"Pipekuroniyu bromide": malangizo ntchito

Mankhwala ulesi minofu chigoba, ankagwiritsa ntchito osati pa njira opaleshoni ya nthawi sing'anga ndi yaitali, komanso mchitidwe zoopsa ndi cholinga repositioning kapena mafupa apulasitiki. "Pipekuroniyu bromide" amatanthauza gulu antidepolyarizuyuschih relaxants ndipo ali ndi nthawi pazipita kanthu kwa mphindi 50-70 malingana ndi makhalidwe a chamoyo. Tiyeni tione malangizo ntchito mankhwala, ndipo makamaka ntchito kuchita mankhwala ochititsa.

pharmacological mapangidwe

Limagwirira cha zochita za mankhwala kugwirizana ndi kutsekereza kufala synaptic pa synapse neuromuscular. Chifukwa ichi, pali chopinga wa zosayembekezereka ya angathe kuchitapo kanthu pa Kakhungu minofu CHIKWANGWANI, ndipo motero, minofu selo wotaya umatha mgwirizano.

Ndi kukhudzana yaitali mankhwala salembedwa "pipekuroniyu bromide" chigoba musculature pansi. Popeza kuti nicotinic cholinergic maselo a mtundu ili osati kukhudzana m'dera ulusi efferent somatic mantha dongosolo ndi maselo minofu minofu chigoba ndi ganglia mu mantha dongosolo autonomic, kumayambiriro Mlingo waukulu wa medicament anachititsa zotsatira ganglioblokiruyuschimi ofooka. Ichi ndi chifukwa kutha kwa kufala kwa mopupuluma mitsempha kwa nembanemba postsynaptic wa manyuroni, imbaenda ku kuchepa zimakhudza wachifundo ndi parasympathetic.

zikuonetsa

Kukonzekera "pipekuroniyu bromide" akusonyeza kuti zosangalatsa a minofu chigoba pa opaleshoni. Mphamvu ya mankhwala ndi cholinga tracheal intubation ndi mpweya makina.

contraindications

Monga mankhwala kuti "pipekuroniyu bromide" malangizo, mankhwala mwamtheradi contraindicated pamaso pa hypersensitivity ndi pamaso pa myasthenia (yosowa chibadwa anatsimikiza matenda, zomwe ndi kuphwanya malemeredwe pa chitukuko neuromuscular synapse ndi kufooka minofu).

mankhwala ali contraindicated odwala mu magawo oyambirira mimba. Mu masiteji ina ya mankhwala zingagwiritsidwe ntchito, monga mitanda chotchinga placental ndalama zazing'ono.

zotsatira zoyipazi

Mankhwala akhoza ziletsa ntchito za chapakati mantha dongosolo, chifukwa hypersensitivity zochitika.

Kuchokera mbali ya zotsatira mtima mbali chifukwa cha chopinga wa HIV cholinergic pa synapses lapansi. Kuchita zimenezi kuchepetsa mlingo mtima, kuthamanga kwa magazi m'munsi, ischemic m'mnyewa wamtima choipa, ubongo kugwirizana ndi utachepa perfusion.

Atadziŵa zotheka maganizo a dongosolo kupuma wa ntchito kupuma, pakutchulidwa wa apnea kapena apnea (makamaka pa zotsatira za mankhwala).

Mankhwala kumakhudzanso kagayidwe ndipo amatha kuyambitsa kuwonjezeka mlingo magazi potassium kuwonjezeka mlingo wa amkati creatinine ndi milingo m'munsi plasma shuga.

Mankhwala "pipekuroniyu bromide" - malangizo ntchito

mankhwala chikuyendetsedwera yekha kuyang'aniridwa ndi katswiri. Patsogolo makonzedwe mankhwala ayenera kuonanso kupezeka kwa anticholinesterases ( "Neostegmina" kapena "Pyridostigmine") kapena anticholinergics ( "atropine").

Pambuyo mpheto mosalekeza mtima polojekiti ikuchitika nthawi kuchira pambuyo mankhwala ochititsa dzanzi ndi wodwalayo matenda minofu kamvekedwe.

