Analogs "Ksarelto": mtengo, malangizo ntchito

Mmodzi mankhwala, limene ndi gulu pharmacological wa wothandizila anticoagulant, mankhwala ndi "Ksarelto". Izi mankhwala kumabwezera mmbuyo chinthu Xa, ndipo nawonso, ndi chigawo chimodzi cha prothrombin activator ndi chimodzi pa kupereka yake magazi coagulation (katundu amenewa ndi analogues "Ksarelto").

Today ikuchitika anayesera njira zambiri amamupeza mupewe mankhwala, zomwe zimakhala zofanana ndipo motero kupereka osachepera mavuto. Patapita nthawi yambiri angapo khama woyenera mnzake - mankhwala "Pradaksa". The mankhwala - yekha mmalo kuti kwathunthu angagwiritsidwe ntchito m'malo mwa "Ksarelto" kukonzekera. makhalidwe ake ali pafupifupi zofanana kwa pamwamba, kusiyana kokha - ndi yogwira pophika okhutira, amene zokonzekera zonse ndi rivaroxaban.

pharmacodynamics

analogues onse "Ksarelto" kuchita chimodzimodzi. Chinthu chokha chimene iwo amasiyana - ndi kachulukidwe ndi Mkhalidwe chizindikiro cha mavuto. The woyenera analogue mankhwala lomwe lili ndi zotsatira yofanana ndi iyo, ndi mankhwala "Pradaksa".

Izi mankhwala ndi lofanana ndi Russian "Ksarelto" ali mwachindunji kwambiri kusankha mankhwala ziletsa kanthu za Factor Xa, mwachitsanzo ziletsa izo. Izi mankhwala ali mkulu m'kamwa bioavailability Koma enteral njira ya utsogoleli chapakati kwa izo.

Chapakati udindo mu kugwa kwa coagulation chinthu X kutsegula masewero wotsatira biotransformation chinthu Xa kudzera njira mkati ndi kunja coagulation.

umboni

Childs, analogs "Ksarelto" ndi kukonzekera yokha ntchito zinthu zotsatirazi:

• Kupewa ndi prophylaxis a sitiroko.
• Kupewa ndi chithandizo cha zokhudza zonse embolism.
  
  (Mu Zikatero, medicament akusonyeza odwala ndi fibrillation matenda, chimene chiri sanali valvular chiyambi.)

• Kuchotsa kapena kupewa plugging a kwambiri mtsempha thrombi.
• Kupewa zisadzachitikenso wa embolism m'mapapo mwanga.

Mankhwala "Pradaksa", omwe ndi ofanana ndi amenenso anasonyeza kuti kupewa zochitika venous thromboembolic odwala amene maopaleshoni m'malo imodzi mwa mfundo za miyendo m'munsi.

contraindications

Aliyense wofanana Russian "Ksarelto" ali ndi contraindications zotsatirazi (angakhale osiyana, koma Pamlingo zing'onozing'ono):

• tilinazo kapena chiopsezo maonekedwe a thupi lawo siligwirizana ndi zinthu zopezeka medicament ya;
• yogwira magazi amene waukulu informativeness ndi Kupenda matenda (mwachitsanzo, intracavitary magazi kapena kukha magazi mu ubongo);

• vuto limene pali chiopsezo magazi voliyumu, mwachitsanzo, pa njira yogwira chilonda kapepala kakuti m'mimba adakula;
• mankhwala wothandizira amene adzalandira katundu zofanana - kuteteza coagulation;
• ntchito unfractionated heparin pa mlingo koyenera kuti ntchito zogwira mtima wa catheter ya;
• matenda osiyanasiyana chiwindi, chitukuko cha zimenezi zingachititse magazi a etiology osiyanasiyana;
• zonse Anzawo "Ksarelto" ali contraindicated odwala ndi insufficiency aimpso, kunachitika gawo lililonse;
• lactose tsankho, osakwanira zili galactose mu thupi;
• mimba ndi mkaka wa m'mawere;
• komanso mankhwala ndi analogs zosiyanasiyana "Ksarelto" ulipo m'badwo malire 18+.

Category la anthu amene akhoza kutenga mankhwala mosamala ndi kuyang'aniridwa ndi katswiri

Mosamala ndi kuyang'aniridwa ndi dokotala akuonetsa ntchito "Ksarelto" malangizo ntchito (monga analogues) milandu zotsatirazi:

• ankachitira odwala amene ali pangozi yaikulu ya magazi mu mapangidwe ndi kuchuluka;
• Posachedwapa anasamutsa matenda anam'peza ndi kumakhala kutengera kuti ayambiranso;
• chithandizo kulephera aimpso amawasonyeza mosiyanasiyana limodzi ndi mankhwala kuti kuonjezera zili rivaroxaban mu thupi la wodwalayo;
• Odwala likufa mankhwala mankhwala angathe utithandize hemostasis;
• Kukonzekera amene angathe kuwonjezera mlingo wa rivaroxaban, mwachitsanzo, antifungal mankhwala azole gulu;
• mankhwala ndi analogue mapiritsi "Ksarelto" ali contraindicated odwala ndi HIV, ngati iwo anangoyamba zosiyanasiyana zoletsa protease wa HIV.

Kumwa pa mimba ndi yoyamwitsa

Chibwenzi, si yeniyeni mtima, monga chikoka "Ksarelto" analogues wa mankhwala pa efficacy ndi chitetezo amayi apakati.

Zatsopano inkachitikira nyama zasayansi asonyeza kutchulidwa kawopsedwe wa chinthu yogwira lokonzekera pa zamoyo mayi woyembekezera, monga mankhwala amachititsa aakulu kawopsedwe ubereki wabwino wa thupi wamkazi.

