"5-NOC" - ndemanga kukonzekera

Ngakhale kuti thupi la munthu wapatsidwa chitetezo chokwanira ndipo amatha kulimbana ndi matenda ambiri lokha, muli tizilombo ndi matenda amene angathe kuthetsedwa popanda thandizo la mankhwala. mankhwala akhoza ziletsa kapena kusiya kukula kwa tizilombo toyambitsa matenda, ndipo potero adzathetsa cholinga cha kutupa. Miyala ndi "5-NOC" Gulu la mankhwala. Umboni musonyeze mkulu mu mankhwala a matenda a dongosolo genitourinary. Komanso, chida ichi ndi wangwiro kupewa zisadzachitikenso kutupa m'njira aakulu matenda.

yogwira mankhwala

Nitroxoline yogwira mankhwala ndi mankhwala yogwira "NOC-5." Ndi mapangidwe kupanga, ndilochokera pa 8-hydroxyquinoline. Kudzera chigawo ichi, mankhwala kulowa m'thupi angayambe maselo tizilombo ndi ziletsa DNA awo. kusankha njira ya kanthu amalola kuti asiye kuchuluka kwa tizilombo toyambitsa matenda ndi sizidzawapweteka maselo wathanzi.

Kuwonjezera nitroksolin amalowa anachita ndi yogwira zidulo mkati ndi michere amene ali zitsulo osayenera awo. thunthu amapereka kuchira ndondomeko ya tizilombo toyambitsa matenda ali amphamvu bactericidal kanthu motsutsana ndi sipekitiramu lonse tizilombo. Choncho mogwira akulanga anthu ta kusamva mankhwala magulu ena a antibayotiki. Medicine "NOC-5 'mavoti zikutsimikiziridwa kukhala wogwira mtima ndi yotchipa njira ndi matenda oyamba ndi bowa, mabakiteriya ndi tizilombo toyambitsa matenda matenda zonyamula mankhwala ena a kanthu antibacterial ndi antiseptic.

mawonekedwe Ndinamasulidwa zikuchokera

medicament The amachoka mu mawonekedwe a mapiritsi TACHIMATA. Iwo ali lalanje kapena wachikasu, mu mawonekedwe a chonse, lenticular, pali khalidwe luster. Waukulu yogwira pophika - nitroksolin. Wothandiza zigawo za zikuchokera: sucrose, colorant E110, carboxymethylcellulose, lactose.

Kodi tizilombo kumenyana mankhwala

Onani kuti chiphunzitso kumakhudza mbali ndi othandiza kwambiri ndi ena tizilombo ta tizilombo toyambitsa matenda:

• Thupi ndi anaerobic galamu HIV zamoyo - Enterococcus faecalis, Streptococcus spp. (Pneumoniae tizilombo ta, pyogenes).
• Staphylococcus spp., Chikukoka aureus, Bacillus subtilis, Corynebacterium spp.
• Anaerobic ndi tizilombo aerobic (gram) - Klebsiella spp, Proteus spp, Shigella spp, nsomba spp, Haemophilus influenzae, Enterobacter spp, Escherichia coli, Neisseria gonorrhoeae ......
• Matenda oyamba ndi la Mycobacterium TB ya Mycoplasma hominis, Trichomonas vaginalis, wa Ureaplasma urealyticum.

Amatha kuumba, dermatophytes, bowa wa candida, ena zamoyo kuchititsa matenda kwambiri mafangasi - matenda amenewa Zimathandizanso kuchepetsa mankhwala "5-NOC". Reviews madokotala kuonetsa luso la mankhwala kuchepetsa guluu wolimba kwambiri ya zinthu uropathogenic ku linga la catheter (kukhetsa mkodzo odwala) ndi mkodzo wosanjikiza thirakiti zaminyewa.

pamene kutumikiridwa

Chifukwa osiyanasiyana m'malo lonse ntchito mankhwala kulimbana ndi matenda otsatirawa:

• Aakulu, pachimake, matenda kobwereza (opatsirana etiology) mkodzo thirakiti oyamba ndi bakiteriya galamu alibe ndi galamu HIV ndi bowa.
• Epididymitis.
• Pyelonephritis: aakulu pachimake mawonekedwe.
• Urethritis.
• Cystitis.
• Adenoma ndi carcinoma (zabwino) za prostate.
• Kupewa matenda (kobwereza) thirakiti mkodzo.
• Ikani pambuyo njira yodziwira ndi mphuno thirakiti mkodzo: impso opaleshoni, cystoscopy, catheterization.

Dziwani kuti mankhwala chithandizo chokwanira malinga ndi kukula kwa matenda zitha kukhala dokotala. Miyala "5-NOC" Akatswiri amakambirana izo zikutsimikiziridwa kuti mkulu bioavailability - 90%. Iwo mofulumira odzipereka kapepala kakuti m'mimba ndi kuwafika plasma apamwamba ndende pasanathe maola 1.5-2.

