Kukonzekera kwa Antiestrogenic: kufotokozera, kugwiritsa ntchito

Esitirojeni-blockers ndi mankhwala mankhwala kuti ndigwire ntchito timafunika. mankhwala Antiestrogen ntchito mankhwala a matenda osiyanasiyana. Iwo ankagwiritsa ntchito zochizira khansa ya njira wam'mawere ziletsa kukula chotupa kapena kupewa kumwa. Monga momwe zilili ndi mankhwala ena kuti mucheze ndi mahomoni m'thupi, mankhwala ayenera kugwiritsidwa ntchito moyang'aniridwa ndi achipatala.

Phindu ndi mopweteka timafunika

Esitirojeni, kapena timadzi steroid apanga makamaka ndi thumba losunga mazira ndi. Zingamvekere angapo njira ya thupi. Akazi wobereka ali ndi mlingo wokweretsa wa timadzi achilengedwe. An yambiri Komabe, zikhoza kubweretsa matenda odziwika monga hyperestrogenia. matenda Zimenezi zingachititse kuti ndondomeko khansa ya m'mawere ndi khansa endometrial. mankhwala Anti-esitirojeni ndi esitirojeni blockers ndi zoletsa aromatase izo zingakhoze kukonza zonse. mankhwala amenewa, ndi zotsatira zabwino ndi zoipa pa amuna ndi akazi.

Mitundu timafunika-blockers ndi ntchito

Pali mitundu yosiyanasiyana timafunika-blockers. zoletsa aromatase kwenikweni ndigwire kupanga timafunika. Kusankha esitirojeni cholandilira modulators, monga "Tamoxifen" "Clomiphene" lakonzedwa kuti ndigwire esitirojeni zolandilira, ndi kuchita mosiyana kwa anthu osiyanasiyana nsalu. Antiestrogens komanso kutchinga esitirojeni zolandilira.

Antiestrogens kuteteza kutembenuka kwa testosterone kuti estradiol ndi esitirojeni mahomoni Kusiya ntchito kapena oletsedwa.

Mankhwala khansa, mankhwala ndi ntchito kuchedwetsa kukula kwa zotupa. Pankhaniyi, kusankha esitirojeni modulators cholandilira akhoza timalembera anthu zolandilira yeniyeni esitirojeni. Blockers, kuphatikizapo "Clomiphene" Nthawi zina amagwiritsidwanso ntchito pa matenda a osabereka, iwo akhoza kuthandiza akazi ena amene amavutika kukhala ndi pakati. Mankhwalawa amagwiritsidwa ntchito ndi ena clinicians mankhwalawa ana ndi kuchedwa kutha msinkhu mpaka atafika.

Pakati bodybuilders izo ntchito timafunika-blockers chifukwa cha estrogenic ya mpweya wambiri wa testosterone mu thupi. Testosterone ndi kalambulabwalo timafunika ndi, zoletsa aromatase angagwiritsidwe ntchito kuletsa mapangidwe minofu misa owonjezera timafunika, kukhalabe mlingo wochepa thupi. Mwambo umenewu kwachititsa ambiri, makamaka mankhwala odana esitirojeni ntchito makamaka popanga zodzoladzola. Pankhaniyi, anthu kugwiritsira ntchito mapiritsi ndi zowonjezera zakudya popanda achipatala.

zotsatira zoyipazi

Pali mphamvu ya mankhwala odana esitirojeni. Angathe kuyambitsa chizungulire, kupweteka mutu, thukuta, amamva ndi chisokonezo. Only m'thupi yemwenso angaone mlingo zoyenera kwa mtima zoopseza, ndi pakhomo zovomerezeka mavuto. The m'thupi yemwenso amathanso mankhwala MAGAZI wokhazikika kwa timadzi ta m'thupi pamene akuona thanzi akukhudzidwira wodwalayo kuti atsimikizire kuti ntchito odana estrogens ndi otetezeka ndi zinchito wodwalayo.

amuna chithandizo

Ndi zaka, amuna milingo testosterone kusiya. Komabe, ngati testosterone yatsala kapena achepetsa zingachititse kuti chitukuko cha hypogonadism. boma amakhala ndi kulephera thupi kutulutsa timadzi yofunika imeneyi, angachititse zizindikiro zosiyanasiyana, kuphatikizapo:

• imfa ya libido;
• kuchepetsa zokolola ndi khalidwe la umuna;
• erectile kukanika;
• kutopa.