Mlingo wa medicament pamaziko a Kupenda zovuta wodwalayo ndi deta kufufuza njira kusanthula zasayansi. Pamaso pa kulephera kwa aimpso excretory ntchito zinchito kulephera chiwindi, kunenepa - mlingo ayenera kukhala wotsika medicament.

njira zakonzedwa asanalankhule makonzedwe mankhwala "pipekuroniyu bromide." Fomu mankhwala kumasulidwa - vayozi wa ufa lyophilized munali 0.004 ga mankhwala yogwira.

Kwa odwala ndi mkhutu magazi electrolyte bwino ndi moyenera asidi-m'munsi ali kunatanthauzanso kusintha mlingo. Ŵakwenera kuchepetsa ndende ion mu madzi a m'magazi, hypothermia ndi ntchito ya glycosides mtima (pa digitalization) amatha kutalika nthawi ya mankhwala. Pa nkhani ya zosangalatsa minofu mu gulu la odwala poyamba ayenera matenda a electrolyte magazi, ndiyeno kuchita minofu zosangalatsa. Pankhani ya odwala ndi kulephera aakulu mtima, magazi mwina m'mbuyo kutambasuka kwa nthawi zobisika mmene mankhwala (kuwonjezeka nthawi pakati oyendetsa isanayambike zochitika).

Mutha kugwiritsa ntchito mankhwala ana 1 chaka. Pankhaniyi tiyenera kukumbukira kuti thupi mwana ndi saganizira zotsatira za minofu anasiya, ndi moyenera, kukwaniritsa zotsatira anakhumba, mlingo wa mankhwala ayenera ziwonjezeke.

tchuthi mankhwala

Mankhwala mankhwala kuti "pipekuroniyu bromide" Chinsinsi ku Latin simungathe ngakhale kupezeka dokotala. bungwe Medical amalandira mankhwala amphamvu pa mndandanda A yekha pa pempho ndipo pa maziko a dziko. Pa nkhani zosiyana, "pipekuroniyu bromide" Chinsinsi mwina mankhwala katswiri ntchito "ofiira" mawonekedwe, si onse maukonde kuchipatala kulandira kukwaniritsidwa mankhwala ozunguza bongo zovuta, kuphatikizapo relaxants minofu.

maina malonda

Mu msika mankhwala mankhwala alipo pansi mayina malonda "Arduan" "Vero pipekuroniyu", "Aperamid", "pipekuroniyu bromide." Trade dzina la mankhwala amadalira Mlengi, kupereka mankhwala ndi msika mankhwala.

ambiri osokoneza

An ambiri osokoneza cha mankhwala ndi zotsatira kuchepetsa n'zotheka chifukwa kumayambiriro anticholinesterases. Mankhwalawa kuthandiza kuonjezera ndende ya mtundu acetylcholine, potero kupikisana ndi minofu anasiya kwa malo pa lilime kumanga.

Komanso, mitsuko achire ku ambiri osokoneza cholinga chake ndi kulimbikitsa magazi, kukhala ntchito yofunika thupi, kuphatikizapo likuvutika mpweya makina.

Mwanjira mankhwala

mankhwala sangathe wothira njira zosiyanasiyana kulowetsedwa, kupatula njira isotonic wa sodium kolorayidi ndi dextrose. Kukula kwa zotsatira mankhwala kubweza pansi, zothandiza achire mlingo ndi kuchuluka pansi chikhalidwe cha utsogoleli preoperative munthu wodwala ndi zoletsa cholinesterase.

Mu ntchito limodzi ndi minofu anasiya chomwa mankhwalawa analgesics zotheka maganizo a pakati kupuma ndi chitukuko cha matenda obanika kutulo.

Ntchito ya mankhwala ndi depolarizing relaxants minofu mtundu wa kanthu onse patsogolo ndi kusokoneza wonse minofu anasiya kwenikweni. chochitika ichi ndi chifukwa mlingo wa mankhwala, nthawi ya boma ndi tcheru munthuyo mankhwala.

Pomaliza

Kunyamula minofu zosangalatsa pa opaleshoni - mbali yofunika ya mankhwala ochititsa dzanzi Integrated. Mankhwala "pipekuroniyu bromide" ali bwinobwino ntchito yochizira matenda kwa zolinga zimenezi.

Kumbukirani kuti kumayambiriro mankhwala amachititsa osati zosangalatsa a minofu chigoba udindo kuyenda kwawo, komanso amachititsa ziwalo za minofu kupuma. Popeza ichi, mankhwala ntchito kokha m'mikhalidwe ndi opaleshoni tima mayunitsi chisamaliro.