Norma CRP mu umagwirira magazi

C-zotakasika mapuloteni (CRP kapena CRP kwa English C-zotakasika mapuloteni) koma atanthauzira kuti mapuloteni madzi a m'magazi. CRP mu ndi kusanthula amuzolengedwa magazi mwamsanga zambiri amayankha pomwepo ndi kuwonjezeka mlingo ndende ya gawo wokonda aliyense ndondomeko yotupa zikuchitika mu thupi.

Zimenezi n'chofunikira zozitetezera. Zolinga matenda CRP kusanthula limodzi ndi muyeso ESR ntchito monga chizindikiro cha kutupa.

C-zotakasika mapuloteni - ndiko

Dzina la mapuloteni ichi chinali chifukwa cha luso mpweya (ku Latin mawu praecipitatio, amatanthauza kugwa pansi, mwachitsanzo kumanga ndi mpweya). Izo zikuwamanga kwa C-polysaccharide wa pneumococci chotero amateteza thupi ku matenda.

CRP kumapangitsa yopanga maselo oyera, amenenso ali chotchinga matenda bakiteriya ndi zina. Komanso mapuloteni kumathandiza ntchito zinchito za T-lymphocytes zimene zimakhudza phagocytosis, agglutination ndi mpweya zosiyanasiyana zikuchitika mu thupi.

Udindo wa CRP mu thupi

Kodi udindo wa mapuloteni izi mu thupi chiyani? CRP akutumikira kuchotsa thupi ku zidulo mafuta ndi lysophospholipids bioactive kuti amapangidwa chifukwa cha kuwonongeka kwa nembanemba Selo kutupa kapena aliyense minofu necrosis.

Phosphatidylcholine - ndi n'chofunika kwambiri pa nembanemba selo onse. Mwachibadwa, izo lili mkati wosanjikiza Kakhungu ndipo si wapezeka padziko awo. Pamene kutupa amapezeka kuwonongeka selo choncho nembanemba awo. Phosphatidylcholine ndi wosanjikiza kunja kwa nembanemba selo. Kodi patsogolo awo phosphatidylserine ndi fosfadiletanolaminom. phospholipids awa hydrolyzed ndi n'kukhala owayimira ndi mphamvu zambiri mu thupi la njira amuzolengedwa.

Choncho amathandiza kuti hemolysis (chionongeko) maselo a magazi ndi kukhala mavuto aakulu pa nembanemba selo okha. Zimenezi amakwiya mapangidwe chitetezo ndi antigens ena kuti ekspoziruyutsya padziko khungu ndi kukhala CRP kumanga malo ndi Kakhungu zowonongeka selo. Patsogolo kutsegula kwa macrophages, amene kenako zimatenga zotsalira za maselo owonongeka.

Choncho, CRP mu kusanthula amuzolengedwa magazi ndi chizindikiro cha kuwonongeka minofu pa kutupa aliyense, kuvulala ndi necrosis.

Zifukwa kuwonjezeka CRP

CRP amapangidwa ndi maselo chiwindi ndipo ndi glycoprotein. CRP kusanthula - ndichiyani? Mothandizidwa owayimira biologically yogwira (a iwo tatchulazi), ndipo pansi hydrolysis wa phospholipids, kumapangitsa yopanga CRP. wokhutira anayamba kukwera mu maora pang'ono. A tsiku pambuyo chiyambi cha yotupa kapena zina pathologic ndondomeko CRP mapuloteni mu phunziro la sayansi magazi akhoza kukhala pamwamba tenfold yachibadwa. Makamaka bwino m'kukoma matenda bakiteriya.

CRP chinawonjezeka ndi kusintha necrotic mu zimakhala kuti zidzachitika matenda a mtima, kufa ziwalo ndi kuwola zotupa. Zotsatira za kafukufuku wa posachedwapa zachipatala zasonyeza kuti ponso mapuloteni izi mu seramu Ndi mmene kwa atherosclerosis ziwiya magazi. Anapeza kuti kusintha atherosclerotic mtima kumachitika flaccid kutupa Mitsempha. Zinthu zimathandiza kuti kusintha pathological, ali motere:

• kusuta,
• kunenepa
• shuga.

Mmene CRP kuti matenda a mtima

Ngakhale kuwonjezeka yaing'ono CRP mu kusanthula amuzolengedwa magazi kungasonyeze kusonkhezera kutupa mu Mitsempha ndipo motero kukhala chizindikiro cha kusintha atherosclerotic.

Amadziwika kuti kuchuluka kaperekedwe ka otsika kachulukidwe lipoprotein (LDL) zimakhudza mapangidwe mipukutuyi atherosclerotic mu lumina mtima. Koma kafukufuku wa posachedwapa wasonyeza kuti odwala ndi okhutira mkulu wa CRP madzi a magazi ndi wabwinobwino wa LDL chiopsezo zochitika mtima ndi apamwamba kuposa anthu amene CRP zizindikiro ndi zabwinobwino, ndi kuchuluka zili LDL.

