Mankhwala 'kashiamu pantothenate': makhalidwe ndi ntchito mankhwala

asidi Pantothenic (mlingo mawonekedwe - mankhwala "kashiamu pantothenate") mgulu la vitamini B. Izi wochuluka, optically yogwira madzi, kwambiri sungunuka m'madzi, mosavuta lamamatira pansi zochita za kutentha, zidulo ndi alkalis.

asidi Pantothenic amapezeka mu zakudya ndipo apanga ndi microflora matumbo (Escherichia). Pambuyo mayamwidwe chimatilowetsa m'magazi ndi ikuchitika ziwalo zonse ndipo zimakhala, uyikidwa mu chiwindi, mwina mu myocardium, impso ndi minofu chigoba. Mu thupi, makamaka asidi kugwirizana ndi mapuloteni ndi gawo la CoA (coenzyme A). kusokonezeka zinthu za mankhwala "kashiamu pantothenate" excreted mu mkodzo ndi ndowe. Izo ziyenera kuti chiwerengero cha asidi anasankha pantothenic nthawi zonse kuposa zimene analowa thupi ndi chakudya. Ichi ndi chifukwa kaphatikizidwe ake bakiteriya.

asidi Pantothenic ndi chigawo chimodzi cha CoA, chomwe ndi zigawo zitatu: otsala tiolamina, asidi pantothenic, 3-phospho-5adenozin-5-diphosphate. CoA ndi imodzi mwa mfundo kagayidwe, mtsikanayu kugwira ntchito ndi Krebs mkombero mu kaphatikizidwe kwachilengedwenso ndi makutidwe ndi okosijeni chakudya, lipids, glucosamine mapangidwe, acetylcholine, asidi hippuric, porphyrins, etc.

Mankhwala "kashiamu pantothenate" - pang'ono chikasu kapena ufa woyera ndi kulawa zowawa, odorless, sungunuka m'madzi. njira amadzimadzi thermally khola, koma mofulumira kuphwanya atadziŵa acid ndi soda. Yokonza mankhwala amapangidwa ngati miyala, ufa ndi njira mu mbale.

Ake zochita pharmacological kukonzekera "kashiamu pantothenate" akusonyeza pambuyo asidi pantothenic lidzasinthidwa coenzyme A, amene amathandiza beta-makutidwe ndi okosijeni, mafuta asidi kaphatikizidwe, decarboxylation zobwera chifukwa cha okosijeni, ndipo akatembenuka asidi pyruvic ndi ketoglutaric acetyl. Amathandiza mayamwidwe a shuga mu intestine, ndi kumawonjezera mlingo wa glycogen mu chiwindi, normalizes udindo m'thupi la chamoyo, makamaka pa mimba.

Pa akusowa asidi pantothenic mu thupi imathetsa timadzi ntchito pituitary, adrenal England ndi kapamba. The zopangitsa adrenal kumachepetsa mlingo wa mahomoni steroid, yomwe mtundu wa tsitsi ndi khungu. matenda kagayidwe kachakudya amakwiya dermatitis, khungu depigmentation. kusintha osachiritsika anati mu zopangitsa kwa adrenal ndi minofu mantha. Iwo akhoza kusweka galimoto kuyenda, kuvutika matenda a impso, mtima, matumbo ndi m'mimba. Zimayambitsa chachikulu cha kuperewera kwa vitamini ali osakwanira ndalama vitamini izi mu zakudya, matenda matumbo, ndi ntchito yaitali mankhwala (sulfonamides, mankhwala).

Waukulu matenda zizindikiro za kusowa kwa asidi pantothenic mu thupi - maganizo, kutopa, kufooka, kusowa tulo, mutu ndi ululu minofu, nseru, m'mimba, ankatenthetsa wa khungu amasiya, mmatumbo chilonda. Pa akusowa vitamini yafupika immunological kukana wa chamoyo. Against maziko awa, nthawi zambiri pali matenda kupuma.

zambiri, madokotala mankhwala mankhwala "kashiamu pantothenate" kwa lamulo njira kagayidwe kachakudya. Kuvomereza anati medicament polyneuritis, paresthesia, neuralgia, matenda, chikanga, dermatitis, zilonda zamoto, zilonda trophic, mimba toxicosis, TB hypothyroidism, kapamba, gastroduodenitis, etc. Medicine "kashiamu pantothenate" bwino analekerera ndi thupi. Pakuti makonzedwe enteral mwina dyspeptic zizindikiro, ndi parenteral (mu mnofu jekeseni) - soreness.

Oversupply kashiamu (hypercalcemia) angayambe chifukwa kukanika kwa endocrine zopangitsa (parathyroid England). Hypercalcemia m'kaundula okalamba. hypercalcemia Clinic angasonyeze omangana n'kufooka ambiri, kusowa chilakolako cha nthawi zina anaona ndiponso kudzimbidwa.