Bisphosphonates - ndichiyani? Bisphosphonates chifukwa kufooka kwa mafupa

dongosolo minofu ndi mafupa amachita imodzi mwa ntchito zikuluzikulu za thupi. Kuti ndi kuthandiza a matupi onse. Bone thanzi amagwira ntchito yofunika kwambiri. Pamene muli mavuto zimfundo, msana, fractures pafupipafupi zimachitika, khalidwe la munthu wa moyo kwambiri yafupika. Mmodzi matenda amenewa omwe kaŵirikaŵiri limodzi ndi zizindikiro amenewa ndi kufooka kwa mafupa.

Ngati nthawi kuwona dotolo, n'zotheka kwambiri kusintha mmene alili. Panopa bisphosphonates ntchito pofuna kuchiza kufooka kwa mafupa. Mankhwalawa angathe kupereka kuchiritsidwa. Tiyeni tiwone mtundu wa mankhwala.

ndi bisphosphonates Kodi

Dzinali, gulu la mankhwala walandira chifukwa cha zomwe zili mu dongosolo la phosphonates awiri. Limagwirira kanthu kogwira chifukwa cha kufanana yaikulu ndi pirofosfonatami yoyipa lalikulu pa malamulo a zili kashiamu mu mafupa.

Ndi kapangidwe zofanana, bisphosphonates ziletsa michere kuti akhoza kuwataya pirofosfonaty. Amaoneka kuti amange kashiamu ayoni ndi amawatunga ku fupa.

The mbali zabwino phwando la mankhwala awa ndi mankhwala okhala bisphosphonates, kokha zotsatira kusankha pa dongosolo chigoba, kumene kudzikundikira calcium.

Chifukwa cha zimenezi mankhwalawa kufooka kwa mafupa n'zotheka kupewa imfa ya kashiamu ndi phosphorous, amene ali ndi ubwino mankhwala.

mitundu ya bisphosphonates

Ambiri sadziwa za bisphosphonates. Ndi chiyani icho? Tsopano anayamba mbadwo wachitatu wa gulu la mankhwala. Madokotala kugwiritsa ntchito mankhwala, ndi mibadwo iwiri yoyambirira. Tsopano mankhwala ambiri analandira muli bisphosphonates, onse a iwo akhoza kugawidwa m'magulu awiri akuluakulu:

1. Zambiri osati munali asafe.
2. Gulu la bisphosphonates, monga asafe - aminobisphosphonates.
   

Kusiyana pakati pa magulu awiri kwagona kuti iwo ndi zotsatira zosiyana pa osteoclasts.

Asafe munali bisphosphonates

Ndi chiyani icho? Ndalama zimenezi mu kapangidwe kake lili popanga mfundo zotsatirazi:

1. Ibandronatovaya asidi wa m'badwo wachitatu, apanga posachedwapa ntchito bwinobwino kwambiri kupewa kufooka kwa mafupa mu akazi, makamaka azimayi amsinkhu umenewu amakumana.
2. Zolendronovaya asidi kusankha amachita pa minofu fupa, ali ndi kutchulidwa odana ndi chotupa tingati. Pamaziko a mankhwala opangidwa mankhwala ichi monga "Zometa", "Zolendronat".
3. Alendronate ndi sodium correctors anafotokoza kuti sanali m'thupi kagayidwe mu minofu fupa, amalimbikitsa mapangidwe moyenera dongosolo fupa.
4. Ibandronate ndi sodium limene kubala "Bonviva", "Boniva", "Bondronat" kumabwezera mmbuyo ntchito osteoclast, koma sikumangotikhudza chiwerengero chawo. Izi bisphosphonates mankhwala kufooka kwa mafupa zimathandiza makamaka ngati wothandizira prophylactic mu akazi azimayi amsinkhu umenewu amakumana.
   