Ngati ife kulankhula za esitirojeni, woyamba chinthu anthu amaganiza kuti ndi timadzi wamkazi, koma kupezeka kwake amaonetsetsa kuti thupi mwamuna bwino ntchito. Pali mitundu itatu ya estrogens: estriol, estrone ndi estradiol. Estradiol - ndi mtundu waukulu yogwira timafunika kuti amuna. Umagwira ntchito yofunika kwambiri kukhalabe ntchito mfundo za mafupa yamphongo ndi ubongo minofu. mankhwala Antiestrogen imaperekanso umuna amakula bwino.

Mahomoni vutoli - kulera mlingo timafunika ndi utachepa testosterone - amalenga mavuto. esitirojeni kwambiri mu thupi mwamuna kungachititse kuti:

• gynecomastia (kwambiri chitukuko ya m'mawere minofu);
• mavuto mtima;
• kuchuluka chiopsezo sitiroko ndi;
• kunenepa;
• Mavuto ndi prostate.

Inu mukhoza kutenga zinthu zingapo kubwezeretsa bwino mu mlingo timafunika. Mwachitsanzo, ngati esitirojeni anu owonjezera amagwirizana ndi pamlingo wochepa wa testosterone, zimene zingakhale zothandiza ngati testosterone m'malo mankhwala timafunika blocker.

Mankhwala esitirojeni-blockers

Mankhwala ena mankhwala zingabweretse esitirojeni-kutsekereza zotsatira za amuna. Monga ulamuliro, nthawi zambiri iwo anafuna kuti ntchito ndi akazi, koma kupeza mu kutchuka pakati pa anthu, makamaka amene akufuna kukhala ndi ana. Testosterone zowonjezera kungayambitse osabereka. Koma esitirojeni blockers monga "Clomid" angathe kubwezeretsa bwino m'thupi popanda kusemphana chonde.

mankhwala angapo amadziwika monga kusankha modulators esitirojeni cholandilira, amangoona akugulitsa mankhwala zochizira khansa. Koma iwo Angagwiritsidwenso ntchito kuti asalalikire timafunika kuti amuna. Mankhwalawa ntchito zosiyanasiyana zinthu zokhudzana testosterone otsika, kuphatikizapo:

• osabereka;
• otsika umuna chizengerezo;
• gynecomastia;
• kufooka kwa mafupa.

Mankhwalawa ayenera kugwiritsidwa ntchito kusankha, malingana ndi wodwalayo. Kugwiritsa ntchito ngati mankhwala odana esitirojeni. Pa mankhwala mukhoza kugula:

• "Tamoxifen".
• 'Arimidex.
• "Letrozole."
• "Raloxifene".

Mmene fupa

Malinga clinicians, kukhudzana yaitali mankhwala esitirojeni zikhoza kuyambitsa khansa endometrial mu akazi. "Raloxifene" - munthu kusankha esitirojeni cholandilira modulator - chingalepheretse chitukuko cha khansa, kusankha midadada mayamwidwe timafunika. Izi mankhwala Komabe, komanso amatha inhibiting zotsatira zabwino timafunika pa mafupa. The mankhwala atsopano - "lasofoxifene" - akhoza kukonza vutoli. Ndi kupewa kukhala ndi mafupa osalimba mu akazi postmenopausal ndipo kumachepetsa brittleness minofu fupa. Kugwiritsa ntchito mankhwala zambiri otetezedwa, koma achuluke magazi kuundana.

