"Pradaksa" - analogues. "Warfarin", "Ksarelto": ndemanga, mitengo

Mwa nthumwi antithrombotic ntchito kuchotsa thromboembolism mu mitsempha pambuyo opaleshoni, zotsogola kwambiri chimasonyeza kukonzekera "Pradaksa". analogues yake zikuonetsa timapangira ntchito ndi kukonza ndi zosakaniza zosiyanasiyana yogwira. Anticoagulants akupezeka olimba mlingo mawonekedwe ndi Mlingo osiyana.

Kufotokozera "Pradaksa" mankhwala

Wopanga antithrombotic ndi anticoagulant mankhwala "Pradaksa" kampani "Boehringer Ingelheim Pharma GmbH & Co. KG. KG ". Zilipo njira mu makapisozi imene anaigwira mwakhama zili mkati yaing'ono pellets chikasu. The yogwira thunthu dabigatran etexilate ankaona mawonekedwe wofooka, chiwerengero cha amene amasankha mlingo wa mankhwala. Kungakhale 75 mg, 110 mg wa ndi 150 mg.

Kodi mankhwala "Pradaksa" ntchito

Cholinga cha makapisozi chikugwirizana ndi kupewa thromboembolism venous pambuyo m'madipatimenti opaleshoni mu dongosolo minofu ndi mafupa.

Kodi chida "Pradaksa"

Iwo amagwirizana ndi yimitsira wa limagwirira thrombin ntchito kanthu za mankhwala "Pradaksa". Analogs kuonetsa katundu yosiyaniranapo. Kukhala molekyulu yaing'ono, dabigatran etexilate alibe kanthu pharmacological.

Only analowa m'thupi la munthu, thunthu ng'ambidwa pambuyo hydrolysis kwa dabigatran ufulu zachangu kusintha mwachindunji mpikisano woletsa wa thrombin enzyme. Udindo wa thrombin amamanga kuti Ulimbo, thrombin, kuchepetsa selo loitanirana wa kupatsidwa zinthu za m'mwazi chifukwa cha ntchito thrombin.

zida

Ndi mankhwala "Pradaksa" Akhristu. Koma mu kapangidwe kake, iwo mulibe dabigatran etexilate, izo zatha ndi atumiki anticoagulant. Choncho, yogwira pophika ofanana amatanthauza "Warfarin" ndi warfarin, mu medicament "Ksarelto" lili rivaroxaban. Mau ofanana kukonzekera "Pradaksa" yakuti "Marcumar" ndi "Fenilin" akuphatikizapo phenprocoumon ndi phenindione motero.

Kufotokozera "Warfarin" mankhwala

Takambirana kale adazifuna, amene mankhwala "Pradaksa" Akhristu. Tiyeni tsopano tione mwatsatanetsatane imodzi mwa iwo.

The medicament "Warfarin" amapangidwa mu mawonekedwe a mapiritsi mlingo wa yogwira pophika, 2.5 mg. Mlengi wa mankhwala ndi Russian kampani "Kanonfarma kupanga."

Pali mlingo (1 mg, 2 mg, 3 mg wa 5 mg) yachilendo mankhwala pogwiritsa warfarin. The mawonekedwe, mtundu ndi kukula kwa miyala ndi osiyana mbali ya mlingo ntchito mg.

Pakuti mankhwala ntchito

Phwando "Warfarin" n'zotheka:

• thrombosis a dongosolo venous kapena kutengera za;
• zochizira prophylactic wa thrombosis ndi thromboembolism;
• mu pachimake venous thrombosis mkati ndi embolism mu minofu m'mapapo;
• pa thrombosis postoperative;
• pachimake m'mnyewa wamtima mtima minofu;
• pa opaleshoni ndi mankhwala thrombolytic wa thrombosis;
• nafe chosakhalitsa ischemic;
• mankhwala yaitali thrombosis kobwereza venous;
• pa vavu apulasitiki mu mtima.

