Mankhwala "Ofloxacin": wodwala umboni. Malangizo ntchito mankhwala "Ofloxacin"

Kukonzekera "Ofloxacin" mavoti odwala amene makamaka zabwino, akuimira wothandizila antimicrobial ku gulu la fluoroquinolones yotakata sipekitiramu ntchito. Mankhwala kumakhudzanso DNA gyrase - mpukutu bakiteriya, kupereka supercoiling choncho mtendere wa mabakiteriya DNA (chifukwa cha destabilization ya DNA timafupa kufa).

pharmacodynamics

Amatanthauza "Ofloxacin" - maantibayotiki ogwira za tizilombo yotulutsa beta-lactamase, komanso mofulumira kukula atypical mycobacteria. Kuti mankhwala ali tcheru, ambiri mabakiteriya galamu alibe, kuphatikizapo tizilombo kuti ndi kugonjetsedwa methicillin ndi maantibayotiki ena. Streptococci, enterococci, ndi Mycobacterium TB yodziwika ndi wosakhazikika chiwopsezo mankhwala "Ofloxacin". Reviews madokotala akusonyeza kuti mankhwalawa matenda anaerobic chifukwa cha peptostreptokokki, peptokokki ndi anaerobes zina, mankhwala nthawi zambiri sizithandiza.

Pharmacokinetics

Pa kulandira medicament mu mayamwidwe ndi zonse (peresenti 95) komanso kusala kudya. Bioavailability - kuposa peresenti 96. Kugwirizana kwa mapulotini plasma - 25 peresenti. Pambuyo ola limodzi kapena awiri pambuyo makonzedwe m'kamwa mwa ndende apamwamba mfumukazi. Ndi kumwa mankhwala amadalira: ntchito limodzi la mamiligalamu mazana awiri, zinayi kapena mazana asanu ndende mankhwala anali ankalemekeza 2.5, 5 kapena 6,9 ug / ml.

mowa chakudya zingakhudze mayamwidwe mbali ya slowdown, koma ziribe mphamvu kwambiri pa bioavailability. Kukonzekera "Ofloxacin" - maantibayotiki ndi buku ndithu yogawa (zana malita), kotero kuti kukonzekera kutumikiridwa ndi pafupifupi ndalama zonse likulowerera momasuka ku maselo. The woipa apamwamba ali zimakhala, madzi a m'thupi ndi ziwalo: ku maselo (macrophages alveolar, leukocytes), zofewa minofu, khungu, fupa, dongosolo kupuma, m'chiuno ndi m'mimba zibowo zam'mano, malovu, Prostatic secretions, mkodzo, ya ndulu. The bwino medicament likulowerera placental ndi magazi ubongo chotchinga, ndi tochoka mkaka wa m'mawere ndi cerebrospinal madzimadzi alowa pa sanali chofuna ndi chofuna nembanemba ubongo (14 peresenti 60).

Za 5 peresenti ya mankhwala ndi zimapukusidwa mu chiwindi kupanga dimetilofloksatsina ndi N-okusayidi wa ofloxacin. Kaya mlingo theka moyo pakati anayi ndi theka maola asanu. Linanena bungwe zikutsatiridwa mankhwala ndalama peresenti 75-90 a impso, mu kuchuluka kwa 4 peresenti - mu ya ndulu ya. peresenti zosakwana 20 chilolezo extrarenal. Pambuyo mlingo umodzi wa mamiligalamu mazana awiri wothandizila ndi zimadziŵika mu mkodzo kwa maola 20-24. Pankhani ya kwa chiwindi kapena aimpso excretion akhoza mochedwa. Pamene dialysis chikutha ndi 10 peresenti 30 a mankhwala.

zikuonetsa kuti

Matenda opatsirana ndi yotupa chifukwa cha tizilombo zosiyanasiyana yasonyezedwa ntchito medicament "Ofloxacin". Reviews mwasonyeza kuti chiri chabwino kwambiri pa matenda kupuma thirakiti (chibayo, chifuwa), chapamwamba kupuma thirakiti (media otitis, sinusitis, laryngitis, pharyngitis). Perekani mankhwala zofewa zotupa minofu, mafupa, mafupa, khungu, biliary thirakiti, kapepala mkodzo (urethritis, cystitis), impso (pyelonephritis), zinthu zonse m'mimba, maliseche (orchitis, colpitis, epididymitis), ziwalo m'chiuno (salpingitis, prostatitis, cervicitis, endometritis, oophoritis, magawo).

Wogwira mankhwala kwa ureaplasmosis, chlamydia, chinzonono. Ntchito kupewa matenda odwala ndi matenda odetsedwa cha m'thupi (kuphatikizapo neutropenia a).

Mlingo mawonekedwe. kapangidwe

Kumasulidwa kwa medicament ndi mu mawonekedwe a lokutidwa woyera kapena pafupifupi woyera filimu TACHIMATA mapiritsi biconvex mawonekedwe chonse. The mtanda yachigawo noticeable zigawo ziwiri, mmodzi amene ali ndi kulocha chikasu. Yogwira chigawo amachita monga ofloxacin. piritsi limodzi ali misa 200 kapena 400 mg. Minor zosakaniza ndi primelloza (croscarmellose ndi sodium), microcrystalline mapadi, Aerosil (colloidal pakachitsulo woipa), silika titania, povidone, hydroxypropyl methylcellulose (hypromellose), talc, magnesium stearate, polyethylene glycol 4000 (macrogol). A mwayi wa mankhwala "Ofloxacin" - mtengo. Miyala yomwe 200 mg wa mankhwala yogwira ndi avareji rubles 16-20 pa zidutswa 10, ndi anthu okhala 400 mamiligalamu ofloxacin, ndalama za 50-55 rubles pa ndalama 10.

