"Fosfomycin": analogues, malangizo ndi ndemanga

Ngakhale wothandizila antibacterial ndi chiwerengero chachikulu cha mavuto, izo Sizotheka kukana ntchito yawo. Chinthu chachikulu kuti mankhwala anasankhidwa molondola ndi kupereka zotsatira ankafuna.

Mkulu Mwachangu mu mankhwala a matenda losiyana medicament "Fosfomycin". Mankhwala analogues kuchita chimodzimodzi. "Fosfomycin" ndi inakhazikitsa mu mawonekedwe a granules ndi madzi sungunuka ufa anafuna njira, ali lonse sipekitiramu antimicrobial ntchito.

Limagwirira cha zochita za mankhwala

Maantibayotiki mogwira matenda amene chitukuko ndi chifukwa mmene thupi la tizilombo toyambitsa matenda (galamu zabwino ndi galamu zoipa). Zotsatira antimicrobial zimatheka pa ndalama za yogwira mankhwala fosfomycin trometamol. kanthu antibacterial ikuchitika ndi kuphwanya mapangidwe makoma bakiteriya selo.

Pharmacokinetics

Pamene ndende yaikulu ya pophika yogwira, pazipita anati mankhwala ntchito "Fosfomycin 'chili mu madzi a m'magazi. Guide imasonyeza kuti maola 2-2,5 pambuyo malowedwe a mankhwala mu thupi. "Fosfomycin" oyenera makonzedwe parenteral ndi m'kamwa. Mankhwala ingestion, mofulumira odzipereka kwa mundawo m'mimba, ndipo zimafunika ku trometamol fosfomycin. Mayamwidwe mu osiyanasiyana 34% kuti 65% (chakudya kumachepetsa index, mankhwala bwino kumwa madzi chopanda kanthu m'mimba). Pakuti theka miyoyo chofunika 4 hr. Fosfomycin trometamol kwathunthu excreted mu ndowe ndi mkodzo, makamaka ndi impso (pafupifupi 90%).

zikuonetsa

Kawirikawiri "Fosfomycin" analogs medicament akutengedwa pakamwa matenda opatsirana a dongosolo mkodzo. Mankhwala bwinobwino kuchitira cystitis ndi urethritis bakiteriya etiology, bacteriuria yaikulu, nthawi zina amapezeka amayi apakati ndi akhoza alibe kuonekera. Mu nthawi postoperative, izi wothandizila antibacterial kuteteza zikamera wa pathologies opatsirana.

M'majakisoni tikuonera mankhwalawa ambiri matenda obwela ku chiwonongeko mabakiteriya a thupi:

• purulent pleurisy;
• pachimake cystitis;
• pyelonephritis;
• adnexitis;
• septicemia;
• chibayo;
• bronchiectasis;
• m'chiuno matenda.

Zikavuta kuphatikiza chithandizo zotheka, koma pamene "Fosfomycin" ena ntchito mankhwala. Kwenikweni "Fosfomycin" (analogs) ntchito limodzi ndi mankhwala beta-lactam.

Contraindications ndi zofooka

mankhwala si kutumikiridwa pa tilinazo okwera kwa pophika yogwira ndi zigawo wothandiza. mankhwala ali contraindicated odwala omwe ali bwino aimpso (creatinine chilolezo zosakwana 10 mL / min.).

Pamene kuyan'anila "Fosfomycin" ntchito za chiwindi ndi impso ntchito mosamala pa mimba ndi mkaka wa m'mawere - yekha kuyang'aniridwa ndi katswiri.

tingagwire chofunika mankhwala a odwala pansi zaka 5 ndi zaka 75 zakubadwa (ana osaposa zaka 5 "Fosfomycin" zotchulidwa osowa).

Ntchito "Fosfomycin"

Mkati ntchito pellets poyamba kusungunuka mu madzi jakisoni kutenga njira injectable anakonza kuchokera ufa "Fosfomycin" kukonzekera. Analogs, ndipo chida ichi ntchito Mlingo wa analimbikitsa ndi dokotala nawo. Mlingo zimadalira matenda ndi ukulu wake.

malangizo zikutanthauza pazipita mlingo mwachindunji pamene Ingestion: ana - 2 gm patsiku, akuluakulu - magalamu 3 pa tsiku. Mwana angathe kuperekedwa kudzera m'mitsempha zosaposa 100-200 mg / kg pa thupi, wamkulu - osapitirira 2-4 ga Granules kamodzi watenga chopanda kanthu m'mimba kapena maola 2 mutadya. Pankhaniyi chakudya lotsatira n'zotheka osati kale kuposa pambuyo 2 hr. Iwo m'pofunika kuti makhwalawa asanagone pambuyo kutaya chikhodzodzo.

zotsatira zoyipazi

Mankhwala okhala fosfomycin trometamol, analogs cha chida, komanso mankhwala ena aliwonse kungachititse kuti chitukuko cha zochita osafunika. The chisokonezo zotsatirazi kapepala kakuti m'mimba:

• kusintha m'manyi;
• flatulence;
• nseru, kenako anayamba kusanza.

wamanjenje dongosolo nthawi zina anati kuchuluka mantha, chizungulire, kupweteka kwa mutu, munthu nthawi zonse ndikufuna kugona.

