyanasiyana tizilombo toyambitsa matenda. Mankhwala, mwachitsanzo, akhoza kulimbana ndi tizilombo ta matenda, meningococci, chindoko ndi kuchuluka kwa streptococci ndi staphylococci. Anali jekeseni ngati kapepala kakuti m'mimba si odzipereka benzathine benzylpenicillin.

Chinsinsi ku Latin nthawi zambiri zotchulidwa madokotala, ndiyeno mtima ndi zovuta kumvetsa zimene iye anapatsidwa. Kuti asasokonezeke izi, inu muyenera kudziwa dzina la mankhwala la chinenero - Benzathine benzylpenicillinum.

Childs, mankhwala chikuyendetsedwera m'nsinga kapena intramuscularly. Koma n'zotheka ndi mankhwala yobereka mu thupi mwa msana ngalande, subcutaneously kapena mwa zinkakhala m'dera.

Benzylpenicillin - mankhwala anapeka ku chinthu chomwecho yogwira. Koma akulowa mankhwala mu mawonekedwe a salt. Choncho mankhwala akhoza kusungidwa kwa nthawi yaitali popanda kuswa pansi. Ndipo pambuyo kumayambiriro penicillin G adzamasulidwa ku thupi la salt ndipo akuyamba ntchito zake antibacterial.

Malinga dongosolo limene mchere ndi chinthu yogwira, muli mitundu yambiri ya mankhwala. Ngakhale onsewo ali pafupifupi zotsatira zofanana, ndipo modes osiyanasiyana oyendetsa nthawi ya phindu.

umboni

Benzathine benzylpenicillin Kwalamulidwa kwa matenda otsatirawa:

• Matenda a ziwalo kupuma (pleurisy, chibayo, chifuwa, empyema , ndi zina zotero.).
• Matenda a dongosolo genitourinary (chindoko, mabomu, urethritis, cystitis, adnexitis, salpingitis).
• Matenda a chapamwamba kupuma thirakiti (fever, zilonda zapakhosi, sinusitis, media otitis, sinusitis, laryngitis, etc.).
• matenda Purulent cha ziwalo zithunzi, mafupa ndi khungu, zikopa mucous (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, cellulitis, namkulunga, matenda, ndi zina zotero.).
• Brain abscess.
• Purulent meninjaitisi.
• Septicemia, sepsis.
• Nyamakazi.
• Peritonitis.
• Matenda oyamba ndi spirochetes (yaws, tizilombo ta matenda, etc.).
• Malungo chifukwa cha makoswe kuluma.
• Matenda oyamba ndi Listeria, Clostridium, Pasteurella.

Komanso, mankhwala ndi kutumikiridwa mu zosokonezeka prophylactically postoperative ndi mavuto ndi matenda streptococcal (endocarditis, enaake ophwanya m'thupi, glomerulonephritis ndi zina zotero.).

Pharmacokinetics

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) yomweyo pambuyo makonzedwe akuyamba apasuke, potulutsa mankhwala yogwira. Pa nthawi yomweyo mankhwala amakhalabe mu magazi milungu 3 pambuyo jekeseni ya. Thunthu madzi likulowerera kuposa mu minofu. Ziyenera adzanyamula kukumbukira kuti benzyl penicillin ndi wakutheker kugonjetsa chotchinga placental ndi kuonekera mu mkaka wa amayi unamwino. Excreted kudzera impso mu mawonekedwe sichinasinthe. Pa tsiku loyamba masiku 8 anamasulidwa pafupifupi 33% ya mlingo kutumikiridwa.

Mimba ndi kuyamwitsa

Monga taonera, mankhwala akhoza umalowa mu nsengwa ndi kulowa mu mkaka wa m'mawere. Choncho, yoyamwitsa ayenera anasiya kupereka mankhwala.