Kodi nthumwi

zinthu zenizeni za nkhani "warfarin" kuchepetsa magazi clotting zinthu ziletsa yopanga (X, IX, VII, II), vitamini K amadalira magazi ndi chifukwa coagulation. Kwa chiwindi anticoagulant mapuloteni C ndi S ali apanga Pamlingo wamng'ono atamwa mankhwala. Zonsezi amachepetsa mapangidwe magazi kuundana kuti kuyambitsa mapangidwe magazi kuundana.

Kuthetsa venous thrombosis madokotala mankhwala mankhwala ndi anticoagulants zina. Izi si adzathe kukhala thrombosis, yomwe INGATHE kuyambitsa mavuto.

Mawerengedwe a mlingo wa warfarin pamlingo wosiyanasiyana INR

Pangano "Warfarin" mankhwala zotheka ndikatha kumfunsafunsa mwatsatanetsatane, imene limatchula contraindications onse. The kusanthula mankhwala zina anasankha kuchuluka Napempha kwa medicament "Warfarin". Mlingo patsiku sayenera upambana 5 mg wa chinthu chachikulu yogwira. Ndi osakwanira achire zotsatira za mankhwala ikuchitika uphungu. Ndi bwino kulemba mlingo analandira, milingo INR ndi zotsatira akuwuka kwa kusanthula mankhwala.

Mu INR (mayiko dekhetsa chiŵerengero) kutanthauza muyezo tipeze ntchito za zinthu clotting magazi. magazi clotting zinthu zimakhudza mtengo wa chizindikiro. Nkofunika kuyan'ana INR pamene kulandira "warfarin" kovuta amene ali inversely molingana ndi clotting magazi. Choncho, pa mkulu dekhetsa chiŵerengero kubweza clotting ndi kuonjezera hypocoagulation.

Pamene limati osiyana ayenera kuunikira mu INR ena.

1. Pakuti wathanzi chamoyo, ponseponse ake ndi za 1.0 (kapena kumbali pang'ono - kuchokera 0,85 kuti 1.25).
2. Matenda matenda fibrillation pamene kulandira "Warfarin" pellets ayenera chiŵerengero dekhetsa mayunitsi 2.0 kuti 3,0.
3. Mawotchi vavu prosthesis yodziwika ndi INR wa 2.0 kuti 3,0, mwamwambo apulasitiki mitral vavu kuchokera 2.5 kuti 3.5.
4. Mankhwalawa thromboembolism mu mtsempha wamagazi m'mapapo mwanga ndi zilema mtima muyenera mlingo index wa 2.0 kuti 3,0.
5. Pofuna kupewa thrombosis mu mitsempha kwambiri pambuyo opaleshoni ndi mankhwala thrombosis venous, kutsatira mfundo za 2.0-3.0.

Mankhwala "Warfarin" ayenera kuchitidwa ndi polojekiti mosamala INR index ndi okhwima zachipatala mabwana, kuti athe kusintha mlingo. Olimba dekhetsa chiŵerengero ndi kusankha kuchuluka ofunikira medicament ikuchitika kwa sabata imodzi, ndiyeno pa masabata 4 mtengo uwu ndi kufufuzidwa.

Kubwera ku zotsatira za ntchito "Warfarin" mankhwala, mmene kuposa kusamba pansi ndi ngati kuphatikiza chakudya, muyenera kudziwa. Mapiritsi kumwa masana, osati kaphatikizidwe ndi kumwa chakudya. Natsuka pansi ndi madzi ndi kumamwa nthawi yomweyo. Komanso yobereka za kufufuza pa INR ayenera ola lomwelo ndi zasayansi okhazikika. Pamene timabwerera Mlingo zofunika kuti achite gawo lotsatira la nthawi phwando.

Pamlingo zosakwana 2.0 INR imatengedwa magazi wandiweyani, mankhwala ndi operewera Choncho, m'pofunika kugwiritsa ntchito apamwamba mlingo "warfarin".

