Malangizo ntchito, maganizo ndi analogi "Ketanova"

Chifukwa adzaika analogi "Ketanova" ndipo anati mankhwala yokha? Izi adzaphunzilanso pa zipangizo za nkhaniyi. Ifenso timathandiza kuti malangizo ntchito mankhwala, mfundo pa mawonekedwe kumasulidwa, zochita zoipa, zikuchokera, contraindications, ndalama ndi zina zotero.

Zikuchokera, ma CD, mawonekedwe kumasulidwa

Analogue "Ketanova" ndipo ankaimira ndi chida lokha mwina maonekedwe osiyana kwambiri ndi kumasulidwa. ntchito zimadalira chikhalidwe cha ululu, malo malo awo ndi mmene wodwalayo.

Panopa, mankhwala "Ketanov" likupezeka mu mitundu iwiri yosiyana. Tikambirana aliyense zimenezi mwatsatanetsatane.

• Film TACHIMATA miyala. The yogwira zikuluzikulu za mankhwala ndi ketorolac tromethamine. Koma zigawo wothandiza, ndiye iwo monga chimanga wowuma, mankhwala enaake a stearate, microcrystalline mapadi ndi colloidal pakachitsulo woipa. The zikuchokera ❖ kuyanika filimu limapangidwa mapiritsi hydroxypropylmethylcellulose, madzi oyera, polyethylene glycol, titaniyamu woipa ndi talc mwayeretsa. Tikumbukenso kuti analogi "Ketanova" monga "Ketorolac", muli yemweyo yogwira mankhwala. Ankaona kukonzekera akugulitsa matuza zotayidwa, amene anaikidwa mulu wa mapepala. phukusi wina akhoza kukhala ku miyala khumi zana.

• Jekeseni "Ketanov". Majekeseni, analogues amene ali pansipa, muli izi pophika yogwira monga ketorolac tromethamine. Komanso, njira zikutanthauza kapangidwe kake ndi zigawo wothandiza mu mawonekedwe a sodium kolorayidi, madzi a jekeseni, disodium edetate, Mowa ndi hydroxide ndi sodium. Mankhwala chogulitsidwa vayozi wa milliliter wina. The katoni mwina zisanu kapena khumi mbale.

The pharmacodynamic katundu wa analgesic ndi

katundu Kodi pharmacodynamic amaonedwa mankhwala ndi lofanana ndi? "Ketanov" (mapiritsi ndi jakisoni) ali ndi kutchulidwa zotsatira analgesic. Mankhwala ali zolimbitsa antipyretic ndi odana ndi yotupa katundu.

Malinga ndi akatswiri, mfundo ya zochita za mankhwala kugwirizana ndi chopinga (sanali kusankha) ntchito za enzyme Cox-2 ndi Cox-1. ndondomeko kumachitika zimakhala zotumphukira. kukhudzana amenewa amachititsa chopinga wa PG biosynthesis, mwachitsanzo modulators thermoregulation, ululu tilinazo ndi kutupa.

mapiritsi ntchito "Ketanov" kapena makonzedwe mu mnofu wa njira amalimbikitsa mapangidwe racemic osakaniza [-] S- ndi [+] R-enantiomers. Zodabwitsa ndizakuti, zotsatira analgesic mankhwala nkwa kuti [-] S-mawonekedwe.

Ziyenera kukhala makamaka kudziŵika kuti medicament yogwira alibe nkhawa kupuma, alibe mphamvu pa maselo a opioid, izo alibe anxiolytic ndi sedative zotsatira ndipo sayambitsa chidakwa.

Kodi mukufuna kudziwa asanadye mankhwala kapena lofanana ndi? "Ketanov" (mapiritsi ndi jakisoni) pa mphamvu zotsatira zake analgesic angafanane ndi wa morphine. Akatswiri amanena izi zikutanthauza kwambiri kuposa mankhwala ena onse amene sanali steroidal.

Pambuyo m'kamwa kapena mu mnofu makonzedwe analgesic zotsatira zimawonedwa mu ola limodzi ndi theka, motero. Zotsatira pazipita mankhwala zimatheka kupyolera mphindi 60-120.

katundu pharmacokinetic

Mankhwala pachiyambi, komanso analogue aliyense "Ketanova" pambuyo ingestion m'malo bwino chosakanikirana kapepala kakuti m'mimba. Ndende apamwamba mankhwala magazi kukufika pambuyo pa makumi Mphindi pambuyo ingestion kudya miyala (10 mg). Tikumbukenso kuti kumwa wochuluka ndi zakudya zosapatsa thanzi angathe kuchepetsa ndende pazipita mankhwala mu magazi ndi kusunga kupambana kwake pa mphindi makumi asanu.