Woyembekezera, poika mankhwala n'chotheka ngati phindu akazi ndi wamkulu kuposa mavuto mwanayo. chisankho izipangidwa ndi dokotala, kuchenjeza mayi tsogolo zotsatira zake zonse zitheka.

contraindications

Benzathine benzylpenicillin (Chinsinsi mwina mankhwala dokotala) angapo a contraindications. Sitiyenera mankhwala kwa anthu amene ali ndi matenda otsatirawa:

• Kusagwirizana ndi penicillin kapena cephalosporin, ndi matupi awo sagwirizana anachita iwo.
• The mkulu mlingo wa potaziyamu mu magazi (hyperkalaemia).
• Arrhythmia.
• Chimfine.
• Bronchial mphumu.
• Aimpso insufficiency.
• Pseudomembranous matenda a m'matumbo.

CHENJEZO medicament kutumikiridwa kwa ana mpaka miyezi isanu ndi asanakalambe.

zotsatira zoyipazi

Benzathine benzylpenicillin zingachititse ena obwera osafunika, lembani m'munsimu.

Various matupi awo sagwirizana zochita:

• malungo;
• ming'oma;
• okhadzula pa nembanemba wa mucous ndi khungu;
• olowa ululu;
• eosinophilia;
• erythema multiforme;
• Angioedema;
• exfoliative dermatitis;
• anaphylactic mantha.

zosiyanasiyana chokhwima a dongosolo mtima:

• thrombocytopenia;
• magazi m'thupi;
• matenda coagulation;
• leukopenia.

Kuwonjezera:

• stomatitis;
• mutu;
• glossitis;
• ululu m'dera la utsogoleli;
• abscesses;
• infiltrates;
• yade zotumphukira;
• fistulas.

Ndi ntchito yaitali bowa zoipa ndi yaying'ono-zamoyo angathe kukana, ndiye mankhwala adzautaya nchito zake.

Benzathine benzylpenicillin: malangizo ntchito

Odwala wamkulu kuposa zaka 12, mankhwala ngati muyeso njira ndi chithandizo cha matenda opatsirana chikuyendetsedwera kamodzi pa sabata pa mlingo 300 600 zikwi. Mayunitsi kapena kawiri pa mwezi pa mayunitsi 1.2 miliyoni.

Monga zodzitetezera kuti vuto la misempha pokha mankhwala kwa masabata 6, kamodzi pa sabata kwa mayunitsi 600 zikwi. Pa nthawi yomweyo mankhwala aspirin kapena NSAIDs ena.

Odwala wamng'ono kuposa zaka 12, mankhwala chikuyendetsedwera kamodzi pa sabata pa mlingo wa 5-10 zikwi. Mayunitsi pa 1 makilogalamu.

Pakati jekeseni ayenera kutenga malo masiku osachepera 8. Wapakati mlingo wa mayunitsi okwana mamiliyoni 2.3.

Pamaso ntchito, mankhwala anali kusungunuka mu saline, madzi a jekeseni chisawawa kapena novocaine (2.5% kapena 5%).

Chosavuta mankhwala akhoza kukhala m'njira zotsatirazi:

• mu mnofu;
• mtsempha;
• subcutaneous;
• Lumbar (kudzera m'njira msana);
• pleural (mwa pleura m'mapapo mwanga);
• subconjunctival (kudzera zimakhala ocular);
• adzagwa mwa khutu;
• adzagwa mwa mphuno;
• mwachindunji wathuyo limba minofu.

Limodzi ndi mankhwala ena

Benzathine benzylpenicillin (malangizo mwachindunji malinga) Mwina kucheza ndi mankhwala ena. Choncho benzylpenicillin angakhale ndi zotsatirazi: a synergistic, odana nafe ndipo bacteriostatic.

Komanso, mankhwala kumawonjezera mphamvu ya mankhwala, yoperekedwa kwa anticoagulants zina. Ndipo amachepetsa mphamvu ya ethinyl estradiol ndi kulera zosiyanasiyana m'kamwa.

