Kodi "Lyrics" piritsi? Ntchito mtengo

Medicine "mawu" (mapiritsi), mtengo wa wochokera rubles 700 mpaka 4000, -. Mokwanira odziwika mankhwala. Yogwira mankhwala - pregabalin - analogi wa Popanga madzi a gamma-aminobutyric (GABA) asidi (GABA). Kenako m'nkhani adzapatsidwa Zamkati mankhwala. Tiyeni tione zimene mankhwala "Lyrics" ntchito odwala.

limagwirira kanthu

Pregabalin akusonyeza kugwira kwake pa matenda a matenda ashuga neuropathy ndi postherpetic neuralgia, umene mankhwala "mawu" zotchulidwa mlingo kwa masabata 13 ndi mlingo tsiku wambiri nthawi 2 ndi kwa masabata 8, 3 pa tsiku. Against maziko a chitukuko cha njira anasonyeza zotsatira chomwecho mbali. Kugwirizana ndi m'minofu ndi kuoneka bwino kuchepetsa zizindikiro ululu Point tikadwala Mlingo wa mankhwala a 300-600 mg wa pa tsiku. Daily mlingo wa 450 mg wa ndi 600 mg angayerekezedwe kwa dzuwa, koma chomalizachi ndi zochepa bwino analekerera. Mankhwala amachepetsa kukula kwa khunyu khunyu, limene miyala "mawu" amalangiza njira ya masabata 12, 2 kapena 3 pa tsiku. Pa phwando Zimachitika chitsanzo mavuto ndi mphamvu ya mankhwala pa mlingo uwu. chopitirira pafupipafupi wayamba ndichepe kale mu masabata loyamba la mankhwala. Symptomatology ya Nkhawa matenda limasonyeza chizolowezi ndichepe mu masiku asanu ndi awiri a mankhwala. Patapita masabata asanu ndi atatu 52% mwa odwala mankhwala kulandira pregabalin ndi 38% odwala kulandira placebo, anasonyeza kuchepetsa 50 peresenti zizindikiro za Hamilton lonse (HAM-A).

Pharmacokinetics

The medicament "mawu" (piritsi) - wogwiritsa akutitsimikizira nkhani imeneyi - mu analimbikitsa Mlingo tsiku ndi mbali pharmacokinetic yodziwika linearity, otsika (<20%) interindividual masiyanidwe. Mobwerezabwereza ntchito ya pharmacokinetics mankhwala akhoza ananeneratu pamaziko a gulu la deta mlingo. Choncho nthawi zonse muzionetsetsa kuti ndende ya pophika yogwira Sikuti. magawo Pharmacokinetic wa mankhwala "Lyrics" mu odzipereka wathanzi, odwala khunyu amene akulandira antiepileptic, komanso kulandira mankhwala kwa kupondereza ululu syndromes ofanana.

Mayamwidwe ndi kuwonongedwa

Atakhala pa chopanda kanthu m'mimba pregabalin imatsala mofulumira kwambiri. ola limodzi mtsogolo, plasma Cmax zimatheka pamene ntchito kwa nthawi yoyamba, ndi mobwerezabwereza. Pa maziko a pregabalin bioavailability m'kamwa ndi pa ≥90% ndipo zimadalira pa mlingo. Mgwirizano zimatheka pamene mukumwa mobwerezabwereza m'nyengo ya maola 24-48. Ngati mankhwala umagwiritsidwa pambuyo chakudya, ndi Cmax mwina kuchepetsedwa ndi 25-30% ndipo kuonjezera kupambana kwake nthawi maola 2.5. Komabe, palibe zotsatira kukomoka chidwi mayamwidwe wa mankhwala analibe chakudya. Kwenikweni mankhwala excreted ndi impso sichinasinthe. T1 / 2 maola 6.3.

Pharmacokinetics milandu wapadera

Ngati inu kusweka ntchito aimpso, m'pofunika kuganizira peculiarity wa pregabalin chilolezo, ndi mwachindunji njila kwa creatinine chilolezo. Kwenikweni mankhwala excreted ndi impso, choncho m'pofunika vuto la kuphwanya ntchito zawo kuchepetsa mlingo. Kupatula impso, ndi medicament ungagwire amachotsedwa plasma ndi hemodialysis (4 maola hemodialysis gawo amapereka 50% kuchepa ndende mankhwala plasma) kenako zambiri zofunika mlingo kusankhidwa mankhwala. Kafukufuku chapadera wa pharmacokinetics wa wothandizila "Lyrics" odwala ndi mkhutu ntchito chiwindi sizinachitike maphunziro.

