"Amoxiclav 625": malangizo ntchito, Akhristu enieni

Pakati pa nthumwi antimicrobial yokonza "Amoxiclav 625" umboni mtima ndi akatswiri kuwulula kopambana. mankhwala imatengedwa kuti kwambiri ambiri mankhwala choncho anafunika onse. Chifukwa zosiyanasiyana za lonse la zinthu, chitetezo cha ana ndi akazi lactating, "Amoxicillin-clavulanate" pafupifupi kwathunthu chimakwirira dera la wazotsatira mankhwala outpatient kupuma ndi matenda a njira ya mkodzo.

Kumasulidwa Mfundo ndi analogues

Kukonzekera "Amoksiklav 625" umatulutsa Chisiloveniya Lek ndi pabwino monga mankhwala yogwira mankhwala ndi aminopenicillin amoxicillin ndi asidi clavulanic. Woyamba atenge mbali ya mankhwala ndi asidi amateteza bakiteriya beta-lactamases. Monga mbali ya "Amoksiklav 625 mg ndi" miyala mankhwala amapanga 500 mg wa mankhwala, ndi 125 mg wa auxiliaries clavulanate.

Kukonza ndi yogwira mankhwala amoxycillin opangidwa pansi zosiyanasiyana mayina. The analogues kwambiri Mkhalidwe izi kutetezedwa aminopenicillin "Amoklav", "Augmentin", "Flemoklav", "Amklav", "Farmentin", "Amoksikar Plus", "augment", "Medoklav". Palinso penicillin mosadziteteza, amene analogues wa kalasi "Amoksiklava": "Amoxicillin", "Amoksikar", "Amosin", "Hikontsil" ndi ena. Mwachangu awo akuti ndi pafupi zofanana.

Kufunika kwa mankhwala

Pa tsiku lokonzekera "Amoxiclav 625" ndemanga Akatswiri bwino kwambiri. Izi medicament Mkhalidwe, mmodzi yekha mankhwala m'kamwa antimicrobial amene yodziwika ndi zotsatira otsika mbali. Pachifukwa chimenechi ntchito milandu yonse imene amoxicillin anali oyenerera. Ndipo "Amoxiclav" ndi nthumwi ya mankhwala ophatikizana. Iwo kutetezedwa asidi clavulanic ndi penicillinase, ndi puloteni kuti wawononga lactam mphete wa antibayotikiyo. Zikomo kutetezeredwa "Amoxiclav" anayambiranso kulalikira mwakhama kwambiri ponena za maselo tating'onoting'ono.

umboni

Mayina mankhwala "Amoxiclav 625" Buku ili ndi malangizo kwa matenda opatsirana, matenda a omwe amaloledwa kugwiritsa ntchito maantibayotiki. Kawirikawiri osauka kupuma, m'mimba, genitourinary matenda a wofatsa kapena zolimbitsa mwamphamvu. M'njira bata wa monotherapy yoyenera, koma yabwino ndi aakulu amafunika chithandizo mu Zipatalazo ndi inpatient wa osakaniza mankhwala. Ambiri, zikuonetsa ntchito "Amoxiclav 625 mg wa" kukonzekera kalozera anafotokoza motere:

• matenda a ziwalo chapamwamba kupuma (aakulu ndi mitundu pachimake a zilonda zapakhosi, pharyngitis, sinusitis, otitis TV);
• matenda opatsirana matenda m'munsi kupuma thirakiti (mitundu pachimake ndi aakulu chifuwa, chibayo);
• matenda bakiteriya a dongosolo urogenital (pyelonephritis, urethritis, cystitis, oophoritis, m'chiuno kutupa, endometritis, chinzonono, amapatsirana);
• aakulu osteomyelitis;
• Matenda a pakhungu, matenda kulumidwa nyama, namkulunga, kulamulira ndi mabakiteriya,
• periodontitis.

