"DioCore 160": malangizo ntchito, Akhristu enieni. "DioCore payekha 160": malangizo ntchito kwenikweni

The anthu ambirimbiri zina akudwala BP. Komabe, chikhalidwe chotere pathological osati kumabweretsa kusapeza kwambiri kwa mtima, komanso likuoneka moyo wake. Choncho, msika mankhwala masiku ano pali zinthu zambiri zimene zimachititsa kutsitsa magazi.

Wotchuka kwambiri pakati pa anthu amene amakonda akudwala matenda oopsa, akugwiritsa ntchito mankhwala monga "DioCore 160". Malangizo ntchito, analogues mankhwala, komanso ndemanga za izo, mbali ndi katundu Adzaperekedwa pang'ono.

Zikuchokera, maonekedwe, ma CD ndi mawonekedwe

Medicine "DioCore 160" mfundo uli mu bokosi chidapangidwa kuchokera ku katoni, chopangidwa mu mawonekedwe a mapiritsi. Iwo filimu-lokutidwa ndi ali zosakaniza ngati yogwira monga valsartan ndi hydrochlorothiazide. Komanso lipoti njira zikuphatikizapo microcrystalline mapadi, sodium lauryl sulphate ndi wowuma mbatata, talc, wowuma chimanga, croscarmellose ndi sodium, magnesium stearate, colloidal anhydrous silika ndi opadry II Orange.

Sitingathe kunena kuti mankhwala, ndipo angapezeke pa malonda monga "DioCore payekha 160". Kuchokera yapitayi kumasiyana kuti pophika ake yogwira amachita kokha valsartan.

Mfundo ntchito medicament ndi

Kodi mankhwala "DioCore 160"? Malangizo malipoti ntchito kuti wothandizila izi antihypertensive, amene wapangidwa ndi diuretic thiazide ndi angiotensin II cholandilira antagonist.

chida ichi ali osiyanasiyana zotsatira zokhudza thupi lomwe akutengedwa ngati gawo mozungulira m'mbali mwa lamulo magazi. Angiotensin II Ichitu vasoconstrictor wothandizila chifukwa cha pressor zotsatira mwachindunji. Komanso akuzengereza ndi soda ndi kumapangitsa munthu katulutsidwe wa aldosterone.

Valsartan otchedwa yogwira mosabisa angiotensin II cholandilira antagonist. Bukuli lakonzedwa kuti makonzedwe m'kamwa ndi kusankha kuchita zimene AT1 cholandilira subtype kuti ali ndi udindo zotsatira za angiotensin II. Tsankho agonist ntchito pa lilime subtype AT1, chinthu ichi sangosonyeza.

Komanso valsartan osati ziletsa Ace, amene otembenuka angiotensin ine angiotensin II, bradykinin kuwononga. Mwaonapo ndi mavuto chifukwa cha bradykinin.

Mu anthu ndi oopsa, mankhwala zimayambitsa kuchepa magazi. Pankhaniyi, izo ziribe mphamvu pa mlingo mtima.

odwala ambiri pambuyo mlingo umodzi wa nkhani mankhwala kuyambira ntchito antihypertensive anati pasanathe maola 2, ndi kuchepetsa magazi pa maola 6.

Zotsatira antihypertensive mankhwala timavutika kuposa tsiku. Pa mapiritsi zonse pazipita achire zotsatira zimatheka mwa masabata anayi ndipo anakhalabe mu njira ya mankhwala yaitali.

Pharmacokinetics

ndi chibadidwe kayendedwe katundu wa medicament "DioCore 160" Kodi? Malangizo ntchito (mapiritsi ayenera mankhwala dokotala yekha) limanena kuti kumwa mankhwala mkati mayamwidwe wa hydrochlorothiazide ndi valsartan mofulumira kwambiri. Wapakati bioavailability mtheradi wa wothandizila ichi chinali 23%.

The kinetics wa valsartan ndi liniya. Mobwerezabwereza ntchito mankhwala sumabala kusintha kulikonse. Ndi piritsi limodzi la kudzikundikira awo ndi negligible.

