Mankhwala "Linezolid": malangizo ntchito, mtengo Anzawo, amasulidwe mawonekedwe ndi ndemanga

Ambiri mwa odziwika mankhwala toyambitsa tizilombo matenda amenable mankhwala ndi mankhwala ochiritsira. Komabe, pali toyambitsa kuti ndinazolowera otchedwa zinthu nosocomial. polimbana iwo ndi yovuta kwambiri, chifukwa mankhwala ambiri amangoika sizikugwira ntchito. Mankhwala "linezolid" amatanthauza mankhwalawo ndi amene angathe kuchitidwa ndi matenda otchedwa nosocomial kapena zina kugonjetsedwa ndi zina mankhwala. Ndicho za izo ndi ayankhidwa m'nkhaniyi.

mafotokozedwe

Mankhwala "Linezolid" malangizo ntchito kwa antimicrobial yotakata-sipekitiramu. Malinga ndi katundu amafotokoza ndi makhalidwe adzaupereka kwa oxazolidinone kalasi kuti mphamvu ndi osiyanasiyana nkhondo tizilombo zinthu zambiri kuposa mankhwala "Vancomycin" ndi mankhwala ena ndi zikuchokera ofanana.

Lero, pali mitundu ingapo ya antimicrobial wothandizila "linezolid". Mankhwala mawonekedwe, Kawirikawiri ntchito mankhwala - ndi miyala Kakhungu chipolopolo munali 400 kapena 600 mg wa mankhwala yogwira. Komanso, zochiritsira njira kulowetsedwa amagwiritsidwa ntchito imene aliyense milliliter lili 2 mg wa mankhwala yogwira ndi ufa (granules) kukakukonzerani kuyimitsidwa, ndende ya pophika yogwira ndilo 100 mg pa 5 ml ya chomaliza mankhwala.

zikuonetsa

Monga tanena kale m'nkhani ino, mankhwala "Linezolid" malangizo Buku akuonetsa kuti ntchito pamaso pa matenda oyamba ndi mabakiteriya kugonjetsedwa ndi maantibayotiki ena. Zikuphatikizapo onse galamu HIV ndi galamu alibe tizilombo za thupi anaerobic kapena mitundu aerobic kuti apanga kukana (bata) kuti methicillin, mankhwala gikopeptidnym, penicillin ndi mankhwala ena.

Mndandanda wa matenda amene ndi "linezolid" medicament malangizo zikuphatikizapo:

• kuchipatala kapena dera anapeza chibayo;
• Matenda a pakhungu;
• minofu zofewa matenda;
• matenda ena oyambitsidwa ndi mankhwala zosagwira Enterococcus.

Monga ulamuliro, musanagwiritse ntchito mankhwala imachitika kafukufuku kudziwa kulimbikira kwa tizilombo toyambitsa matenda mankhwala ena. Ngati palibe chikupezeka, mankhwala ikuchitika ndi thandizo la mankhwala ena antimicrobial.

contraindications

Waukulu ndi zofunika kwambiri contraindication kugwiritsa ntchito mankhwala 'Linezolid malangizo ntchito amatanthauza hypersensitivity kwa izo. Amagwiritsidwanso osavomerezeka ntchito mankhwala chithandizo cha odwala amene akutenga mankhwala ena ku gulu la Mao zoletsa. Komanso, osavomerezeka chifukwa wothandizila pamodzi ndi antidepressants tricyclic ndi zinthu angathe kuukitsa magazi (Epinephrine, dopamine, ndi triptan zina).

Kukonzekera "linezolid" (mapiritsi, kulowetsedwa njira ndi slurry) ali contraindicated matenda monga matenda oopsa, hyperthyroidism, kapena seratoninovy carcinoid syndrome, feohromotsitoz. Pamaso pa contraindications awa ayenera kuonedwa isanayambe mankhwala pogwiritsa ntchito mankhwala.

