"Octagam": malangizo ntchito, zizindikiro, mavuto

Zimatanthauza mankhwala timapitiriza chitetezo cha m'thupi, "Octagam". Malamulo adzakhala kukumbukira kuti ndi mankhwala aakulu, ndipo anayambitsa yekha mu chipatala, mosamalitsa pa mankhwala. Ntchito ngati m'malo ndi immunomodulatory chithandizo.

Fomu kumasula mankhwala ndi kapangidwe kake

Chifukwa amapangidwa kokha mu mawonekedwe a njira kukonzekera kulowetsedwa "Octagam". Malangizo Ufumuyo ndi umamumvera kuphunzira kuvomerezedwa patsogolo ntchito. Yankho mandala, ndi kum'chitira chikasu. mankhwala amapangidwa mu mbale galasi 20, 50, 100, 200 ml, amene atsekedwa ndi pakamwapo mphira ndi burnishing zotayidwa odzaza mukatoni, kumene kuwonjezera malangizo ntchito ndi mwini pulasitiki-mauna.

The medicament lili mu 1 ml ya osachepera 95% immunoglobulin G. The chizindikiro Matanthawuzo ndi kuchuluka kwa mapuloteni ali madzi a m'magazi anthu. zinthu zina mu zikuchokera mankhwala ndi:

• maltose;
• octoxynol;
• tributyl mankwala;
• madzi jekeseni.

Mankhwala ayenera amaundana kapena poyera kwa dzuwa. Iwo kusungidwa kutentha 2-8 ° C, ana sangawapeze.

Mankhwala ndi pharmacokinetics

Mankhwala "Octagam" (Buku akuchenjeza za contraindications ndi zotsatira mwina ntchito mankhwala) amakhudza chitetezo anthu ndipo amatanthauza immunoglobulins.

Mankhwala ndi gawo la immunoglobulin kalasi G, omwe umatulutsa mankhwala akupha ndi njira zosiyanasiyana matenda m'thupi. Mankhwala lili subclasses wa immunoglobulin G, zofanana ndi plasma anthu, kubwereza onse katundu ndi makhalidwe. Mawu oyamba a mankhwala mu thupi limabwezeretsa amaudindo wotsikirapo wa IgG, chimtsogolera ku boma yachibadwa. IgG mamolekyulu chifukwa enzymatic ndi mankhwala oopsa sizinasinthe. Ntchito ya chitetezo anali okhoza kupulumutsa kwathunthu.

Pokonzekera "Octagam" si oposa 3% polima, yotsala udzayesedwa chifukwa monomers ndi dimers ndi 90%.

Pamene munakonza chida ntchito magazi a 3500 othandizira ndalama wathanzi kwathunthu. Zimawatengera kuti analipo mu madzi a anthu awa anakhala pokonzekera izi zikutsatiridwa ndi kukhala kwathunthu yogwira.

Pambuyo makonzedwe mankhwala mu mtsempha immunoglobulin G yomweyo akulowa zokhudza zonse kufalitsidwa, amene anagawana pakati pa danga mtima ndi madzi a m'magazi. Posonyeza "Oktagama" alili bwino mu masiku 3-5. Linachokera mankhwala pa 24-36 tsiku TH. Hafu ya moyo osiyana aliyense ndipo zimadalira m'badwo wodwala, mlingo wa immunodeficiency. Immunoglobulin G kapena maofesi ena m'thupi munali yogwira chigawo, anawononga dongosolo reticuloendothelial.

Pamene ntchito "Octagam"?

Anagwiritsa ntchito "Octagam" m'malo mankhwala pamene pali chachikulu immunodeficiency syndromes, poyamba pa zonse, ndi hypogammaglobulinemia kobadwa nako, agammaglobulinemia ndi matenda Wiskott-Aldrich. Izi zikuphatikizapo variable unclassifiable immunodeficiency mtundu ndi immunodeficiencies pamodzi.

The chosonyeza kuti mankhwala cholinga myeloma angapo, lymphocytic aakulu mawonekedwe. Kwalamulidwa mankhwala odwala matenda kobwereza, ndi matenda a HIV ndi ana.

Mankhwalawa wapeza ntchito popanga mankhwala. Ndiko kuti, ntchito idiopathic thrombocytopenic purpura (ITP), limodzi ndi chiopsezo cha magazi kuchuluka. Komanso, mankhwala ntchito pamaso opaleshoni kuti matenda kupatsidwa zinthu za m'mwazi kuwerengedwa. Kwalamulidwa mankhwala ndi matenda Guillain-Barré. Ali ngati limasonyeza kuti matenda Kawasaki mu ana ndi akulu.

