Prostaglandin - izo ... Prostaglandins (mankhwala): dzina mtengo

Ambiri mwa njira mu thupi lathu zimadalira prostaglandins, amene amapangidwa pafupifupi zimakhala onse. Iwo amaona kuti mahomoni Komabe, iwo sali. Amachita preferentially pa malo kaphatikizidwe kenako pansi chiwonongeko. The mahomoni komanso mphamvu zawo pa mtunda ndi amadziŵika yekha ndi zopangitsa za endocrine ndipo zimakhala si kwa gawo lalikulu.

kaphatikizidwe wa prostaglandins

Tiyeni tione mapangidwe mankhwala mu thupi. Prostaglandin - mankhwala anapanga pa kagayidwe asidi arachidonic, ali Eicosanoids. zidulo mafuta ndi gawo la phospholipids, zimene zimapezeka mu zimakhala onse. Mu zochita za phospholipase A2 limawola n'kusanduka asidi arachidonic, kenako kukudza cyclooxygenase kapena lipoxygenase njira. Prostaglandins kupangidwa ndi woyamba.

ndi udindo mu thupi chiyani?

Eicosanoids kuchita zosiyanasiyana ntchito. Prostaglandin - mankhwala amene amagwira ntchito mwachangu kwambiri njira zinkachitika mu thupi lathu. Mwachitsanzo, prostaglandin E ali depressor tingati i.e. amachepetsa magazi ndi zokhudza mtima kamvekedwe. Komanso, prostaglandins (mankhwala ndi zachilengedwe) kuti yambitsa ndi contractile ntchito ya myometrium chifukwa cha zomwe ntchito kupatsidwa ulemu ntchito. zinthu zimenezi kuwonjezera kaphatikizidwe wa ntchofu kuti amapangidwa ndi maselo muyeso m'mimba. Ntchofu imagwira ntchito ndi zoteteza, kuteteza kanthu zinthu mwamakani pa mucosa lapansi. Komanso, chifukwa zinthu zimenezi ndi kuletsedwa mapangidwe pepsin ndi hydrochloric acid, amene bwino ntchito pa matenda a matenda chapamimba kucheza ndi anthu katulutsidwe wa zinthu zimenezi. Iwo bwanji katundu rheological magazi, inhibiting kupatsidwa zinthu za m'mwazi loitanirana. Prostaglandin E bwanji minofu maselo yosalala ya trachea ndi bronchi, kumalimbikitsa zosangalatsa, ndipo motero, kukula kwa Airways. Udindo wa prostaglandins mu kutupa ndi ululu. zinthu zimenezi si zokhazo bwanji mathero mitsempha ndi ulusi, komanso ali nawo maonekedwe a zizindikiro zina kutupa. Kusintha mu kamvekedwe mtima pansi zochita za prostaglandins zikubweretsa kuchulukana, ndi kuwonjezeka mu permeability a linga - chifukwa cha mapangidwe edema. Prostaglandins, kuwonjezera pa amadza mwina pa mitsempha vagus, kuchititsa kunyansidwa ndi kusanza. Woterowo zotsatira mbali nthawi zambiri ndi odwala. Prostaglandins - mankhwala (maina pansipa) ntchito kokha pansi zikuonetsa kwambiri.

Mogwirizana kwa prostaglandins ndi mankhwala odana ndi yotupa

Prostaglandin - ndi ophunzira mwachindunji mu ndondomeko yotupa. The kanthu za NSAIDs zachokera kuchepetsa kaphatikizidwe (cyclooxygenase enzyme ndi zoletsedwa). Yaitali ntchito NSAIDs kumabweretsa kupanda prostaglandins, chifukwa mu makutu chotchinga ntchito ya m'mimba - kuchepa katulutsidwe wa ntchofu. Ichi ndi zazikulu mbali zotsatira za mankhwala.

Prostaglandins - kukonzekera: dzina

Mankhwalawa amagwiritsidwa ntchito makamaka kwa matenda a m'mimba ndi duodenum chilonda, erosive chikhalidwe. Komanso, iwo kutumikiridwa kuti Zimachititsa chidule cha myometrium ndi kusintha magazi rheology.

"Misoprostol"

Prostaglandins (mankhwala) ndi inafalitsidwa mu zilonda zam'mimba muzituluka ndi mmatumbo chifukwa ntchito zake odana ndi secretory. Zimenezi amagwirizana ndi gwero pa prostaglandin zolandilira, zomwe zili maselo chapamimba parietal. Motero, "Misoprostol" ntchito ngati njira prostaglandin achilengedwe. Kukondoweza kupanga ntchofu amathandiza kuteteza Kakhungu mucous ndiponso kupewa mapangidwe zilonda latsopano. Zonsezi amalenga yabwino kwa machiritso a zilonda ndi erosions.

"Alprostadil"

Mankhwalawa ndi prostaglandin mankhwala E. Nthawi zambiri kutumikiridwa mu nthawi imene chofunika kuwonjezeka kuchepetsa myometrium wa - kupatsidwa ulemu ntchito. Komanso, mankhwala ntchito bwino magazi - chopinga wa kupatsidwa zinthu za m'mwazi loitanirana ndi vasodilation (atherosclerosis). Ilipo mu vayozi makonzedwe mtsempha.

contraindications

Onse mankhwala si kutumikiridwa, ngati pali hypersensitivity kuti prostaglandins ndi analogs zace. Pakati contraindications ndi - zaka 18, mimba ndi yoyamwitsa. Komanso kusamala awo odwala ndi insufficiency aimpso ndi kwa chiwindi, pathologies wa endocrine dongosolo, enterocolitis, magazi m'thupi.

Self-ka prostaglandin mankhwala popanda kufunsa katswiri sikuloledwa. Only dokotala akhoza kupeza mulingo oyenerera kusintha ndondomeko chithandizo, kutenga nkhani makhalidwe munthu wodwala. Malinga malo anu asintha mtengo. Prostaglandin alipo zosiyanasiyana ndi pansi zosiyanasiyana mayina mtundu, komanso mmoyo mtengo.

zotsatira zoyipazi

Nthawi zambiri, pamene mukumwa mankhwala kuyambitsa kuvutika a dongosolo m'mimba - nseru, kusanza, kutsekula m'mimba ndi matenda dyspeptic. Ngati inu matupi awo sagwirizana, amalembedwa pruritus, zotupa redness ndi kutupa, ndi zotheka anaphylactic zosiyanasiyana. Administration mankhwala akhoza kugwirizana ndi kusamba osasamba, dysmenorrhea. Kuchepetsa myometrium izo zambiri yodziwika ndi ululu pamimba. Mwa zotsatira mbali inayo - chizungulire, kupweteka kwa mutu, thupi kusinthasintha.

Mlingo wa chiopsezo mavuto ndi munthu aliyense wodwala. Pamene kuona zochitika ayenera kudziwitsa dokotala wanu ndiponso kusintha ndondomeko mankhwala.

Prostaglandin - mankhwala ofunika pa matenda a zilonda matenda chilonda ndi pathologies ena. Iwo kawirikawiri pamodzi ndi mankhwala ena kuti tikwaniritse zotsatira ankafunila. Kusankha mankhwala ndi mlingo wake zimadalira choncho matenda ndi makhalidwe mtima munthu.