Mwanjira mankhwala

Esitirojeni blocker "Tamoxifen" kungathandize khansa. odwala khansa nthawi zambiri ankavutika maganizo, ndi gulu ili la mankhwala akhoza kucheza zoipa ndi mankhwala, antidepressants. Ayenera kutsatira "Paroxetine" chifukwa chakuti amai "Tamoxifen" ndi "Paroxetine", zochepa chiopsezo cha imfa kuposa akazi amene 'Tamoxifen "ndi antidepressant ina. Ichi ndi chifukwa "Paroxetine" amachita kusankha.

Antiestrogen wothandizila ndi mankhwala

The zokhudza zonse za ndalama amenewa akusonyeza kuti aliyense mankhwala ntchito payekha pa nkhani zosiyanasiyana.

"Clomid" kapena "clomiphene citrate" anali mmodzi wa mankhwala choyambirira ntchito pa matenda a gynecomastia, chifukwa zimautsa mlingo thupi testosterone achilengedwe. Pali zotsatira zina mbali ku ntchito nthawi yaitali, monga mavuto masomphenya. Pali zinthu aluso pa msika, amene zinthu m'njira yomweyo koma "Clomid" lili bwino ndipo yotchipa Kusakaniza kwa wothamanga aliyense.

Izi si steroid anabolic, mankhwala ambiri zotchulidwa kuti azitithandiza pa akazi ndi osabereka, chifukwa ali ndi luso kutchulidwa yotithandiza ovulation, amene zimatheka ndi kutsekereza / kuchepetsa zotsatira timafunika mu thupi. Kukhala zenizeni kwambiri, "Clomid" - katundu mankhwala kupanga esitirojeni agonist / antagonist. Mu zimakhala ena chandamale zikhoza kutchinga luso timafunika kuti amange kuti cholandilira chogwirizana. ntchito zake matenda ndi kutsutsa mayankho zoipa timafunika mu dongosolo ubongo imene imalamulira kutentha-pituitary-yamchiberekero, amene kumapangitsanso amasulidwe LH ndi FSH. Zonsezi kumabweretsa ovulation.

Zolinga zamasewera "clomiphene citrate" akazi ziribe mphamvu. Mu amuna Komabe, pali chinawonjezeka yopanga FSH ndi (makamaka) luteinizing timadzi kumene kumapangitsa testosterone achilengedwe. Amenewa n'kopindulitsa makamaka wothamanga pa mapeto a mkombero steroid pamene milingo amkati testosterone akuvutika maganizo. Popanda testosterone (kapena androgens zina), "tochepa" Chikupambana ndipo amagwira mapuloteni kaphatikizidwe mu minofu. Koma mwamsanga "adya" ambiri a minofu atsopano pambuyo Kulipira. Clomid kungathandize kwambiri popewa kulephera izi iyende masewera. Kwa amayi, ubwino kanthu Clomid - Luso kulamulira amkati esitirojeni mlingo. Izi kuonjezera imfa ya mafuta ndi minofu, makamaka m'madera monga ntchafu ndi matako. "Clomiphene citrate" Komabe, kawirikawiri mavuto mu akazi, koma, koma ankafuna mwa gulu la othamanga.

"Tamoxifen" kutsekereza esitirojeni zolandilira maselo khansa. Izi kugwira esitirojeni ku zimavuta nawo ndiponso kupewa kukula ndi kugawikana maselo. Ngakhale "Tamoxifen" amachita ngati antiestrogen mu mammary maselo England, iwo ukuchita monga timafunika kuti zimakhala ena: fupa ndi chiberekero.

