Mankhwala "Aspekard": malangizo ntchito, analogs, ndemanga

asidi Acetylsalicylic (ASA) akunena kuti mankhwala ndi zotsatira antipyretic, odana ndi yotupa ndi antiplatelet. Mu yochizira matenda ndi ntchito zaka zoposa 125, chifukwa ndi imodzi mwa mankhwala kwambiri kuphunzira. M'menemo ASA tsopano likupezeka monga kardioformy kuchepetsa chiopsezo thrombosis inatsekeratu mtsempha wamagazi, amene kumalepheretsa chitukuko cha infarction m'mnyewa wamtima. Chitsanzo chabwino ndi kukonzekera "Aspekard" lomwe lili acetylsalicylic asidi mu mulingo woyenera mlingo zotsatira antiplatelet.

Information pa kumasulidwa mawonekedwe ndi Mlengi

Mlengi wa mankhwala ndi Chiyukireniya kampani "Stirolbiopharm". Choncho, njira kupanga ntchito, umatulutsa wosiyanasiyana mawonekedwe zheludochnorastvorimoy pa mlingo wa mg wa 100 piritsi. Njira mapiritsi mawonekedwe:

• katoni mapiritsi 120 (10 mpaka 12 matuza tsamba.);
• chidebe polymeric mapiritsi 100.

Piritsi "Aspekard" lili 100 mg wa ASA, microcrystalline mapadi, croscarmellose sodium, colloidal pakachitsulo dioxide, asidi stearic.

Zivomerezo za kuikidwa

Pokonzekera "Aspekard" ntchito yopapatiza zokwanira, ngakhale lili ndi malangizo malangizo zochizira matenda ambiri kuphatikizapo matenda enaake ophwanya. Wopanga analimbikitsa "Aspekard" ndipo ngati wothandizira antipyretic kapena analgesic. Ndipotu, mu mlingo wa mankhwala acetylsalicylic asidi zitha bwino ntchito ngati mankhwala kumathandiza kupatsidwa zinthu za m'mwazi loitanirana.

Zikuonetsa "Aspekard"

Pa yokonza "Aspekard" malangizo ntchito, amakambirana akatswiri kafukufuku matenda ndi kupereka zambiri zokhudzana antiplatelet mankhwala. Iwo anasonyeza zinthu zotsatirazi:

• pamene (ACS), pachimake inatsekeratu syndrome (pa sitepe pachimake okwera m'mnyewa wamtima infarction, maganizo kapena labwinobwino cha ku Switzerland gawo malo, mu wosakhazikika angina);
• ndi sitiroko (ischemic sitiroko kapena chosakhalitsa ischemic kuukira);
• ngati kutsimikiziridwa matenda mtsempha wamagazi monga njira kupewa inatsekeratu syndrome pachimake ndi sitiroko;
• kupewa zinthu zochititsa kobwereza wa inatsekeratu syndrome pachimake ndi sitiroko;
• ndi pamaso pa mitsempha varicose;
• monga nthumwi njira, chenjezo shunt thrombosis pambuyo CABG;
• ndi oopsa pa nkhani ya mkulu chiopsezo mtima.

Mkulu mtima chiopsezo ndi mfundo akaphatikiza monga pamaso pa limba kuwononga chandamale ku matenda oopsa ndi matenda okhudzana: shuga, inatsekeratu mtsempha wamagazi matenda, TSVB.

NKHANI mlingo regimens analimbikitsa ndi Mlengi

Pokonzekera "Aspekard" sewerolo malangizo si utsogoleri waukulu wa mankhwala wodwala. Lili zambiri za utsogoleli wa mankhwala munyengo zosiyanasiyana matenda kuyambira kupewa zochitika atherothrombotic mu CHD ndi TSVB kutsiriza ndi matenda wokonda aziyenda ndi mtima ubongo. kuchotsa Izi imatengedwa kunyalanyaza ndi unprofessional maganizo ndi nkhani ya mankhwala ndi m'munsili zipangizo zawo zambiri. Komanso amalenga preconditions kwa buku Unyinji wa nkhani imene Mlingo analimbikitsa amasiyana.