Wodwala, ndi limatiphunzitsa zokhudza "Amoxiclav" kukonzekera - malangizo Buku. 625 mg wa thunthu mankhwala, anatchulidwa triplicate munthu wamkulu, angathandize kuchiza matenda a dongosolo kupuma chifukwa cha galamu HIV advantageously zomera. Ndipo pa ARI mankhwala nthawi zambiri masiku 5-7.

contraindications

mbiri chitetezo mankhwala ndi onyozeka kawopsedwe wa penicillin si kukusalani pamaso pa contraindications.

Iwo ali ndi mankhwala pang'ono. Iwo zokhudzana kaya pamaso pa matenda concomitant, matupi awo sagwirizana anachita kapena boma zokhudza thupi la chamoyo. Contraindications monga:

• kupezeka limasonyeza pakutchulidwa wa matenda a chikasu ndiyo cholestatic, kuchuluka aminotransferase ntchito kapena kukula kwa chiwindi chifukwa cha ntchito kale "Amoksiklava", analogs kapena oimira gulu la penicillin;
• kwa chiwindi insufficiency, lymphatic khansa, mononucleosis chifukwa akuchuluka wa chiwerengero ndi kukula kwa mavuto;
• matupi awo sagwirizana zina mankhwala kapena zigawo zake;
• mmene zikamera wa msanga mtundu matupi awo sagwirizana zochita pamene mukumwa ena beta-lactam wothandizila antimicrobial;
• wachibale nthawi contraindications: mimba mu trimester 3 wa mkaka wa m'mawere.

Kusamala angathe kukhala chifuwa

Ngati mbiri wodwala pali mawu onena za mtundu m'dera la ziwengo, "Amoxiclav" sanagaŵiridwe. Ngati anayamba anaphylaxis kapena angioedema poyankha kulandira ena beta-lactam wothandizila antimicrobial, ndi "Amoxicillin-clavulanate" ayenera sichizalandiridwa. Ndiye mankhwala wosankha ndi nthumwi za ambiri mwa macrolides mu njira zolimbitsa, kapena fluoroquinolone.

dosing regimens

Kuchuluka kwa mankhwala "Amoksiklav 625 mg," amene chofunika kuchipatalako zimadalira zaka ndi kulemera kwa wodwalayo. matenda kupuma rationally perekani kwa 2 gm akuluakulu magalamu 1.3 achinyamata. The "Amoxiclav" pa mlingo wa 625 mg wa yekha ndiye mwana ndi wamkulu mankhwala. Kwa ana osapitirira zaka 12, pali mankhwala pa mlingo m'munsi.

Standard Mlingo wa munthu akulemera makilogalamu 40 ndi zaka zoposa 12 zakubadwa ndi 625 mg ndi kawiri pa tsiku. Akuluakulu zaka 18 Kwalamulidwa 625 mg wa katatu patsiku. Izi akukwana zochizira zolimbitsa ndi kuwala, ndiye outpatient matenda a khungu, kupuma, dongosolo urogenital. Mu matenda akulu anatumizidwa 1000 mg (875 mg wa amoxycillin ndi clavulanate 125) kawiri pa tsiku. Anandilola zitatu ntchito 1000 mg.

mbali zotsatira

Ngakhale kupingasa okwanira kanthu achire, pali mavuto. Iwo amagwirizana ndi matenda wamba a ntchito matumbo ndi chapamimba, komanso chifukwa mankhwala kuledzera kuwola maselo bakiteriya, monga zotsatira mankhwala bactericidal.

The pafupipafupi kwambiri (1-10%) ndi milandu nseru, kusanza kapena kutsekula m'mimba zikuchitika pambuyo ntchito nthumwi antimicrobial. Ndipo iwo amaoneka masiku 2-4 pambuyo chikuonetseratu. N'zochititsa chidwi kumawonjezera Mwina wa dyspepsia chisokonezo kale mu makhalidwe matumbo, ndi matenda m'munsili: kapamba ndi insufficiency excretory, enteritis chikhalidwe pambuyo resection a m'mimba kapena matumbo, aakulu matenda a m'matumbo.