Gwiritsani ntchito "Octagam" (wogwiritsa ntchito mwatsatanetsatane njira oyendetsa mlingo wa mankhwala) mu allogeneic mafupa kupatsidwa zina.

Contraindications kwa infusions

Limatichenjeza kuti m'pofunika kuganizira contraindications nkhani pamaso ntchito "Octagam" kukonzekera malangizo. Musagwiritse ntchito mankhwala pamaso pa hypersensitivity kwa zinthu zake constituent kapena immunoglobulins magazi.

Ndi changu chisamaliro anaika odwala mankhwala amene ali wonenepa. Ali ndi kutengera za kukhala thrombosis. Zikutanthauza contraindicated ngati pali "matenda a matenda oopsa," matenda a shuga, matenda a dongosolo mtima, kukhala anawonjezera popanda magalimoto, kuwonjezera pa kukhuthala magazi.

Pamene kukhuthala mkulu wa madzi immunoglobulin, kulowa m'magazi, n'zothandiza chiopsezo infarction m'mnyewa wamtima, embolism m'mapapo mwanga, sitiroko, thrombosis venous.

CHENJEZO ayenera kugwiritsa ntchito mankhwala, odwala ndi kulephera aimpso ndi odwala hypovolemia kulandira mankhwala wothandizila nephrotoxic. Ngati pali makonzedwe pachimake matenda immunoglobulin gawo aimpso, ndi "Oktagamom" mankhwala ndi ndinayima.

Odwala ndi kulephera pachimake aimpso mu mawonekedwe komanso anthu ndi mavuto thromboembolic la kukapanda kuleka mtsempha kapena jekeseni, mankhwala chikuyendetsedwera pang'onopang'ono ndalama kochepa.

Mphamvu ya mankhwala mu akazi apakati ndi lactating sizinachitike kuphunzira, choncho nthawi anasonyeza mankhwala ayenera kugwiritsidwa ntchito mosamala kwambiri. Ngakhale, udokotala limasonyeza kuti ntchito immunoglobulins zimachokeradi zotsatira zoipa pa mimba. Mankhwala alibe mphamvu pa mwana wosabadwayo ndi sikumangotikhudza mwanayo kudzera mu mkaka wa mayi. Immunoglobulins, kulowa mumkaka, musati avulaze kwa ana akhanda, ndi chitetezo ali momwemo yekha zimathandiza kuti mapangidwe chitetezo chokwanira amphamvu.

Mlingo

"Octagam" mankhwala chikuyendetsedwera m'nsinga yekha. Asanayambe kutenthetsa kwa firiji, ndondomeko njira. The madzi ayenera kukhala mandala kwathunthu ndipo alibe precipitate ndi turbidity.

Aliyense makonzedwe mankhwala unalembedwa mu mbiri ya matenda. Palinso kupanga mankhwala mtanda nambala ndi dzina. Izi zachitika kusintha kuwunika alili. Mankhwala otsalira pambuyo kulowetsedwa, sangakhoze kusungidwa ndi ziyenera kuwonongeka.

Mlingo woyambilira wa oyamba sostvlyaet ml ya 0.01 kuti 0,02 / kg thupi mu miniti imodzi, ndi zina zotero kwa theka la ola. Ndi zabwino tolerability mlingo medicament pang'onopang'ono akhoza ziwonjezeke kwa 0,12 ml ya / kg thupi mphindi.

Kuchuluka kwa mankhwala ndi nthawi ya mankhwala atsimikiziridwa munthu mmodzi wodwala aliyense. Zonse zimadalira yankho matenda wodwalayo makamaka, chikhalidwe chake ndi matenda a matenda.

M'MALO immunomodulating mankhwala mu immunodeficiency yaikulu imakhudza kuchuluka kwa immunoglobulin G kuti 4.0-6.0 g / L, izo anali anayeza isanafike aliyense kulowetsedwa. Pofuna kukwaniritsa ngati chithunzi Pakufunika miyezi 3-6 mankhwala. Koyamba mlingo makonzedwe ndi 0.4-0.8 g / kg. Kenako mankhwala chikuyendetsedwera odwala milungu itatu iliyonse pa 0.2 g / kg. Pofuna kukwaniritsa chandamale immunoglobulin 6,0 g / L, wodwala ayenera kuyikidwa pa mwezi 0.2-0.8 g / makilogalamu mankhwala. Kamodzi akadzabweranso mtima boma wabwinobwino, mankhwala akupitiriza kuperekedwa pa masabata 2-4, pambuyo kuyeza ndende ya immunoglobulin G mu magazi. Zimenezi zingakuthandizeni kusankha mlingo mulingo woyenera.