N'zimene regimens pamaziko a ayamikira lonse

Pamaziko a malangizo lonse anayamba ndi European Community wa Cardiology (Esc) ndi American Heart Association (Eya) ndi kusinthidwa ndi unduna wa zaumoyo, mwanjira ntchito asidi acetylsalicylic ali motere:

• mogwirizana mwadzidzidzi pa matenda pachimake inatsekeratu kuti azipereka wodwalayo kutafuna miyala 3 "Aspekard 100". Malangizo ntchito saidziŵa, ndipo mlingo umodzi wa 300 mg;
• aakulu mtima ischemia (CHD) pa phwando nthawi zonse anatumizidwa wina piritsi a 100 mg madzulo pambuyo pa chakudya;
• ndi oopsa odwala ndi chiopsezo cha mavuto a mtima, komanso venous varicose zonse amawatenga 100 mg (piritsi 1) madzulo pambuyo pa chakudya.

njira zina za makonzedwe mankhwala "Aspekard" malangizo Esc ndi Ha sasamalira. M'pofunikanso kukumbukira kuti mfundo mlingo "Aspekard" ndi 100 mg wa ASA. Pakuti kupewa matenda pamwamba, malinga ndi malangizo Esc ndi Eya, ntchito mlingo wa 75 mg. Komabe, 100 mg anatumizidwa odwala pambuyo CABG kuteteza thrombosis wa shunt lapansi. Nthawi zina kumafunika kuti ntchito 75 mg, i.e. kuchuluka kwa ASA, amene amathandiza okwanira antiplatelet zotsatira ndipo ali osachepera chiopsezo gastrotoxicity.

Komanso, Mlengi sasamalira zofunika pa chiyembekezo chakuti mankhwala. Malinga ndi kafukufuku, kutha mwadzidzidzi chifukwa cha 10,2% ya zochitika pachimake mtima. Ndipo amapezeka pambuyo pafupifupi 10,6 masiku kuchokera tsiku Kulipira ASA. Nthawiyi ndi avareji ndi kulingaliranso nthawi imene anthu onse yafupika kupatsidwa zinthu za m'mwazi cyclooxygenase kugwira ntchito. Chifukwa cha zimenezi, n'zotheka magazi kuundana limzake. Chifukwa mankhwala ayenera kumwedwa mosalekeza, pamene poika wothandizila wina antiplatelet m'malo "Aspekard" maonekedwe a matenda thirakiti m'mimba chofunika.

Contraindications "Aspekard" kukonzekera

Chitetezo cha mankhwala onse mankhwala ndi wachibale, chifukwa iwo ali ndi mavuto. Pa nthawi yomweyo iwo chifukwa ena contraindications. Makamaka:

• matenda a coagulation magazi (hemorrhagic diathesis, amapatsira mwana wake A ndi B);
• matenda a mbali m'mimba (erosions, zilonda pachimake cha m'mimba ndi duodenum 12);
• pa trimester mimba ndi mkaka wa m'mawere;
• mu aakulu kuwonongeka aimpso kapena kwa chiwindi;
• pamene thupi lawo siligwirizana ndi salicylates;
• ana osakwana zaka 18;
• pamaso pa mphumu bronchial;
• mankhwalawa methotrexate.

contraindications Awa ndi mtheradi, ngakhale nthawi zina: mkaka wa m'mawere, mimba, kukokololoka kwa nthaka ndi zilonda wa kapepalako m'mimba, wakhanda. Ndipo pali gulu la limati, pamaso amene amafuna polojekiti zonse ndi dokotala. Izi ntchito munthawi yomweyo antiplatelet mankhwala ndi anticoagulants, ndi kuchiza odwala pambuyo inatsekeratu opaleshoni mtsempha wamagazi kulambalala. Ngati ntchito impso ntchito mankhwala "Aspekard" malangizo ntchito amafuna kuchepetsa mlingo kapena kumaliza chiyembekezo chakuti m'kupita kwa mankhwala.

Zotsatira olowa "Aspekard"

asidi Acetylsalicylic angapo wa zotsatira kuti tizikonda kapena nkhawa zimene mankhwala angapo. Makamaka:

• ASA timapitiriza zotsatira za anticoagulants aliyense ndi wothandizila antiplatelet;
• ASA timapitiriza antipyretic ndi analgesic zotsatira za NSAIDs, amakulitsa antirheumatic zotsatira "Meloxicam";
• pamene pamodzi ndi mankhwala cytotoxic timapitiriza gastrotoxicity awo;
• pamene anatengedwa ndi mowa chiopsezo mavuto chilonda kapena ukuwonjezeka magazi;
• glucocorticoids kuwonjezeka gastrotoxicity "Aspekard";
• ACK attenuates zotsatira diuretic pamene pamodzi okodzetsa "Furosemide", "torasemide", "spironolactone".
• "Aspekard" imafoola zotsatira za wothandizila uricosuric, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable Mankhwalawa ayenera kumwedwa kuchepetsa mayamwidwe wa "Aspekard".

