Calcitonin - ndichiyani? Analysis kwa calcitonin. Calcitonin: akazi yachibadwa

Thyroxine ndi triiodothyronine - izi timadzi chithokomiro opangidwa ndi mabele England. Komanso C-maselo a thupi angathe secreting calcitonin. Ndi chiyani icho? Izi timadzi ndi chizindikiro cha kagayidwe kashiamu ndi akhoza kupangidwa osati mu chithokomiro England, komanso mu ziwalo zina. Makamaka bwino mapapo ndi thymus. Calcitonin kumatanthauza lamulo la kagayidwe mchere ndipo ali ndi zovuta mankhwala dongosolo ongokhala unyolo amino zidulo. Aliyense kuphwanya ndondomeko izi zimabweretsa kuti timadzi wotaya ntchito zake kwachilengedwenso.

Calcitonin - ndichiyani?

Ngati zichitika kuti vuto mu thupi, madokotala anafunsa kudziwa chifukwa cha magazi. Nthawi zina kuwulula nkhani za wambirimbiri amafotokozera ndi monga calcitonin. Ndi chiyani icho? Izi timadzi chithokomiro kutulutsa chake C-maselo. Iye oncomarker matenda a khansa chithokomiro tizidziwe kagayidwe kashiamu mu thupi.

ndi ntchito ya calcitonin chiyani?

Ntchito yaikulu ya calcitonin ali kukhazikitsa kanthu ankatsutsa ndi ulemu kwa timadzi parathyroid, amene amapangidwa ndi zopangitsa za parathyroid ndi nthawi kagayidwe kashiamu ndi kuonjezera wokhutira m'magazi. Calcitonin amalimbikitsa lamulo kashiamu ndi phosphorous misinkhu. Zolandilira kwa mankhwala akupezeka mu magazi (monocytes), nsengwa, m'mapapo, chiwindi, maselo fupa chapakati mantha dongosolo, Ziwalo zoberekera, impso.

Mafupa a timadzi izi kumathandiza leaching wa calcium, kotero kuti pali thandizo kwa kapangidwe ka mafupa. Calcitonin n'kofunika kwambiri pa nthawi imene mchere ndi anthu amadya lalikulu zedi. Zinthu ngati zidzachitika kukula yogwira wa mwana, mimba ndi mkaka wa m'mawere.

Magazi, timadzi izi ndi zofunika ndipo limachita hypocalcemic. Calcitonin amalimbikitsa amasulidwe salt mu mkodzo ndi Sachita adani awo mu intestine lapansi. Komanso Sachita milingo mwazi wa phosphorous, amene ali ndi mphamvu pa kachigawo m'mimba ndi impso.

Mabele England ambabala timadzi zedi ang'ono, ndi wokhutira magazi si kwambiri. Iwo akhoza kupangidwa m'matumbo, koma mu Mlingo miniscule kwambiri.

Calcitonin m'magazi

Chifukwa chiyani kuli kofunikira kuchita kusanthula pa calcitonin? A C-maselo, yotulutsa timadzi ichi, khansa limakula chithokomiro - carcinoma medullary, kapena carcinoma C-selo. Kukula kwa zotupa ngati akuchedwa, koma zovuta kwambiri, kufalitsa metastases kuti lymph mfundo pakhosi, ndi ziwalo zina zambiri. Ndi zovuta mankhwala amphamvu.

Popeza C-maselo kutulutsa timadzi calcitonin, nyamuka ake lakuthwa m'magazi angasonyeze pamaso khansa medullary chithokomiro. matenda oyambirira a matenda chakupulumutsa ambiri anthu.

Kodi milandu mwazi wa calcitonin chiyani?

maselo chotupa zambiri cholowa. Achibale onse a wodwalayo ayenera nthawi zonse amapereka magazi timadzi izi. Kuwonjezera diagnostics amenewa ntchito kuzindikira zisadzachitikenso kwa chotupa chotupa. Ngati pa ntchito histology anatsimikizira pamaso khansa medullary, kenako magazi calcitonin ayenera kutenga pa miyezi 3 kapena miyezi isanu.