"Ofloxacin" mankhwala. Malangizo ntchito

Mapiritsi ayenera kumwa isanayambe kapena itatha chakudya. Iwo ayenera kuwameza lonse, popanda kutafuna, ndi kumwa madzi zedi yaing'ono. mlingo ayenera kusankhidwa payekha malinga ndi kukula kwa matenda, ndi kutanthauzira kwa matenda a AIDS, wodwala matenda ambiri, ntchito impso, chiwindi, ndi mabakiteriya osiyanasiyana.

Monga ulamuliro, mankhwala a "ofloxacin" wapangidwa kwa masiku asanu kapena khumi. Wamkulu tsiku Kwalamulidwa madyedwe a mazana awiri, mamiligalamu mazana asanu kawiri pa tsiku. Mlingo akhoza ziwonjezeke kwa mamiligalamu eyiti mu nkhani ya matenda aakulu, kapena ngati wodwala kwambiri. mlingo wa mamiligalamu anayi akhoza kumwedwa nthawi imodzi, makamaka m'mawa.

Odwala ntchito mkhutu aimpso kamodzi sitingakhoze kutenga mamiligalamu oposa mazana awiri mankhwala, mlingo pazipita masiku kuwonongeka kwa chiwindi - mamiligalamu mazana anai. Pambuyo mofulumira zizindikiro ndi normalization kutentha, ngakhale kwa masiku awiri kapena atatu ayenera kupitiriza mankhwala.

Mankhwalawo. umboni

Si odwala onse azamankhwala "Ofloxacin" bwino analekerera. Ndemanga za anthu ena zili ndi mfundo zimene mankhwala amachititsa mutu, nseru, kusanza, kutsekula m'mimba, kenaka utentha mamba, dzanzi wa malekezero. Pa mbali ya dongosolo m'mimba angathe monga kupweteka m'mimba, gastralgia, bloating, cholestatic matenda a chikasu ndiyo, anorexia, hyperbilirubinemia, pseudomembranous enterocolitis, ndi wamanjenje dongosolo - kupanda kayendedwe, omangana, maloto kwambiri, zochita psychotic, mukubwadamuka, nkhawa, chisokonezo, phobias, kuyerekezera zinthu m'maganizo, maganizo.

Komanso, pali chiopsezo kuyan'anila za dongosolo injini (arthralgia, tendonitis, myalgias), oganiza (matenda kulawa, mtundu masomphenya, kumva, bwino, fungo), dongosolo mtima ndi mtima (kuchepetsa magazi, tachycardia), khungu (dermatitis, mfundo kukha mwazi papular totupa), wa hematopoiesis (thrombocytopenia, kuchepa magazi, leukopenia). Atalandira "Ofloxacin" mankhwala (ndemanga akutitsimikizira izi), zina zikuoneka kuyabwa khungu, bronchospasm, urticaria.

contraindications

Kulandira medicament choletsedwa tsankho ofloxacin ndi ena ofanana nawo fluoroquinolone, mu nkhani ya akusowa shuga-6-mankwala dehydrogenase, khunyu, zotupa za tendons ndi kuchepetsa kulanda pakhomo. Komanso, inu simungakhoze kutenga mankhwala amayi apakati ndi lactating "Ofloxacin" ana osakwana zaka khumi ndi zisanu ndi zitatu. Ndi kukonzekera bwino Kwalamulidwa kwa matenda magazi mu ubongo oziziritsa mtima atherosclerosis, kulephera aimpso mu aakulu CNS zotupa chikhalidwe organic.

Medicament "Ofloxacin" pa ureaplasma a. Reviews

Chinthu chachikulu ndi zimene anthu amanena, ntchito malonda - ndi zotsatira zake mwamsanga. Odwala amanena kuti chifukwa ndi noticeable kale pa tsiku lachitatu kapena wachinayi. Koma m'pofunika kuchenjeza kuti izi sizitanthauza isanayambike mankhwala. Odwala amene asiya kumwa mapiritsi, sitinadzere mwa maphunzirowa zonse, ndiye kachiwiri kuonetsa zizindikiro ureaplasmosis chifukwa bakiteriya sizinachitike kwathunthu inathetsedwa.

Kusamala

Pamene chibayo chikwiyire ndi pneumococcus, mankhwala operewera. Komanso, si anasonyeza zochizira zilonda zapakhosi pachimake. M'pofunika kuti asiye mankhwala ngati pa maziko a anavomereza kuona sayanjana, ndi CNS chisokonezo pseudomembranous matenda a m'matumbo. Akazi kugwiritsa ntchito njira "Ofloxacin", izo osavomerezeka ntchito tampons, chifukwa Pankhaniyi pali chiopsezo kukhala thrush kuchuluka.