Mankhwala "Baraklyud": malangizo ntchito, maonekedwe, zikuchokera ndi ndemanga

"Baraklyud" amatanthauza mankhwala odana retroviral, mbali ya gulu la analogues nucleoside. Kwalamulidwa kwa chithandizo cha matenda HBV kachilomboka. The yogwira pophika ndi entecavir mankhwala msanga limaleka kugawanika tizilombo a chiwindi.

Iwo ayenera kukhala anaphunzira Zamkati asanadye mankhwala. Malinga ndi malangizo ntchito? "Baraklyud" (Baraclud) - mankhwala amene anafuna kuyamba backflow njira fibrotic odwala ndi matenda enaake chiwindi.

mankhwala

Mankhwala akupezeka yachiwiriyo mlingo - 0,5 ndi 1 mg entecavir yogwira chigawo zowoneka zimasiyanasiyana utoto mtundu (loyera kapena pinki, motero).

lokonzekera mulinso:

• polysorbate;
• mankhwala enaake a stearate;
• lactose monohydrate;
• Valium;
• povidone;
• colorant Opadry.

zotsatira pharmacological

Chofunika yogwira ndi entecavir chomwe ndi analogue a guanosine nucleoside, ananenera ntchito kusankha kwa chiwindi B.

Entecavir ndi phosphorylated kwa triphosphate yogwira ndi theka moyo pafupifupi 15 maola, okhutira okhudza maselo ambiri amene akugwirizana ndi ndende ya entecavir maselo kunja. Pamene izi silinkachitidwa appreciable kudzikundikira mankhwala yogwira m'thupi. Medicine "Baraklyud" malangizo ntchito zimene zikusonyeza dzuwa ake okwezeka, limaleka ntchito polymerase tizilombo, pofikira imodzi pa mfundo zitatu:

• kaphatikizidwe chingwe zabwino DNA HBV;
• chigamulocho galamafoniyo wa ulusi zoipa pregenomic mRNA;
• HBV priming enzyme.

Triphosphate si retarders amphamvu michere DNA ma, ngakhale zili yokulirapo zopanda phindu pa kwa mayitirokondiriyoni DNA kaphatikizidwe.

zotsatira za mankhwala

The yogwira mankhwala mankhwala amatha nthawi yochepa limbikirani kwa dongosolo m'mimba ndipo umalandira pazipita zomwe zili mphindi 30-90 pambuyo pakumwa mapiritsi a.

Mwachinsinsi kuwonjezeka Cmax ndi akalozera AUC amapezeka ntchito wotsatira wa 0.1-1 mg wa medicament "Baraklyud". Malangizo ntchito akulankhula za kukwaniritsa bwino mu tsiku 6-10-TH a mlingo umodzi wa mankhwala patsiku. Ntchito zakudya mafuta kwambiri complicates entecavir mayamwidwe ndondomeko, Kuchotsera Kutsatsa Cmax ndi AUC ndi 45% ndi 20% motero.

mankhwala mofulumira odzipereka mu minofu ndi 13% womangidwa kwa mapulotini plasma. The yogwira chigawo mankhwala si ntchito magawo, zoletsa enzyme kapena inducers a dongosolo P450. Iwo amatha kudziunjikira mu thupi ndi linanena bungwe mwa dongosolo aimpso ndi kusefera glomerular ndi kumaliseche tubular.

zikuonetsa

Medicament "Baraklyud" analimbikitsa kutenga mankhwala zovuta za matenda B:

• Ndi zizindikiro panopa kugawanika tizilombo ndi kuchuluka kwa mlingo wa ntchito transaminases ku seramu, mu kukhalapo kwa mawonetseredwe histological wa kupitirirabe kutupa chiwindi.
• Unrecovered chiwindi zotupa.

chithandizo chapadera cha zizindikiro chiwindi matenda zimachitika pambuyo makonzedwe mankhwala "Baraklyud". Mapiritsi malangizo Buku akuonetsa kuti odwala ndi aakulu chiwindi B, chiwindi matenda kobvuta zotsatirazi:

• ili decompensated;
• pathological chikhalidwe chiwindi mu malipilo sitepe pamene anaika mawonetseredwe tizilombo tizilombo ta matenda a fibrosis chiwindi ndi kuchuluka Ast ndi alt.

contraindications

Mankhwala "Baraklyud" ali ndi contraindications zotsatirazi:

• kuchuluka chiwopsezo kuti entecavir ndi zinthu zina m'gulu zikuchokera mankhwala;
• cholowa lactose tsankho, shuga-galactose malabsorption, akusowa kapena kusapezeka mu thupi la lactase enzyme ;
• zaka zosakwana zaka 18.

Anthu ndi kulephera impso ayenera kutenga mankhwala pa mankhwala ndi moyang'aniridwa nthawi zonse zachipatala.

Phwando "Baraklyuda" pa mimba ali osavomerezeka pa mankhwala ayenera kusiya kuyamwitsa mwana mkaka.

zotsatira zoyipazi

Pangakhale zosiyanasiyana matenda a dongosolo m'mimba pa mankhwala "Baraklyud". Malangizo ntchito bwino anafotokoza mavuto:

• matenda m'mimba;
• m'mimba;
• kunyansidwa ndi kusanza;
• dyspepsia.

Inu akhozanso mutu, kusowa tulo kapena kugona, kusafuna kudya, ndipo thupi lawo siligwirizana.

Kugwiritsa ntchito mankhwala monga yekha achire wothandizila kapena limodzi ndi mankhwala ena ochepetsa zingachititse hepatomegaly aakulu ndi steatosis, kungachititse kuti imfa wodwalayo.

