Ndi sodium nitroprusside: malangizo ntchito

Pali mankhwala ambiri amene ali ndi zotsatira hypotensive. Mankhwala kuchepa magazi, nthawi ntchito zovuta kwambiri (nthawi 1-2 tsiku). Choncho ankachitira oopsa. Nthawi zina, kabwerebwere mankhwala kuchepetsa magazi sizikhudza. Ndiye ntchito mankhwala mphamvu monga njira 'a nitroprusside ndi sodium. " Izi mankhwala si ntchito mwadongosolo ndipo popanda kufunika lalikulu. Si mankhwala kusankha mankhwala oopsa ndi kulephera aakulu mtima. Izo ntchito pokha pokha zadzidzidzi, pamene thupi la munthu sakugonja ndi mankhwala ena amene amachepetsa magazi (okodzetsa, Ace zoletsa). yankho A 'a nitroprusside ndi sodium "sangathe kutumikiridwa yekha popanda dotolo.

Kodi zotsatira mankhwala ali pa thupi?

Kukonzekera "Sodium nitroprusside" (chilinganizo - C ₅ FeN ₆ Na ₂ O) amatanthauza gulu la vasodilators zotumphukira. Lili thunthu mdima mtundu wofiira mu mawonekedwe a makhiristo kapena ufa. Koma kukonzekera kuchepetsedwa ndi madzi ndi ntchito mu madzi mawonekedwe. Chifukwa chakuti pali nitroso gulu, ntchito mankhwala amachititsa vasodilation mu zikuchokera thunthu. Izi zimachitika motere: Izi pawiri mankhwala pamene ingested ali n'kukhala okusayidi nitric ndi imayendetsa enzyme - guanylate cyclase. Umene kumatheka mapangidwe cGMP zomwe zimakupangitsani kudziunjikira mu minofu mtima yosalala ndi amachititsa zosangalatsa ake. Motero, medicament "Sodium nitroprusside" amapereka zotsatira izi ndi arterio venodilatiruyuschy ndi hypotensive. Kupyolera mu ntchito iyi ya dongosolo mtima akupeza mwamsanga bwino. Komanso, njira ukugwira ntchito molingana ndi mtundu wa glycosides mtima, i.e. amachepetsa kufunika m'mnyewa wamtima oxygen. Amenewa zimatheka ndi zi- ndi afterload kuchepa.

zikuonetsa medicament

Iwo ayenera kumvetsetsa kuti mankhwala ntchito pokha pokha mwadzidzidzi matenda aakulu ndi kukana wa chamoyo kuti magulu ena a medicaments. Zikuonetsa ntchito mankhwala amatchedwa:

1. Pachimake mtima kulephera. Makamaka tili mu malingaliro chitukuko cha edema m'mapapo mwanga (mtima mphumu). The mankhwala ndi mofulumira kumathandiza boma ndi zopanda phindu la okodzetsa.
2. Matenda mtima kulephera, aakulu. Gawo lotsiriza la kulephera aakulu mtima (2b, 3) Sikuti nthawi zonse kuyankha chithandizo. Choncho, pamene kukana mankhwala ena ndi chikhalidwe aakulu wodwalayo mankhwala vasodilators zotumphukira.
3. Pachimake inatsekeratu syndrome. Nthawi zina, mankhwala ntchito infarction m'mnyewa wamtima, kuchepetsa kuthamanga mu mtsempha wa mtima, komanso kupewa chitukuko cha mantha cardiogenic.
4. Osamva mankhwala chikhalidwe cha matenda oopsa. Vasodilators akhoza kugwiritsidwa ntchito mu pheochromocytoma, mavuto paroxysmal, komanso kakulidwe ka mavuto aakulu chifukwa cha kuchuluka lakuthwa magazi (sitiroko, kusokonezeka psychogenic, mtima).
5. Ergot poizoni. zomera ndi lakuthwa vasospasm, amene angafooketse kudzera medicament "ndi sodium nitroprusside." Malangizo ntchito mu phukusi oyika ayenera bwinobwino ndi madokotala "ambulansi" ndi kuwatsitsimula.

