"Nimid" (mapiritsi): Malangizo ntchito ndi mayankho

Anthu akuvutika ndi matenda a m'mafupa, mafupa ndi minofu monga symptomatic mankhwala Madokotala amakonda kulemba "Nimid" (mapiritsi). Malangizo ntchito lili ndi mfundo zimene mankhwala osati amachotsa ululu, komanso ali wotsutsa-yotupa kanthu. Tiyeni tiyese kufufuza ntchito za mankhwala mwatsatanetsatane ndi kupeza chimene milandu akhoza kuthandiza.

mawonekedwe mankhwala ndi zikuchokera

Pankhani mitundu ya mankhwala, ndiye lero mu pharmacies mungagule piritsi, kuyimitsidwa, granules ndi gel osakaniza. Waukulu yogwira pophika nawo nimesulide. Piritsi chiphunzitso cha mankhwala anamasulidwa mu zidutswa 10 matuza. piritsi limodzi lili 100 mg wa nimesulide, ndipo zigawo wothandiza ntchito mankhwala microcrystalline mapadi, ndi sodium stearate, croscarmellose soda ndi Aerosil 200. Zimenezo muli mfundo zoterezi zikuchokera "Nimid" kukonzekera (mapiritsi) malangizo ntchito.

ufa amapangidwa sachets mlingo. mawonekedwe mankhwala othandiza zochizira ana. Ndithudi, zikuchokera, kupatula nimesulide, povidone K-30, tabletozy 80 Aerosil 200 lili excipients monga saccharin sodium, citric acid, ndi flavorings. Patalipatali wachimwemwe kumwa zokoma kuphika makolo ake achire "omwera".

Mu 1 ml ya kuyimitsidwa, ndi 1 g wa gel osakaniza lili 100 mg wa nimesulide. Monga wothandiza chigawo m'njira awiriwa ntchito propylene glycol, sodium gidroskid, carbomer 940 Cha, disodium edelat, aromotizator, madzi oyera ndi methylparaben.

The kanthu pharmacological mankhwala

Nimesulide, ndilo yogwira pophika medicament ali gulu la nonsteroidal odana sulfonanilides. Kamodzi mu thupi la munthu, izo kusankha kumabwezera mmbuyo Cox-2 ndi kumabwezera mmbuyo kaphatikizidwe wa prostaglandins mu yotupa locus. Analgesic, antipyretic ndi odana ndi yotupa kwenikweni zimatheka pambuyo limodzi "Nimid" Mapale. Malangizo ntchito lili mudziwe zambiri zokhudza mankhwala mlingo.

Kuwonjezera pa pamwamba, mankhwala akhoza ziletsa amasulidwe mpweya ufulu ankafuna kusintha zinthu mopitirira ndi ziletsa amasulidwe myeloperoxidase, ndi zopanda phindu pa chemotaxis ndi njira phagocytosis.

Koma kanthu odana ndi yotupa mankhwala, izo zimatheka ndi mphamvu nimesulide zisokoneze owayimira yotupa ndi kuchepetsa chotupa necrosis zinthu. Ndi inhibiting kaphatikizidwe wa interleukin-6 ndi urokinase kukonzekera "Nimid" (malangizo Buku akutsimikizira zimenezi) chindiletsa kunyoza proteoglycans ndi kolajeni chichereŵechereŵe. Komanso, nimesulide atagwira midadada kwa nociceptive ululu zikhumbo dongosolo.

Ngati tikambirana limagwirira wa analgesic kanthu, amagwirizana ndi chopinga wa histamine kumasulidwa ndondomeko ya maselo ambiri mlongoti ndiponso zochita za yogwira pawiri pa zolandilira glucocorticosteroid.

Ngati dokotala wanu wadzikakamiza "Nimid" (mapiritsi), ndi malangizo ntchito ayenera mosamala pamaso kumwa mankhwalawa. Ndipotu, chikalata ichi lili ayamikira kuti ayenera n'komwe m'kati mwa mankhwala.

Pharmacokinetics

Atalandira mlingo wa mankhwala ndi mwachangu odzipereka kwa mundawo m'mimba. Ndipo pambuyo maola 1.5-2.5 anasonyeza ndende pazipita yogwira pophika mu madzi a m'magazi. Mbali khalidwe la kukonzekera ndi luso mkulu kucheza ndi mapuloteni, komanso malowedwe chotchinga magazi ubongo ndi gematoplatsentarny. Pa woipa mkulu wa nimesulide anatsimikiza pa locus kutupa, ndi madzimadzi synovial.

kagayidwe mankhwala akupezeka chiwindi, etc., ku mbali yaikulu mu zikutsatiridwa mawonekedwe metabolites yogwira, likuchotsedwa kudzera impso (mu mkodzo), pa - ndowe za. Hafu ya moyo wa chinthu yogwira Zimapezeka maola 3.5-5. Lili deta kutchula pharmacokinetic "Nimid" kukonzekera malangizo ntchito.

umboni

Mogwira medicament chothandizira kuti silipita matenda a chapamwamba kupuma thirakiti thirakiti chapamwamba kupuma. Nthawi zambiri mankhwala mankhwala kwa anthu amene akudwala nyamakazi, myalgia, nyamakazi, bursitis, tendonitis, ndi matenda ena minofu, mafupa ndi olowa limodzi ndi matenda ululu. Mu mchitidwe mano ndi matenda ululu postoperative ndi postrevmaticheskih komanso ntchito "Nimid" medicament. Malangizo ntchito Zikatero ndi bwino kugula piritsi, ufa kapena granules.