Kumbali ya INR amaona magazi kuposa 3,0 madzi, magazi kumachitika, choncho m'pofunika kugwiritsa ntchito osachepera mkulu mlingo wa mankhwala.

Mtengo wa mankhwala "Warfarin"

Poyerekeza ndi German mankhwala "Pradaksa" Russian lofanana ndi la "Warfarin", mtengo wa wochokera rubles 80 pa paketi, ndi mtengo kwambiri ndipo mosavuta.

Kufotokozera "Ksarelto" mankhwala

Pa medicament "Pradaksa" analogs akhale ndi katundu anticoagulant, ali ndi chikoka mwachindunji. mankhwala "Ksarelto" amatanthauza iwo. Zinabala mu mawonekedwe a wozungulira filimu mapiritsi TACHIMATA mu kampani German "Bayer".

The zikuchokera ali rivaroxaban mu mawonekedwe micronized. Miyala "Ksarelto" ali Mlingo zotsatirazi: 2.5 mg, 10 mg, 15 mg ndi 20 mg.

limagwirira kanthu

Rivaroxaban amatchedwa kwambiri kusankha mwachindunji chinthu Xa zoletsa kuti ndi mkulu bioavailability anati pambuyo makonzedwe m'kamwa.

Kugwa coagulation aumbike mwa kutsegula kwa chinthu X, amene, chifukwa mkati ndi kunja coagulation njira ndi n'kukhala chinthu Xa. chigawo ichi kumatanthauza mapangidwe a prothrombinase pawiri kuchokera kanthu komwe prothrombin ndi kutembenukira ku thrombin. pasukuluyi kupanga Ulimbo aumirira, ndi imayendetsa othandiza magazi kuundana. Pali "mkangano" limene chifukwa chinthu chimodzi Xa molekyulu ndi apanga kuti chikwi chimodzi maselo amenewa magazi.

Kugwiritsa zoletsa kusankha kuti kuchepetsa ntchito activator amapezeka asiye "thrombin kuphulika". Action rivaroxaban walangizidwa kusintha zotsatira za inayake ambiri kusanthula zasayansi ndi kuyerekeza ndi boma la dongosolo coagulation. Factor Xa ntchito mosiyanasiyana malingana woletsa mlingo, amene akutumikira monga mankhwala "Ksarelto" (15 mg a mapiritsi kapena mlingo zina).

Kuti mankhwala ndi mankhwala

Buku anafotokoza ntchito medicament kwa kupewa imfa pambuyo matenda a mtima kugwirizana ndi m'mnyewa wamtima minofu mtima ndi pachimake inatsekeratu syndrome. Medicine "Ksarelto" zabwino khalidwe mavoti analandira zothandiza osakaniza mankhwala molumikizana ndi aspirin kapena aspirin ndi thienopyridine.

Kodi kutenga Mlingo osiyana mankhwala

mankhwala cholinga ntchito mkati. Mapiritsi Mlingo onse anatengedwa ndi chakudya.

Pofuna kuthetsa pachimake inatsekeratu syndrome akulangizidwa kuti atenge limodzi la 2.5 mg ndi kawiri pa tsiku. Pamodzi ndi kukonzekera "Ksarelto" (mavoti amasonyeza mphamvu ya ntchito osakaniza ngati Hud) angathe kuperekedwa asidi acetylsalicylic mu mlingo tsiku la kwa 75 100 mg, ndi osakaniza aspirin ndi clopidogrel mu kuchuluka kwa 75 mg pa tsiku. mankhwala Izi zimafuna nthawi zonse achipatala malamulo a muyezo, amene kuchepetsa mbali imodzi zingathe kubweretsa mavuto ischemic kapena magazi. Kutenga mankhwala yaitali ndipo amatenga chaka chimodzi, odwala ena mpaka zaka ziwiri.

