Mitundu ya peroxidation. Matenda a lipid ndi matenda a mtima wa ischemic

Lipid peroxidation (LPO) ndi mgwirizano wofunika kwambiri mu kagayidwe kamene kagayidwe kamene kagayidwe kamene kagayidwe kake kagayidwe kamene kagayidwe kake kagayidwe kake kagayidwe kake kagayidwe kake kagayidwe kamene kagayidwe kamene kamayambitsa matenda. Ntchito yake yaikulu ndikusintha ma lipid of cell membranes.

Munthu yemwe ali ndi thanzi labwino, mankhwala omwe amachititsa kuti piritsididation ayambe kugwiritsidwa ntchito amatetezedwa ndi omwe amatchedwa antioxidant, omwe amachititsa kuti phosphorylation ikhale yogwira ntchito kapena kuwononga peroxides yokwanira kuti zisawonongeke. Kulimbitsa ndondomeko ya okosijeni kungakhale chiyambi poyambitsa matenda a chiwerengero cha matenda ambiri. Kuchita izi kumaphatikizapo magawo a autoxidation enzymatic and non-enzymatic.

Mitundu

Oxydatic oxidation amachitika kuti asinthe phospholipid piritsi ya membrane. Kuphatikiza apo, zimakhudza kupanga mapangidwe a zinthu zamoyo, kutulutsa thupi, kusintha kwa thupi. Kachilombo kosakhala ndi enzymatic kamadziwonetsera ngati chinthu chowononga m'moyo wa selo. Chifukwa cha kukhazikitsidwa kwa zida zowonjezera zaulere komanso kusungunuka kwa peroxides, ntchito ya antioxidant imachepa ndipo, motero, kufa kwa maselo kumachitika.

Ulendo wa LPO

Kwa kuyambira kwa lipidoni peroxidation, kukhalapo kwaufulu mpweya wothamanga, pokhala ndi mphamvu yochuluka mphamvu imodzi yopanda mphamvu electron, ndi kofunika. Pambuyo pa moleculeyo, mpweya wochuluka wa oxyoxide umapangidwa, womwe umachita ndi maatomu a haidrojeni, n'kusanduka hydrogen peroxide. Pofuna kuteteza kuchuluka kwa superoxide mkati mwa selo, pali superoxide dismutase yomwe imapanga hydrogen peroxide, ndipo puloxidase imapangitsa kuti madziwo asamangidwe. Ngati zamoyo zakhala zikudziwika ndi ma radiation, ikuluikulu ya zowonongeka za hydroxyl idzawonjezeka kwambiri. Kuphatikiza pa mpweya wa hydroxyde ndi mitundu ina yowonjezera ikhoza kukhala ngati oyambitsa njira yothetsera peroxidation.

Mankhwala a peroxidation amadzimadzi amagwiritsidwa ntchito ndi thupi kapena amagwiritsidwa ntchito pa kaphatikizidwe ka prostaglandins (zinthu zomwe zimagwira ntchito yotupa), thromboxanes (kuphatikizapo kutuluka kwa machitidwe a thrombus-forming reaction), mahomoni adrenal.

Njira yoyendetsera

Malinga ndi kapangidwe kakang'ono ka selo, maselo, ntchito ndi kuchuluka kwa mankhwala opangidwa ndi okosijeni amatha kumasiyana. Kotero, mwachitsanzo, ntchito ya lipidocidation ndi yapamwamba kwambiri pamene unsaturated mafuta acids amalowa mu selo khoma , ndipo pang'onopang'ono ngati maziko a CS ndi cholesterol. Kuonjezera apo, mavitamini opangidwa ndi mavitamini ndi chinthu chomwe chimapanga kuchuluka kwa kuchuluka kwake ndi kuchuluka kwa mapangidwe a mpweya wofewa, komanso kugwiritsa ntchito peroxides. Ngakhale momwe lipidosis ikuyendera, zinthu zomwe zimakhudza chilembo cha memphane ndi kusinthika kwake molingana ndi zosowa za thupi zimatenga mbali. Izi zikuphatikizapo vitamini E ndi K, thyroxine (hormone ya chithokomiro), hydrocortisone, cortisone ndi aldosterone (pambali ya ndemanga). Ioni yachitsulo, vitamini C ndi D. zimathetsa khoma la selo.

Kuchita Zachiwawa

Zamagetsi zamadzimadzi amadzimadzi amatha kusonkhanitsa minofu ndi mazimadzi a thupi ngati antioxidant silingathe kuwataya pa mlingo woyenera. Chotsatira chake, kutumiza kwa ions kudzera mu membrane kamene kumasokonezeka, zomwe mwachindunji zingakhudze maonekedwe a ionic mu gawo la magazi, kuchuluka kwa polarization ndi depolarization ya minofu selo membranes (kusokoneza kutentha kwa mitsempha, chigwirizano chawo, kuwonjezera refractory nthawi), kulimbikitsa madzi kuthamanga mu extracellular malo (edema, Kuthetsa magazi, kuphwanya mphamvu ya electrolyte). Kuwonjezera pamenepo, mankhwala opangidwa ndi mankhwala ozunguza bongo, pambuyo pochita zinthu zamoyo, amatembenuzidwa kukhala aldehydes, ketoni, zidulo, ndi zina zotero. Zinthu zimenezi zimakhala ndi poizoni thupi, zowonongeka pa mlingo wa DNA, kufalikira kwa capillary permeability, kuwonjezeka kwa oncotic pressure, monga Zotsatira zake, matenda a sludge-syndrome.

