Dendritic maselo: khalidwe, ntchito, ntchito chitetezo antimicrobial. maselo Dendritic ndi khansa

Pali zambiri kumuopseza kuti akhoza amavutitsa kwambiri ndi thupi la munthu. Monga zitsanzo za mitundu yowala osiyanasiyana matenda ndipo ngakhale khansara. Ndipo n'kofunika kuti, pamodzi ndi njira mwachizolowezi ya chithandizo cha matenda amenewa monga malo ano sayansi ndi zipatala ayamba kugwiritsa ntchito maselo dendritic. zimakhudza awo ndi kusintha uku mu chandamale chamoyo, chifukwa kukondoweza yokumba wa ntchito m'thupi.

maselo dendritic

The Ndipotu mmene bwino munthu adzatha kugwira ntchito zake zofunika, koma pa zinthu zambiri zimadalira mkhalidwe wake chitetezo. Popanda chitetezo ichi, thupi kunapezeka kuti osatetezeka kwambiri ku nkhope ngakhale ang'ono ndi miyezo yamakono ya matenda. Ndipo udindo wofunika kwambiri chitetezo cha m'thupi amachita yovuta ya nkhondoyo wa maselo a khansa. Komanso, monga yolimbirana thanzi la thupi chikuchitika mosalekeza.

Ngati kumvetsera kwambiri zimagwirira chitetezo ya thupi, ndiye mungaone kuti chimodzi mwa zigawo zofunika a dziko loipali ndi Antigen-kupereka maselo. Nawonso, anawagawa m'magulu atatu ofunika: B-lymphocytes, macrophages ndi maselo dendritic. Ndipo chifukwa chakuti nkhani khama otsiriza, ndipo adzakhala bwino.

Ngati timamasulira mawu kuchokera dendron Greek, izo zikutanthauza kanthu, ngati mtengo. Mawu amenewa ntchito udindo mtundu pansi kulingalira chifukwa maselo ali enieni nthambi dongosolo.

Features

mtundu wa khungu Sikuti pofotokoza zinthu phagocytic, koma udindo wawo mu analamula Poyankha cha m'thupi sitingalephere kukambapo. Maselo a mtundu akhoza kukhala mwina okhwima kapena ayi. Yotsirizira nthawi zambiri anakonza khungu.

maselo Dendritic amatha kukhala ngati mafupa-anachokera, ndipo osati (myeloid ndi lymphoid).

Kutanthauzira kwa mtundu lymphoid - ndi ndulu, thymus, lymph mfundo ndi magazi. Cholinga chawo mu chidwi thymus chifukwa kumeneko ali ndi udindo kusankha negative. Ndi ndondomeko izi anamvetsa kuchotsa T-lymphocytes, omwe ali ndi luso kuchita antigens kudzikonda.

Pankhani maselo myeloid, ali minofu interstitial, zikopa mucous ndi khungu. Pankhaniyi, iwo akhoza yodziwika monga mafoni.

Palibe fupa maselo mafuta-linachokera, nayenso zili follicles ziwalo lymphoid. Iwo kudzapereka Antigen wa B-lymphocytes, ndipo pamwamba pa maofesi m'thupi.

kapangidwe

Musanayambe kulabadira mmene mankhwala anachita ndi maselo dendritic, muyenera tcheru dongosolo lawo. Fotokozani mmene akhale sakanikira gulu, amene lagawidwa mitundu iwiri zimagwira ntchito zosiyanasiyana Chrixitu. Komabe, mitundu onse zooneka ngati zofanana.

Mtundu wa selo uli nkhani zithunzi: ali wozungulira (nthawi zina chowulungika) ndi wamkulu mokwanira. Pa nthawi yomweyo iwo apanga nthambi, contours osasamba ndi ndondomeko. Iwo ndi phata ndipo cytoplasm ladzala mkati organelles awo. Koma pamwamba, ndiye wakhala lolunjika kwambiri za maselo.

maselo amenewa m'thupi ambiri ndi iwo ali pafupifupi zimakhala onse ndi ziwalo.

Dendritic maselo: Ntchito

Monga tanena, cholinga chachikulu cha mtundu uwu maselo yafupika Antigen ulaliki. Mawu amenewa amagwiritsidwa ntchito ponena kuti ndondomeko imene loyamba chiwonongeko cha zinthu mlendo, ndipo pambuyo - Kupha (zabiranie) zigawo kupanga ukulimbana ndi tinthu yachilendo.

Mwa njira: kuti n'chongoletsa zigawo zikuluzikulu woopsawo ntchito phagocytosis. Kamodzi kuopseza angathe yathetsedwa, ndi antigens anagwidwa ndi kunditumiza ku maselo ena immunocompetent. zoyendera zimenezi n'kofunika kuti kufala kwa uthenga ku mbali zonse za dongosolo chitetezo. Mwachidule, maselo dendritic kupereka uthenga chitetezo chokwanira kuti inalembedwa ngozi. Chifukwa, chitetezo zapatsidwa kwa boma, titero, tcheru ndi purposefully midadada anasankha kuopseza.