Dziŵani kuti muyenera musalankhule medicate, mankhwala ayenera zotchulidwa dokotala.

bisphosphonates yosavuta

Osati munali asafe mankhwala bisphosphonate chifukwa kufooka kwa mafupa amagwiritsidwa mwakhama ntchito. Njirazi ndi monga:

1. "Etidronate" mu maonekedwe a mapiritsi ndi jekeseni. nthawi zambiri zotchulidwa kufooka kwa mafupa osati kokha, komanso matenda Paget a, hypercalcemia, lomwe limapezeka pa maziko a khansa.
2. "Clodronate" ndi inakhazikitsa mu mawonekedwe a makapisozi, miyala ndi mavutowo. Kugwiritsa kufooka kwa mafupa ndi osteolysis.
3. "Tiludronate" Nthawi zambiri zotchulidwa okha akulu amene amadwala matenda Paget a. Ana, ndi contraindicated.
   

Amakhulupirira kuti magulu awiriwa mankhwala ndi zotsatira zosiyana pa mwamuna ndi thupi wamkazi, kotero madona okongola bwino yosayenera asafe munali mankhwala. Mulimonsemo, kusankha ndi kuchita yekha dokotala.

Efficacy matenda osiyanasiyana

Pali mndandanda wonse wa matenda amene bisphosphonate mankhwala akhoza kukhala ndi zotsatira zabwino.

1. Kufooka kwa mafupa.
2. Myeloma.
3. Deforming osteodystrophy.
4. Pulayimale hyperparathyroidism.
5. Kuphwanya dongosolo la mapangidwe fupa.
6. Pamene fupa metastases.

Aliyense wa zinthu izi zokha dokotala n'kukulemberani mankhwala, mlingo wake ndi nthawi ya ntchito. Chinkhoswe kudzipatsa chithandizo, likhoza kuwononga thupi.

limagwirira kanthu

Popeza bisphosphonates kwa mankhwala kufooka kwa mafupa ndi ambiri chimagwiritsidwa ntchito kwambiri, m'pofunika elucidate limagwirira cha zochita zawo.

maselo onse mu thupi lathu ndi kusinthidwa nthawi, yemweyo tinganene za fupa. Kukunenedwa ndi muyezo wa osteoblasts, amene ali ndi udindo kaphatikizidwe wa minofu yatsopano, ndi osteoclasts ali ndi udindo uwonongedwe. Choncho, BF mwanjira mozizwitsa kungafoole ntchito osteoclasts, ndi zina ngakhale hule limagwirira wa okha.

Akuti pa nthawi ino, asayansi alephera mokwanira muganize momwe angathetsere bisphosphonates chiwonongeko chipika fupa. Amadziwika yekha kuti mankhwala akhoza zolumukizidwa ndi hydroxyapatite mu magawo fupa, potero kusintha fupa kupinda.

Mungathe kuona kuti ngati ntchito kwa nthawi yaitali, kuti khansa mankhwala malangizo amenewa bisphosphonates zochepa zapitazi ntchito pofuna kuchiza kufooka kwa mafupa.

Bisphosphonates metastases

Ndi chitukuko cha khansa akubwera siteji pamene maselo a khansa kusiya chotupa chachikulu ndi kufalitsa thupi lonse. Pa malo atsopano iwo amagwira ndi kuyamba kukula, kupanga metastases.

Minofu fupa nthawi zonse chifukwa kusinthidwa, choncho kumachititsa matenda mwa hematogenous. Pamene maselo a khansa kulowa m'mafupa, iwo kusokoneza interplay yachibadwa pakati osteoclasts ndi osteoblasts, imbaenda nthenda chitukuko cha minofu fupa.

Popeza kudziwa pamaso pa metastasis ndi zovuta, chifukwa mu magawo oyambirira, ndondomeko izi zimachitika pafupifupi popanda zizindikiro, ndi khansara ndidzadutsa bwinobwino kudziwa foci sekondale.

Mwa njira zonse metastases Bisphosphonates ankagwiritsa ntchito. Mankhwalawa ndi mosavuta analekerera ndi odwala, iwo kawirikawiri ndi mavuto.