Valsartan wamangidwa kwa mapulotini plasma pa 94-98%. excretion ake ikuchitika pamodzi ndi ndowe ndi mkodzo. Pamene anatengedwa pamodzi ndi AUC wa valsartan chakudya yafupika ndi 48%.

Atalandira mapiritsi mkati hydrochlorothiazide mayamwidwe limapezeka m'malo msanga (za 2 hours). Komanso, bioavailability ake ndi 60-80%. Atachitira mu mkodzo.

Ndi mitundu valsartan ndi hydrochlorothiazide zokhudza zonse bioavailability wa iwowa yafupika ndi pafupifupi 30%.

mapiritsi zikuonetsa

Kodi zinthu wodwala Akhozanso kusankha mankhwala "DioCore 160"? Malangizo ntchito, madokotala kwenikweni amanena kuti chida ichi bwino kuonekera oopsa, komanso kusowa mphamvu ya matenda ndekha.

Contraindications kulandira magomewo

Kodi mukudziwa kuti nthawi zina, osati Kwalamulidwa mankhwala "DioCore 160"? limati Manual kuti mankhwala otere contraindicated mu tsankho munthu wa kaphikidwe kake.

Komanso, ndikoletsedwa ntchito odwala ndi cholestasis, aakulu kuwonongeka chiwindi, ndi matenda enaake biliary. Komanso, si Kwalamulidwa kwa anthu amene amadwala zilizonse kwambiri ndi zolimbitsa kukanika aimpso, chizindikiro cha anuria, yafupika soda ndi potaziyamu misinkhu mu magazi, hypercalcemia ndi hyperuricemia.

Miyala "DioCore 160": malangizo ntchito

Tinganene, kuthetsa BP kunyumba kwa odwala kulengeza ntchito limodzi piritsi "DioCore 80" kamodzi pa tsiku. Koma "DioCore 160" mankhwala, izo Kwalamulidwa yekha m'chipatala. Pankhaniyi, wodwala ayenera kukhala kuyang'aniridwa zonse dokotala.

Monga mmene angachitire, ngati zotsatira noticeable pa matenda oopsa amphamvu anati masabata 2-3 ukatha mwambo wa mankhwala.

Kwa anthu ndi zolimbitsa kapena kwambiri kwa chiwindi kapena aimpso kuwonongeka chofunika kuchita zofunika kuwukonza mlingo osiyanasiyana (payekha).

Kutalika kwa mankhwala ndi mankhwalawa tiyenera kuyesetsa kokha ndi dokotala nawo.

zotsatira zoyipazi

Kodi mtundu mavuto kwa wodwalayo ayenera kudziwa musanayambe kugwiritsa ntchito mankhwala "DioCore payekha 160"? Malangizo Ntchito limanena kuti ankaona mankhwala kawirikawiri amachititsa zochitika chokhwima kuti ndi kusakhazikika ndiponso kudwala chimatanthauza khalidwe.

Pafupifupi 1% odwala pamene akumwabe mankhwala anaonekera mutu ofooka, kupweteka kwa msana, kutopa, chifuwa, chizungulire ndipo nasopharyngitis.

Zosakwana 1% anadandaula ululu m'mimba, kuda nkhawa kusapeza mu khosi ndi chifuwa, kutopa, molumikizana mafupa, matenda serous, kugona, laryngitis, kufupika kwa mpweya, matenda otsekula m'mimba, yafupika erection, kuchepa salivation, hypotension, gastroenteritis, paresthesia, kuchuluka thukuta, utachepa tilinazo, omangana minofu tulo, edema zotumphukira, nseru, matenda khutu, kuchulukana m'mphuno ndi kuwuka pang'ono thupi kutentha. Nthawi zina odwala chakhungu masomphenya, wosakhazikika tachycardia ndi tinnitus. Tikumbukenso kuti kugwirizana ndi pakutchulidwa mosiyanasiyana awa ndi mankhwala sichinayambe anakhazikitsa.