Akazi ndi yozungulira chifuwa "Tamoxifen" khansa olanda angagwiritsidwe ntchito zaka 5-10 pambuyo opaleshoni, kuchepetsa mosavuta kufalitsa metastasis. Komanso amachepetsa ngozi ya kudwala kansa mwa bere ena. Pakuti gawo oyambirira kukonzekera ichi ntchito kwenikweni kwa odwala amene safuna kusintha. zoletsa Aromatase ndi njira imene amasankha akazi azimayi amsinkhu umenewu amakumana.

"Tamoxifen" amathanso kuletsa kukula kapena usachite zotupa odwala ndi odwala metastatic khansa. Angagwiritsidwenso ntchito kuchepetsa kufala kwa osauka njira chifuwa onkologicheskihz.

Izi mankhwala anatengedwa pakamwa, kawirikawiri mu mawonekedwe a mapiritsi.

Mavuto a mankhwala odana esitirojeni monga kutopa, amamva, dryness nyini kapena mvula ndi mmene alili.

Akazi ndi metastases mu minofu fupa kumachitika ululu ndi kutupa mu minofu ndi mafupa. Nthawi zambiri Sichikhala yaitali, koma nthawi zina kawirikawiri, akazi Komanso kofunikira kwambiri kashiamu m'magazi, amene si prokontroliruesh. Zimenezi zikachitika, ndiye mankhwala akhoza inaimitsidwa kwa kanthawi.

Osowa, koma yaikulu kwambiri mavuto komanso zitheka. Mankhwalawa angathe azitaya khansa ya myometrium mu akazi ndi kusintha kwa thupi. Kuchuluka magazi clotting wina zotheka zotsatira zina zoyipa. thrombosis zozama mtsempha zikachitika, koma nthawi zina chidutswa cha magazi aumirira akhoza kusiya ndipo m'kupita ndigwire mtsempha wamagazi mu mapapo (embolism m'mapapo mwanga).

Kawirikawiri "Tamoxifen" anali chifukwa cha sitiroko ndi matenda a mtima pa akazi postmenopausal.

Malinga za azimayi amsinkhu umenewu amakumana akazi "Tamoxifen" angakhale ndi zotsatira zosiyana pa fupa. Mu akazi premenopausal, "Tamoxifen" zingachititse kupatulira mafupa, koma akazi positi-azimayi amsinkhu umenewu amakumana kumawonjezera mlingo wa calcium, koyenera kuti mafupa olimba.

Ubwino mankhwala kuposa kuopsa kwa pafupifupi onse akazi ndi timadzi amadalira khansa olanda.

Mofananamo, mankhwala ndi "Toremifene", omwe ali wobvomerezeka mankhwala khansa ya m'mawere metastatic. Komabe, mankhwala chithe ngati ntchito ndi "Tamoxifen", koma popanda zotsatira.

"Fulvestrant" ndi mankhwala midadada woyamba esitirojeni cholandilira, kenako Imathetsanso cholandilira kumangako mphamvu. Iwo amachita monga odana ndi esitirojeni thupi lonse.

"Fulvestrant" amagwiritsidwa ntchito pofuna kuchiza akuthamanga metastatic khansa ya m'mawere ndi zambiri ntchito pambuyo mankhwala ena m'thupi ( "Tamoxifen" ndi zoletsa aromatase) amene anasiya kugwira ntchito.

Zotsatira Common mbali zingaphatikizepo azimva kutentha, Thukuta usiku, wofatsa kunyansidwa komanso kutopa. Theoretically, zikhoza kufooketsa mafupa (kufooka kwa mafupa), akamwedwa kwa nthawi yaitali.

Izi mankhwala ali anapambana kuzindikira ntchito akazi postmenopausal amene salabadira "Tamoxifen" kapena "Toremifene." Nthawi zina ntchito cholinga chake mu akazi premenopausal, nthawi zambiri osakaniza ndi luteinizing timadzi-kumasuka agonist kuti zimitsani thumba losunga mazira.