Mokhudzana ndi mankhwala mawonekedwe gel osakaniza, kuti cholinga ntchito apakhungu mu minofu chofuna (zofewa) omwe amayamba ndi mabvuto osiyanasiyana. Mogwira amatanthauzanso mu njira yotupa ndi matenda osachiritsika a dongosolo minofu ndi mafupa, nyamakazi, ankylosing spondylitis , ndi ena. Ilo lili ndi mndandanda kukodzedwa kwa zikuonetsa ntchito ndalama "Nimid" malangizo ntchito kwa Mlengi.

Phwando zinthu ndi dongosolo dosing

Pankhani kumwa mankhwala mu mawonekedwe a mapiritsi, suspensions, m'pofunika ntchito pokhapokha chakudya. Ndi zofunika kuti zapita mphindi zosachepera 20 pambuyo ingestion, mwinamwake pharmacokinetic zotsatira za nimesulide kubweza. Pankhani njira dosing ndi nthawi ya mankhwala, kuti mafunso amenewa ayenera kuyankha mwachindunji kwa dokotala kupezeka kutenga nkhani makhalidwe munthu wodwalayo ndi digiri ya kusalekerera matenda. Choncho, tikambirana yekha malangizo ambiri, muli nkhani zokhudza mankhwala "Nimid" malangizo Buku.

Mapiritsi amapatsidwa kawirikawiri akuluakulu kawiri patsiku pa 100 mg. M'njira choopsa cha matenda mlingo tsiku mwina kawiri. Ana a zaka 12 mpaka 18 analimbikitsa kuwerengera mlingo wa mlingo mankhwala 1.5 mg wa pa 1 makilogalamu thupi. Ngati chithandizo chofunika ndi ana ochepera zaka khumi ndi ziwiri, ndipo ake kulemera kuposa makilogalamu 40, izo Kwalamulidwa 100 mg wa mankhwala pa tsiku ndi kugawa mlingo pa magawo awiri. Nthawi yapadera, adokotala akhoza kuwonjezera mlingo.

Zikutanthauza mu mawonekedwe a granules ntchito ana kwa zaka 12 ndi akulu: 1 sachet m'mawa ndi madzulo. Nkhani za thumba ndi kuchepetsedwa mu 100 ml ya madzi ofunda ndi kumwa mukatha kudya.

Pankhani gel osakaniza "Nimid", izo - si oposa 4 pa tsiku - wosanjikiza woonda (popanda akusisita) pa thupi gawo ndi ululu kwambiri. Pambuyo ntchito mankhwala, kusamba m'manja ndi sopo pansi madzi.

Izi mankhwala contraindicated?

Musati mankhwala kwa anthu ndi zilonda matenda chilonda, kuyan'anila aakulu a chiwindi ndi impso, komanso zochita hepatotoxic kuti mbiri nimesulide. Mwamphamvu contraindicated mankhwala pa zizoloŵezi osiyana magazi, insufficiency mtima ndi hypersensitivity kwa zigawo chimodzi kapena zingapo mwa medicament "Nimid forte". Malangizo ntchito ndi kakunena pa lamulo la ntchito ndalama limodzi ndi mankhwala zingakhale hepatotoxic chothandizira limati chimfine ndi amaganiziridwa pachimake kudwala opaleshoni.

Koma ndalama mu mawonekedwe a gel osakaniza, izo si Kwalamulidwa kwa odwala pansi zaka 12 ndi anthu amene sachedwa thupi lawo siligwirizana. Zimawonjezera matenda pa ntchito medicament mwina chifukwa dermatitis, kuvulala khungu ndi matenda, komanso bronchial mphumu, amene amayamba ndi ASA. Choncho si Kwalamulidwa amatanthauza "Nimid" mu pathologies pamwambapa. Malangizo mapiritsi ntchito Zikatero, nayenso, osavomerezeka.

Kodi ndingachite mankhwala pa mimba?