Pa nkhani ya chitetezo ku matenda, muyenera khutu ku mtundu uwu maselo dendritic ngati zinthu plazmotsitoidnye. Mu mapangidwe awo nawo chimodzimodzi nyongolosi selo, mu nkhani ya lymphocytes. Mtundu wa midadada selo ndi kupitirira matenda mwa Kupeleka interferon.

zotsatira za ndondomekoyi

Dziwani ndi Ubale umene ndi maselo dendritic, immunology, ndi mankhwala a khansa.

Pankhaniyi, poyamba ndi zofunika kuti Atchule chakuti maselo amenewa mosavuta chinaonekeranso mu zasayansi zamakono. Kuti tikwaniritse zotsatira izi, m'pofunika nadzawasankhula monocytes ku zigawo zina magazi. Sitepe kumakhala vuto luso. Pamakhala kukhudzana ndi maselo chikhalidwe ndi zinthu zina, kwa masiku angapo kapena maselo tsinde kusandulika monocytes mu zinthu dendritic, amene anali cholinga choyambirira.

Tsopano pali zipatala zambiri kuti mupereke chida zochizira maselo dendritic. Immunology watsala ndi kanthawi kochepa choncho mpaka kutsogolo kuti njira imeneyi zimathandiza kuti bwino kulimbikitsa matenda m'malo zovuta, kuphatikizapo chilengedwe oncological.

Komanso, kafukufuku zatsimikiziridwa chifukwa chakuti oyamba a zinthu za chitetezo cha m'thupi akhoza kupereka amphamvu zotsatira zabwino mu chithandizo cha odwala amene akudwala matenda aakulu ndi zaka zoposera imodzi.

A pang'ono zimenezi vuto lalikulu monga khansa

Kumvetsetsa momwe izo zimachitika mankhwala ndi khansa selo dendritic, n'zomveka kulabadira vuto palokha.

Choncho, ngati inu mutayang'ana pa thupi kwambiri, mungapeze mfundo odziwika ndi thupi lopangidwa ndi maselo, kapena kani, dongosolo lonse, umene aliyense chigawo amachita ntchito yeniyeni. Nthawi zina zimachitika kuti azikula, sayenda ndiponso kukula kwa gulu linalake atayika. Chifukwa cha imfa ichi mofulumira ndi kusalankhula kuchuluka kwa maselo amenewa, amene ayamba kudutsa minofu, ili pafupi nthawi yomweyo.

Nkhani ya maselo kugonjetsedwa ndi khansara mu thupi si zokhazo: ilowa m'magazi kapena lymphatic njira, kenako kufalikira ku madera ena a thupi kupanga metastases ndi bulanchi chotupa. Komanso Dziwani chakuti zotupa okha kwambiri - oposa zana mitundu. Ndipo aliyense wa iwo ndi wapadera.

Mfundozi zachokera kuti madokotala ali pa mphindi, tikhoza kunena motsimikiza kuti munthu wa zinthu zofunika zimene kudziwa za tsogolo la chotupa, ndi chitetezo munthu. Ndicho chifukwa dendritic maselo ndi khansa - izo ndi njira zothandiza kuthana ndi chotupa.

ndi mankhwala Kodi

maselo kholo yeniyeni olekanitsidwa magazi wodwalayo. N'zofunika kwa kukula wotsatira maselo dendritic. Pambuyo pake, kulenga zinthu zonse zofunika kuonetsetsa kuti khalidwe anakhumba, yomwe ili yofunika kwambiri pa chitukuko zina zakuthupi osungidwa.

Akatswiri kudikira gawo imene yakucha, ndipo anawonjezera kuti chikhalidwe selo chotupa nyumba akamagwira kukonza majini. Salamulidwa kugwiritsa ntchito otchedwa zinyalala ndi chotupa mtima. Komanso pali adani selo kalambulabwalo oopsa amafotokozera, kenako kusintha kapangidwe ake.

Phindu mnjira kwagona maselo dendritic anayamba yeniyeni kuzindikira chizindikiro khalidwe kwa zotupa. Komanso, zochitika zimenezi imafalikira ndi dongosolo lonse mthupi.

Chomaliza - anadzetsa thupi wodwala, maselo dendritic. Katemera ndi imodzi mwa njira wamba wochita ntchito imeneyi. Kamodzi njirayi imagwiridwa, pali gulu yogwira maselo mu mwanabele ndi kutsegula wotsatira wa cytotoxic T-lymphocytes. asangalatsi Awa anakumana ndi zinthu monga chotupa kuwononga iwo kwathunthu.

Kamodzi kuopseza wakhala wapezeka ndipo anazindikira, amayamba kufufuza ake mu m'magazi ndi thupi zimakhala. Kamodzi chandamale chikupezeka, selo yoimba adzakupanikizani kuwonongeka chakupha mchitidwe ankhanza ndi amatithandiza mfundo imeneyi kwa chitetezo cha m'thupi kudzera yopanga zinthu zenizeni.

