Chithandizo cha Antifungal "Rumikoz". Malangizo ogwiritsidwa ntchito

Rumikoz ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pa onychomycosis, masikidwe otentha a mycoses, vulvovaginal candidiasis, ndi zinyama zambiri. Ndi mycosis ya pakamwa, maso ndi khungu, zomwe zimayambitsidwa ndi nkhungu ndi yisiti bowa kapena dermatophytes, mankhwala "Rumikoz" amagwiritsidwanso ntchito. Malangizo ogwiritsiridwa ntchito amasonyeza mankhwalawa mu myicoses systemic, mwachitsanzo, monga aspergillosis (ngati akulephera kulekerera amphotericin B), paracoccidioidomycosis, cryptococcal meningitis), sporotrichosis, histoplasmosis, blastomycosis.

Ntchito yogwira ntchito Rumikoza - itraconazole. Mankhwalawa amachokera m'thupi mwathunthu, ndipo phwando nthawi yomweyo chakudya chitapangitsa kuti mankhwalawa akhale "Rumikoz". Malangizowo amasonyeza kuti mankhwalawa amalowa m'ziwalo ndi ziwalo, amasonkhanitsa mu impso, chiwindi, mapapo ndi mafupa, minofu ya mitsempha ndi m'mimba. Kuchuluka kwa mphamvu yogwira ntchito kumadutsa m'matenda amenewa plasma muwiri kapena kanayi. Kutalika kwa mankhwalawa m'thupi kumapezeka maola atatu kapena anayi, ndipo mankhwalawa amamatira mapuloteni a plasma ndi 99.8%.

Matendawa amatha kupezeka mkati mwa sabata imodzi ndikukhala patatha miyezi isanu ndi umodzi pambuyo pa chithandizo cha miyezi itatu. Izi zimagwiritsidwa ntchito pa misomali, ndipo pakhungu, mwachitsanzo, kusungira zotsatira zabwino kumachitika mkati mwa masabata awiri kapena anayi pambuyo pa nthawi yomweyi. Moyo wa hafu ya mankhwala yogwira ntchito ndi tsiku. Rumikoz amatembenuzidwa m'chiwindi, ndi chiwerengero chachikulu cha metabolites. Mankhwalawa amatulutsidwa kwa mlungu umodzi ndi impso ndi m'matumbo.

Zotsutsana ndi zotsatira zake

Kugwiritsa ntchito wothandizira "Rumikoz" ndi mowa nthawi imodzi ndizoletsedwa. Popeza mankhwalawa amachititsa kuti mankhwala asokoneze chiwindi, mbali yotsutsa mowa imatha kuwonongeka kwa chiwindi, mpaka chiwindi chikhoza kuchepa. Sikoyenera kuti muzimwa mowa musanafike milungu iwiri mutatenga kachidutswa kotsiriza ka Rumikoza. Zotsutsana zokhudzana ndi kugwiritsira ntchito mankhwalawa, kupatula kwa hypersensitivity kwa mankhwala yogwira ntchito, ndi lactation ndi mimba.

Zotsatira zoyipa panthawi ya kayendetsedwe ka mankhwala "Rumikoz" malangizo akufotokoza motere. Chiwalo cha m'mimba chingakhale kunyoza ndi kusanza, kudziletsa, kudzimbidwa, kuwonjezeka kwa kudya, kutaya thupi, kupweteka kwa m'mimba, matenda a chiwindi, kuphatikizapo, ntchito ya matenda a chiwindi amakula. Kuchokera kumaganizo ndi dongosolo lamanjenje lingakhoze kuwonedwa mutu, phokoso la ubongo, chizungulire, kugona, kutopa. Pa mtima wamtima, Rumikoz akhoza kuchita motere: kuthekera kwa matenda opatsirana kwambiri ndi kuperewera kwa mtima kumakula, nthawi yowumitsa imakhala yaitali, mlingo wa transaminases m'magazi a magazi umakula, pali ngozi ya thrombocytopenia ndi leukopenia.

Komanso pa nthawi ya kumwa mankhwalawa "Rumikoz" malangizowa amasonyeza zotsatira zina - kumeta, pulmonary edema, hypokalemia, kupindula. Zomwe zimawoneka ngati zotupa, zothamanga, khungu, angioedema, mng'oma, matenda a Stevens-Johnson. M'thupi lanu, zotsatira zotsatilazi zikhoza kuchitika: dysmenorrhea, albuminuria, edematous syndrome, kusintha kwa mkodzo kumdima, kusowa mphamvu, kuchepa kwa libido.

Mankhwala ofanana

Pofuna kuchotsa matenda a fungal, simungagwiritse ntchito Rumikoz okha. Chimodzimodzinso cha mankhwalawa chingakhalenso chothandiza. Komabe, mankhwala omwewo ndi ofanana, kupatula kwa Itraconazole, yomwe imatsutsana ndi kuwonetseratu mankhwala ena (magawo a isoenzyme CYP3A4, midazolam ndi triazolam, komanso ergot alkaloids, ndi ena). Mafano ena a Rumikoz, omwe ali pafupi kwambiri ndi ake, malingaliro ndi zotsutsana - Itrazol, Itramikol, Irunin, Orungamin, Orunit, Orungal, Teknazol.