Odwala ndi zotupa decompensated view laktatsiadoz kumachitika chiwindi, amene amakhala ndi:

• ambiri minofu kufooka;
• mofulumira kupuma ndi maonekedwe a kufupika kwa mpweya;
• nseru;
• kuchepetsa kwambiri thupi;
• ululu peritoneum ndi, epigastric.

Komanso, mankhwala zingachititse anasiyana ndi thupi:

• chinawonjezeka chiwerengero cha transaminases kwa chiwindi;
• zotupa pa khungu;
• anaphylactoid anachita.

Odwala komanso kuvutika decompensated chiwindi matenda, kuwonjezera, maganizo ndi owonetseredwa chamoyo:

• aimpso kulephera (mu nthawi zina);
• kuchuluka bilirubin zili mu mwazi;
• . Kutsitsa kupatsidwa zinthu za m'mwazi, ayesere 50 zikwi / mamilimita ³ kapena zochepa;
• kuchepetsa bicarbonate m'mwazi;
• kuenjezera alt;
• zoposa zitatu khola kuwonjezeka mu ntchito ya lipase;
• yafupika kaperekedwe ka albumin.

Medicament "Baraklyud": Mlingo ndi yoyendetsa

mankhwala ayenera kumwedwa pa chopanda kanthu m'mimba, kwa nyengo pa chakudya otsiriza isanafike dosing akhale maola oposa awiri.

Pamene kulipidwa kuwonongeka chiwindi analimbikitsa phwando "Baraklyuda" 0.5 mg ndi tsiku. Kudziwa kukana kuti lamivudine mlingo ayenera kawiri.

Odwala ndi zotupa chiwindi unrepaired Kwalamulidwa kudya tsiku la 1 mg. Okalamba ndi odwala insufficiency aimpso, mlingo ayenera kusintha malingana ndi kuchuluka kwa CK (creatinine ndende) m'magazi.

ambiri osokoneza

Information pa milandu mankhwala ambiri osokoneza bongo sikokwanira.

Odzipereka, amene anali kukomoka anayesedwa, analandira mlingo tsiku la 20 mg pa masabata awiri anawapatsa umodzi apamwamba mlingo - 40 mg wa mankhwala "Baraklyud". Malangizo Ntchito limanena kuti mavuto amene wapezeka.

Analimbikitsa posindromnoe chithandizo kuyang'aniridwa ndi mawonetseredwe matenda.

Mogwirizana ndi mankhwala ena

Chifukwa chakuti yogwira chigawo entecavir ndi excreted poyambilira kudzera dongosolo aimpso mankhwala zovuta limodzi ndi mankhwala ena amene amapereka zotsatira mwachindunji kapena mozungulira pa ntchito impso ndi kukhudza katulutsidwe tubular, angachotsedwe kuwonjezeka mu thupi la entecavir ndi yogwira wa mankhwala.

Mogwirizana "Baraklyuda" ndi adenovirom, tenofovir, lamivudine sizinalembedwe.

kusamala

Kuvomereza odwala mankhwala kugonjetsedwa lamivudine kumabweretsa chiopsezo amayamba kukana.

Komanso, pali umboni wa zosayembekezereka ya exacerbations a chiwindi B pambuyo discontinuation wa mankhwala "Baraklyud". Malangizo ntchito akufotokoza mpumulo wa exacerbations popanda mankhwala owonjezera.

Kusamala

Phwando "Baraklyuda" mu chimango cha monotherapy ndi ophatikizana mankhwala ndi atumiki ma ARV, angachititse lactic acidosis, hepatomegaly ndi steatosis. Pankhaniyi, pali chiopsezo cha imfa.

Pachiopsezo odwala zikuphatikizapo magulu otsatirawa:

• akudwala hepatomegaly;
• kuchitiridwa ntchito analogues nucleoside;
• ndi onenepa;
• odwala wamkazi.

Malangizo ntchito mankhwala "Baraklyud" anatero kuthekera mapangidwe mitundu kugonjetsedwa tizilombo. Yogwira pophika entecavir mankhwala ali osavomerezeka zochizira kamene kamawononga chitetezo m'thupi chifukwa cha dzuwa ake umenewu sizinathe anaphunzira zonse.

Mankhwalawa odwala kudwala a dongosolo aimpso, ndikofunikira kuti akonze mlingo.

Chitetezo ndi mphamvu ya ntchito "Baraklyuda" zochizira odwala pambuyo kupatsidwa zina chiwindi ndi samadziwika ndi amafuna miyeso wapadera chisamaliro litsatidwe.

zinthu yosungirako ndi mtengo

Yosungirako ndi mayendedwe a pellets ayenera idzachitika mu kutentha osiyanasiyana 15-25 ° C. lokonzekera sangagwirenso ntchito kwa zaka ziwiri kuchokera tsiku kupanga.

mankhwala ali nawo mu gulu osiyana mankhwala ofunika, ndi chifukwa siyana zina za nzika za kumasulidwa yobereka mankhwala "Baraklyud". Malangizo ntchito analanda mfundo imeneyi.

Price kudzera mu pharmacies Moscow akuyamba ku 12 chikwi. Rubles.

Views odwala

Izi zikusonyeza mkulu efficacy wa mankhwala "Baraklyud" malangizo Buku. Price, ndemanga imene imasonyeza kuti chinali demokalase poyerekeza ndi analogues wa mankhwala, zimasiyanasiyana pakati 12-17 zikwi pa phukusi, imene pellets 30. Izi zimapangitsa mankhwala wotchuka kwambiri ndi mu ankafuna pakati pa odwala zochizira chiwindi B.

Mu maganizo olakwika makamaka anatchula proitvopokazaniya ndi mbali zotsatira za mankhwala monga kusowa tulo, ndiponso nseru.