Pharmacokinetics

lokonzekera ali ndi luso otsika kuphatikiza ndi mapuloteni plasma. Ndende apamwamba mankhwala yogwira anasonyeza mu mkodzo wa wodwalayo. The mankhwala ndi zimapukusidwa makamaka chiwindi ndi excreted ndi impsozo. A kuchuluka kwa mankhwala atachotsedwa thupi ya ndulu ya - nyengo ya maola 2 tisaiwale kuti deta pa pharmacokinetics wa mankhwala ana, anthu wokalamba odwala ndi insufficiency aimpso ndi chiwindi sizinachitike anaphunzira .. Choncho, muyenera kupeza oyenerera dokotala upo pamaso kupereka mankhwala "5-NOC". Reviews Akatswiri kuona kuti ana bwino analekerera mankhwala ngati kumvera ndi mtima wonse ndi mlingo ndi chithandizo regimens. chisamaliro liyenera kutsogolera Ataona kuti mwanayo, amene sizinawakhudze zaka 3 zakubadwa.

Kodi kutenga

Ndi bwino kutenga mankhwala pa chakudya kapena pambuyo. Mapiritsi musati kutafuna, kumeza lonse, ndasambitsa pansi ndi madzi woyera. Mlingo okwanira:

• Wamkulu odwala - 100 200 mg, maulendo 4 tsiku. Onani kuti pa chikhalidwe cha ntchito mosalekeza kwa mlingo mapiritsi akhoza musalumphe masiku 30. Komabe, maphunziro ndi zotheka mankhwala ndi kusinthana: masiku 14 kumwa mapiritsi, masiku 14 sanatenge mankhwala. Njira imeneyi zimathandiza kuti kupereka chithandizo kwa miyezi ingapo.
• Kupewa matenda pambuyo popanga munthu opaleshoni, njira yodziwira - 100 mg mpaka nthawi 4 tsiku. Chotero medicament phwando mode amatenga masabata 3. Kwa odwala ndi mkhutu chiwindi ntchito ndi impso koyamba mlingo 50% ya analimbikitsa.

Tikumbukenso kuti mankhwala ndi "5-NOC" cystitis, pamene umboni uperekedwa mtima akutitsimikizira izi, mwamsanga kumachepetsa kutupa ndi kumatha kupweteka kwambiri. Komabe, ngakhale mu mwambo ndi ubwino wa chithandizocho osavomerezeka pakamwa Inde zotchulidwa dokotala, mwinamwake pali chiopsezo zisadzachitikenso.

Mlingo wa ana

Kumbukirani kuti mlingo chokwanira cha mwana akhoza kudziwa yekha dokotala pamaziko a kafukufukuyu. mankhwala nthawi zotchulidwa motere:

• Khanda kwa miyezi 2 12 mawerengedwe anapangidwa, zochokera pathupi mwana kulemera: 25 mg / kg pa tsiku. mankhwala onse ayenera kugawidwa Mlingo 4 fupipafupi. Nthawi mankhwala ndi kwa masiku 10 kuti masabata 3. Mu nkhani ya matenda aakulu - mwezi 1.
• Pa zaka miyezi 12 mpaka 14 Kwalamulidwa madyedwe a mg ndi 50 100 maulendo 4 tsiku. Maphunzirowa anatsimikiza ndi katswiri, koma ndi phwando mosalekeza izo sizingakhoze upambana masiku 30. Pamene mode interleaved 2 masabata - phwando, ndipo masabata 2 - yopuma yokambirana ntchito yaitali mankhwala "5-NOC". Ana, madokotala ndemanga za zikusonyeza njira ayenera mankhwala pokha pokha kwambiri pamene chithandizo ndi mankhwala ena anasonyeza operewera.

chingachitike mbali

Onani kuti mavuto odwala ndi osowa, koma m'pofunika likhoza asayembekezere yomweyo funsani dokotala. Kuti muletse mankhwala ndi kuchititsa mankhwala symptomatic mankhwala "5-NOC". Malangizo amakambirana madokotala izi mawonetseredwe zoipa mankhwalawa:

• Kusanza, nthenda chiwindi ntchito, nseru, anorexia, mu nthawi zina.
• Tachycardia.
• Paresthesia, polyneuropathy.
• Mkhutu kugwirizana, chizungulire, kupweteka kwa mutu, nthawi zina imfa ya chikumbumtima.
• Chamawonedwe neuritis (ndi miyala ntchito yaitali).
• Urticaria, zotupa pa khungu ukuchoka.
• Thrombocytopenia, nthawi zina mkodzo kudetsa mu kwambiri chikasu hue, kuchuluka uric asidi index mu madzi a m'magazi.

Monga ulamuliro, zinthu zonse chowawa sachedwa kutha pambuyo discontinuation lathunthu la mankhwala, "5-NOC". Umboni kukuwonetsani kumva akudwala, Koma ngati cha mankhwala osokoneza bongo kapena kugwilizana osauka.

contraindications

Ngati wodwalayo sayanjana kapena kukhumudwitsa m'modzi wa zigawo zikuluzikulu za zikuchokera, si ololedwa Ndinapereka mankhwala. Iwo ali osavomerezeka kutsatira medicament pa yoyamwitsa, ng'ala, nthenda chiwindi ntchito ndi impso.

Dziwani kuti mankhwala ndi "5-NOC" akazi ndemanga za zikusonyeza nthawi zambiri zotchulidwa pa mimba. Zilibe kukhazikitsa milandu zoipa thanzi la mayi tsogolo ndi mwana wosabadwayo. Childs, mankhwala Kwalamulidwa kwa cystitis pachimake, matenda ukazi ndi mawonetseredwe mafangasi (thrush).

Sikuti kutenga mankhwala pa nthawi imodzi mankhwala okhala hydroxyquinoline. poyizoni poizoni angayambe kuchokera zotsala mankhwala yogwira m'thupi.