About 99 peresenti ya ndalama limakhudza zonsezo plasma. Pamene chiwerengero cha ufulu hypoalbuminemia zinthu mu ukuwonjezeka magazi. Pankhani ya bioavailability wa mankhwala, ndi za 80-100%.

Ngati makonzedwe mu mnofu mofulumira ndi atamezedwa kotheratu mu m'magazi mankhwala "Ketanov". Analogs (Ukraine wakhala kubala kokha "Ketorolac") komanso odzipereka.

Pambuyo mu mnofu jekeseni wa 30 mg wa mankhwala ndi ndende 1,75-3,2 ake apamwamba micrograms / ml ya ndipo ntchito 60 mg - 3,25-5,75 g / ml. Ndende pazipita mankhwala magazi zimawonedwa mphindi 15-20 ndi 35-65, motero.

Kaya mankhwala likulowerera mu mkaka wa m'mawere? Ndipo mtengo, ndi wotchipa analogue "Ketanova", ndipo ankaona mankhwala mosavuta kudutsa mu mkaka wa m'mawere. Izi zimachitika nthawi yomweyo pambuyo pa mlingo woyamba wa medicament mu kuchuluka kwa mamiligalamu 10. Ndende apamwamba mankhwala mkaka pa mlingo wa kukufika pafupifupi 120 Mphindi ndi 7.3 ng / l.

Pafupifupi 50% ya mlingo kutumikiridwa mankhwala ndi zimapukusidwa mu chiwindi. Chifukwa, metabolites anafooka anapanga. Chief mwa iwo chigawo gidroksiketorolak ndi glucuronides. Nthawi zambiri impso (pafupifupi 91%) ndi intestine ndi (pafupifupi 6%).

The theka moyo wa mankhwala odwala ndi ntchito yachibadwa aimpso ndi za 5.4 maola. Khalidwe limeneli ndi ndinasintha kuchuluka okalamba ndi amachepetsa wamng'ono.

chiwindi alibe mphamvu pa hafu ya moyo wa mankhwala. Iwo ayenera kukumbukira kuti mankhwala sizimawoneka mu ndondomeko ya dialysis.

zikuonetsa

Kodi zikutanthauzanji mankhwala "Ketanov"? Analogues wa mankhwala ndi m'pofunika kwambiri mpumulo yochepa ya ululu ya chiyambi zosiyanasiyana.

Choncho, medicament ankaona analamula kuti:

• postoperative ululu (kuphatikizapo pambuyo mafupa, matenda ndi m'mimba opaleshoni);
• kwa dzino (kuphatikizapo pambuyo opaleshoni ku mano);
• ululu syndromes atalandira wovulala, dislocation, ndi kuvulala minofu zofewa;
• ululu postpartum;
• ululu syndromes kunachitika nyamakazi;
• ululu syndromes kuti kuyambitsa khansa;
• sciatica.

anthu ochepa mukudziwa, koma ntchito mapiritsi "Ketanov" ndi njira injectable osati tikuonera syndromes aakulu ululu. mankhwala ndi zina okha Kupha yochepa nkhawa. Kutenga mankhwala pa nthawi yaitali ndikoletsedwa.

contraindications

Monga ena mankhwala si steroidal kukonzekera "Ketanov" ntchito mu ululu ali contraindications zosiyanasiyana. N'chifukwa chake musanamwe muyenera kufunsa dokotala ndi kuwerenga malangizo. Limati pa contraindications zotsatirazi:

• erosive ndipo anam'peza zotupa pa mundawo m'mimba, makamaka gawo pachimake, hypocoagulation (kuphatikizapo amapatsira mwana wake) ndi chironda chachikulu;
• Kuchuluka kudziwa ketorolac mtima ndi NSAIDs zina, bronchospasm, kuchepa madzi m'thupi, angioedema, ndi aspirin mphumu, hypovolemia (kaya chifukwa cha pakuwonekera kwake);
• chiwindi kapena matenda a impso (pa kulephera), makamaka plasma creatinine pa 50 mg / l;
• hemorrhagic sitiroko (amaganiziridwa kapena anatsimikizira), hemorrhagic diathesis, kuchuluka chiopsezo zisadzachitikenso kapena magazi (kuphatikizapo pambuyo opaleshoni), ntchito concomitant wa NSAIDs zina, mkhutu hematopoiesis;
• zaka pansi zaka 16;
• Woyembekezera, ndondomeko kubadwa ndi pa mkaka wa m'mawere;
• Chithandizo cha ululu aakulu syndromes khalidwe;
• mankhwala ochititsa dzanzi pamaso opaleshoni ndipo pamene iwo (chifukwa cha kutenga magazi kuchuluka).