"Raloxifene" ntchito ndi akazi kuti kupewa ndi kuchiza wa imfa fupa kapena kufooka kwa mafupa pambuyo kusintha. Izi zimathandiza kusunga mafupa, kuchepetsa chiopsezo cha fractures.

"Raloxifene" komanso chingalepheretse yatsoka ndi khansa ya m'mawere olanda pambuyo kusintha. Iye sali esitirojeni timadzi, koma amachita ngati timafunika kuti mbali zina za thupi, monga fupa. M'madera ena a m'thupi (chifuwa ndi chiberekero), "Raloxifene" amachita ngati esitirojeni blocker. Iye sikuti kuthetsa zosiyanasiyana syndrome azimayi amsinkhu umenewu amakumana. Raloxifene chikukhudza gulu la mankhwala odziwika monga kusankha esitirojeni cholandilira modulators-SERMs (estrogenic ndi mankhwala antiestrogenic).

mankhwala Anti-esitirojeni ndi Sports

Mankhwala ena ankagwiritsa ntchito bodybuilders kumanga minofu.

"Cyclofenil" - ndi neanabolichesky / androgenic steroid. Iwo amagwira ntchito monga odana ndi esitirojeni ndi testosterone monga stimulant ndi. "Cyclofenil" ndi ofooka kwambiri ndi wofatsa esitirojeni, koma chimango esitirojeni zolandilira ndiponso kupewa ankameteramo ubweya wa zolandilira zachilengedwe esitirojeni. Ndipotu umathandiza kwambiri moti ena othamanga kutenga mankhwala pa chithandizo steroid kuti akhalebe amphamvu otsika timafunika. Zotsatira - kuchepetsa kuchuluka kwa madzimadzi mu thupi, amene analengedwa ndi mankhwala ndi kuchepetsa gynecomastia. The wothamanga ali kunja amphamvu, pogwiritsa ntchito mankhwala, chimene chingalowe zingakhale kumwedwa pa pokonzekera mpikisano. Bodybuilders Komabe, ntchito zochepa zambiri chifukwa iwo amakonda angakwanitse kwambiri 'Nolvadex' ndi 'Proviron. "

Ngati "Clomid", "Cyclofenil" ndi operewera mu akazi, monga kumakhudza zabwino zokha pa ulimi wa mahomoni anthu. Kulera mlingo wa testosterone chifukwa cha mankhwala sikokwanila kulankhula za patsogolo kwakukulu, koma adzapereka mphamvu phindu, ngakhale kuwonjezeka yaing'ono thupi, kuwonjezereka kwambiri mphamvu ndi kuwonjezeka mu kusinthika zotheka. Zotsatira izi ndi kuonekera makamaka othamanga zapamwamba amene n'zosathandiza zinachitikira ndi mankhwala. Gwiritsani ntchito zotsatira za kukhala zooneka pokhapokha sabata.

Nthawi zina, othamanga akuona kuphulika monga ziphuphu zakumaso, kuchuluka pagalimoto kugonana ndi amatuluka otentha. Zizindikiro zimenezi ndi umboni makamaka zimasonyeza kuti pawiri kwenikweni ogwira. Pambuyo discontinuation ena lipoti maganizo maganizo ndi kuchepa pang'ono mphamvu. Anthu amene mankhwala monga odana ndi esitirojeni pamene chithandizo steroid, tingathe kuona kuti azisiyana pamene zotsatira za wothandizila ndi ndinayima.

Proviron ndi imodzi mwa anabolic androgenic steroids pamsika. Mwamwamtundu wotchedwa Mesterolon, umakhalabe mmodzi wa anabolic steroid osatchuka kwambiri pakati pa ogwiritsa ntchito.