The jekeseni kumapweteketsa pa malo jekeseni, kumverera kwa ludzu. Pambuyo utsogoleli wa mankhwala motere ena odwala ndi thrombocytopenia, leukopenia, kwa thupi lawo siligwirizana - anaphylactic mantha, khungu kuyabwa zidzolo, urticaria. Zotsatira zake zoyipa mulinso kuoneka edema zotumphukira, ndi khunyu. Si lilibe chiwonetsero cha zotsatira zina zoyipa.

Mu ambiri osokoneza zochita osafunika ndi yapadera kwambiri. Nkofunika kumamwa kowirikiza madzi, kuwonjezera, m'pofunika kuti agwire mankhwala symptomatic.

Pambuyo akudzizindikiritsa mavuto mankhwala "Fosfomycin" malangizo amaletsa ntchito zina. Doctor mankhwala m'malo izipangidwa.

Kusamala

Izo ziyenera zimachitika chifukwa cha mankhwala ndi zinthu zina. Iwo ali osavomerezeka kutenga "metoclopramide" njira, mwachitsanzo. Kwa. The chifukwa cha ntchito mogwirizana ndi kuchepetsa mphamvu ya "Fosfomycin".

Musawachite mankhwala odwala amene sachedwa mawonetseredwe awo sagwirizana. Monga mankhwala akudutsa mu mkaka wa m'mawere, chithandizo m'nthawi ya kuyamwitsa ayenera anasiya kapena kuchita mosamala.

"Fosfomycin" analogues, ofanana mankhwala akutenga maphunziro. Pa mankhwala, mankhwala sangathe anaphonya, m'pofunika ntchito poona intervals ofanana. Ngati panali chikudutsa mlingo chofunika ayenera kutengedwa ngati (yekha kukachitika kuti si koyenera kumtengera mlingo lotsatira posachedwapa) posachedwapa.

ndemanga Analogs

M'malo mwake, mankhwala "Fosfomycin" ingagwiritsidwe ntchito mankhwala, analogs ndi mankhwala-ofanana. Koma iwo amayenera kusankha dokotala amachitira. Dziwani kuti "Urofosfabol" ndi "Monural" amagwiritsidwa ntchito m'malo monena za zipangizo. Iwo akhoza kukhala ndithu bwinobwino m'malo "Fosfomycin". Analogues ku Ukraine kuperekedwa ndi mankhwala. Mankhwalawa bwino kupirira ntchito ndipo angagwiritsidwe ntchito pofuna kuchiza matenda mofanana "Fosfomycin". Mofanana ndi atumiki antibacterial, iwo ndi zotsatira zina zoyipa. "Urofosfabol", "Monural" watengedwa ndi kusamala kwambiri, chinthu chomwecho chingagwiritsidwe ntchito mankhwala "Fosfomycin". Mnzake mu Russia, umene uli wotchuka - "Monural" komanso "Urofosfabol" sapeza pharmacies.

"Monural" nthawi zambiri zotchulidwa zochizira matenda pachimake thirakiti mkodzo opatsirana zimachitika popanda mavuto chifukwa cha tizilombo atengeke mankhwala. Mankhwala ntchito mu ntchito ndi njira yodziwira. "Urofosfabolom" kuchiza matenda opatsirana ndi yotupa, koma okhawo amene ali tcheru zinthu zake yogwira. Pali options ochepa kuti akhoza m'malo "Fosfomycin". Analogues wa Ukraine ndi Russia ntchito chimodzimodzi.

Reviews amasonyeza kuti "Fosfomycin" sangathe nthawi zonse amapezeka pharmacies, ndipo mtengo wa n'chapatali, osati aliyense angathe kugula. Koma "Monural" nthawi zonse zilipo. Ndi wotsika mtengo koma sachita poipa. Anthu amene analandira "Fosfomycin" zindikirani kuti ali anthu a mtima msanga zokwanira. Komabe, sikuti aliyense amaona mmene positive. Nthawi zina, pofuna kuchiza matenda, m'pofunika kuti asankhe mankhwala wina. Nthawi zina, zochita mbali zidzachitika, mwachitsanzo. K. Thupi la munthu aliyense ali osiyana ndi kuyankha zinthu pano mu kukonzekera mosiyana.