Kodi zotsatira zina zikhoza kuchititsa mankhwala "DioCore payekha 160"? Malangizo pa ntchito ukusonyeza kuti ntchito chida ichi panali malipoti wakutali wa isanayambike totupa, kuyabwa ndi zina mawonetseredwe awo sagwirizana, kuphatikizapo vasculitis, ndi matenda seramu. Komanso, odwala amatha kukhala myalgias ndi nefralnaya kukanika.

chosowa kwambiri mawonekedwe mavuto pamene mukumwa "DioCore 160" mankhwala ndi zovuta sanali cardiogenic edema kuti amagwirizana ndi tsankho munthu wa hydrochlorothiazide.

Kafukufuku wasonyeza kuti odwala ena ankachitira ndi chida ichi, utachepa potaziyamu mu magazi, kuika creatinine ndi urea, komanso akudzizindikiritsa neutropenia wofatsa.

Zizindikiro cha mankhwala osokoneza bongo

ndi zizindikiro za "DioCore payekha 160" ndi mlingo waukulu wa mankhwala chiyani? limati Manual kuti Zikatero sakudziwika pa nthawi ino.

The chizindikiro chachikulu cha kuchuluka mlingo wa mankhwala akhoza kukhala aakulu hypotension. Ngati mankhwala Analeredwa ndi posachedwapa, wozunzidwayo chofunika chongopeka kupangira kusanza. Komanso nkhondowo hypotension akhoza ikuchitika ndi makonzedwe mtsempha wa saline yachibadwa.

Tiyenera kukumbukira kuti n'zosatheka tikuona mankhwala ankaona m'thupi mwa hemodialysis. Ichi ndi chifukwa chakuti valsartin, m'gulu kapangidwe kake, umakaphatikizana ndi mapuloteni plasma. Komabe, tisaiwale kuti hydrochlorothiazide likuchotsedwa motere ndithu bwinobwino.

Mwanjira mankhwala ndi mankhwala ena

Kodi n'zotheka zimagwirizizirana ndi njira zina "DioCore 160"? Malangizo limanena kuti kuphatikiza kwa mankhwala ndi mankhwala ena antihypertensive gulu angathandize kuti patsogolo zotsatira za kutsitsa magazi.

The ntchito munthawi yomweyo ya medicament ndi zina potaziyamu munali, okodzetsa wofatsa, solezamenitelyami ndi zinthu zimene zimawonjezera zili potaziyamu mu thupi, amafuna zonse mayeso ambiri potaziyamu mu seramu magazi.

Pamene munthawi yomweyo makonzedwe "DioCore" ndi zoletsa Ace akhala kuzindikiridwa kusintha kuwonjezeka mu ndende ya lifiyamu m'magazi.

Kodi mankhwala akhoza bwinobwino ntchito mankhwala "DioCore 160"? Guide inanena kuti monotherapy oopsa chida ichi silinkachitidwa mogwirizana iliyonse ndi "glibenclamide", "amlodipine", "warfarin", "cimetidine", "Digoxin", "furosemide", "indomethacin" Atenolol ".

Popeza mankhwala zikuchokera pansi kulingalira zikuphatikizapo thiazide diuretic gulu chake ankachita Nkosatheka zotsatirazi:

• ndichepe tingati diuretic mankhwala pamene ntchito pamodzi ndi NSAID (mwachitsanzo, salicylates kapena "Indomethacin");
• potentiation wa relaxants minofu.

mankhwala zimene ankachita ena ayenera kudziwa pamaso kutenga "DioCore 160"? Malangizo, ndemanga akusonyeza kuti pamene ntchito chida ichi ndi okodzetsa kaliynesberegayuschimi, salicylates, ACTH, amphotericin karbenokslolonom ndipo mwina kuchepa lakuthwa mu ndende ya potaziyamu m'magazi.

Pamene ntchito jekeseni ndipo m'kamwa mankhwala antidiabetic ayenera idzachitika payekha kusintha mlingo awo.