Limagwirira cha zochita za mankhwala m'thupi

Action "Linezolid" mankhwala chifukwa umatha ndigwire ntchito yomasulira ndondomeko ya nyumba mapuloteni mu maselo mabakiteriya. Chifukwa cha kuchuluka kwa tizilombo ndi alimira pali imfa. Kukana kwa mankhwala ambiri mabakiteriya amapangidwa pang'onopang'ono.

Pambuyo ingestion ya mankhwala yogwira pophika imagwiritsidwa metabolite hydroxyethyl glycine. Mlingo wa kucheza ake ndi mapuloteni plasma amakwaniritsa uchita 31%. Zasayansi maphunziro anapeza kuti pawiri likulowerera mu zimakhala onse ndi ziwalo. Lilinso ndi mphamvu kudutsa latuluka mu wosabadwa ndi mkaka (chuma ichi mankhwala umaonekera malangizo a kutenga mankhwala ndi amayi apakati ndi lactating).

Hafu ya moyo wa chinthu udakali metabolite ake excreted ndi maola 4.5-5. Excretion ndi kudzera dongosolo mkodzo (50% monga metabolite ndi 35% labwinobwino), ndipo kudzera thirakiti m'mimba (osachepera 9%). Complete excretion amapezeka mkati maola 8-12 atalandira medicament.

Kodi kutenga "Linezolid"

Akatswiri amanena kuti nthawi zambiri wodwala paokha kusankha njira ya phwando "Linezolid" mankhwala. Dziwani, mapiritsi, njira ndi emulsions amene saona monga kukonzekera osiyana, ndipo ngati njira mankhwala, munali mfundo mwatsatanetsatane. M'munsimu muli mfundo zikuluzikulu za mlingo ndi nthawi ya mankhwala.

Medicine "Linezolid" malangizo Buku zikusonyeza ntchito njira zotsatirazi:

1. yankho A chifukwa kulowetsedwa ndi kutumikiridwa m'nsinga nthawi 2 tsiku. A mlingo umodzi wa 400-600 mg ndi yogwira mankhwala. Kutalika kwa nthawi yoperekera chithandizo kumatengera ndi kukula kwa matenda ndi kutanthauzira kwake. Childs, matenda ambiri amafuna nyengo ya osachepera 10 ndipo palibe masiku zoposa 14, ndipo okha matenda oyamba ndi enterococci, mankhwala kumatenga kwa masabata 2 mpaka 4.
2. Kukonzekera "linezolid" (mapiritsi) amatengedwa ngati nthawi 2 tsiku ndi kuchuluka kwa mg wa 400 kapena 600 pa phwando. Kwa odwala zaka 5 mpaka 14, mlingo ndi kuchita masamu pa maziko a thupi ndipo anali 10 mg pa makilogalamu 1 thupi, nthawi 2 tsiku. Mlingo pazipita pa ingestion (p.o.) sayenera upambana 600 mg. Kutalika kwa mankhwala anatsimikiza ndi magawo chomwechi ankatengedwa pamwamba.
3. Granules, amene anapanga emulsion ndi, anagwiritsa ntchito chiwembu pamwambapa. mlingo mawerengedwe pamene kuli kofunikira kuchita motsatira malangizo chomwecho.

Popeza mankhwala "Linezolid" akapatsidwa kokha chifukwa mankhwala ndi ntchito kokha mu chipatala, ndi ambiri osokoneza a malo ndi maonekedwe a zotsatira kutchulidwa mbali ali pafupifupi inathetsedwa. Madokotala ndemanga zawo anatchulapo milandu la kudzikundikira owonjezera mu thupi la mankhwala yogwira mankhwala ndi metabolites ake chifukwa matenda ziwalo mkodzo ndi chiwindi. Zotsatira za overdoses amenewa zambiri mofulumira kwambiri kuchotsedwa, monga wodwala ndi kuchitiridwa kuyang'aniridwa zonse akatswiri.