Iwo akhoza pamodzi radiotherapy ndi mankhwala amphamvu. Pamene ntchito mankhwala anafotokozedwa kuchepetsa kufala kwa fupa metastasis khansa ya m'mawere ndi myeloma angapo.

Pamene akufotokozera hypercalcemia amene ali pafupifupi yachibadwa pa matenda oncological, mankhwala ndi cholinga chachikulu mu mawonekedwe a jekeseni ndi infusions. zotsatira zabwino asonyeza njira monga "Zolendronovaya asidi", "Pamidronate". masiku kale ochepa ukatha mwambo mayesero chithandizo kusonyeza normalizing magazi calcium, ndi mmene ukapitirize kwa masiku angapo.

ayamikira Specific kulandira bisphosphonates

Ngati iwe sunamve za bisphosphonates, chimene icho chiri, uzani adokotala. Kuvomereza mankhwala ayenera kuchitidwa mogwirizana ndi malamulo ena:

• Muyenera kumwa mankhwala pambuyo kudzutsidwa, ola osachepera limodzi musanadye chakudya.
• Sambani pansi ndi madzi ambiri akhale.
• Musagwiritse ntchito zapivaniya zakumwa zina, monga madzi, tiyi, khofi. Iwo kuteteza mayamwidwe bisphosphonates.
• Pambuyo ntchito miyala sanganame pansi, limatenga theka la ola mu malo olungama mphamvu ya kum'mero anali kochepa.
• Iwo ali osavomerezeka kuphatikiza phwando BF ndi kashiamu supplementation, magnesium, chitsulo ndi zotayidwa.

Ngati mutsata onse malangizo awa, bisphosphonate Sindizakubweretsanso zotsatira zapathengo mbali.

Bisphosphonates chifukwa kufooka kwa mafupa: ubwino ndi kuipa

Mankhwalawa bisphosphonates chotchuka ntchito kufooka kwa mafupa. Mankhwalawa amagwiritsidwa ntchito mofanana bwino kwa amuna ndi akazi. Ubwino waukulu wa mankhwala ingakhale monga iyi:

• Iwo lilibe mahomoni.
• Musati amathandiza kuti chitukuko cha matenda a mtima.
• zotupa zilonda ntchito BF osati patsogolo.

Koma mafuta aliyense nthawi zonse n'zotheka kupeza ntchentche mu mafutawo. Bisphosphonates, ngakhale efficacy awo mankhwalawa kufooka kwa mafupa, akadali opanda ungwiro. Kugwiritsa entrainment wa phwando angapereke zotsatirazi mavuto:

• Kusokoneza chiwindi ndi impso.
• Ngati kutumikiridwa m'nsinga, ndi angayambe hypocalcaemia.
• Kungakhale kum'mero kapena m'mimba chilonda.
• Pali totupa pa thupi.
• Mu ena pali ambiri kufooka, malaise, ndiponso nseru.
• Kupweteka minofu.
• mavuto masomphenya.
• Kutsekula m'mimba.
  

Sitingathe kunena kuti zonse zotsatira osafunika ayenera kuonekera yense Wopirira, koma muyenera kudziwa za iwo. Ngati ndinu akuchipatala bisphosphonates, chimene icho chiri, kufotokoza kwa dokotala, iye adzasankha chimodzimodzi mankhwala mlingo ndi nthawi ya mankhwala.

mankhwala oyenera mankhwalawa kufooka kwa mafupa ndi matenda ena. Musanayambe perekani mankhwala, dokotala ali wofunikila kuchita kafukufuku kuti tipeze boma la kagayidwe mu fupa ndi calcium homeostasis, choncho musaganize nokha kuti mankhwala mankhwala mu gulu ili.

Inu muyenera kukhala ndi moyo wathanzi, potsatira malangizo onse a madokotala, kudya bwino kupewa kukhala amachita mankhwala. Only mu nkhani iyi, anu dongosolo chigoba zikhala bwino.