Pogwira ntchito, proviron imachita ntchito zinayi zofunika, zomwe makamaka zimagwira ntchito. Choyamba, chimakhala chimodzi mwa anabolic steroid wamphamvu kwambiri, chifukwa chimawonjezera kuchulukitsa kwa testosterone yaulere, yomwe ndi yofunika kwambiri kwa anabolic njira zogwiritsira ntchito thupi. Njira yosavuta kuyang'ana izi: ngati mutenga anabolic steroid, ndiye kuti minofu ikukula.

Proviron amatha kuyanjana ndi aromatase, yomwe imayambitsa kutembenuza testosterone ku estrogen. Kuphatikizana ndi aromatase, Proviron ikhoza kuimitsa ntchito yake, motero imateteza chitetezo cha mayendedwe a estrogenic.

Pa "Mesterolon" imakhalanso ndi mgwirizano wolimba wa receptionor ndi androgen. Izi anabolic steroid, zomwe siziletsa ma gonadotropins mofanana ndi anabolic steroid zina. Izi zimapangitsa kuwonjezera kukula kwa umuna, popeza kuti androgens ndizofunikira pofuna kutulutsa spermatogenesis. Izi zimangowonjezera kuchuluka kwa umuna, komanso zimapangitsanso ubwino wake.

Zotsatira za "Proviron" siziphatikizapo gynecomastia kapena madzi owonjezera. Izi zidzathandizanso kuchepetsa chiopsezo cha kuthamanga kwa magazi komwe kumakhudzana ndi kutenga anabolic steroids. Ndipotu, "Proviron" imakhala ndi anti-estrogenic zotsatira potseka kutembenuka kwa testosterone mu estrogen kapena kuchepetseratu njirayi.

Kukonzekera kumene tatchulidwa pamwamba pa maselo a estrogen sikungachepe, koma kumakhudza kagayidwe ka maselo ambiri.

Gulu la antiestrogenic mankhwala limaphatikizansopo agonists pa zimasulidwe za mahomoni a gonadotropic (Buserelin ndi zifaniziro zake), megestis acetate (Megeis), Parlodel ndi Dostinex amagwiritsidwa ntchito pokonzekera kutseka chitetezo cha prolactin. Kuzigwiritsa ntchito mwachangu pa chithandizo ndichabechabechabe.

Kuchiza kwa matenda a chilengedwe

Kuphatikiza pa "Tamoxifen", izi zikugwiritsidwa ntchito ndi estrogen receptor blockers.

Mankhwala atatu omwe amaletsa kugwiritsidwa ntchito kwa estrogen m'mayi am'mawopawa amavomerezedwa kuti azitha kuchiza khansa yoyambirira komanso yamtsogolo: Letrozole (Fehmara), Anastrozole (Arimidex) ndi Exemestane (Aromazine) .

Njira yothandizira anti-estrogen yokonzekera gululi ndi kulepheretsa kwa enzyme (aromatase) mu minofu yambiri, yomwe imayambitsa zochepa za estrojeni m'mayi am'maopa a pambuyo pake. Sizimakhudza mazira ambiri, kotero zimakhala zokhazokha kwa amayi omwe mazira awo sagwira ntchito, mwina chifukwa cha kutha kwa thupi kapena chifukwa cha mphamvu ya limuinizing hormone analogue. Mankhwalawa amatengedwa tsiku ndi tsiku ngati mapiritsi. Amagwira ntchito moyenera pa njira zothandizira zamoyo mu mammary gland ndi prostate.

Nthawi zina chithandizo cha khansa ya m'mawere chimafuna kupuma kwa odwala. Izi zingatheke mothandizidwa ndi mafananidwe a luteinizing kutulutsa hormone (LHRH), mwachitsanzo, "Goserelin" ("Zoladex") kapena "Leiprolide" ("Lupron"). Mankhwalawa amaletsa chizindikiro chimene thupi limatumiza ku mazira, kuti apange estrogen. Zikhoza kugwiritsidwa ntchito payekha kapena ndi "Tamoxifen", aromatase inhibitors, "Fulvestrant" ya mankhwala omwe amachititsa mahomoni.