Mwanjira mankhwala

Chifukwa munthu mitundu mlingo wa mankhwala "linezolid" cholinga cha utsogoleli mtsempha, nkofunika kuti mankhwala kwathunthu yogwirizana ndi njira zofunika ntchito pa mankhwala (5% shuga njira, 0,9% njira ya sodium kolorayidi ndi njira Ringer a).

chidwi ziperekedwe kwa chikhalidwe cha odwala, amene kuwonjezera "Linezolid" kutenga mankhwala adrenergic. Ngati kukana kwathunthu kwa iwowa sizotheka, madokotala ayenera kuonanso mlingo awo.

Medicine "Linezolid '(ofanana mu zikuchokera akhoza ukugwira kwa iwo) amadziwa yogwirizana ndi mankhwala" Chlorpromazine "," Cotrimoxazole "" ntchito diazepam "ndi" Phenytoin ". Ngati wodwala patsogolo ntchito maantibayotiki anatenga anati njira ndi zoyenerera zofunika imeneyi masiku 3 isanafike mankhwala "linezolid" kukonzekera.

Kusamala

Monga ayamikira zina pa ntchito antibayotiki "Linezolid" malangizo Buku lili ndi mfundo zokhudza akazi apakati ndi anthu ndi comorbidities alipo. Komanso, limanena kuti n'zotheka mavuto. Koma zinthu oyamba.

Koma phwando "Linezolid" ndemanga mankhwala madokotala akulankhula za kusamala apadera kutumikiridwa kwa akazi apakati ndi lactating. Ichi ndi chifukwa chakuti zotsatira za mankhwala pa mwana wosabadwayo osauka kapena mwana wongobadwa kumene wakhala insufficiently kuphunzira. Nthawi zambiri, mankhwala ndi ntchito zake m'pofunika pokhapokha ngati chiopsezo kwa mwana wosabadwayo kwambiri pansipa phindu sikhala ndi mayi.

A zovuta aimpso ndi kwa chiwindi kulephera, amafunanso ntchito mosamala mankhwala, chifukwa metabolites ali excreted makamaka ziwalo zimenezi, ndipo kudzikundikira zinthu izi iwo zikhoza kuwonongeka kwa wodwala.

zotsatira zoyipazi

Yachokera pa zotsatira za kuzipenya matenda, zochita osafunika ziwalo zosiyanasiyana ndi machitidwe pa phwando maantibayotiki "linezolid" nthawi zambiri zimakhudza machitidwe mantha ndi m'mimba. About 10% odwala pa mankhwala amene asunga kunyansidwa ndi mutu. A pang'ono pokha nkhawa m'mimba zawo, chizungulire, ndi candidiasis mu mucosa m'kamwa.

Komanso akatswiri inati zotsatira ngati osafunika wa mankhwala monga neuropathy zotumphukira, khunyu, zithunzi kuwonongeka (ndi imfa yake okwana), thrombocytopenia, syndrome serotonin, angioedema ndi anaphylactic mantha. Chifukwa chakuti mankhwala ntchito kokha chilengedwe chipatala, zotsatira zambiri aakulu kupewedwa.

Chithandizo anaonekera zochita osafunika ya symptomatic ndi kachitidwe. Kuchotsa mankhwala ndi zotheka ngati kukula kwa mavuto ndi vuto lalikulu kuposa matenda kuchitiridwa ankaona mankhwala.

Mankhwala analogues "Linezolid"

Owerenga mwina ndi funso lokhudza ngati "Linezolid" analogues wa mankhwala kumeneko. Kumene, mankhwala msika ngati si zonse, ali ndi mankhwala ochepa ofanana izi zikuchokera antimicrobial. Mankhwalawa anafotokoza Serb maantibayotiki "Zeniks" Norway "zyvox" ndi Israeli "Linezolid Teva". The zikuchokera onse mankhwala monga chinthu chachikulu yogwira m'gulu linezolid.