Asayansi anapeza kuti nisumelid amatha zimakhudza chonde. Komanso, kumabwezera mmbuyo kaphatikizidwe wa prostaglandins, amene amadziwika kuti chifukwa cha oligohydramnios, matenda oopsa m'mapapo mwanga, oliguria ndi msanga kuchepetsa Batalova ritsa. Mwina azitaya chifooke ntchito, a edema zotumphukira ndi magazi pamene ntchito mankhwala "Nimid". Malangizo ntchito, miyala ndi zina mankhwala koletsedwa onse pa mimba ndi pa mkaka wa m'mawere. Ndipotu, mankhwala yogwira ndi mkaka wa m'mawere angakhoze kulowamo thupi mwanayo komanso kusokoneza ntchito kwa machitidwe ake ofunika. Nthawi kumene n'zosatheka kuchita popanda mankhwala, ndi ubwino kwa mayi n'kosangalatsa chiopsezo kuvulaza mwana, mlingo ndi zochita chithandizo anatsimikiza ndi dokotala.

zotsatira zoyipazi

Komanso zabwino misa makhalidwe pharmacological, lokonzekera alinso ndi mndandanda chidwi mavuto. Choncho tiyeni tiwone wotani anachita zingachitike pamene inu ntchito "Nimid". Mapiritsi (malangizo Russian zimapangitsa deta zilipo) akhoza kuyambitsa kuyabwa, ming'oma, osiyanasiyana totupa pakhungu, angioedema, ndi zina za Stevens-Johnson syndrome ndi epidermal necrolysis. GI akhoza nayenso, kuyankha mankhwala kwa kudzimbidwa, m'mimba, nthawi zina odwala kubva kuwawa mmimba, nseru. kawirikawiri mankhwala zingachititse perforation wa chilonda ndi chironda chachikulu ndi 12 mmatumbo chilonda.

Popeza ndondomeko ya kagayidwe mu chiwindi, komanso ali ndi vutoli. Choncho yaitali ntchito mankhwala zina, zingachititse kusintha transaminases, cholestasis, matenda a chikasu ndiyo ndipo ngakhale chowawa chiwindi. Monga monyanyira mu chiwindi si miyala yekha ndi granules ndi ufa, koma "Nimid".

Dziwani makamaka limafotokoza zotheka zimene dongosolo urogenital boma mankhwala. Zimakhala ngati edema, dysuria, posungira mkodzo, ndipo oliguria, pachimake kulephera aimpso, interstitial nephritis. Dongosolo kupuma kungakhale dyspnea ndi bronchospasm, ntchito yaitali angachititse chitukuko cha mphumu.

Kuwonjezera zotsatira, wodwala angathe tachycardia, matenda oopsa, hypothermia, kutopa ndi matenda ena. Mumakhala zochita zonse chowawa tikulimbikitsidwa kuti muletse mankhwala ndi kufunafuna chithandizo mwamsanga. Kusakhala imeneyi, muyenera bwinobwino zinthu zonse zitheka za mankhwala ndiyeno nkutenga "Nimid forte" (mapiritsi). Malangizo ntchito, omwe ali yense mankhwala phukusi angakuthandizeni.

Ambiri osokoneza mankhwala osokoneza bongo ndi woyamba aligorivimu chithandizo

Ngati mwangozi upambana mlingo kololeka, mwamsanga kupita kuchipatala. Ndipotu chifukwa cha zolakwa amenewa kungakhale kusinza, nseru, kusanza, kupweteka espigastrii, ulesi, kuthamanga magazi. Uwu ndi mndandanda wa kokha kuwala kwa amadana ndi mlingo wapamwamba mankhwala "Nimid". Mapiritsi - Buku akuchenjeza za - anatengedwa mu kuchuluka kwa ndalama 2-3 kuposa mlingo analola, zingachititse magazi mkati ndi kuyambitsa kulephera impso. Mu yochizira matenda, ngakhale atathana nthawi zina zochita anaphylactoid, maganizo kupuma ndi chikomokere chifukwa ambiri osokoneza za mankhwala.

Ngati ife zodyedwa mlingo ali kuposa, dikirani kwa kuwonetseredwa matenda ndi sikuthandiza. Muyenera yomweyo kusamba kunja m'mimba kutenga mankhwala ofewetsa tuvi tolimba osmotic ndi chelators. Makamaka pambuyo miyezo pamwamba kupita kuchipatala komwe madokotala adzapitiriza mankhwala symptomatic. Tikumbukenso kuti tsiku palibe adakalibe yeniyeni.

Kodi akuganiza za mankhwala kwa odwala?

Ndithudi, matenda ndi ululu pachimake pafupifupi odwala onse amalabadira mankhwala ankaona. Iwo dziwani kuti zotsatira za ntchito mankhwala kumachitika mwachilungamo msanga, amene sakhoza koma kondwerani. ndemanga ndithu ena akhoza anamva pamene odwala apatsidwa njira yaitali mankhwala mankhwala, "Nimid". Mapiritsi (Buku akuonetsa kuti mwapadera kwa chuma ichi pharmacological mankhwala) mofulumira kupweteka, koma patapita masiku ochepa a phwando okha zotsatira kudziwika mbali. Woyamba akuyamba kuchita thirakiti nimesulide m'mimba, mantha dongosolo kenako (izi ziri kuwonetseredwa ndi irritability, mmene alili ndi chizolowezi mphwayi).

Kumene, mosapita m'mbali kuti mankhwala amachita zoipa koposa zabwino, sikutheka. Pajatu zimandithandiza. Koma apa ndi kutenga popanda umboni ndi kopita katswiri ali osavomerezeka.

Ngati mudziwe pamwamba anakhalabe chipeneko kapena kugula "Nimid" (mapiritsi), malangizo, ndemanga, ndi malangizo odwala dokotala angakuthandizeni kusankha mwanzeru.