Mwina ndi ambiri osokoneza ndi zizindikiro zake

Ndi mankhwala "Aspekard" malangizo, maganizo ndi ntchito ziwerengero kwaniritsa mkulu mlingo wokwanira wa chitetezo pa phwando malinga ndi zizindikiro ndi contraindications zosiyana. Izi zikutanthauza kuti mlingo malangizo a 100 mg wa mankhwala ndi otetezedwa mokwanira, ngakhale ulamuliro wa ukupeza n'kofunika. Komanso, chifukwa cha gululo odwala ndi amafuna kudzipha, komanso chiopsezo kuti miyala ya ASA atenge mwana, mwatsatanetsatane chofunika Mwina ambiri osokoneza ndi zizindikiro zake.

Wofatsa poyizoni salicylates, chikwiyire ndi ntchito yokonza "Aspekard" popanda zizindikiro dokotala ayamikira ndi mayiko otsatirawa: chizungulire, kupweteka kwa fossa podlozhechkovoy, m'dera umbilical, nthawi zina ululu, makamaka odwala matenda a impso. Pankhaniyi cha mankhwala osokoneza bongo monga pali akunjenjemera, kusanza, nthawi zina ndi milozo wamagazi. Loyamba ndilochokera kudzera kupatsidwa ulemu yokumba wa emesis: wochuluka ozizira kumwa, adamulowetsa njira makala ndi ehnterosorbentov yobereka m'chipatala.

Chofunika, ndi Mlingo poizoni "Aspekard" malangizo Buku silitchula. Iwo ali osiyana kwa kulemera osiyana ndi zaka za wodwalayo. Mwachitsanzo, munthu wina wamkulu anthu ambiri osokoneza zizindikiro wofatsa ASA zimachitika pa chikuonetseratu umodzi za 5-7 magalamu acid. Ana zokwanira kwa ambiri osokoneza 1.5 ga mlingo umodzi. A ambiri osokoneza ndithu kumachitika pamene ntchito magalamu 7-9 achikulire ndi ana 2-2.5 galamu ASA.

digiri uyu wa mankhwala ambiri osokoneza bongo anaonetsa matenda pamwambapa zokhudza ntchito chidziwitso. Anataya cholemba akuyamba tinnitus maganizo amakhala osokonezeka, kulankhula incoherent. Kusanza zambiri zimachitika, wodwalayo msanga wotaya madzimadzi ku kusanza, kupuma mofulumira pali pachimake mkodzo posungira, kuchuluka kutentha thupi. Kuthandiza wodwalayo zimenezo n'zosatheka paokha - yobereka chofunika mu NICU kwa kulowetsedwa mankhwala bicarbonate, ndi sodium lactate.

Features kanthu achire "Aspekard"

Mayina mankhwala "Aspekard" zikugwira ntchito malangizo limapangidwa limasonyeza phwando piritsi limodzi pa tsiku (100 mg / tsiku). mankhwalawa ASA ndi chokwanila ziletsa kupatsidwa zinthu za m'mwazi cyclooxygenase. Chifukwa ndi chopinga wa kaphatikizidwe thromboxane A2, zomwe kwathunthu kumabwezera mmbuyo mphamvu za maselo kupatsidwa zinthu za m'mwazi loitanirana. Izi kumatha kuthekera thrombosis, omwe chifukwa cha m'mnyewa wamtima kapena oziziritsa infarct.

Kupereka zotsatira antithrombotic asidi acetylsalicylic ayenera odzipereka mu magazi. Komabe, ena mwa iwo ukuchita m'mimba komanso inhibiting cyclooxygenase-1 ndi isoforms ake mu mucosa wa limba. The chifukwa cha njira iyi ndi mbali zotsatira - yafupika luso muco oteteza chotchinga carbonate. Izi kumaonjezera ngozi ya erosions ndi zilonda za m'mimba, kumapangitsa m'mimba-magazi. formulations Enteric amathanso kupangira magazi, koma pafupipafupi amenewa mbali, ali ndi yaing'ono kwambiri.

Mimba ndi mkaka wa m'mawere

Katswiri maganizo, zochokera wounikira zowerengera ndi mndandanda wa zinthu zatsopano, wakupatsani kuti kumvetsa bwino tanthauzo la "Aspekard" mankhwala pa mimba. Makamaka, 1 trimester ntchito ndikoletsedwa. Pa 2 ndi 3 trimester ntchito amaloledwa, koma pambuyo aziona ntchito achire ndi kuyerekezera phwando ngozi. Mu ambiri matenda zinthu kusankhidwa ASA poponya, ngakhale NSAIDs zina timatha azitaya padera.

