Ace zoletsa - mankhwala bwino cardiology zamakono

Zoletsa kapena Ace angiotensin akatembenuka chinthu otchedwa vasodilators amphamvu ntchito cardiology zochizira matenda oopsa. Zimene gulu la mankhwala osokoneza bongo yaitali kutsekereza adrenal timadzi angiotensin II - pressor waukulu chinthu zokhudza phindu magazi. Ace zoletsa kuteteza kuwonongedwa bradykinin, amene amakhudza chikhalidwe ziwiya, choncho pa msinkhu wa magazi. Mankhwalawa kuthandiza kuonjezera kuchuluka kwa magazi a prostaglandins vasodilator kuchepetsa zizindikiro za kulephera aakulu mtima, nthawi zambiri anamuona pa odwala matenda oopsa n'kofunika. Pa nthawi yomweyo, Ace zoletsa, mosiyana ndi mankhwala ena kuti kuchepetsa magazi ziribe mphamvu pa shuga ndi zamadzimadzi kagayidwe, kuchepetsa mkodzo impso mapuloteni.

Ace zoletsa ntchito kwa zaka zoposa 40. Woyamba wa gulu la mankhwala mu 1975 anali apanga captopril, ntchito lero. Patapita zaka zingapo iye analandira enalapril ndi lisinopril. Iwo m'malo ndi zambiri zamakono zoletsa Ace mbadwo watsopano.

Mu cardiology ano Ace zoletsa ntchito ngati mankhwala waukulu zochizira hypertensive matenda, matenda ischemic mtima, kulephera aakulu mtima.

Ace zoletsa gulu

Pali classifications angapo Ace zoletsa, zomwe ndi zochokera kuchotsa njira ya mankhwala m'thupi, malingana ndi gulu mankhwala molekyulu unayenera ndi Ace pakati pa masitepe ntchito. Gulu ambiri kanthu pharmacological.

Malinga kanthu pharmacological wa angiotensin akatembenuka zoletsa zinthu zonse anawagawa m'magulu atatu.

Gulu loyamba ndi captopril kapena nyumba, umene mwachindunji kumabwezera mmbuyo, i.e. kumabwezera mmbuyo ndi angiotensin Ine akatembenuka ntchito timadzi mu gawo wotsatira - angiotensin II. Kukhalabe captopril kapena kapoten yachibadwa magazi anatengedwa katatu kapena anayi pa tsiku.

Kwa gulu lachiwiri a enalapril, ramipril, trandalopril, tsilazipril, fosinopril, quinapril ndi mankhwala ena kuti mtima mu thupi mu mankhwala ochita ndi vasodilatory kwenikweni. Mankhwalawa ndi kokwanira kutenga kamodzi kokha patsiku.

Pomaliza, gulu lachitatu tichipeza lisinopril Zestril, prinivil, prestarium kapena perindopril. Ace zoletsa ndi gulu lachitatu bwino kutenga kamodzi kapena kawiri pa tsiku.

Zotsatira zoyipa za Ace zoletsa

Mukalandira gulu la mankhwala ayenera kukhala tcheru ndi zotheka chitukuko cha mavuto. Nthawi zina, kutenga zoletsa Ace angaoneke chifuwa youma, kuchuluka misinkhu potaziyamu mu magazi, chizungulire, matupi awo sagwirizana zotupa pa khungu angioedema. mavuto awa kwathunthu inathetsedwa pambuyo achire mankhwala. chifuwa youma amapezeka mu lachitatu chachisanu tsiku la mankhwala. chikuoneka chifukwa kudzikundikira mu mapapo bradykinin. Chifuwa Mwamsanga kwathunthu pambuyo discontinuation la zoletsa. Odwala ena ndichepe kudya ndi okhumudwa kukoma likukula.

Mmodzi wa contraindications akuluakulu kugwiritsa ntchito Ace zoletsa ndi amgwirizano aimpso mtsempha wamagazi constriction. Pankhaniyi, kuthamanga kwa magazi ndi chinawonjezeka ndi kulera mlingo wa renin mwazi umene mankhwala ziribe mphamvu.

kusamalidwa ayenera kuperekedwa Ace zoletsa matenda aakulu a chiwindi ndi impso ndi chitukuko cha zizindikiro za kwa chiwindi ndi aimpso insufficiency.