M'MALO mankhwala mankhwala amachitika aakulu lymphocytic khansa wakupambana kwa hypogammaglobulinemia sekondale mu mawonekedwe kwambiri, mu myeloma angapo, komanso matenda a "HIV" ana ndi kobwereza ndi njira opatsirana. Mlingo Choncho fluctuates padziko 0.2-0.4 g / kg. Multiplicity kumuwonetsa - pa masabata 3-4.

Pa matenda a nkhani wokonda idiopathic thrombocytopenic purpura (ITP) amagwiritsidwa ntchito mlingo wa mankhwala 0.8-1.0 g / makilogalamu pamene kutumikiridwa mu tsiku loyamba. Ngati ndi kotheka, ndi zingagwiritsidwenso ntchito ya medicament opangidwa pa tsiku 2-5 mu kuchuluka kwa 0.4 g / kg. Ngati milandu exacerbation la matenda anawathetsa akuyambiranso, mankhwala chikuyendetsedwera kachiwiri.

Guillain-Barre syndrome mankhwala kumafuna pa 0.4 g / makilogalamu mankhwala pa tsiku kwa masiku 3-7. Pankhaniyi, kugwiritsa ntchito mankhwala kwa ana ndi zochepa kwambiri.

matenda Kawasaki mu ana ndi akulu ankachitira ndi mlingo wa 1.6-2.0 g / kg. mankhwala ndi kutumikiridwa mu mlingo chomwecho pa masiku 2-5. Anandilola chiphunzitso umodzi mankhwala ndi kuchuluka kwa 2.0 g / kg. Pa mankhwala kopitirira wodwala imodzi ndi kumayambiriro "Oktagama" zofunikira kugwiritsa ntchito aspirin.

Immunoglobulin ntchito pambuyo allogeneic mafupa kupatsidwa zina mankhwala kukonzekera. Administration mankhwala ndi kupewa yatsoka kachilombo ndi chitukuko cha matenda a "kumezanitsa molimbana ndi khamu". Mlingo wa wodwala aliyense amasankhidwa payekha. Ndi bwino kuyamba kwa mlingo wa 0,5 g / makilogalamu pa sabata. jekeseni ndondomeko ayenera kuyamba sabata pamaso adziwitse limba kupatsidwa zina. Therapy anapitiriza kwa miyezi itatu opaleshoni. Ngati pali chosowa zonse immunoglobulins, mankhwala ntchito 0,5 g / kg pa mwezi uliwonse kwa nthawi yaitali amanena sabwerera kuchepetsa yachibadwa.

zotsatira zoyipazi

Mutu phunziro kuvomerezedwa patsogolo ntchito mankhwala "Octagam" malangizo Buku. Chitukuko mavuto pogwiritsa ntchito mankhwala zimadalira mlingo ndi mlingo wa utsogoleli.

Mtsempha jekeseni mankhwala zingachititse leukopenia, hemolysis ndi kusintha hemolytic magazi m'thupi. Mankhwalawa ndi zotheka zoipa zimene chitetezo cha m'thupi, zomwe zili chiwonetsero cha hypersensitivity. Nthawi zina uka anaphylactoid ndi zochita anaphylactic, puffiness ya nkhope, angioedema.

mankhwala HIV ana ndi mankhwala a matenda ena zimayambitsa kupweteka kwa mutu. N'kovuta matenda okhudza ubongo wa magazi, amaika chisangalalo, kakhosi aseptic. Mankhwala zingachititse mutu, paresthesia ndi vertigo.

Pa mankhwala, pali mwina zosayembekezereka wa infarction m'mnyewa wamtima. Pakhoza kukhala kugunda chinawonjezeka ndi tahikradiya. Nthawi zina nkhawa cyanosis, hypotension ndi thrombosis. N'kovuta ndithu magazi insufficiency, thrombosis kwambiri mtsempha, matenda oopsa.