Sitingathe kunena kuti mankhwala zotchulidwa mosamala odwala ndi cholecystitis, mphumu, kulephera aakulu mtima, chakhungu impso ntchito (pamene madzi creatinine zosakwana 50 mg / l), wolumikizira oopsa, yogwira chiwindi, cholestasis, sepsis, zokhudza zonse lupus lupus, komanso okalamba (zaka 65) ndi amene ndi tizilombo ting'onoting'ono mu zilonda za nasopharynx ndi mphuno.

Mankhwala "Ketanov": malangizo ntchito

Analogs ndi njira zofanana pa njira ya ntchito ndi mlingo. Koma pofuna kupewa overdoses pamaso ntchito zawo tikulimbikitsidwa kuwona dotolo.

Kodi ndimwe mapiritsi "Ketanov"? mawonekedwe mankhwala m'pofunika kuti atenge limodzi m'kamwa (10 mg). Ngati ndi kotheka (mwachitsanzo, ndi amphamvu ululu syndrome) medicament mlingo akhoza kawiri. Komabe, tisaiwale kuti mlingo tsiku la mankhwala sayenera upambana 40 mg.

Pamene ingestion wa Inde mankhwala nthawi ndi masiku asanu (osati kwambiri).

Ngati pazifukwa wodwala wina sangakhoze kutenga mawonekedwe m'kamwa mankhwala (mwachitsanzo, mu kukhalapo kwa erosive kapena zotupa anam'peza m'mimba, matumbo), ndiye kuti anatuma njira jekeseni. mtundu otere kutumikiridwa intramuscularly.

Pa chiyambi cha mankhwala ntchito Mlingo osachepera ogwira mtima amene asankhidwa mogwirizana ndi mphamvu ya syndromes ululu ndi zimene wodwalayo. Ngati ndi kotheka, wodwalayo Kwalamulidwa ndi zina opioid analgesics.

A mlingo chiphunzitso ndekha kwa osakwatira jekeseni mu mnofu:

• anthu pansi ndi zaka 65 - za 10-30 mg (malingana ndi mphamvu ya ululu);
• Anthu oposa zaka 65, komanso odwala ndi mkhutu impso ntchito - 10-15 mg.

Mlingo pambuyo mobwerezabwereza makonzedwe mu mnofu:

• anthu 65 - za 10-30 mg, kenako yofanana mawola anayi zisanu ndi ziwiri;
• anthu aakulu kuposa zaka 65 ndipo odwala ndi ntchito mkhutu impso - 10-15 mg wa mawola 4-7.

Mlingo tsiku la mankhwala pamene kutumikiridwa intramuscularly kwa akuluakulu sayenera upambana 90 mg. Kwa odwala okalamba ndiponso ndi ntchito mkhutu impso m'pofunika kuchepetsa kuchuluka kwa 60 mg. Kutalika kwa mankhwala sayenera masiku opitirira asanu.

Pa kusintha kwa oyang'anira mu mnofu wa mankhwala pa mankhwala mu okwana mlingo tsiku mitundu onse sayenera upambana 90 mg pa achikulire ndi 60 mg odwala okalamba kapena odwala ndi ntchito mkhutu impso.

Zizindikiro cha mankhwala osokoneza bongo

Pa mlingo waukulu wa anati medicament mu mtima zingaoneke kusanza, kupweteka m'mimba, ntchito aimpso, kagayidwe kachakudya acidosis, nseru, erosive gastritis ndi chironda chachikulu.

Monga mankhwala a zinthu zimenezi pogwiritsa ntchito chapamimba lavage ndi oyamba adsorbents zosiyanasiyana. Komanso symptomatic mankhwala (ie kuthandiza ntchito yofunika kwambiri ya thupi).

Mwanjira mankhwala

Pamene ntchito anzake a mankhwala pansi kulingalira ndi NSAIDs zina, wodwala angathe mphamvu ya Kuwonjezera, ndi anticoagulants (kuphatikizapo "heparin" pa mlingo ang'ono ndi "Pentoxifylline") - magazi.

Ngati concomitant ntchito mankhwala atsogolere ndi zoletsa Ace, pangakhale monyanyira mu impso ndi.