Ameneyo ndi zovuta, koma ogwira mankhwala mkombero tsopano likupezeka zikomo kufufuza m'munda wa immunology.

Katemera, zomwe ndi zochokera maselo dendritic

Pali mankhwala ambiri ogwira mtima, monga mfundo pamwambapa. Chitsanzo chimodzi cha katemera "Stivumaks". cholinga chake chachikulu - ndi kuwalimbikitsa yankho zonse za chitetezo cha m'thupi kwa maselo a khansa, zikuchokera amene glycoprotein mucin-1. Izi ndi Antigen zofala.

Lachiwiri mayeso gawo mankhwala anasonyeza zotsatira zabwino, ngakhale, ndithudi, ndipo pali contraindications ena.

Pofuna kukhala a mtima chitetezo cha m'thupi, dokotala ayenera katemera mu minofu subcutaneous wa pamimba wodwala. Kale Mphindi 15 pambuyo akamaliza njirayi, wodwala kupita kunyumba.

Koma m'pofunika kuti nthawi zonse pitani dokotala chokuchititsani MAGAZI - izo kupereka chithunzi chooneka bwino cha njira zimene zimachitika mu chitetezo cha m'thupi. Ngati zonse zili bwino, anthu ambiri ndikukhazikitsa maselo kuwononga chotupacho, ayenera kwambiri kuonjezera. Kamodzi msinkhu wawo wayamba kusiya, m'pofunika kuchita kukonzanso katemera.

Dziwani kuti khansayo - ili si vuto okha amene angathetse maselo dendritic. Ntchito chitetezo antimicrobial a dongosolo chithandizocho komanso kukambapo, chifukwa angathe kuyambitsa kutsegula kwa chitetezo cha m'thupi, womwe kumabweretsa kuwonongedwa kwathunthu kwa matenda.

chingachitike mbali

Katemera, kuphatikiza zotsatira amphamvu zoteteza, kungachititse kuti ena kukumana ndi mavuto. Ndipotu, tikulankhula za mawonetseredwe m'munsili zimene ambiri a chitetezo cha m'thupi. Pa ndondomeko iyi pali kutulutsidwa kwa zinthu zomwe kutenga nawo mbali pa matenda yotupa matenda.

Ngati ife kulankhula za zinthu zenizeni, ndi pamene sakutchula kufooka ndi malungo ofunika. Nthawi zina pangakhale redness a khungu mu malo jekeseni anapatsidwa. Nthawi zina muyenera kuthana ndi kuwonjezeka mu mwanabele.

Ubwino wa mankhwala ndi maselo dendritic

Ngati tikambirana njira zimenezi wa kulimbana khansa monga radio- ndi mankhwala amphamvu, n'kosatheka kuti muzindikire zoonekeratu - thupi nthawi ili akupanikizika kwambiri. Koma ndi maselo onse dendritic kuti amagwiritsidwa ntchito pofuna kuchiza - ndi mwini zoteteza dongosolo la munthu ndi mbali yake yeniyeni. Kusiyana ndi njira iti kuposa noticeable.

Ndipo ngakhale njira imeneyi Kodi ndi mavuto, iwo ankaona n'chosoŵa, ndiponso kuwonongeka chifukwa iwo sangathe adzatchedwa kwambiri. Ubwino wina yaikulu ya mankhwala ndi kuonetsetsa kuti njira zonse kuchira angathe kuchitidwa pa outpatient maziko, kutanthauza kuti wodwalayo sayenera momwemo kuchipatala.

malo chithandizo Russian

Mu CIS Imachitika kafukufuku umalimbana kulenga grafts, zomwe ndi zochokera maselo dendritic. Novosibirsk - ndi umodzi mwa mizinda kumene malo ziwalo. Ndipo ngati tikambirana dera lino, ndi kutchula Institute of zamphongo Research ofunika. Izo zinali mu anayambitsa izi anayesedwa katemera amene angapereke wotsutsana ndi chotupa cha. Mankhwalawa khansa colorectal, zotsatira zabwino zimapezeka.

Koma Institute Research - si malo okha, pamene kufufuza wochititsidwa kuti ntchito maselo dendritic. Chithandizo mu St. Petersburg ndipo pa mlingo olemekezeka, ndi ntchito mfundo European. Mwapadera pa ntchito ya katemera munthu, n'zomveka kukumbukira RNHI iwo. Polenov.

Ambiri, mu Russia nkhani imeneyi yowalanga kwambiri. Ndipo ulosiwu, ndithudi, tinganene kuti tisafooke.

zotsatira

Mtundu wa khansa chotupa kuthetsa, monga kugwiritsa ntchito maselo dendritic angatchedwe njira wachinyamata. Koma izi sizisintha chakuti kutchuka kwake mu asayansi ikukula mofulumira chifukwa mkulu mlingo wa dzuwa.

Komanso, mu Germany pali makampani inshuwalansi, komanso kampani ya inshuwalansi, amene kale anayamba kuphimba ndalama kugwirizana ndi chithandizo chotere.