Miyala mu mlingo wa 10 mg rivaroxaban kutenga nthawi ina tsiku. The chakumwa choyamba pambuyo maola 6-9 opaleshoni kumunda ndi hemostasis ogwira. Kutalika kwa chithandizo anatsimikiza mu wambirimbiri mankhwala kwa wodwala aliyense payekha, malinga ndi chiopsezo venous thromboembolism, Kuvuta ndi mtundu wa ntchito.

Pamene liwu mankhwala makonzedwe "Ksarelto" ntchafu m'malo (10 mg) amatenga masabata 5, pa bondo arthroplasty amatengedwa masiku 14.

Ngati wodwalayo ndi waiwala kumwa mlingo wina wa rivaroxaban, tiyenera nthawi yomweyo ankadya, ndi tsiku lotsatira kupitiriza mankhwala, piritsi 1.

Mlingo apamwamba a 15 mg kapena 20 mg wa komanso osati kutenga pa chopanda kanthu m'mimba.

Pofuna kuteteza boma ndi sitiroko ndi embolism khalidwe zokhudza zonse ndi anthu amene sanali valvular matenda fibrillation zachilengedwe mtima matenda pogwiritsa ntchito piritsi mlingo wa 20 mg wa kamodzi pa tsiku.

Mu kulephera aimpso, pamene mlingo wa creatinine Kupha theka moyo wa zosakwana 30 ml ya kwa mphindi 1, ntchito mlingo wa 15 mg wa 1 nthawi patsiku.

Kutalika kwa nthawi yoperekera chithandizo kumatengera pamaso pa kuwopsyeza kwa kufa ziwalo ndi thromboembolism boma mwadongosolo.

The pazipita chocheperako tsiku mlingo sayenera oposa 20 mg wa rivaroxaban.

Thrombosis wakuya mtsempha zokhudza, chifukwa kupewa zisadzachitikenso ya matenda ndiponso thromboembolic okhudza mtsempha wamagazi m'mapapo mwanga, ntchito mlingo woyambilira wa 15 mg kawiri pa tsiku pankhondo yoyamba masabata atatu. Kenako kusamukira mapiritsi a 20 mg wa rivaroxaban kamodzi pa tsiku kwa mankhwala yaitali kupewa kukonzanso thrombosis ndi kobwereza m'mapapo mwanga embolism.

Izo Sizotheka kuti odwala kumeza phale lonse, makamaka chachikulu, ndiye amaloledwa akupera ndi kusakaniza ndi madzi woyera kapena chakudya madzi musanayambe kumwa. Chikadzangotha kutenga mankhwala wodwala sayenera kudya.

Ndi zotheka kuti atchule wosweka mankhwala ndi gavage, udindo umene mu dongosolo m'mimba ndi mgwirizano pasadakhale ndi dokotala. Terms kupanga mapiritsi wosweka motere tichipeza mu kusakaniza mankhwala ndi pang'ono madzi ndi wotsatira ku makonzedwe. Pambuyo wodzala ndi madzimadzi pang'ono kuchotsa zatsalira mankhwala kuchokera kafukufuku. Zotsatirazi mankhwala zofunika kuti agwire enteral kudya chakudya.

Mtengo wa mankhwala "Ksarelto"

chida imeneyi imagwira ntchito mankhwala kunja ndi kukwera mtengo. Mwachitsanzo, mankhwala "Ksarelto" mtengo wa mlingo wochepetsetsa adzakhala 56 pellets pafupifupi 950 rubles. Ndi kwambiri mtengo kuposa analogue ake Russian - mankhwala "Warfarin". Mankhwala "Ksarelto" mtengo ukuwonjezeka malingana ndi kuwonjezeka mlingo. Choncho, phindu mapiritsi 14 15 mg rivaroxaban adzakhala 850 rubles, pamene atanyamula (28 zidutswa za miyala) ndi mlingo wapamwamba (20 mg wa yaikulu yogwira pophika) kulipira kuchokera 1450 rubles.