Mankhwala zingachititse anakwiya pa mbali ya dongosolo kupuma. Izi kulephera kupuma, edema m'mapapo mwanga, kupuma movutikira. Zotsatira zoipa ndi m'kukoma nawo kukhosomola, bronchospasm, m'mapapo mwanga embolism.

Mankhwalawa angathe kuyambitsa nseru, kusanza reflex, kupweteka m'mimba, kutsekula m'mimba. Nthawi zina, pali chikanga, urticaria ndi kuyabwa. Odwala ena akachoka mankhwala adanyamuka dermatitis, alopecia, ndi pruritus.

Iwo kawirikawiri anati zosiyanasiyana monga kupweteka kwa msana dera myalgia ndi arthralgia. More mankhwala angathe insufficiency aimpso, kuchuluka seramu creatinine, kusokoneza malungo, kutopa kwambiri, kusapeza anachita zimachitika pa malo jekeseni. Pa zochitika infrequent chowawa anati kuzizira, kupweteka pachifuwa, ankatenthetsa, malaise, zotupa ndi pyrexia. Mu zochitika zina odwala magazi anu amayenda mochedwerako, anaphylactic mantha.

Maonekedwe a chingachitike mbali odwala, utsogoleli wa mankhwala analekerera poyamba bwino. "Octagam" amachititsa kuwonjezeka mu michere chiwindi ndi woipa shuga mu maphunziro zasayansi magazi.

Pamene anasankha bwino mlingo kumachitika overdosing zizindikiro. Koma zimakhala madzimadzi posungira mu thupi, kuwonjezera magazi kukhuthala, amene asunga mwa anthu ndi matenda a impso, ndi odwala okalamba.

Nthawi zonse pamwamba, mankhwala symptomatic bwino.

Kusamala

Mankhwala akhoza kuchepetsa zotsatira za katemera moyo attenuated HIV kwa nthawi ya masabata asanu ndi limodzi kwa miyezi itatu. Popewa izi, muyenera kudikira pambuyo ntchito "Octagam" miyezi itatu kukonzekera. Mankhwala amachepetsa mphamvu ya katemera chikuku chaka, lisanagwe staging a katemera uyu zifunike titer chikuku chitetezo.

Chithandizo ndi mankhwala akhoza kuyambitsa angapo mavuto, Choncho ndikofunikira kutsatira mosamalitsa malangizo kwa mlingo ndi mlingo utsogoleli. Mu njira ya mankhwala n'kofunika nthawi zonse kuwunika thanzi la odwala.

Odwala amene kutumikiridwa mtsempha immunoglobulin, ayenera kulandira hydration chokwanira asanayambe ndondomeko, kuchititsa kuwunika mkodzo linanena bungwe ndi magazi creatinine. M'pofunika kuchotsa kwathunthu ntchito ya "kuzungulira" okodzetsa.

Ngati pali kukwiya zofunika kuchepetsa mlingo wa utsogoleli mankhwala kapena kwathunthu kusiya ntchito. chithandizocho zikudalira pa mwamphamvu ndi chikhalidwe cha zochitika chowawa. Ngati pali mantha kwambiri, m'pofunika amachita chithandizo odana ndi mantha, zimene ziyenera pamodzi ndi mankhwala.

Nthawi zambiri amayambitsa zosiyanasiyana chokhwima kugunda kwambiri kwa boma makamaka hypo- ndi agammaglobulinemia ndi kugwiritsa immunoglobulin chachikulu. Zotsatira zoyipa kumachitika pamene posamutsa wodwala ndi immunoglobulin wopanga imodzi mankhwala wina, ndipo ngati kwambiri za nthawi kuchokera pamene kulowetsedwa lomaliza.

Control wa odwalawo (Izi zikuphatikizapo odwala ndi HIV HIV) ayenera ikuchitika mosalekeza kwa zaka za kulowetsedwa loyamba kanthu, makamaka pa maola choyamba pambuyo ndondomeko. Odwala amene zotsatira palibe mbali, ayenera kukhala pansi dokotala pambuyo kulowetsedwa "Oktagamom" mphindi 20 choyamba.

Pa mankhwala ayenera kusamalitsa muyezo kuteteza matenda kuti nzotheka ntchito mankhwala opangidwa kuchokera ku magazi a munthu kapena madzi a m'magazi. Zikuphatikizapo kusankha othandizira ndalama abwino, kuyan'anila za servings munthu ndi maiwe plasma kwa zolembera enieni matenda. Zimenezi pazikhalanso mulinso njira inactivation / Kupha mavairasi.