Malinga anapezazo choyezera, mankhwala "Ksarelto" analogue kuti ndi ofanana ndi iwo a kanthu pharmacological angathe kuwoloka latuluka, kotero mankhwala ali contraindicated.

Komanso m'nthawi ya ntchito "Ksarelto" akazi Tisaiwale za miyeso bwino kulera, kuyambira mimba, amene umabweretsa Kusinthanitsa kwa ndalama ya mankhwala, kungakusokonezereni chitukuko yoopsa.

Cholinga ziweruzo za zotsatira za mankhwala ntchito mu nyengo ya mkaka wa m'mawere, pa mphindi kulibe, koma maphunziro zasayansi nyama zasayansi amati yogwira mankhwala - rivaroxaban - amatha metabolize osati excreted mu mkaka wa m'mawere. Choncho, yoyamwitsa ayenera kusiya ntchito ya mankhwala.

Kuchokera pa deta imene maphunziro choyezera, tikhoza kunena kuti rivaroxaban sikumangotikhudza luso la kugonana okhwima chamoyo kulenga yotheka mbewu makoswe, koma anthu a mtundu ngati umenewu zatsopano akhala akufufuza.

Kagayidwe ndi kuwonongedwa njira

Pakuti phwando enteral pali njira zitatu kuswana, omwe akufanana ndi mmodzi mwa atatu chiwerengero cha sanali zimapukusidwa mankhwala:

• mkodzo excretion;
• excretion mu chimbudzi;
• Kupha kudzera aimpso excretion mzere (mu nkhani iyi, pafupifupi yachabechabe zimapukusidwa ndi inathetsedwa mu mawonekedwe unmodified).

Biotransformation rivaroksaba anachita ndi asilikali amene osadalira pa dongosolo cytochrome.

The njira yaikulu - pa makutidwe ndi okosijeni wa gulu morpholino komanso kukula kwa nsinga amide ndi madzi.

Studies amachitika m'galasi, mukhoza kuweruza kuti rivaroxaban ndi maziko P-glycoprotein ndi mapuloteni omwe amapereka kukaniza matenda oncological m'mawere.

Childs, kuchotsa metabolites ikuchitika nthawi 5-9.

zotsatira zoyipazi

Iye akuti malangizo pokonzekera ntchito: analogues "Ksarelto" kapena mankhwala kudzikonda ayenera kumwedwa yekha mankhwala. Langizo yokha mwatsatanetsatane dongosolo la mlingo wa mankhwala, kapena analogues ake. Onetsetsani kuwerenga malangizo phwando!

Pansipa akuganizira njira zonse osafunika ndi zochita amene anali mankhwala "Ksarelto" analogs. Price mankhwala - kuchokera rubles 900. Ndi yotchipa Mukaganizira kuti ambiri mavuto ndi mwaiwala zimene malamulo.

• Zotsatira zoyipa zimene anaona pamene kudziyesa magazi ndi dongosolo lymphatic, ndi magazi m'thupi ndi thrombocythemia, wosawoneka infrequently.
• Tachycardia - yekha anakwiya pamene mukumwa mankhwala.
• Kutayika kwa magazi.

Awa ndi mfundo contraindications mankhwala "Ksarelto" malangizo.

Analogs za mankhwala zikhoza kubweretsa wonongeka pa mundawo m'mimba: magazi, isanafalikire ululu, zizindikiro dyspeptic, nthawizina - pakamwa youma.

Chifukwa cha oyamba a zochita rivaroxaban m'dera angayambe: malungo, kutupa pa malo jekeseni pamene kutumikiridwa parenterally njira, kufooka ndi malaise.

Zikamera a pasukuluyi amathandiza kuti kukonzekera "Ksarelto" Akhristu. Mtengo wa mankhwala, monga ulamuliro, ndi muyezo pa unyolo wonse mankhwala.

Njira Ntchito ndi Mlingo

Tsatanetsatane za phwando zolondola angapereke mankhwala kapena kwathunthu "Ksarelto" malangizo. Analogues wa mankhwala pa nkhani imeneyi si mwapadera.

Izi mankhwala ndi alembedwe piritsi, kotero mapiritsi akutengedwa enterally. Ngati wodwala chifukwa ena sangathe kumeza phale - akhoza kuuluka ndi kusakaniza madzi abwino (tiyi, madzi).

Atalandira mankhwala mwamsanga kutsatira chakudya.

ambiri osokoneza

Kulephera kutsatira malamulo phwando "Ksarelto" zotheka ambiri osokoneza, amene zambiri ankachitira symptomatically, monga mankhwala ali adakalibe yeniyeni.

Pofuna kuchepetsa kumamatira ya mankhwala mu intestine ang'ono angathe kukhala sorbent iliyonse, monga adamulowetsa mpweya. Komanso kuti imathandizira excretion wa metabolites kofunika kupereka simuchita diuresis, yomwe ikuchitika kudzera ntchito yambiri madzimadzi ndi ntchito okodzetsa.

mitengo

Malinga Mlengi, mtengo ndi zimasiyanasiyana "Ksarelto" mankhwala kwa 899,00 rubles. chifukwa mapiritsi 10, amene ali ndi 10 mg wa yogwira pophika, kuti 1740,49 opaka.

Phukusi, imene 30 pellets, zikhoza kugulidwa kwa 3300,00 rubles.

The phukusi waukulu lili makapisozi 100, ndalama 8600 rubles.

Mitengo Policy "Pradaksa" mankhwala zimadalira zili kachulukidwe wa yogwira pophika pa kapisozi:

• 75 mg - 716,00 pakani.
• 110 mg - 1574,00 pakani.
• 150 mg - 1676,00 pakani.