Pali zifukwa zina kudutsa kufufuza:

• kudziwa matenda akuwuka chifukwa kagayidwe nthenda kashiamu;
• kwa matenda a kufooka kwa mafupa;
• kudziwa kubala zotupa;
• ndi fractures pafupipafupi ndi zizindikiro za matenda awo.

Norma calcitonin

Tiyenera kukumbukira kuti palibe chinthu monga m'munsi womangidwa miyezo timadzi pa mayeso magazi calcitonin. Norma adzakhala kukachitika kuti ndi mlingo ziro m'magazi. Nkofunika kuti si olumpha malire chapamwamba yachibadwa.

Mu Laboratories osiyana mlingo wa calcitonin m'magazi zingasiyane. Izi anafotokoza chifukwa chakuti reagents osiyana ndi zida apadera ntchito phunzirolo. Komanso, chifukwa zimadalira msinkhu ndi kugonana. A Kafukufuku njira ziwiri: mwa immunoassay enzyme ndi immunohemilyuminestsentnym.

Immunoassay njira ali zotsatirazi Buku mfundo timadzi zotere calcitonin:

• mlingo mu akazi - 0,07-12,97 PG / ml ya;
• mlingo wa amuna - 0,68-32,26 PG / ml ya;
• wakudziko ana - mpaka 79 PG / ml.

Ponseponse pa njira immunohemilyuminestsentnom:

• Akazi - 1,46 pmol / L;
• mwamuna - 2,46 pmol / l.

The chifukwa cha kuwunika zingasiyane mu akazi pa mimba ndi pamene yoyamwitsa.

Kodi akhoza kunena kuti mkulu mlingo wa timadzi chiyani?

Ngati wodwala calcitonin kuchuluka, ndipo ziribe kanthu momwe, Mulimonsemo ndi vuto lalikulu kwambiri kuti pamafunika zambiri mozama Kupenda Akatswiri kwambiri akatswiri ndi woyenera. Ngati zosonyezera calcitonin mu mwazi oposa 100 PG / ml, ndi pafupifupi 100% ndithu tinganene chotupa chija. The zambiri okwera timadzi mlingo ali, m'pamenenso ananyalanyaza ndi chotupa ndi wamkulu Mwina kupeza mu mfundo za lymph ndi ziwalo zina metastases ake.

Ngati wodwala ali chithokomiro tinatake tozungulira, ndipo anaikidwa kukhala singano biopsy, amene anasonyeza kuti ndi mtima wabwino ndi magazi calcitonin timadzi kuchuluka, m'pofunika kukhulupirira kwambiri chifukwa cha kuwunika, popeza n'zoona pafupifupi nthawi zonse. Pamene kuwonjezeka amphamvu kwambiri timadzi magazi kwenikweni opaleshoni kuti achotse kwathunthu chithokomiro England pamodzi ndi ozungulira mwanabele.

Komanso milingo medullary khansa timadzi kukwera pamene matenda otsatirawa:

• C-selo hyperplasia;
• ; Ellison - Zollinger
• mowa ndi matenda enaake;
• khansa ya neuroendocrine chikhalidwe;
• timathawa magazi m'thupi;
• psevdogipoparatireoidizm;
• carcinoid syndrome;
• thyroiditis ndi kapamba;
• matenda a m'mapapo a khalidwe chosaopsa;
• aakulu aimpso kulephera.

Pa chitsimikiziro cha matenda amenewa ayenera kuonetsetsa kuwachitira.

Pomaliza

odwala ambiri, madokotala mankhwala magazi mayeso yobereka kuti calcitonin. Ndi chiyani icho? Izi timadzi chithokomiro, omwe amaonjezera milingo zingasonyeze kukhalapo kwa chotupa chotupa cha thupi. Ndi kudziwika yake khansa medullary ndi chithandizo opaleshoni angathe kunena kuti vutoli kulibenso. Komanso, matenda amachititsa timadzi ta m'thupi achuluke zifukwa zina kuti ndi mankhwala nthawi yake kwa dokotala angathe kuchizidwa bwinobwino.