Ntchito pamodzi ndi NSAIDs, allopurinol, okodzetsa zotsatira wotsikirapo katulutsidwe tubular ndi kuchuluka woipa wa yogwira pophika. Komanso, allopurinol kumawonjezera kwambiri chiopsezo thupi lawo siligwirizana.

kusamala

Kwenikweni pamaso pa jekeseni woyamba m'pofunika aspirate. Ngati mankhwala mwangozi afika mu zotengera mwazi, chifukwa angayambitse ischemia kapena embolism. Komanso, pali kumverera nkhawa, maganizo, chosakhalitsa amaona masomphenya.

Pa nthawi imene muyenera kuchita jakisoni awiri pa nthawi, mankhwala ndi kutumikiridwa mu mikono osiyana kapena matako.

Pamene mawonetseredwe woyamba wa mankhwala awo sagwirizana ayenera udzasokonezedwa yomweyo. Malinga ndi mmene zinthu zilili dokotala mankhwala ziwengo mankhwala.

Nthawi zambiri benzylpenicillin adzaika "Levorinum" kapena "Nystatin", pali chiopsezo matenda a mafangasi. Choncho nthawi yaitali mankhwala mankhwala kumachitika chopinga wa microflora matumbo omwe amapanga mavitamini B. Mu nkhani imeneyi, angathe kuperekedwa kwa makonzedwe mu mnofu wa mavitamini izi.

Kusamala

Benzathine benzylpenicillin anatumizidwa ndi kusamala odwala amene asunga zosiyanasiyana ntchito impso, pali kutengera za ku mawonetseredwe awo sagwirizana ndi tilinazo mkulu kwa pophika yogwira. Chigamulo chomaliza nthawi zonse chimakhala ndi dokotala, amene ayenera kudziwa mbiri ya mtima wake.

Osavomerezeka mankhwala zochizira neurosyphilis, kuyambira matenda sizingatheke ndende anakhumba zinthu mwakhama magazi wodwalayo.

analogs

Pali mankhwala ena omwe ndi cholinga chofanana monga benzathine benzylpenicillin. Analogs, ndithudi, komanso m'gulu la Penicillin. Tikungotchula wotchuka kwambiri komanso zothandiza:

• "Gramoks-D" - amapangidwa mu mawonekedwe a ufa anafuna kuswana ndi makonzedwe m'kamwa.
• "Amosin" - kamapangikira makapisozi, miyala ndi ufa yoyang'anira m'kamwa.
• "Nthomba" - analengedwa mu mawonekedwe a madzi.
• "Hikontsil" - alembedwe wa ufa ndi makapisozi kwa makonzedwe m'kamwa.
• Azlocillin ndi sodium mchere - ufa mankhwala kumene kupanga njira jekeseni mtsempha.
• "Ampicillin" - akupezeka mapiritsi, makapisozi, granules, atsopano kupanga slurry, ndipo anatengedwa pakamwa.
• "Ekobol" - opangidwa miyala.
• "Ospamoks" - analengedwa mu mawonekedwe a mapiritsi, makapisozi ndi ufa yoyang'anira m'kamwa.
• "Phenoxymethylpenicillin" - akupezeka mapiritsi, dragees, granules ndi ufa.
• "Star-Cholembera" - analengedwa mu mawonekedwe a granules, amene kuchepetsedwa ndi anatengedwa pakamwa.
• "Oxacillin" - analengedwa mu mawonekedwe a mapiritsi, makapisozi, ufa, kumene, njira jekeseni.
• "Standatsillin" - akupezeka makapisozi.
• Carbenicillin disodium mchere - amapangidwa mu mawonekedwe ufa kupanga njira jekeseni.

Choncho, ngakhale kuti ndi yaitali ndi mankhwala mankhwala, iye Zatsala mmodzi wa wothandizira yabwino kwambiri ndi zosiyanasiyana matenda.