Gulu la mavuto infrequent (0,001-0,0001%) ndi chiwindi matenda: kuchuluka transaminases ndi zolembera za hepatocyte cytolysis, cholestasis ndi matenda a chikasu ndiyo, leukopenia. Pafupipafupi angioedema, urticaria ndi anaphylaxis ndi yosadziŵika. Chifukwa cha ichi ndi kuwonjezeka pang'onopang'ono kwa chiwerengero cha thupi lawo siligwirizana chifukwa zina oyambirira a ana.

Kenako, izo kumawachititsa kuti kuchepetsa kufunika achire mankhwala "Amoxiclav". Malangizo ntchito 625-mg wa piritsi sanayambebe analetsa amayi unamwino. Komabe, izi posachedwapa zimachitika. Ndiye muyenera kuyang'ana kwa mankhwala atsopano a kwa amino ndi dzuwa lofanana. Mwachibadwa, kuti latsopano mankhwala mankhwala akhala apanga ndi kuyesedwa, koma kukhazikitsa mpaka chuma disadvantageous, chifukwa "Amoxiclav" likukwaniritsa zofunikira za clinicians.

Phwando pa mimba ndi mkaka wa m'mawere

Malinga ndi mfundo FDA, "Amoxiclav" alibe zotsatira teratogenic. Mfundo imeneyi ndipo kunatha pambuyo akafufuza nyama, chifukwa analogues onse mankhwala m'gulu Category B ndi FDA (USA). Komabe, chifukwa mantha zomveka wa akuchuluka toxicosis "Amoxiclav 625" pa mimba pafupifupi sanagaŵiridwe mu trimester. Mu II ndi III trimesters wa phwando ake amaloledwa.

Aminopenicillin mu kufufuza chimachititsa mu mkaka wa m'mawere, amene kugwera mu kapepala m'mimba mwa ana akhanda. Komabe, kuyan'anila kwambiri mu thupi lake, sayambitsa, chifukwa cha zimene "Amoxiclav 625" sangathe kuletsa pa mkaka wa m'mawere. The kuchotserapo okha milandu ya thupi lawo siligwirizana wa mwana kapena vulvovaginal nembanemba mucous kapena kachigawo m'mimba, chifukwa mu ntchito "Amoxicillin". Ndiye pamafunika kapena chiyembekezo chakuti mayi kulandira ndi wothandizila antimicrobial, kapena - pa mucosal candidiasis - osati kuyamwitsa.

chitetezo mankhwala Mbali

Miyala "Amoxiclav 625" ali kunena yotakata sipekitiramu wa kanthu achire, n'kupeŵa poizoni. Komanso, palibe zotsatira chapakati, chifukwa cha zimene angaperekedwe kwa odwala amene amayendetsa galimoto kapena njira zina ikuyenda. Iye sichichititsa kuyan'anila za kukumbukira, kutsitsimuka, chidwi, kapena kuganiza.

Komabe, pali ambiri osokoneza syndrome mankhwala. Zikatero n'zochepa, ndipo zidzachitika yekha milandu tikamangoganizira mlingo umodzi wa magalamu 5 kapena kuposa mankhwala. Zizindikiro ndi makhalidwe awa: matenda otsegula m'mimba kugwirizana ndi kukula kwa zowawa m'mimba, bloating, kutsekula m'mimba, kunyansidwa ndi kusanza.

Pali milandu crystalluria, mating ndi madyedwe a amoxicillin nthawi zina wopita ku chitukuko cha kulephera aimpso. Komabe, zodabwitsazi angayambe pamene kulandira mlingo achire mankhwala. Zikutanthauza nefroprotektsiya mankhwala ndi dialysis, zimathandiza kuchotsa mwazi wa amoxicillin ndi asidi clavulanic.

kusamala

Odwala khansa lymphatic, kapena matenda mononucleosis mankhwala "Amoksiklav 625", analogs ndi generics si anasonyeza chifukwa mosavuta mkulu wa morbilliform totupa. Ndipo chifukwa cha kuchepa mphamvu ya kulera m'kamwa pa chithandizo "Amoxicillin" chofunika yothandizana ndi chitetezo osafunika njira mimba chotchinga (makondomu).