Iwo ali osavomerezeka kutsatira medicament ankaona pamodzi ndi okodzetsa thiazide gulu, monga izi umene umakulitsa zotsatira tatchulawa mbali ya mankhwala ndi chifukwa zochita hypersensitivity.

Pamene ntchito imodzi ndi methyldopa hydrochlorothiazide angathe hemolytic magazi m'thupi.

Zimagwira mankhwala "DioCore 160" ndi kolestiraminom amachepetsa bioavailability ake ndi mayamwidwe.

Pamaso mankhwala a vitamini D mu magazi ndende kashiamu akhoza ziwonjezeke odwala.

Iwo amaletsedwa kujambula "DioCore" ndi cyclosporine, monga izi zingachititse zizindikiro ndi chikhalidwe podagropodobnye giperurikekii.

ayamikira enieni mapiritsi

Kodi mukufuna kudziwa musanayambe kugwiritsa ntchito mankhwala "DioCore payekha 160"? Malangizo ntchito, ndemanga kuti pa mankhwala ndi wothandizila ichi mu mtima ayenera nthawi zonse kuwunika milingo seramu wa electrolytes m'magazi.

Ndi chitukuko cha hypotension anakhudzidwa ayenera n'kukhala ndi udindo yopingasa. Ngati chofunika, achite ndi kulowetsedwa mtsempha wa saline yachibadwa. Pambuyo ofunika kuthamanga chithandizo akhoza anapitiriza.

Anthu ndi unilateral kapena amgwirizano aimpso mtsempha wamagazi stenosis kulandira valsartan zikhoza kuwonjezeka mu seramu creatinine kapena magazi urea.

Pamene kugawa ndi medicament odwala mkhutu impso kusintha ntchito mlingo chofunika, koma pamafunika nthawi kuwunika creatinine acid uric, ndipo zili potaziyamu magazi.

Pali umboni kuti okodzetsa thiazide akhoza zimawonjezera zokhudza zonse lupus erythematosus. iwonso kusintha shuga kulolerana wodwalayo, kuwonjezera ndende ya mafuta, ndi asidi uric mu triglyceride magazi. Pa nkhani imeneyi, odwala matenda a shuga kungafune kusintha kwa mlingo wa wothandizila m'kamwa hypoglycemic kapena insulin.

Odwala ndi zolimbitsa zazing'ono kuwonongeka chiwindi popanda cholestasis ndi kusintha mlingo chofunika. Koma pansi pa zikhalidwe izi mankhwala ayenera kumwedwa mosamala kwambiri.

Pali malipoti a photosensitivity pa mankhwala ndi okodzetsa thiazide. Ngati mu njira ya mankhwala ndi izi zikutanthauza kuti pali zimene photosensitivity, mankhwala ayenera anasiya.

Ngati ndi kotheka, mobwerezabwereza ka diuretic ndi tikulimbikitsidwa kuteteza mbali osatetezeka cheza yokumba ultraviolet kapena dzuwa.

analogues mankhwala

Kodi tinganene kuti m'malo njira yathu? Malinga aluso ofanana katundu ndi mankhwala monga "Air nyanja", "Dentokind", "Intsena", "Cinnabsin", "Softovak", "Medotsef" "Vinblastine-Teva".

Reviews kukonzekera

Tsopano inu mukudziwa momwe ntchito mankhwala "DioCore 160". Malangizo ntchito mankhwala wakhala anafotokoza pamwamba.

chida ichi chotchuka kwambiri pakati pa odwala ndi madokotala. Akatswiri amanena kuti mogwira kumaonekera pamaso pa aakulu hyperplasia wolumikizira. Ogula kwathunthu kugwirizana ndi ichi. Malinga ndi mayankho awo kutenga limodzi amalimbikitsa kubwezeretsedwa kwa magazi, komanso atsogolere chikhalidwe chawo.

N'kosatheka kuona chakuti mankhwala umakhala yabwino ya kumasuka ndi mlingo. Komabe, kutenga mlingo wapamwamba mankhwala ayenera kukhala mu chipatala, kuyang'aniridwa ndi dokotala.