Ngakhale malangizo onse mankhwalawa mankhwala, sitingathe kukusalani kuthekera kulanda angapo obweretsa matenda, mavairasi ndi tizilombo toyambitsa matenda ena. Onse miyeso pamwamba ntchito mu mtima wa zakutidwa mavairasi HIV, matenda a chiwindi B ndi C. The amatha kudziwa onyamula parvovirus B19 ndiponso gipatita A. chipatala zinachitikira wothandizila mankhwala okhala immunoglobulin anthu zikusonyeza kuti parvovirus B19 ndi chiwindi A mankhwalawa mankhwala si opatsirana deta. Chofunika kwambiri pa chitetezo mavairasi oyambitsa ndi kukhalapo mu mankhwala mankhwala lolingana chitetezo.

Pa ndime ya Inde achire ankangokhala anasamutsa chitetezo mu magazi wodwalayo mwina zotsatira zabodza pamene tikugwira mayesero serologic. Maltose ali lokonzekera amatha monama kusokoneza mlingo shuga magazi.

Kupititsa patsogolo ntchito mu shuga magazi ndende anaona pa kuchotsa mankhwala kuchokera chamoyo kapena maola khumi pambuyo kutsekedwa ake. Pankhaniyi, pali kuthekera kwa zolakwika cholinga insulin mlingo kuti kungakhale hypoglycemia. Choncho yekha glyukozospetsificheskie njira kudziwa mlingo wa shuga m'magazi kugwiritsidwa ntchito pa matenda a "0ktagamom". Mayeso zida m'mene polojekiti ikuyendera shuga ayenera kudziwa chizindikiro ichi odwala akumwa mankhwala ndi maltose.

Ngati si anatsirizika, ndiye amaloledwa kusunga mankhwala "Octagam" (50 ml ya 100 ml) pa kutentha kwa + 25 ° C kwa miyezi itatu popanda sekondale kuwayika mu firiji. Makuponi kwa nthawi ananenera, mankhwala ziyenera kuwonongeka.

Mankhwala sikumangotikhudza kuthekera kuyendetsa ndi kuchita zinthu zimene amafuna wapadera utali chidwi ndi zochita mofulumira psychomotor.

Mankhwala "Octagam": Anzawo

mankhwalawa angapo a analogues kuti akhoza m'malo mwake vuto la kusowa, izo ndi:

• "Biaven VI."
• "Veegum-liquidity."
• "Venoglobulin".
• "Gabriglobin".
• "Gabriglobin-IgG».
• "Veegum-C."
• "Gamunex."
• "Popanga madzi a gamma globulin Hooman".
• "IG Vienna N.I.V. ".
• "Imbioglobulin".
• "Immunoglobulin".
• "Imbiogam".
• "Immunovenin".
• "Intratekt".
• "Sandoglobulin".
• "Endobulin".
• "Flebogamma 5%."
• "Humaglobin".

mmalo Russian ndi mtengo kwambiri anthuwa kuposa lina. Mulimonsemo, mankhwala onse aakulu zokwanira kukatenga ndipo ayenera m'malo yekha ndi dokotala, potengera mmene alili.

"Octagam" Medicine: mtengo

Mtengo wa mankhwala si mkulu. Izo zikhoza kugulidwa kwa rubles 9,5-12 zikwi ndi 50 ml ya mankhwala "Octagam". 100 ml Price kuzungulira 20-24 zikwi rubles.

Malingaliro a odwala ndi madokotala

Mankhwala "Octagam" ali ndemanga makamaka positive. Timaliyamikira kwambiri anthu ake quality, amene kupezanso ndi immunodeficiency ndi matenda Guillain-Barré. Amagwiritsidwa ntchito kawirikawiri kwa anthu ndi AIDS kukhala ndi thanzi lawo. Iye anatsimikizira kukhala lothandiza aakulu lymphocytic khansa, myasthenia gravis. Akazi ntchito mankhwala pakati ndi kubereka mwana.

Odwala ambiri ndi kusakhutira ndi mtengo wa mankhwala, iwo dziwani kuti n'zovuta kugula mu pharmacies. Anthu ena ankanena kuti kufooka, mutu, ndi malaise ambiri.

Madokotala amanena kuti ndi kukonzekera koyera, ndi bwino chosakanikirana ndi thupi, mosiyana immunoglobulins zoweta zokayikitsa chifukwa chifuwa.