Ndi kukula m'mimba pa ntchito "Amoksiklava" amafunika kuchotsa mankhwala ndi chithandizo cha matenda a m'matumbo (pseudomembranous kapena hemorrhagic). Imeneyi, ntchito ndi inadmissible "Loperamide". Komanso, nthawi yaitali ntchito "Amoksiklava" limathandiza kuti chitukuko cha madera ambiri tizilombo tating'onoting'ono zimakumana antimicrobials. Angathe kuyambitsa mavuto a matenda.

Mwanjira mankhwala amadziwika

Urikozostatichesky mankhwala "allopurinol" pa phwando pamodzi ndi "Amoksiklava" kumaonjezera ngozi ya totupa pakhungu. Ntchito urikozuricheskogo amatanthauza "Probenecid", "oxyphenbutazone," "phenylbutazone", "sulfinpyrazone" kapena asidi acetylsalicylic amachepetsa Kugawilidwa kwanthaka wa aminopenicillin (koma osati asidi clavulanic), chifukwa chimene pang'ono kumaonjezera ndende ya mankhwala mu seramu magazi ndi kupitiriza zotsatira zake.

Kuphatikiza mankhwala "Amoksiklav 625 mg ndi" ndi antimicrobials bacteriostatic zopanda nzeru chifukwa cha yimitsira Mwachangu onse awiri. Kukonzekera ena okhala amoxicillin Safunikanso pamodzi bacteriostatic: chloramphenicol, macrolides, tetracyclines ndi sulfonamides. Mothandizana ndi mankhwala bactericidal kumabweretsa mwagwirizana kuwonjezeka antimicrobial ntchito.

Ikani "Amoxiclav" pa mankhwala m'kamwa kulera adadzonga chifukwa chiopsezo kuchuluka prothrombin nthawi ndi thrombosis. Wogwira izi kulera zosiyanasiyanazi ali kwambiri yafupika. Other yotakata sipekitiramu mankhwala komanso ayimire zotsatira za kuchepetsa mphamvu ya kukonzekera m'kamwa kulera.

Ntchito "Amoksiklava" oportunisticheskih pa matenda akuwuka pa maziko a mankhwala methotrexate, kwambiri kumawonjezera kawopsedwe wa masika. Izi kumawonjezera Mwina wa thrombocytopenia, leukopenia, zilonda pakhungu, zilonda m'mimba ndi erosions. Ndiye analimbikitsa kusiya aminopenicillin ntchito macrolides, kupitiriza mankhwala nanu methotrexate.

Mofanana ndi aliyense mankhwala yotakata-sipekitiramu, "Amoxiclav" kumawonjezera dzuwa la anticoagulants zina. Therapy "warfarin" chifukwa cha kupondereza wothandizila antimicrobial ku mabakiteriya kuti lithe vitamini K akutitsogolera kuti kuchepa prothrombin index ndi kuchuluka INR. Chifukwa ndi pachiopsezo chachikulu chotenga magazi.

Mbali ophatikizana mankhwala antimicrobial

Mankhwala "Amoxiclav 625" ndi Akhristu ake generic angathe azidwala m'mimba, ngati ntchito ndi wothandizila ena antimicrobial. makalasi aliyense wa mankhwala ndi amoxicillin kwambiri N'kutheka kuti amayambitsa kutsekula m'mimba, amene sakhoza ankachitira mothandizidwa ndi peristalsis wopondereza. pochita ndi "loperamide" ndi analogues ake, contraindicated mu m'mimba matenda. Pankhaniyi, matenda otsekula m'mimba oyamba ndi kugwiritsa ntchito "Amoksiklava" ayenera kulandira chithandizo ndi mankhwala.