Iwo ayenera kukumbukira kuti ntchito mankhwala pansi review, ndi "Probenecid" kumawonjezera theka moyo wa ketorolac ndi ndende zake plasma.

Ngati inu kutenga mankhwala ndi lifiyamu, n'zotheka kuti muchepetse chilolezo aimpso wa lifiyamu ndi kuonjezera ndende zake plasma, koma ndi "Furosemide" - kutsitsa zotsatira zake diuretic.

Pa ntchito ya "Ketorolac" palibe chifukwa chopatula opioid analgesics.

The analogue bwino

"Ketanov" - ichi ndi amphamvu kwambiri komanso zothandiza analgesic mankhwala, amene anagulitsa pafupifupi drugstores. Ponena za analogs ake, n'zovuta dzina mankhwala yabwino kwambiri. Choncho, kwa chithandizo mofulumira syndrome ululu zambiri madokotala mankhwala odwala awo ndi mankhwala. Koma ngati pazifukwa zina mankhwala ali contraindicated kwa inu, Mpofunika kuti m'malo ndi "Ketorolac". Malinga ndi dera wopanga mtengo chida angakhale osiyana. Mtengo wa atanyamula miyala Russian akuyamba pa 20 rubles, Chiyukireniya - 35, ndi Indian - 45.

Kodi aliyense amaona mankhwala akhoza m'malo? Kodi ndi analogue ina? "Ketanov" popanda dongosolo, inu nthawi zonse kugula mankhwala a. Mu m'njira yofanana mugule maganizo ofuna zofanana "Adolor", "Torolak", "mankhwala Akyular", "Toradol", "Dolak", "Ketofril", "Dolomin", "Ketorolac tromethamine-Farmaplant", "Ketadrop "" Ketorolac tromethamine, "" Ketalgin "," Ketorolac-Eskom "," Ketokam "," Ketorolac-Verte "," Ketolak "," Ketorolac-OBL "," Ketorolac Rompharm "," Ketorol "ndi ena.

Mtengo wa mankhwala awa akhoza kukhala apamwamba apachiyambi pansipa. Kumbukirani kuti mankhwala "Ketanov" (mapiritsi 10) zikhoza kugulidwa kwa 50-70 rubles. Tiyeneranso ananena kuti ali osavomerezeka ilo pa nzeru zawo.

Amene chida ntchito mpumulo m'dera ululu? Kodi pali mtundu lolingana za "Ketanov" mankhwala? Mafuta (analogs wa anati wothandizila mapiritsi akhala anapereka pamwamba) ndi mankhwala yemweyo yogwira n'kovuta kupeza. Komabe, pali mankhwala amene angagwiritsidwe ntchito timitu. Izi 2% ya mankhwala otchedwa "Ketorol" (anapanga India). Chotero njira akupezeka machubu 30-gram mwamsanga amachotsa syndromes aliyense ululu (pamene ntchito timitu).

Ndemanga za mankhwala othetsa ululu

Tsopano inu mukudziwa kuti ndi mankhwala "Ketanov", chomwe cholinga. Tikumbukenso kuti pafupifupi onse odwala Reviews a medicament ali positive. Anthu amene nthawi kugwiritsira ntchito mapiritsi kapena njira jekeseni "Ketanov" boma kuti mankhwala mofulumira kwambiri kumatha syndromes aliyense ululu.

Malinga ndi yochizira matenda, mphamvu ya mankhwala ochititsa kumatenga maola 12-15 (nthawizina yaitali). Patapita nthawi ino, mankhwala ayenera mobwerezabwereza (ngati ululu sichimaperekedwa).

Komabe, n'zosatheka osanenapo chakuti mankhwala, monga NSAIDs ena, pali zambiri mavuto. Malinga ndi mayankho odwala, nthawi zina mankhwala amachititsa nseru ndi ululu m'mimba. Pankhaniyi, akatswiri amalangiza m'malo mawonekedwe m'kamwa mwa jekeseni mankhwala. Pajatu aliyense osati mwachinsinsi kuti NSAIDs zingachititse mavuto aakulu ndi m'mimba (mwachitsanzo, zimathandiza kuti maonekedwe a zilonda kapena erosions).

Tiyeneranso anati odwala ambiri makamaka adakondweretsa zida mtengo malipoti. Poganizira kuti m'pofunika kutenga kamodzi, ndipo pa nthawi yochepa, chithuza ndi mankhwala chingakhale chokwanira ndithu nthawi yaitali. N'chimodzimodzinso ndi mawonekedwe jekeseni ya mankhwala.