Contraindications ndi zotsatira zake zoyipa

Mankhwala sayenera kugwiritsidwa ntchito mu hemorrhagic sitiroko, komanso pambuyo. Izo contraindicated kwa anthu odwala matenda aakulu impso ndi hypothyroidism. nawonso osavomerezeka chifukwa anthu ndi kuthamanga intracranial. Kugwiritsa ntchito mankhwala amene amaletsa ana, amayi oyembekezera ndi anthu ukalamba. contraindication wina ndi wovuta yogwira wothandizila ndi chitukuko cha thupi lawo siligwirizana.

Mwa mavuto ku ntchito "ndi sodium nitroprusside" kukonzekera ndi kupereka kuchepa lakuthwa magazi (mu nkhani iyi, ndi chotheka kuti achepetse nthawi yomweyo makonzedwe), kuchulukitsidwa kugunda kwa mtima, chizungulire, kunyansidwa komanso kufooka ambiri.

Mankhwala anachita ndi nitroprusside ndi sodium

Powonjezera popereka zotsatira akangofika ndi sodium nitroprusside mankhwala ntchito zosiyanasiyana mankhwala. Ngati wothira ketone thupi (acetone) ndi kuikidwa m'malo zamchere, inu mukhoza kuwona kusintha chodabwitsa mu mtundu pawiri lapansi. Pakuti kusinthika kotereku ntchito 4 machubu. Aliyense aikidwa chinthu chimodzi chokha - sodium wochuluka nitroprusside, acetone, soda, acetic acid. Mbali yoyamba yankho chifukwa anatembenuka yowala lalanje-wofiira hue. Kenako, pawiri izi wasukuluka ndi asidi acetic. Mtundu kachiwiri anasintha, nthawi imeneyi madzi amakhala mdima ofiira kapena zofiirira.

Kukonzekera "Sodium nitroprusside": malangizo ntchito

Kulowa mankhwala, m'pofunika kupeza mwayi mtsempha. Asanalankhule chiyambi cha kulowetsedwa mankhwala, ayenera kuchepetsedwa mu 5% shuga njira. Chifukwa chaichi, 1 nsupa ya mankhwala syringe ndi kuchepetsedwa ndi 5 ml ya madzi. The osakaniza chifukwa anali jekeseni mu mbale ndi 5% shuga kupasuka kachiwiri. Pambuyo pake, kukatenga mlingo ankafuna. Iwo ranges kuchokera 0,3 8 ga pa makilogalamu 1 thupi. The kulowetsedwa amapangidwa mwa dongosolo. Iwo ayenera kuyamba ndi mlingo wochepa ndi pang'onopang'ono kuwonjezera izo pansi pa ulamuliro wa zizindikiro yofunika (kuthamanga kwa magazi, kugunda kwa mtima, zimachitika). M'pofunikanso chitsanzo zovomerezeka mlingo kulowetsedwa wofanana 2.5-3 mg / kg pa mphindi 1. Mlingo zimadalira nthawi ya utsogoleli mankhwala. Yaitali kulowetsedwa iyenela kuyan'ana mlingo wa cyanide munali medicament mu "Sodium nitroprusside". Malangizo ntchito mankhwala ayenera bwino anaona.

Mogwirizana ndi mankhwala ena

Sitikudziwa amalangiza ntchito mankhwala ndi zina wothandizila antihypertensive, ngati nkotheka chitukuko cha boma kakasi. Chonde kudziwa kuti ntchito za kulera m'kamwa amachepetsa mphamvu ya mankhwala. Pamene pamodzi ndi medicament mankhwala "Dobutamine" zizindikiro yofunika wodwala ayenera kuyang'aniridwa (mwina kuchepetsedwa kuthamanga, wedging mu zotengera m'mapapo komanso kukweza mtima).