Pregabalin zimapukusidwa pafupifupi si poyera, chimaonetsedwa pamodzi ndi mkodzo mu mawonekedwe zikutsatiridwa Koma chakhungu chiwindi ntchito si kwambiri bwanji ndende ya mankhwala mu madzi. Pamene mankhwala amaperekedwa kwa odwala pa zaka 65, muyenera kukumbukira kuti ndi zaka Pregabalin chilolezo amamuchititsa ndichepe. Ngati munthu wina wachikulire wa utachepa ntchito aimpso, m'pofunika kuchepetsa mankhwala zotchulidwa mlingo.

mlingo

Kuchuluka tsiku la yokonza akufotokozera mg wa 150-600 patsiku. Chikuonetseratu ikuchitika kawiri kapena katatu, kaya chakudya. The medicament "mawu" (mapiritsi) malangizo Buku akuonetsa kumwa ndi ululu neuropathic pa mg wa 150 patsiku. Ngati zotsatira zimatheka ndi tolerability zabwino sabata imodzi tsiku mlingo akhoza ziwonjezeke kwa 300 mg (tisonyezeni "mawu 300" mapiritsi). Ngati ndi kotheka, mlingo pazipita 600 mg pa tsiku akhoza kutumikiridwa sabata imodzi. Mofananamo masamu mlingo pa matenda a khunyu. Monga tatchulazi, yovomereza mankhwala zochizira m'minofu, amene mapiritsi "mawu" ndi kutumikiridwa mu mlingo wa 75 mg pa tsiku Mlingo awiri. Kuwonjezeka mlingo kwa 300 mg bwanji zotsatira zimatheka ndi tolerability. Ngati palibe ubwino, akawawonjezere mlingo wa mankhwalawa 450 mg, ndipo ngati pakufunika - sabata imodzi 600 mg. Kuchitira Nkhawa matenda ayamba ndi mlingo wa 150 mg. Komanso sabata, kuona zotsatira zimatheka ndi tolerability, mlingo tsiku kuchuluka 450 mg, ndipo pakutha masiku 7 - mpaka 600 mg (ngati n'koyenera).

kuchotsa mankhwala

Ngati ndi kotheka, mankhwala discontinuation tikulimbikitsidwa kuchita izo osachepera kwa sabata kuchepetsa pang'onopang'ono mlingo. Odwala amene chakhungu impso ntchito, ikuchitika kusankha munthu wa Mlingo. Mu chochitika cha mavuto odwala kulandira amatanthauza "Lyrics" mapiritsi-zofanana amasankha katswiri. Mwa njira ambiri ndi zotsatira zofanana ndi kutchulidwa mankhwala "Mydocalm" "Apizartron" "Sedavit" "Ambene".

umboni

Mankhwala akulimbikitsidwa kuwonongedwa kwa ululu neuropathic, monga mankhwala adjunctive kwa khunyu tsankho a khunyu, amene anatsagana kapena ayi limodzi ndi generalization sekondale. Njira anasonyeza kuti anthu odwala matendawa zowombetsa mkota chikhalidwe, komanso m'minofu.

contraindications

Palibe deta pa ntchito mankhwala ana ndi achinyamata zaka 17 kuphatikiza. Mogwirizana ndi mankhwala akapatsidwa okha akulu. Contraindications monga matenda cholowa monga galactose tsankho, akusowa lactase, komanso malabsorption shuga / galactose. chida si anasonyeza kuti hypersensitivity. Kuti tikhale ndi kugwiritsa ntchito bwino mankhwala odwala ndi kulephera aimpso ndi mtima.

zotsatira zoyipazi

Malinga ndi zimene zinachitikira ntchito yachipatala wa medicament, mu kugona Amowabu ndi chizungulire monga zotsatira osafunika. zinthuzo amakonda zimachitika digiri zolimbitsa kapena wofatsa. Mwa zotsatira zina mbali zinachititsa discontinuation wa mankhwala, tisaiwale asthenia, chisokonezo, kusawona bwino, incoordination, ataxia, edema zotumphukira. Palinso mavuto taonera mutu, kusowa kutsitsimuka, khunyu, kutupa lilime, kutsekula m'mimba, kunyansidwa, keratitis. Sindipeza kuyabwa khungu ndi angioneurotic anachita. Pali mkodzo posungira, edema m'mapapo mwanga ndi gynecomastia. Mwa zotsatira zina mbali amatchedwa kutopa.