Pa mkaka wa m'mawere, ntchito mankhwala "Aspekard" analogues iye, generics, komanso mankhwala onse ndi asidi acetylsalicylic mu zikuchokera ndikoletsedwa. Chifukwa cha ichi ndi kugunda mankhwala mkaka wa m'mawere. izo likulowerera ngakhale naye mu thupi mwana. Ndipo ngozi yake ndi chiopsezo osauka syndrome Reye a - ndi aakulu zedi kwa chiwindi encephalopathy, zomwe zimabweretsa ubongo kutupa ndi imfa ya mwana. Zifukwa zofanana, linaletsa ntchito ya mankhwala pamaso pa zaka 16-18.

Zofunika Reviews akatswiri ndi odwala

Amakhala mankhwala "Aspekard" mtima maganizo nthawi zambiri maganizo okondera. Iwo ndithu imawunikidwa pa mtengo wa mankhwala, popeza pafupifupi otsika mwa anzawo. Komabe, ndemanga zokhudza ntchito yeniyeni ya zochepa zimasonyeza sungathe kuti aone digiri odwala kuchepetsa chiopsezo thrombosis mtima. Kumbali ya mavuto ananenedwa ndi odwala, mankhwala amakhala ngati mokwanira otetezeka.

Maganizo a akatswiri amanena momveka bwino: Choyamba, mankhwala othandiza kuchepetsa chiopsezo thrombosis, ndipo kachiwiri, odwala kutsatira antiplatelet mankhwala ndi apamwamba chifukwa cha otsika "Aspekard" mtengo wa mankhwala. Analogs wa gulu la wothandizira antiplatelet ndi apamwamba kwambiri. M'banja enteric kukonzekera "Atsekardol" zodula ndi 50%, pamene mtengo wa imports apamwamba ndi zina 7-10. Koma potengera wothandizila ochepa mavuto enteric, komanso apeza chuma, ndi zofunika kuika patsogolo "Atsekardolu". Mtengo wa chithandizo mwezi Kukhala 20 rubles.

Cholinga kupanda kardiopreparata "Aspekard"

Mayina mankhwala "Aspekard 100" malangizo Buku limanena kuti mankhwala alipo mapiritsi. Iwo kupasuka m'mimba ndi kutulutsa ndende mkulu. Kupereka gastrotoksichesky zotsatira m'deralo, mankhwala wotaya mankhwala Safety Other, ndicho enteric. muzituluka magazi chiopsezo pamene ntchito yamasika zochepa kwambiri.

Zitsanzo za mankhwala otetezeka ndi motere: ". Aspirin Cardio" "Atsekardol", "Polokard", "Cardiomagnyl" Komanso, anati njira komanso akupanga mankhwala enaake a hydroxide, akhoza kuteteza mucosa ku choipa ndi asidi acetylsalicylic. Komabe, mankhwala "Aspekard" akhoza ntchito kupewa thrombus mapangidwe, ngakhale ndi malamulo. Komabe, odwala ndi mucosal kukokoloka, chilonda 12 duodenum kapena m'mimba, kuphatikizapo aakulu, ndi bwino kutenga enteric kardioformy asidi acetylsalicylic.

Vneotraslevoe ntchito kardiopreparata "Aspekard"

Ambiri mwa malangizo logwiritsidwa ntchito zikusonyeza kukhalapo antiinflammatory ndi katundu antipyretic mankhwala "Aspekard 100". Ndipotu, mankhwala zonse mavuto achire nthawi 5 umodzi mlingo - 500 mg. Mlingo wa 100 mg ndi oyeretsedwa mtima, ndipo zotsatira zake si zokwanira bwino kuchepetsa kutentha matenda opatsirana.

Kardioforma kukonzekera kupanga mlingo wa 100 mg, ndi oyenera ululu ndi mpumulo malungo okha ndi mlingo umodzi wa mapiritsi 5. Choncho predominance selectivity kwa cyclooxygenase 1 Mzimuyo pamaso pa kuchuluka kwa zochita mbali. Choncho, monga febrifuge "Aspekard" mankhwala, ndithudi, ali oyenera. Komabe, pakadali pali angapo a mankhwala otetezeka naonetsere selectivity kwambiri cyclooxygenase 2. kuti zotsatira ochepa zimapezeka ndi kuphwanya kuchuluka kwa epithelium m'mimba.

Safety kalasi Anzawo "Aspekard" mankhwala

A azimuth ofanana unkachitika mu mankhwala a matenda enaake ophwanya. Ndipo Ufumuyo mankhwala "Aspekard" malangizo ntchito kakunena za mankhwala. Komabe, mlingo ndi a dongosolo la magalamu 5-8 pa tsiku.

ndalamazo asidi acetylsalicylic limasonyeza gastrotoxicity zokhudza mphamvu zotsatira kuposa pamene "meloxicam" asatayike, "celecoxib", "Roferoksib" ndi ena. Ndipo ngati antipyretic chidali kalasi analogue ndi "Ibuprofen".