Mawonetseredwe kuchipatala

Popeza kuchuluka kwa mpweya wokhala ndi mpweya wabwino kumapangitsa kuti khomalo likhale lopweteka, komanso mankhwala owonetsa zamadzimadzi amachititsa kuti thupi liwonongeke komanso kuti liwononge thupi, ndizopangitsa kuti pakhale njira zambiri zochizira matenda. Udindo wa podididation wamadzimadzi ndi wofunikira pa matenda a chiwindi, mapepala, matenda opatsirana a parasitic, matenda a hemodynamic, matenda a chilengedwe, kuvulala ndi kuwotchedwa. LPO ndi chimodzi mwa zinthu zomwe zimayambitsa matenda a atherosclerosis. Mankhwala opatsa mphamvu, oxidizing kolesterolini ndi otsika kwambiri maselo olemera tizigawo ting'onoting'ono, mawonekedwe omwe amawononga mitsempha. Pachifukwa ichi, kuwonongeka kwa zochitika zomwe zimachitika pofuna kuthetsa kuwonongeka kwayambitsa. Izi zimayambitsa thrombosis, kuwonjezeka kwa magazi m'makina a ziwiya zazing'ono kapena kumangirira kumakoma awo. Zotsatira zake, kuyenda kwa magazi m'dera lino kumachepetsanso, chifukwa kuwala kwa chiwiya kwafika kale. Izi zimapangitsa kuwonjezereka kwa magazi. Mitsempha yamakono, aorta, yomwe imawonetseredwa kuchipatala monga zizindikilo za matenda a mtima wodwalayo, amatha kutenga kusintha koteroko.

Njira zothandizira

Ogwira ntchito akuyenera kukumbukira kuti kuchita njira zothandizira ndi zamankhwala zingayambitse njira yothetsera peroxidation. Izi ziyenera kuchenjezedwa wodwalayo. Mankhwala opatsirana pogwiritsa ntchito mankhwala opatsirana pogwiritsa ntchito mankhwala ozunguza bongo (ultrasound), ultraviolet irradiation (chifukwa cha ziphuphu, matenda opweteka a m'mphuno, mankhwala ophera antibacterial malo), maginito (MRI, CT, physiotherapy), magawo a chipani (ndi poliomyelitis, matenda a m'mapiri) ndi zinthu zopweteka .

Kupewa ndi mankhwala

Ogwira ntchito pazipinda zam'malasi, anamwino ndi anamwino, akatswiri a physiotherapy, okwera mmwamba, anthu olemera kwambiri ayenera kudya zakudya zowononga antioxidants: nsomba, mpendadzuwa kapena mafuta, masamba, mazira, tiyi. Kuwonjezera pa kusintha zakudya, ndizotheka kugwiritsa ntchito mankhwala omwe amamanga magulu ena a zowonongeka mopanda malire kapena kuphatikiza ndi zitsulo za valence yosinthika. Motero, amasintha ma molekyulu a mpweya wabwino, osalola kuti amangirire ku LPO amplifiers.

Zofufuza

Pakadali pano kafukufuku wamaphunziro a labotale, timatha kuona peroxides m'thupi la thupi la thupi. Kuti muchite izi, mukuyenera kuyendetsa makina a microscopy. Mwachidule, kuti mudziwe peroxidation. Kufunika kwa chiyeso cha matendawa sikufunikira kufotokoza. Ndipotu, maziko a matenda ambiri ndi ntchito yochuluka ya lipid peroxidation. Kuzindikiritsa chikhalidwe ichi kumayambitsa njira zamankhwala.

Kuchokera pamalingaliro ochiritsira, kuthamanga kwa pirisidi ndi kofunikira kuti apange mahomoni a steroid, omvera opatsirana, ma cytokines ndi thromboxanes. Koma pamene chiwerengero cha mankhwala ogwiritsira ntchito mankhwala osokoneza bongo amatha kupitirira chilolezo chovomerezeka ndi peroxides kuwononga maselo a organelle, kusokoneza kaphatikizidwe ka DNA ndi mapuloteni, antioxidant dongosolo lomwe limachepetsa kuchuluka kwa mphamvu zopanda mphamvu za mpweya, zitsulo zamitengo zomwe zimagwira ntchito zosiyanasiyana zimayamba kugwira ntchito. Kuonjezera apo, imapangitsa kuti puloxidase ayambe kugwiritsidwa ntchito kuti agwiritse ntchito mankhwala osokoneza bongo komanso mankhwala enaake.