Mu odwala matenda a mitima (CHD), komanso odwala omwe anali sitiroko, mtima kapena matenda kulambalala ndondomeko ankadutsa stenosis ya mitsempha inatsekeratu, CRP kusanthula zabwino (pamwamba yachibadwa) ndi chizindikiro cha madokotala ananena zawo osauka. Zimenezi zikusonyeza kuti n'zotheka sitiroko kobwereza kapena vuto la mtima, etc.

Sayansi: CRP pamwamba yachibadwa. Kodi izi kuti

CRP kusanthula - kodi ndi zomwe zingasonyeze ponso chizindikiro ichi? Kuyamba ndi tisaiwale kuti mlingo wa chizindikiro mu magazi ndi kuchokera 0 kuti 0.5 mg / L. Mungawonjezerere ake m'magazi zingakhudze onse njira pathological ndi mfundo zokhudza thupi. Taganizirani choyamba, m'mikhalidwe aliyense pathological achuluke mtengo wa CRP.

njira Pathological kuti kuwonjezera mlingo CRP

Choncho, phindu ili kuchuluka milandu zotsatirazi:

• Pambuyo njira pachimake opatsirana, makamaka ngati ali ndi magwero bakiteriya.
• Pa exacerbation wa matupi awo sagwirizana kapena matenda-yotupa njira, kuphatikizapo kusintha atherosclerotic mu Mitsempha.
• Pamene kuwonongeka kwa umphumphu wa zimakhala (matenda a mtima, opaleshoni, zoopsa, frostbite, amayaka etc.).
• Mu oipa a zotupa pa nkhani ya njira khansa ndi maonekedwe a metastases latsopano.
• Pamene kuthamanga magazi.
• Mu pathologies endocrine (kunenepa, shuga, owonjezera kapena kusowa mahomoni kugonana, etc.).
• Nthawi ya kuphwanya kagayidwe mapuloteni.
• Kusintha atherosclerotic m'zotengera.
• Anthu amene amazunza fodya.

Thupi limati bwanji CRP

Kuwonjezera zinthu izi pathological pa kusanthula amuzolengedwa wa CRP zingakhudze zinthu zina zokhudza thupi. Choncho, mlingo ake adzauka ndi thupi yaikulu kwambiri, monga:

• Othamanga pa mwambo kapena kukana maphunziro.
• Mu akazi woyembekezera, makamaka ngati pali toxicosis.
• Pamene kulandira kulera m'thupi kapena mahomoni ena.
• Kumwa mowa kapena mafuta zakudya tsiku pamaso kupereka magazi kwa kusanthula.
• Pamaso pa grafts kapena amadzala mu thupi.

Nthawi zina, CRP m'munsimu yachibadwa

Komanso, CRP ndende mu kusanthula amuzolengedwa magazi akhoza kusiya pang'ono ndi kukhala m'munsimu yachibadwa odwala kulandira mankhwala ena, makamaka ngati wodwala zimawatengera nthawi yaitali. mankhwala njirazi ndi izi:

• Glucocorticoid mahomoni.
• Nonsteroidal odana ndi yotupa mankhwala.
• Beta-blockers.

CRP: ponseponse

CRP kuphunzira - ndi owonetsetsa chizindikiro. Analysis wa CRP akhoza anachita ntchito njira zosiyanasiyana. Umboni wake zimachitika mosiyana malinga ndi tilinazo reagents zosiyanasiyana. Motero aliyense zasayansi kuti umabala kusanthula CRP, mlingo zikusonyezedwa issuance zotsatira.

Choncho, Laboratories munthu amasonyeza mlingo wa 0 kuti 0.5 mg / L. Ndi ena, ntchito njira zosiyana, taonera zotsatira chikalata cha kuphunzira kuti mlingo CRP - kuchokera 0 kuti 0,3 mg / L. Choncho tikamawerenga chifukwa inayenera kulabadira malamulo mwachindunji.

Komanso, numerically kufotokoza zotsatira za kuwunika uyu akhala posachedwapa. Poyamba, njira zakale ntchito, amene anapereka zotsatira pafupifupi. Mawu akuti kachulukidwe wa kusanthula izi unayambitsidwa mitanda ya. Choncho, ponseponse chifukwa cha "zoipa" (-). Ngati zabwino anali wapezeka, izo unayambitsidwa mu mawonekedwe a ayankhe ngati - "zabwino" (+). M'mabokosi nambala Mitanda olembedwa kwa wina ndi anayi.

Matenda mtengo wa CRP

Zofunika pamodzi ndi zizindikiro zina ndi njira kafukufuku ali DRR. Choncho, mapuloteni izi sagwirizana malowedwe woyamba wa matenda mu thupi, kapena kuti chitukuko cha pathologies ena. Patapita maola ochepa chabe patapita infarction m'mnyewa wamtima mlingo wa chitukuko cha chizindikiro ichi mu magazi akuyamba kukula. Ndipo usiku wonse, iye kuwonjezera tenfold.