Kodi pali kusiyana kwambiri pakati pa njira ndi kukonzekera "Linezolid" tatchulazi? Mtengo wa mankhwala - ndiko kusiyana chachikulu. mfundo ndi yakuti ndi zikuchokera chomwecho, mankhwala zinthu pa thupi la munthu mu chimodzimodzi: akulimbana ndi tizilombo chomwecho, chifukwa chomwecho mavuto ndi contraindications chomwecho. Osati kwambiri mawu osiyana ndi njira mankhwala ndi mlingo.

Monga ulamuliro, ndi zodula analogues kunja "Linezolid" mankhwala ntchito kukachitika kuti mankhwala makamaka ndi kuti Yehova sangapezeke mwa drugstores. Izi zimachitika kawirikawiri, chifukwa cha ntchito yake osiyanasiyana odwala kuli kovuta chifukwa mankhwala mankhwala ndi overdo pa maalumali sadzakhala kuthetsedwa palibe unyolo mankhwala. Kuyambira laling'ono mankhwala bookings chipani, choncho, mwayi nthawi ina kugulitsa katundu wake onse.

Mtengo wa mankhwala

The medicaments wa gulu oxazolidinone ndi kukwera mtengo chifukwa zovuta multistep kupanga mankhwala mu Laboratories mankhwala. Kodi "Linezolid" mtengo mankhwala? Mapiritsi (zili zazikulu yogwira mankhwala 600 mg, paketi zidutswa 10) maunyolo mankhwala ndi osachepera 18 chikwi. Mtengo pazipita fomu iyi mlingo ndi 20 zikwi rubles pa miyala 10. Pang'ono mtengo ndi mankhwala pa mlingo wa 400 mg. mtengo wake ndi za 17-18 zikwi rubles kwa mapiritsi 10.

Njira yothetsera kulowetsedwa "Linezolid" mugule pang'ono mtengo: paketi mapaketi 10 100 ml ndalama 7.5-9 zikwi rubles, mapaketi 10 300 ml ya lililonse - mu 15,3-16,2 zikwi rubles.

Kukonzekera kwa dzina yemweyo, amene mtengo kwambiri, kawirikawiri amayamba kukhala chinyengo ndi, chabwino, ziribe mphamvu pa thupi la wodwalayo. Komabe, akuchedwa mankhwala matendawa, amene amathandiza kuchotsa mankhwala 'Linezolid' palokha ndi oopsa kwambiri. Ndicho chifukwa Akatswiri amalangiza kuti mankhwala yekha mu pharmacies ndi mbiri yabwino.

Comments za mankhwala "Linezolid"

magwero osiyana mocheperapo kupeza ndemanga za mankhwala a kalasi. Zimenezi zikugwira makamaka zokhudza anavomereza, odwala anafotokoza. Ichi ndi chifukwa chakuti odwala ambiri pa mankhwala ali mu chikhalidwe kwambiri, kukumbukira zonse zonyamula patsogolo kumva iwo ndi kovuta.

Akatswiri, nayenso kuyankha mankhwala "Linezolid" zabwino kwambiri. Malinga ndi iwo, mankhwala akhoza kupirira ngakhale majeremusi kugonjetsedwa kwambiri. Iwo amanena kuti chiopsezo cha matenda oyamba chifukwa mavuto kapena ambiri osokoneza pafupifupi kulibeko. Ichi ndi chifukwa chakuti maantibayotiki ntchito kokha zoikamo kuchipatala. Poyamba chizindikiro cha thupi lawo siligwirizana kapena chokhwima kwa mankhwala akutsatiridwa zofunika njira zonse zachipatala kuthetsa iwo.

Kotero, ife anayang'ana pa zochitika zonse za mankhwala "linezolid". Malangizo ntchito, mtengo ndi zochita mankhwala zotheka anatchula mu pepala ili mwatsatanetsatane. Tikumbukenso kuti ngakhale kukwera mtengo kwa mankhwala, ntchito yake ndi wolungamitsidwa mu nkhani iliyonse. Kusankha mankhwala a odwala mankhwala akhoza dokotala yekha.