Kuphunzira chizindikiro ichi pa nthawi chimathandiza dokotala kuweruza mphamvu ya mankhwala osankhidwa. Choncho, kucheperachepera mphamvu ya ndondomeko kapena matenda ena enaake ophwanya adzakhala kuchepetsedwa ndi mlingo wa CRP magazi.

kusanthula Iyi ndi nthawi yaitali akupitiriza nkhani kwambiri, ndipo ngakhale chitukuko cha njira zatsopano matenda a kufufuza sangathe aithamangitse izo.

Momwe mayeso chifukwa C-zotakasika mapuloteni

Pofuna pochitika kusanthula izi, maphunziro apadera chofunika. Koma kumbukirani kuti onse mayesero magazi anatengedwa m'mawa pa chopanda kanthu m'mimba kutenga. Masana, ena mwa zizindikiro zimachitika mosiyana Mwachitsanzo, shuga kapena maselo oyera. kusanthula magazi nthawi kuperekedwa limodzi. Izo zikhoza kukhala mayesero rheumatoid, monga zikuphatikizapo kuphunzira CRP, kapena malamulowa, kumene ESR ndi ankafufuza. Onse a iwo limodzi ndi kuona ndi mbiri zachipatala ndi yofunika kwambiri pa matenda zolondola.

Magazi CRP ndi wachotsedwa mtsempha mu mankhwala chipinda chipatala kapena bungwe zachipatala.

Pamaso magazi alionse pa phunziro ili kupeza zotsatira chodalirika malamulo wamba ochepa ziyenela kuyan'anidwa:

1. Chakudya pa lotsatira sayenera mochedwa ndiponso wodzaza.
2. Asanalankhule yobereka magazi sayenera kutenga chakudya ndipo m'pofunika kuti kusuta. Anandilola kumwa madzi.
3. Pa Hava sayenera kutenga chakumwa chilichonse choledzeretsa, tiyi wamphamvu kwambiri ndi khofi.
4. A maola angapo isanafike yobereka kuwunika Ndi bwino kuti overheat thupi, kapena mosinthanitsa, overcooling. M'mawu ena, n'zosatheka kupita zitsanzo zosankhidwazi magazi nthawi yomweyo pambuyo anthunzi otulutsirako thukuta kusamba, ndi gombe kapena khungu, kapena kusamba mdzenje.
5. Pamaso nduna mphindi makamaka angapo kukhala ndi kumasuka.

Kodi matenda ndi kuchuluka CRP

Ngati atayezetsa zachitika CRP, mlingo uli pamwamba kwa 0.5 mg / L. Ngati mlingo wa chizindikiro ichi pamwamba, malinga ndi zizindikiro zina wodwala akhoza amaganiziridwa matenda otsatirawa:

• matenda zokhudza zonse enaake ophwanya (nyamakazi, zokhudza zonse lupus erythematosus, etc.).
• Pachimake matenda.
• matenda a mafangasi.
• Matenda pa mundawo m'mimba (anam'peza gastritis, chapamimba chilonda kapena duodenum 12, anam'peza matenda a m'matumbo, etc.).
• Azingokhala zotupa zilonda kapena metastases mu njira khansa.
• Angapo myeloma.
• M'mnyewa wamtima infarction (pa tsiku lachiwiri kuchokera kuukira CRP limatuluka ndi linathawa mpaka kumapeto kwa masabata 3, mlingo zinachitikira angina yachibadwa).
• Endocarditis.
• Secondary amyloidosis.
• TB.
• Meninjaitisi.
• Neutropenia.
• neonatal sepsis.
• Zovuta opaleshoni, monga peritonitis ndi magazi postoperative.
• Pankhani ya kupatsidwa zina, kuwonjezeka CRP angasonyeze kukanidwa.

Kotero, ife tinapeza onse kufufuza kuti, monga kusanthula CRP - icho chiri ndipo kodi zinthu zikhoza kuchuluka. Research wa mphamvu CRP akutumikira monga chikhomo, ndipo amalola kulosera mavuto zotheka matenda a mtima. Izi zimapangitsa kuti adzapeze nthawi ndi kupewa kuwonongeka kwa wodwala kupewa mavuto.

Mmene angakhalire ndi CRP kukwezeka

Iwo ayenera kumvetsa kuwonjezeka mu milingo CRP - izo zangokhala chizindikiro, si matenda. Ndani wa pathologies n'zotheka akusonyeza chizindikiro ichi, dokotala mukuganiza. Kuti tichite zimenezi, ayenera bwinobwino deta onse analandira kafukufuku, ndi kufufuza mtima bwinobwino kusonkhanitsa mbiri. Pambuyo pa zimenezi kokha definitively matenda. Chithandizo anatumizidwa popanda zizindikiro zenizeni ndi matenda matenda ambiri.